UCSF Institute for Human Genetics


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Laurie Stevison 
Postdoctoral Researcher
University California, San Francisco
lstevison (at) gmail (dot) com

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Laurie S Stevison

My research is focused on understanding the genetic processes involved in species formation. Understanding how species persist in the face of ongoing hybridization has been a major question in evolutionary biology since Darwin, and is best answered by examining populations at the interface of speciation – closely related species known to hybridize. Recent genetic advances have highlighted the pervasiveness of hybridization in many taxa, increasing the number of relevant species for studying this question. Further, dense marker analysis has revealed that genetic exchange between these species is not uniformly distributed across the genome. This work suggests that species persist despite ongoing gene flow due to local genetic barriers that prevent incorporation of hybrid alleles within the genome. My work has examined how chromosomal inversions accomplish this task by reducing recombination rates specifically in hybrid individuals, thus limiting gene flow between species in these inverted segments of the genome. As a result, these regions have higher nucleotide divergence and less evidence of gene flow between species.

One of my other major research interests is understanding the evolution of recombination rate variation within and between species as well as across the genome. Although recombination rates have been shown to vary depending on environmental conditions for over a century now, recombination events were assumed to be uniformly distributed across the genome until about three decades ago. However, we now know that recombination rates are highly variable across taxa and along genomes. My work aims to document this variation in various taxa and understand the evolutionary consequences of this variation, specifically in the context of speciation.

My work has mainly focused on primates and fruit flies, both model systems for understanding evolutionary genetics. In my research, I take a population genetics approach to understanding speciation by looking at both within and between species variation and how that contributes to speciation, facilitates selection, and contributes to recombination rate variation. The data that are generated from these types of questions can also be useful in examining patterns of diversity and selection within species.

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