Laboratory of Nanosensor Imaging in Cell Therapy (NICE-Lab)

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2021

  • Jianpan Huang#, Jiadi Xu#, Joseph HC Lai, Zilin Chen, Chi Yan Lee, Koon Ho Chan*, Kannie WY Chan*. Relayed nuclear Overhauser effect weighted (rNOEw) imaging identifies multiple sclerosis. NeuroImage: Clinical 2021, 32: 102867. @Link

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  • Jianpan Huang, Joseph HC Lai, Xiongqi Han, Zilin Chen, Peng Xiao, Yang Liu, Lin Chen, Jiadi Xu*, Kannie WY Chan*. Sensitive schemes for dynamic glucose enhanced (DGE) MRI to detect glucose uptake and clearance in mouse brain at 3 T. NMR in Biomedicine 2021, DOI:10.1002/nbm.4640. @Link

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  • Jianpan Huang#, Joseph HC Lai#, Kai-Hei Tse, Gerald WY Cheng, Yang Liu, Zilin Chen, Xiongqi Han, Lin Chen, Jiadi Xu, Kannie WY Chan*. Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer’s disease at 3 T. Magnetic Resonance in Medicine 2021, DOI: 10.1002/mrm.29044. @Link

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  • Xiongqi Han, Joseph HC Lai, Jianpan Huang, Se Weon Park, Yang Liu, Kannie WY Chan*. Imaging Self-Healing Hydrogels and Chemotherapeutics Using CEST MRI at 3 T. ACS Applied Bio Materials 2021, 4(7): 5605–5616. @Link

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  • Jianpan Huang#, Xiongqi Han#, Lin Chen, Xiang Xu, Jiadi Xu, Kannie WY Chan*. Relayed nuclear Overhauser enhancement (rNOE) imaging with magnetization transfer contrast (MTC) suppression at 3 Tesla. Magnetic Resonance in Medicine 2021, 85(1): 254-267. @Link

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  • Ran Sui#, Lin Chen#, Yuguo Li, Jianpan Huang, Kannie WY Chan, Xiang Xu, Peter CM van Zijl, Jiadi Xu*. Whole‐brain amide CEST imaging at 3T with a steady‐state radial MRI acquisition. Magnetic Resonance in Medicine 2021, 86(2): 893-906. @Link

2020

  • Jianpan Huang, Peter CM van Zijl, Xiongqi Han, Celia M Dong, Gerald WY Cheng, Kai-Hei Tse, Linda Knutsson, Lin Chen, Joseph HC Lai, Ed X Wu, Jiadi Xu*, Kannie WY Chan*, Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI. Science Advances 2020, 6: eaba3884. @Link

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  • Xiongqi Han, Jianpan Huang, Anthea KW To, Joseph HC Lai, Peng Xiao, Ed X Wu, Jiadi Xu, Kannie WY Chan*. CEST MRI detectable liposomal hydrogels for multiparametric monitoring in the brain at 3T. Theranostics 2020, 10(5): 2215-2228. @Link

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  • Jianpan Huang, Lin Chen, Kannie WY Chan, Congbo Cai, Shuhui Cai, Zhong Chen. Super-resolved water/fat image reconstruction based on single-shot spatiotemporally encoded MRI. Journal of Magnetic Resonance 2020, 314: 106736. @Link

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  • Lin Chen, Michael Schar, Kannie WY Chan, Jianpan Huang, Zhiliang Wei, Hanzhang Lu, Qin Qin, Robert Weiss, Peter CM van Zijl, Jiadi Xu. In vivo imaging of phosphocreatine with artificial neural networks. Nature Communications 2020, 11(1): 1072. @Link

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  • Lin Chen, Zhiliang Wei, Kannie WY Chan, Yuguo Li, Kapil Suchal, Sheng Bi, Jianpan Huang, Xiang Xu, Philip C Wong, Hanzhang Lu, Peter CM van Zijl, Tong Li, Jiadi Xu. D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI. Journal of Cerebral Blood Flow & Metabolism 2021, 41(5): 1013-1025. @Link

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  • Guohua Wen, Xiaozhen Li, Yachao Zhang, Xiongqi Han, Xiayi Xu, Chao Liu, Kannie WY Chan, Chun-Sing Lee, Chao Yin*, Liming Bian*, and Lidai Wang*. Effective Phototheranostics of Brain Tumor Assisted by Near-Infrared-II Light-Responsive Semiconducting Polymer Nanoparticles. ACS Applied Materials & Interfaces 2020, 12(30): 33492-33499. @Link

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  • Zhengyi Mao, Kunkun Zhu, Lulu Pan, Guo Liu, Tao Tang, Yunhu He, Jianpan Huang, Jinlian Hu, Kannie WY Chan*, Jian Lu*. Direct‐Ink Written Shape‐Morphing Film with Rapid and Programmable Multimotion. Advanced Materials Technologies 2020, 5: 1900974. @Link

2019

  • X. Xu, J. Xu, K. W. Y. Chan, J. Liu, H. Liu, Y. Li, L. Chen, G. Liu, P. C. van Zijl. GlucoCEST imaging with on‐resonance variable delay multiple pulse (onVDMP) MRI. Magn. Reson. Med. 2019:81(1):47-56. @Link

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  • Z. Chen, Y. Li, R. Airan, Z. Han, J. Xu, K. W. Y. Chan, Y. Xu, J. W. Bulte, P. C. Van Zijl, M. T. McMahon. CT and CEST MRI bimodal imaging of the intratumoral distribution of iodinated liposomes. Quant. Imag. Med. Surg. 2019:9(9):1579. @Link

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  • X. Xu, J. Xu, L. Knutsson, J. Liu, H. Liu, Y. Li, B. Lal, J. Laterra, D. Artemov, G. Liu, P. C. van Zijl, K. W. Y. Chan*. The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma. Magn. Reson. Med. 2019:81(6):3798-3807. @Link

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  • L. Chen, Z. Wei, K. W. Y. Chan, S. Cai, G. Liu, H. Lu, P. C. Wong, P. C. van Zijl, T. Li, J. Xu. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. NeuroImage 2019:188:380-390. @Link

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  • J. Ren, J. Li, Y. Li, P. Xiao, Y. Liu, C. M. Tsang, S. W. Tsao, D. Lau, K. W. Y. Chan*, R. H. Lam*. Elasticity-modulated microbeads for classification of floating normal and cancer cells using confining microchannels. ACS Biomater. Sci. Eng. 2019:5(8):3889-3898. @Link

2018 - 2016

  • L. Chen, X. Xu, H. Zeng, K. W. Y. Chan, N. Yadav, S. Cai, K. J. Schunke, N. Faraday, P. C. van Zijl, J. Xu. Separating fast and slow exchange transfer and magnetization transfer using off‐resonance variable‐delay multiple‐pulse (VDMP) MRI. Magn. Reson. Med. 2018:80(4):1568-1576. @Link

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  • Y. Li, Y. Qiao, H. Chen, R. Bai, V. Staedtke, Z. Han, J. Xu, K. W. Y. Chan, N. Yadav, J. W. Bulte. Characterization of tumor vascular permeability using natural dextrans and CEST MRI. Magn. Reson. Med. 2018:79(2):1001-1009. @Link

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  • Y. Li, Y. Qiao, H. Chen, R. Bai, V. Staedtke, Z. Han, J. Xu, K. W. Y. Chan, N. Yadav, J. W. M. Bulte, S. Zhou, P. C. M. van Zijl. G. Liu. Characterization of tumor vascular permeability using natural dextrans and CEST MRI. Magn. Reson. Med. 2018:79:1001-1009. @Link

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  • J. Xu, K. W. Y. Chan*, X. Xu, N. Yadav, G. Liu, P. C. M. van Zijl. (*, authors contributed equally) On-resonance variable delay multipulse scheme for imaging of fast-exchanging protons and semisolid macromolecules. Magn. Reson. Med. 2017:77:730-739. (PMID:26900759) @Link

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  • K. W. Y. Chan, L. Jiang, M. Cheng, J. P. Wijnen, G. Liu, P. C. M. van Zijl, M. T. McMahon, K. Glunde. CEST-MRI detects metabolite levels for monitoring breast cancer cell aggressiveness and chemotherapy response. NMR Biomed. 2016:29:806-816. (PMID: 27100284) @Link

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  • L. Liang, W. Chen, K. W. Y. Chan, Y. Li, B. Zhang, C. Liang, G. Liu, S. Zhang. Using intravoxel incoherent motion MR imaging to study the renal pathophysiological process of contrast-induced acute kidney injury in rats: comparison with conventional DWI and arterial spin labeling. Eur. Radiol. 2016:26:1597-1605 (PMID:26373761) @Link

2015

  • X. Xu, N. Yadav, L. Knutsson, J. Hua, R. Kalyani, E. Hall, J. Laterra, J. Blakeley, R. Strowd, M. Pomper, P. Barker, K. W. Y. Chan, G. Liu, M. T. McMahon, R. D. Stevens, P. C. M. van Zijl. Dynamic glucose-enhanced (DGE) MRI: translation to human scanning and first results in glioma patients. Tomography 2015:2:105-114. (PMID: 26779568) @Link

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  • Y. Li, H. Chen, J. Xu, N. N. Yadav, K. W. Y. Chan, L. Luo, M. T. McMahon, B. Vogelstein, P. C. M. van Zijl, S. Zhou, G. Liu. CEST theranostics: label-free MR imaging of anticancer drugs. Oncotarget 2015:7:6369-6378. (PMID:26837220) @Link

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  • X. Xu*, K. W. Y. Chan*, L. Knutsson, D. Artemov, J. Xu, G. Liu, Y. Kato, B. Lal, J. Laterra, M. T. McMahon, P. C. M. van Zijl. (*, authors contributed equally) Dynamic glucose enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in brain cancer. Magn. Reson. Med. 2015:74:1556-1563. (PMID: 26404120) @Link

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  • A. Bar-Shir, Y. Liang, K. W. Y. Chan, A. A. Gilad, J. W. M. Bulte. Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging. Chem. Commun. 2015:51:4869-4871. (PMID: 25697683; ISSN: 1359-7345) @Link

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  • N. Oskolkov, A. Bar-Shir, K. W. Y. Chan, X. Song, P. C. M. van Zijl, J. W. M. Bulte, A. A. Gilad, M. T. McMahon. Biophysical characterization of human protamine-1 as a responsive CEST MR contrast agent. ACS Macro. Lett. 2015:4:34-38. (PMID: 25642384; ISSN: 2161-1653) @Link

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  • T. Yu*, K. W. Y. Chan*, A. Anonuevo, X. Song, B. S. Schuster, S. Chattopadhyay, Q. Xu, N. Oskolkov, H. Patel, L. M. Ensign, P. C. M. van Zjil, M. T. McMahon, J. Hanes. (*, authors contributed equally) Liposomal mucus-penetrating particles (MPP) for efficient mucosal delivery and intravaginal diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI). Nanomedicine: Nanotechnology, Biology and Medicine 2015:11:401-405. (PMID: 25461289) @Link

2014

  • N. N. Yadav, J. Xu, A. Bar-Shir, Q. Qin, K. W. Y. Chan, K. Grgac, W. Li, M. T. McMahon. Natural D-glucose as a biodegradable MRI relaxation agent. Magn. Reson. Med. 2014:72:823-828. (PMID:24975029; ISSN: 0740-3194) @Link

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  • K. W. Y. Chan, G. Liu, P. C. M. van Zijl, J. W. M. Bulte, M. T. McMahon. Magnetization transfer contrast MRI for non-invasive assessment of innate and adaptive immune responses against alginate-encapsulated cells. Biomaterials 2014:53:7811-7818. (PMID:24930848; PMCID:PMC4112286; ISSN: 0142-9612) @Link

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  • K. W. Y. Chan, T. Yu, Y. Qiao, Q. Liu, M. Yang, H. Patel, G. Liu, K. W. Kinzler, B. Vogelstein, J. W. Bulte, P. C. M. van Zijl, J. Hanes, S. Zhou, M. T. McMahon. A diaCEST MRI approach for monitoring liposomal accumulation in tumors. J Control. Release 2014:180:51-59. (PMID: 24548481; PMCID:PMC4000735; ISSN: 0168-3659) @Link

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  • K. W. Y. Chan, J. W. M. Bulte, M. T. McMahon. Diamagnetic chemical exchange saturation transfer (diaCEST) liposomes: physicochemical properties and imaging applications. WIREs Nanomed. Nanobiotech. 2014:6:111-124. (PMID:24339357; PMCID:PMC3971518; ISSN: 0168-3659) @Link

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  • G. Liu, Q. Qin, K. W. Y. Chan, J. W. M. Bulte, M. T. McMahon, P. C. M. van Zijl, A. A. Gilad. Non-invasive temperature mapping using temperature-responsive water saturation shift referencing (T-WASSR) MRI. NMR Biomed. 2014:27:320-331. (PMID:24395616; PMCID:PMC3989428; ISSN: 0952-3480; 1099-1492) @Link

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  • ​A. Bar-Shir, G. Liu, K. W. Y. Chan, N. Oskolkov, X. Song, N. N. Yadav, P. Walczak, M. T. McMahon, P. C. M. van Zijl, J. W. M. Bulte, A. A. Gilad. Human Protamine-1 as an MRI Reporter Gene Based on Chemical Exchange. ACS Chem. Biol. 2014:9:134-138. (PMID:24138139; PMCID:PMC3985336; ISSN: 0002-7863) @Link

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  • J. Xu, N. N. Yadav, A. Bar-Shir, C. K. Jones, K. W. Y. Chan, J. Zhang, P. Walczak, M. T. McMahon, P. C. M. van Zijl. Variable delay multi-pulse train for fast chemical exchange saturation transfer and relayed-nuclear overhauser enhancement MRI. Magn. Reson. Med. 2014:71:1798-1812. (PMID: 23813483; PMCID: PMC3883792; ISSN: 1522-2594) @Link

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  • M. Yang, T. Yu, Y. Y. Wang, S. K. Lai, Q. Zeng, B. Miao, B. C. Tang, B. W. Simons, L. M. Ensign, G. Liu, K. W. Y. Chan, C. Y. Juang, O. Mert, J. Wood, J. Fu, M. T. McMahon, T. C. Wu, C. F. Hung, J. Hanes. Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth. Adv. Healthc. Mater. 2014:3:1044-1052. (PMID: 24339398; ISSN: 2192-2640 ) @Link

2013

  • K. W. Y. Chan, G. Liu, X. Song, H. Kim, T. Yu, D. R. Arifin, A. A. Assaf, J. Hanes, P. Walczak, P. C. M. van Zijl, J. W. M. Bulte, M. T. McMahon. MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability. Nat. Mater. 2013:12:268-275. (PMID:23353626; PMCID:PMC3578129; ISSN: 1476-1122)(Impact factor: 39.737; Citation: 77/94; Highly cited, Web of Science in 2015) @Link

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  • G. Liu, K. W. Y. Chan, X. Song, J. Zhang, A. A. Gilad, J. W. M. Bulte, P. C. M. van Zijl, M. T. McMahon. NOrmalized MAgnetization Ratio (NOMAR) Filtering for Creation of Tissue Selective Contrast Maps. Magn. Reson. Med. 2013:69:516-523. (PMID: 22499503; PMCID: PMC3404207; ISSN: 0740-3194) @Link

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  • N. N. Yadav, K. W. Y. Chan, C. K. Jones, M. T. McMahon, P. C. M. van Zijl. Time domain removal of irrelevant magnetization in chemical exchange saturation transfer Z-spectra. Magn. Reson. Med. 2013:70:547-555. (PMID: 23798323; PMCID: PMC3742390; ISSN: 0740-3194) @Link

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  • A. Bar-Shir, A. A. Gilad, K. W. Y. Chan, G. Liu, P. C. M. van Zijl, J. W. M. Bulte, M. T. McMahon. Metal ion sensing using ion chemical exchange saturation transfer (iCEST)-19F MRI. J Am. Chem. Soc. 2013:135:12164-12167. (PMID: 23905693; PMCID: PMC3786336; ISSN: 0002-7863) @Link

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  • G. Liu, C. Bettegowda, Y. Qiao, V. Staedtke, K. W. Y. Chan, R. Bai, Y. Li, G. J. Riggins, K. W. Kinzler, J. W. M. Bulte, M. T. McMahon, A. A. Gilad, B. Vogelstein, S. Zhou, P. C. M. van Zijl. Noninvasive imaging of infection after treatment with tumor-homing bacteria using chemical exchange saturation transfer (CEST) MRI. Magn. Reson. Med. 2013:70:1690-1698. (PMID: 24123389; PMCID: PMC3857583; ISSN: 0740-3194; 1522-2594) @Link

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  • G. Liu, X. Song, K. W. Y. Chan, M. T. McMahon. Nuts and bolts of chemical exchange saturation transfer MRI. NMR Biomed. 2013:26:810-828. (PMID: 23303716; PMCID:PMC4144273; ISSN: 0952-3480) @Link

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  • D. R. Arifin, D. A. Kedziorek, Y. Fu, K. W. Y. Chan, M. T. McMahon, C. R. Weiss, D. L. Kraitchman, J. W. M. Bulte. Microencapsulated cell tracking. NMR Biomed. 2013:26:850-859. (PMID: 23225358; PMCID: PMC3655121; ISSN: 0952-3480) @Link

2012 - 2010

  • K. W. Y. Chan, M. T. McMahon, Y. Kato, G. Liu, J. W. M. Bulte, Z. M. Bhujwalla, D. Artemov, P. C. M. van Zijl. Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn. Reson. Med. 2012:68:1764-1773. (PMID: 21919523; PMCID: PMC3201833; ISSN: 0740-3194) @Link

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  • G. Liu, M. Moake M, Y-e Har-el, C. M. Long, K. W. Y. Chan, A. Cardona A, et al. In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes. Magn. Reson. Med. 2012:67:1106-1113. (PMID: 22392814; PMCID: PMC3522097; ISSN: 0740-3194) @Link

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  • G. Liu, Y. Liang, A. Bar-Shir, K. W. Y. Chan, C. S. Galpoththawela, S. M. Bernard, T. Tse, N. N. Yadav, P. Walczak, M. T. McMahon, J. W. M. Bulte, P. C. M. van Zijl, A. A. Gilad. Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer MRI contrast agent. J Am. Chem. Soc. 2011:133:16326-16329. (PMID: 21919523; PMCID: PMC3201833; ISSN: 0002-7863) @Link

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  • X. Song, K. W. Y. Chan, M. T. McMahon. Screening of CEST MR contrast agents. In vivo NMR Imaging: Methods and Protocols. Methods Mol Biol. 2011:771:171-87. (PMID: 21874478; PMCID:PMC3971516; ISSN: 1064-3745) @Link

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  • A. M. Chow, K. W. Y. Chan, S. J. Fan, J. Yang, J. S. Cheung, P. L. Khong, E. X. Wu, In vivo proton magnetic resonance spectroscopy of hepatic ischemia/reperfusion injury in an experimental model. Acad. Radiol. 2011:18:246-252. (PMID: 21111640; ISSN: 1076-6332) @Link

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  • A. M. Chow, I. Y. Zhou, S. J. Fan, K. W. Y. Chan, K. C. Chan, E. X. Wu, Metabolic changes in visual cortex of neonatal monocular enucleated rat: a proton magnetic resonance spectroscopy study. Int. J Dev. Neurosci. 2011:29:25-30. (PMID: 20950681; 0736-5748 ) @Link

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  • K. W. Y. Chan, A. M. Chow, K. C. Chan, J. Yang, E. X. Wu, Magnetic resonance spectroscopy of the brain under mild hypothermia indicates changes in neuroprotection-related metabolites. Neurosci. Lett. 2010:475:150-155. (PMID: 20362032; ISSN: 0304-3940) @Link

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  • A. M. Chow, K. W. Y. Chan, J. S. Cheung, E. X. Wu, Enhancement of gas-filled microbubble R2* by iron oxide nanoparticles for MRI. Magn. Reson. Med. 2010:63:224-229. (PMID: 19953509; ISSN: 0740-3194) @Link

2007 - 2002

  • K. W. Y. Chan, W. T. Wong, Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging. Coord. Chem. Rev. 2007:251:2428-2451. (ISSN: 0010-8545) @Link

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  • K. W. Y. Chan, S. Barra, M. Botta, W. T. Wong, Novel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents. J. Inorg. Biochem. 2003:98:677-682. (ISSN: 0162-0134 ) @Link

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  • C. Li, K. W. Y. Chan, L. Szeto, N,N’-Bis(tert-butoxycarbonyl)thiourea. Acta Cryst. 2003:E59:366-368. (ISSN: 1600-5368 ) @Link

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  • K. W. Y. Chan, W. T. Wong, 2-Hydroxy-3-(p-nitrobenzenesulfonylamino)-propylammonium p-nitrobenzenesulfonate. Acta Cryst. 2002:E58:1048-1050. (ISSN: 1600-5368) @Link

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  • K. W. Y. Chan, C. Yang, L. Szeto, Cyclo-bis(2-methylsulfanylmethyl-6-([1,3,4]thiadiazol-2-ylsulfanylmethyl)pyridinium) perchlorate. Acta Cryst. 2002:E58:1277-1279. (ISSN: 1600-5368 ) @Link