*: CA or equal contributions
[J50]
[J49] Utility of in vitro assay data in read-across prediction of nongenotoxic carcinogenicity of pesticides for cytotoxicity-related rat tumors,
Food and Chemical Toxicology, 202 (2025), 115566.
Kosuke Mizuno, Jun-ichi Takeshita, Yu Harakawa, Takuomi Hosaka, Ryota Shizu, and Kouichi Yoshinari
[J48] Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates,
Toxicology in Vitro, 107 (2025), 106075.
Shunnosuke Kaito, Kiyomi Sato, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, Jun-ichi Takeshita, and Kouichi Yoshinari
[J47] The degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs,
Scientific Reports, 15 (2025), 3514.
Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Toshiki Morimoto, Yasuyuki Higashi, Ke-Yong Wang, Hidenori Higashi, Takuma Kojima, Kazuo Sakurai, Jun-ichi Takeshita, Akihiro Moriyama, Kei Yamasaki, Kazuhiro Yatera, and Yasuo Morimoto
doi:10.1038/s41598-025-87174-6
[J46] Inhalation exposure to cross-linked polyacrylic acid induces pulmonary disorders,
Toxicology, 510 (2025), 154001.
Yasuyuki Higashi, Chinatsu Nishida, Hiroto Izumi, Kazuma Sato, Naoki Kawai, Taisuke Tomonaga, Toshiki Morimoto, Kei Yamasaki,
Ke-Yong Wang, Hidenori Higashi, Akihiro Moriyama, Jun-ichi Takeshita, Takuma Kojima, Kazuo Sakurai, Kazuhiro Yatera, and Yasuo Morimoto
[J45] A model and method for analyzing the precision of binary measurement methods based on beta-binomial distributions, and related statistical tests,
Quality and Quantity, 59 (2024), 1323-1352.
Jun-ichi Takeshita and Tomomichi Suzuki
doi:10.1007/s11135-024-01998-4, arXiv:2008.13619
[J44] Comprehensive analysis of the toxicity-related findings from repeated-dose subacute toxicity studies of industrial chemicals in male rats,
Critical Reviews in Toxicology, 54(10) (2024), 996-1010.
Jun-ichi Takeshita, Yoshitaka Goto, Shinji Yamamoto, Takamitsu Sasaki, and Kouichi YoshinariTomomichi Suzuki
doi:10.1080/10408444.2024.2427221
[J43] Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury,
Xenobiotica, 54(7) (2024), 411-419.
Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, and Kouichi Yoshinari
doi:10.108/000498254.2024.2312505
[J42] A network-based trans-omics approach for predicting synergistic drug combinations,
Communications Medicine, 4(1) (2024), 154.
Midori Iida, Yurika Kuniki, Kenta Yagi, Mitsuhiro Goda, Satoko Namba1, Jun-ichi Takeshita, Ryusuke Sawada, Michio Iwata, Yoshito Zamami, Keisuke Ishizawa, Yoshihiro Yamanishi
doi:10.1038/s43856-024-00571-2
[J41] Intratracheal instillation of polyacrylic acid induced pulmonary fibrosis with elevated transforming growth factor-β1 and connective tissue growth factor,
Toxicology, 506 (2024), 153845.
Yasuyuki Higashi, Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Naoki Kawai, Toshiki Morimoto, Kanako Hara, Kei Yamasaki, Akihiro Moriyama, Jun-ichi Takeshita, Ke-Yong Wang, Hidenori Higashi, Ryohei Ono, Kazuki Sumiya, Kazuo Sakurai, Kazuhiro Yatera, and Yasuo Morimoto
[J40] The effects of endoplasmic reticulum stress via intratracheal instillation of water-soluble acrylic acid polymer on the lungs of rats,
International Journal of Molecular Sciences, 25(7) (2024), 3573
Toshiki Morimoto, Hiroto Izumi, Tomonaga Taisuke, Chinatsu Nishida, Naoki Kawai, Yasuyuki Higashi, Ke-Yong Wang, Ryohei Ono, Kazuki Sumiya, Kazuo Sakurai, Akihiro Moriyama, Jun-ichi Takeshita, Kei Yamasaki, Kazuhiro Yatera, and Yasuo Morimoto
[N13] 非線形解析学と凸解析学の研究：Palais-Smale 列の収束性と大域的最適化,
京都大学数理解析研究所講究録, 2274 (2024), 116-225.
竹下潤一
[J39] DIRECTEUR: Transcriptome-based prediction of small molecules that replace transcription factors for direct cell conversion,
Bioinformatics,40(2) (2024), btae048
Momoko Hamano, Toru Nakamura, Ryoku Ito, Yuki Shimada, Michio Iwata, Jun-ichi Takeshita, Ryohei Eguchi, and Yoshihiro Yamanishi
doi:10.1093/bioinformatics/btae048
[J38] Graph reliability evaluation via random 𝐾-out-of-𝑁 systems,
Communications in Statistics - Theory and Methods, 53(3) (2024), 1024-1034
Hiroaki Mohri* and Jun-ichi Takeshita*
doi:10.1080/03610926.2022.2099897, arXiv:2105.02401
[J37] Quantifying the effect of isolation and negative certification on COVID-19,
Scientific Reports, 3(1) (2023), 11264.
Jun-ichi Takeshita, Michio Murakami, Masashi Kamo, Wataru Naito Tetsuo Yasutaka, and Seiya Imoto
doi:10.1038/s41598-023-37872-w, medRxiv
[N12] 化学構造情報とインビトロ試験データを活用した客観的なリードアクロス手法の開発に向けた取り組み,
日本化学会情報化学部会誌(CICSJ Bulletin), 41(1) (2023), 11−15
吉成浩一, 竹下潤一
[N11] リードアクロスによる毒性予測研究の現状と課題（巻頭言）,
日本化学会情報化学部会誌(CICSJ Bulletin), 41(1) (2023), 1．
竹下潤一
[N10] インビボ毒性試験データベースを用いた反復投与毒性のインシリコ予測,
In:『ケモインフォマティクスにおけるデータ収集の最適化と解析手法』, pp.498-511, 2023, 技術情報協会, 東京.
竹下潤一，吉成浩一
[J36] Catastrophic failure and cumulative damage models involving two types of extended exponential distributions,
International Journal of Reliability, Quality and Safety Engineering, 29(04) (2022), 2141004.
Hiroaki Mohri* and Jun-ichi Takeshita*
doi:10.1142/S0218539321410047, arXiv:2109.08546
[J35] Crosslinked structure of polyacrylic acid affects pulmonary fibrogenicity in rats,
International Journal of Molecular Sciences, 23(22) (2022), 13870.
Taisuke Tomonaga, Chinatsu Nishida, Hiroto Izumi, Naoki Kawai, Ke-Yong Wang, Hidenori Higashi, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Yuki Hata, Kazuo Sakurai, Toshiki Morimoto, Yasuyuki Higashi, Kei Yamasaki, Kazuhiro Yatera, and Yasuo Morimoto
[J34] Small compound-based direct cell conversion with combinatorial optimization of pathway regulations,
Bioinformatics, 38(Supplement_2) (2022), ii99-ii105.
Toru Nakamura, Michio Iwata, Momoko Hamano, Ryohei Eguchi, Jun-ichi Takeshita, and Yoshihiro Yamanishi
doi:10.1093/bioinformatics/btac475
[J33] Effect of different molecular weights of polyacrylic acid on rat lung following intratracheal instillation,
International Journal of Molecular Sciences, 23(18) (2022), 10345.
Chinatsu Nishida, Hiroto Izumi, Taisuke Tomonaga, Ke-Yong Wang, Hidenori Higashi, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Yuki Hata, Kazuo Sakurai, Yasuyuki Higashi, Kei Yamasaki, Kazuhiro Yatera, and Yasuo Morimoto
[J32] COVID-19 testing systems and their effectiveness in small, semi-isolated groups for sports events,
PLoS One, 17(3) (2022), e0266197.
Masashi Kamo, Michio Murakami, Wataru Naito, Jun-ichi Takeshita, Tetsuo Yasutaka, and Seiya Imoto
doi:10.1371/journal.pone.0266197, medRxiv
[C3] Proficiency testing with ordinal categorical data,
In Series on Advances in Mathematics for Applied Sciences, Advanced Mathematical and Computational Tools in Metrology and Testing Vol XII, 2022, pp. 406–417.
Tomomichi Suzuki, Momoko Isono, and Jun-ichi Takeshita
doi:10.1142/9789811242380_0025
[J31] Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation,
Particle and Fibre Toxicology, 19 (2022), 8.
Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Hidenori Higashi, Toru Ishidao, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto
doi:10.1186/s12989-022-00448-z
[J30] Measurement precision with ordinal categorical data considering dose-response relationships,
Total Quality Science, 7(1) (2022), 31–41.
Sunsuke Tanigaki, Jun-ichi Takeshita, Shizu Itaka, and Tomomichi Suzuki
[J29] Association between in vitro unclear receptor activating profiles of chemical compounds and their in hepatotoxicity in rats,
Journal of Toxicological Sciences, 46(12) (2021), 569–587.
Susumu Kodama, Nao Yoshii, Nao Yoshii, Akihiro Ota, Jun-ichi Takeshita, Kouichi Yoshinari, and Atsushi Ono
[J28] Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model,
Food and Chemical Toxicology, 157 (2021), 112547.
Takaho Asai, Jun-ichi Takeshita, Yuki Shimizu, Yoshihiro Tochikubo, Ryota Shizu, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari
[I1] ISO/TR 27877:2021, Statistical analysis for evaluating the precision of binary measurement methods and their results,
ISO/TC69/SC6
[J27] Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs,
PLoS One, 16(6) (2021), e0253855.
Yuki Shimizu, Takamitsu Sasaki, Jun-ichi Takeshita, Michiko Watanabe, Ryota Shizu, Takuomi Hosaka, and Kouichi Yoshinari
doi:10.1371/journal.pone.0253855
[J26] Classification of chemical compounds based on the correlation between in vitro gene expression profile,
Bulletin of Informatics and Cybernetics, 53(4) (2021), 1–14.
Jun-ichi Takeshita, Akinobu Toyoda, Hidenori Tani, Yasunori Endo, and Sadaaki Miyamoto
doi:10.5109/4476055, arXiv:2101.01837
[C2] Analysis of measurement precision experiment with ordinal categorical variables,
In International Workshop on Intelligent Statistical Quality Control, ISQC 2019: Frontiers in Statistical Quality Control 13, 2021, pp. 303–315.
Tomomichi Suzuki, Jun-ichi Takeshita, Mayu Ogawa, Xiao-Nan Lu, and Yoshikazu Ojima
doi:10.1007/978-3-030-67856-2_17
[J25] Effect of disclosing the relation between effort and unit reliability on system reliability: An economic experiment,
PLoS One, 16(4) (2021), e0249722.
Ryoji Makino, Kenji Akai, Jun-ichi Takeshita, Takanori Kudo, and Keiko Aoki
doi:10.1371/journal.pone.0249722
[J24] Association of CYP1A1 and CYP1B1 inhibition in vitro assays with drug-induced liver injury,
The Journal of Toxicological Science, 46(4) (2020), 167–176.
Yuki Shimizu, Takamitsu Sasaki, Eri Yonekawa, Hirokazu Yamazaki, Rui Ogura, Michiko Watanabe, Takuomi Hosaka, Ryota Shizu, Jun-ichi Takeshita, and Kouichi Yoshinari
doi:10.2131/jts.46.167，※ 2022年度日本毒性学会田邉賞受賞
[J23] Predictive biomarkers for the ranking of pulmonary toxicity of nanomaterials,
Nanomaterials, 10(10) (2020), 2032.
Chinatsu Nishida, Hiroto Izumi, Taisuke Tomonaga, Jun-ichi Takeshita, Ke-Yong Wang, Kei Yamasaki, Kazuhiro Yatera, and Yasuo Morimoto
[J22] Inter-laboratory comparison of pulmonary lesions induced by intratracheal instillation of NiO nanoparticle in rats: Histopathological examination results,
Journal of Occupational Health, 62(1) (2020), e12117.
Hideki Senoh, Hirokazu Kano, Masaaki Suzuki, Shoji Fukushima, Yutaka Oshima, Toshio Kobayashi, Yasuo Morimoto, Hiroto Izumi, Yasushi Ohta, Hiroshi Takehara, Takamasa Numano, Mayumi Kawabe, Masashi Gamo, Jun-ichi Takeshita
[J21] Application of cytochrome P450 reactivity on the characterization of chemical compounds and its association with repeated-dose toxicity,
Toxicology and Applied Pharmacology, 288 (2020), 114854.
Michiko Watanabe, Takamitsu Sasaki, Jun-ichi Takeshita, Madoka Kushida, Yuki Shimizu , Hitomi Oki, Yoko Kitsunai, Haruka Nakayama, Hitomi Saruhashi, Rui Ogura, Ryota Shizu, Takuomi Hosaka, and Kouichi Yoshinari
doi:10.1016/j.taap.2019.114854
[P5] Analysis of measurement precision experiment with categorical variables,
In Proceedings of XIIIth International Workshop on Intelligent Statistical Quality Control 2019, 2019, pp. 249–260.
Tomomichi Suzuki, Jun-ichi Takeshita, May Ogawa, Xiao-Nan Lu, and Yoshikazu Ojima
doi:10.1007/978-3-030-67856-2_17
[P4] Designing a measurement precision experiment considering distribution of estimated precision measures,
In Journal of Physics: Conference Series, 2018, p. 212045.
Tomomichi Suzuki, Jun-ichi Takeshita, Junya Ono, Lu Xiao-Nan
doi:10.1088/1742-6596/1065/21/212015
[C1] Application of ISO 5725 to evaluate measurement precision of distribution within the lung after intratracheal administration,
In Series on Advances in Mathematics for Applied Sciences, Advanced Mathematical and Computational Tools in Metrology and Testing Vol XI, 2018, pp. 357–364.
Jun-ichi Takeshita, Junya Ono, Tomomichi Suzuki, Hirokazu Kano, Yutaka Oshima, Yasuo Morimoto, Hiroshi Takehara, Takamasa Numano, Katsuhide Fujita, Naohide Shinohara, Kazuhiro Yamamoto, Kazumasa Honda, Shoji Fukushima, and Masashi Gamo
doi:10.1142/9789813274303_0036
[P3] Analysis of damage induced by two types of shocks,
In Proceedings of the 24th ISSAT International Conference on Reliability & Quality in Design, 2018, pp. 147–150.
Hiroaki Mohri* and Jun-ichi Takeshita*
ISBN:978-099105765-8
[J20] Discriminative models using molecular descriptors for predicting increased serum ALT levels in repeated-dose toxicity studies of rats,
Computational Toxicology, 6 (2018), 64–70.
Jun-ichi Takeshita, Haruka Nakayama, Yoko Kitsunai, Hitomi Oki, Takamitsu Sasaki, and Kouichi Yoshinari
doi:10.1016/j.comtox.2017.05.002
[N9] 化学物質の反復投与毒性予測手法開発の現状と課題，
日本化学会情報化学部会誌(CICSJ Bulletin), 36(3) (2018), 47-50．
吉成浩一, 佐々木崇光, 渡邉美智子, 橘内陽子, 竹下潤一
[J19] Effect of methyl 𝑝-hydroxybenzoate on the culture of mammalian cells,
Drug Discovery & Therapeutics, 11(5) (2017), 276–280.
Hidenori Tani, Jun-ichi Takeshita, Hiroshi Aoki, Kaoru Nakamura, Ryosuke Abe, Akinobu Toyoda, Yasunori Endo, Sadaaki Miyamoto, Masashi Gamo, Masaki Torimura, and Hiroaki Sato
[J18] Identification of RNA biomarkers for chemical safety screening in mouse embryonic stem cells using RNA deep sequencing analysis,
PLoS One, 12(7) (2017), e0182032.
Hidenori Tani, Jun-ichi Takeshita, Hiroshi Aoki, Kaoru Nakamura, Ryosuke Abe, Akinobu Toyoda, Yasunori Endo, Sadaaki Miyamoto, Masashi Gamo, Hiroaki Sato, and Masaki Torimura
[J17] 化学物質代替に伴うリスクトレードオフ評価の枠組みの開発—相対比較によるリスク評価 のアプローチ—,
Synthesiology, 9(4) (2016), 187–197.
蒲生昌志，竹下潤一
[J16] Genome-wide gene expression analysis of mouse embryonic stem cells exposed to 𝑝-dichlorobenzene, Journal of Bioscience and Bioengineering, 122(3) (2016), 329–333.
Hidenori Tani, Jun-ichi Takeshita, Hiroshi Aoki, Ryosuke Abe, Akinobu Toyoda, Yasunori Endo, Sadaaki Miyamoto, Masashi Gamo, and Masaki Torimura
[J15] Criteria for deviation from predictions by the concentration addition model,
Environmental Toxicology and Chemistry, 35(7) (2016), 1806–1814.
Jun-ichi Takeshita, Tasanori Seki, and Masashi Kamo
[N8] 遺伝子発現データのデータ特徴に着目したクラスタリング解析,
ファジィシステムシンポジウム講演論文集, (2016), 431-438.
阿部亮介, 宮本定明, 遠藤靖典, 竹下潤一
[N7] メタ戦略による化学物質の有害性評価に有効なRNAの選定について,
ファジィシステムシンポジウム講演論文集, (2016), 439-444.
豊田章倫, 遠藤靖典, 宮本定明, 竹下潤一
[P2] Ward method of hierarchical clustering for non-Euclidean similarity measures,
In Proceedings of the 2015 Seventh International Conference of Soft Computing and Pattern Recognition (SoCPaR 2015), 2015, pp. 60–63.
Sadaaki Miyamoto, Ryosuke Abe, Yasunori Endo, and Jun-ichi Takeshita
[J14] A water line network failure applications of network design problems,
Journal of Mathematics and System Science, 5 (2015), 493–500.
Hiroaki Mohri* and Jun-ichi Takeshita*
[N6] mRNA機能のオントロジー構造に着目したクラスタリング,
ファジィシステムシンポジウム講演論文集, (2015), 57-61.
阿部亮介, 宮本定明, 遠藤靖典, 竹下潤一, 谷英典
[N5] 遺伝子発現データ間の相関関係を特徴づけるRNAの抽出アルゴリズムについて,
ファジィシステムシンポジウム講演論文集, (2015), 63-68.
豊田章倫, 宮本定明, 遠藤靖典, 竹下潤一, 谷英典
[J13] Investigation of organ-specific assessment factors related to sub-actue and sub-chronic toxicity studies,
Fundamental Toxicological Sciences, 1(1) (2014), 1–6.
Jun-ichi Takeshita, Atuso Kishimoto, and Masashi Gamo
[J12] Investigation of a network failure problem with a significant path, from the perspective of crisis management,
Journal of Mathematics and System Science, 4 (2014), 479-485.
Jun-ichi Takeshita* and Hiroaki Mohri*
[J11] A cooperative game theoretical approach to risk analysis using network structure,
Journal of Risk Analysis and Crisis Response, 4(1) (2014), 42–47.
Jun-ichi Takeshita* and Hiroaki Mohri*
[J10] 不安全行動に対するゲーム理論の適用の試み,
ヒューマンファクターズ, 18 (2014), 78–88.
牧野良次，竹下潤一，松倉邦夫
[N4] 電子商取引システムと連携した水産物放射線リスク評価，
海洋と生物, 生物研究社, 36 (2014), 299-306.
竹下潤一
[N3] 不確実性の下での数理的意思決定の理論と応用：単純な構造をもつネットワーク故障復旧問題について，
京都大学数理解析研究所講究録, 1912 (2014), 131-140.
竹下潤一*，毛利裕昭*
[J9] Game theory analysis of unsafe action in the workspace,
International Journal of Safety, 12(1) (2013), 35–43.
Jun-ichi Takeshita and Ryoji Makino
[J8] A quantitative activity-activity relationship model based on covariance structure analysis, and its use to inferring the NOEL values of chemical substances,
Journal of Math-for-Industry, 5B (2013), 151–159.
Jun-ichi Takeshita, Masashi Gamo, Koji Kanefuji, and Hiroe Tshubaki
[J7] 鉛はんだ代替におけるリスクトレードオフ評価のための用量反応関係の導出,
統計数理, 61(2) (2013), 233–246.
竹下潤一，蒲生昌志
[J6] A game-theoretical meaning of unstable stationary points in the replicator dynamics of asymmetric
two-person games,
Bulletin of Informatics and Cybernetics, 45 (2013), 1–10.
Jun-ichi Takeshita
[J5] Necessary and sufficient conditions for the existence of a pure-strategy Nash equilibrium,
Journal of the Operations Research Society of Japan, 55(3) (2012), 192–198.
Jun-ichi Sato (Takeshita) and Hidefumi Kawasaki
None
[P1] A game theoretical meaning of unstable stationary points for the replicator dynamics,
In Proceedings of the Sixth International Conference on Nonlinear Analysis and Convex Analysis, 2010, pp. 311–320.
Jun-ichi Sato (Takeshita)
[J4] An algorithm for determining a class of two-person games having a pure-strategy
Nash equilibrium,
Bulletin of Informatics and Cybernetics, 41 (2009), 51–58.
Jun-ichi Sato (Takeshita) and Takahiro Ito
[J3] Application of a discrete fixed point theorem to the Cournot model,
Journal of Nonlinear and Convex Analysis, 10 (2009), 419–428.
Jun-ichi Sato (Takeshita)
[J2] Discrete fixed point theorems and their application to Nash equilibrium,
Taiwanese Journal of Mathematics, 13(2A) (2009), 431–440.
Jun-ichi Sato (Takeshita) and Hidefumi Kawasaki
[N2] An extension of the existence theorem of a pure-strategy Nash equilibrium,
京都大学数理解析研究所講究録, 1629 (2009), 67-75.
Jun-ichi Sato (Takeshita) and Hidefumi Kawasaki
[N1] Discrete fixed point theorems and their applications to the game theory,
京都大学数理解析研究所講究録, 1611 (2008), 34-41.
Jun-ichi Sato (Takeshita) and Hidefumi Kawasaki
[J1] On the existence and nonexistence of solutions for an elliptic system in unbounded domains,
Advances in Differential Equations, 12(7) (2007), 759–780.
Jun-ichi Sato (Takeshita)
[Doctoral Thesis] Mathematical studies on discrete structure of non-cooperative games, Doctoral Thesis, Department of Mathematics, Graduate School of Mathematics, Kyushu University (supervised by Prof. Hidefumi Kawasaki), 2009-03-25.
[Master's thesis] On semilinear elliptic systems with superlinear-like nonlinearity in unbounded domains, Master's Thesis, Department of Pure and Applied Physics, Graduate School of Science and Engineering, Waseda University (supervised by Prof. Mitsuharu Ôtani), February 2006-0315.
[Bachelor's thesis] The existence of critical points for non-differentiable functionals, Bachelor's Thesis, Department of Applied Physics, School of Science and Engineering, Waseda University (supervised by Prof. Mitsuharu Ôtani), 2004-3-15.