Jiadi Xu

Jiadi Xu

Jiadi Xu, Ph.D., is an Assistant Professor of Johns Hopkins University and the preclinical MRI facility manager of Kennedy Krieger Institute. He is a MR physicist who has been working in NMR/MRI technical development for a variety of biological systems, ranging from membrane proteins to animal disease models such as stroke, tumor and Alzheimer’s disease. His current research focuses on the technical development and applications of chemical exchange saturation transfer (CEST) and Magnetization transfer (MT) MRI for monitoring brain protein and metabolism and arterial spin labeling MRI techniques (ASL) for mapping brain vasculature. He has published over 75 preferred papers at well-known journals, such as Science、Journal of the American Chemical Society , Neuroimage, Angewandte Chemie International Edition, Magnetic resonance in medicine. His recent research has been featured as Editor’s Pick for the 2018 MRM Oct. issue. His publications have been cited more than 4040 times with a H-index of 30 (Google Scholar).

Creatine and Phosphocreatine Mapping of Brain and Muscle by CEST

(Abstract)

Phosphocreatine (PCr) and creatine (Cr) plays a vital role in cellular energy buffering and energy transport, particularly in brain and muscle with high and fluctuating energy demands. Non-invasive PCr and Cr mapping techniques are critical to achieve insight into cellular energetics and to evaluate in vivo mitochondrial functions. In this presentation, I will demonstrate the PCr and Cr mapping on brain and muscle using a sensitivity-enhancement magnetic resonance imaging (MRI) approach, chemical exchange saturation transfer (CEST) MRI, on a high-field MRI. Their applications on the stroke and tumor disease models will be covered. At last, I will explore the artificial neural network approach to overcome the challenges of implementing the technique on 3T clinical MRI scanners.