Research Program

G protein-coupled receptors (GPCRs) represent the largest class of cell surface receptors in the human genome, and they are involved in almost every physiological process in our body such as cardiovascular regulation, immune response, neurotransmission, behavior and mood regulation. About half of the currently prescribed drugs target this class of receptors including those used in congestive heart failure, hypertension, asthma, allergies, schizophrenia, Parkinson's disease and cancer. GPCRs harbor a conserved seven trasmembrane (7TM) architecture and typically signal through heterotrimeric G-proteins and β-arrestins. We have recently characterized a new sub-class of 7TM receptors, referred to as Arrestin-Coupled Receptors (ACRs), that signal through β-arrestins without detectable G-protein coupling. The overarching goal of our laboratory is to understand the activation, signaling and regulation of GPCRs and ACRs, and leverage this information to improve therapeutic manipulation in human diseases. We utilize a combinatorial approach spanning protein biochemistry, receptor pharmacology, cell signaling, chemical biology and structural biology with the aim of developing a holistic understanding of this versatile class of receptors.