Recent Publications

Irreversible inhibition of IspG, a target for the development of new antimicrobials, by a 2-vinyl analogue of its MEcPP substrate, V. Herrscher, C. Witjaksono, M. Buchotte, C. Ferret, F. Massicot, J.-L. Vasse, F. Borel, J.-B. Behr, M. Seemann, Chem. Eur. J., 2022, 28, e202200241.


  1. Irreversible inhibition of IspG, a target for the development of new antimicrobials, by a 2-vinyl analogue of its MEcPP substrate, V. Herrscher, C. Witjaksono, M. Buchotte, C. Ferret, F. Massicot, J.-L. Vasse, F. Borel, J.-B. Behr, M. Seemann, Chem. Eur. J., 2022, 28, e202200241.

  2. Access to 5-bromopentanal and 6-bromohexanal derivatives via the bromination/hydrolysis of C,O-bis-zirconocenes generated from unsaturated Weinreb amides, A. Coelho, J.-B. Behr, J.-L. Vasse, Org. Biomol. Chem. 2022, 20, 5803-5811.

  3. Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands, K. O. Lamara, M. Makhloufi-Chebli, A. Benazzouz-Touami, S. Terrachet-Bouaziz, A. Robert, C. Machado-Rodriguez, J.-B. Behr, J. Mol. Struct., 2022, 1252, 132153.

  4. Dual activation of unsaturated amides with Schwartz’s reagent: a diastereoselective access to cyclopentanols and N,O-dimethylcyclopentylhydroxylamines, A. Coelho, M.-S. Souvenir Zafindrajaona, A. Vallee, J.-B. Behr, J.-L. Vasse, Chem. Eur. J., 2022, 28, e202103789.

  5. A dansyl-derivatized phytic acid analogue as a fluorescent substrate for phytases: experimental and computational approach, C. Dussouy, E. Dubreucq, P. Chemardin, V. Perrier, J. Abadie, H. Quiquampoix, C. Plassard, J.-B. Behr, Bioorg. Chem., 2021, 110, 104810.

  6. Convergent Evolution of Diastereomeric Mixtures of 5-Methoxy-pentylzirconocenes toward Trans-1,2-substituted Cyclopentanes, A. Coelho, C. Machado-Rodrigues, J.-B. Behr, J.-L. Vasse, Org. Letters, 2021, 23, 772-776.

  7. Tuning the Regioselective Functionalization of Trifluoromethylated Dienes via Lanthanum-Mediated Single CF Bond Activation, T. Kumar, Y. Yang, S. Sghaier, Y. Zaid, X. F. Le Goff, E. Rousset, F. Massicot, D. Harakat, A. Martinez, M. Taillefer, L. Maron, J.-B. Behr, F. Jaroschik, Chem. Eur. J., 2021, 27, 4016-4021.

  8. Selectivity control in the reaction between 2-hydroxyarylaldehydes and 4-hydroxycoumarin. Antioxidant activities and computational studies of the formed products, K. O. Lamara, M. Makhloufi-Chebli, A. Benazzouz-Touami, S. Terrachet-Bouaziz, N. Hamdi, A. M. S. Silva, J.-B. Behr, J. Mol. Struct., 2021, 1231, 129936.

  9. Broadening the reaction scope of unprotected aldoses via their corresponding nitrones: 1,​3-​dipolar cycloaddition with alkenes, Messire, G.; Massicot, F.; Pascual, L.; Riguet, E.; Vasse, J.-L., Behr, J.-B, Org. Biomol. Chem. 2020, 18, 5708-5728.

  10. Homoallylic amines as efficient chiral inducing framework in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines, A. Coelho, J. Rogier, L. Anani, F. Massicot, C. Machado, J.-B. Behr, J.-L. Vasse, Org. Biomol. Chem. 2020, 18, 2632-2636.

  11. Regiospecific formation of sugar-derived ketonitrone towards unconventional C-branched pyrrolizidines and indolizidines, Massicot, F.; Messire, G.; Vasse, J.-L.; Py, S.; Behr, J.-B., Org. Biomol. Chem. 2019, 17, 7066-7077.

  12. Spiro Iminosugars: structural diversity and synthetic strategies, Hazelard, D.; Hensienne, R.; Behr, J.-B.; Compain, P., Top. Heterocycl. Chem. 2019, L. Somsak Ed., Springer Nature Switzerland.

  13. Aza-Henry reaction with nitrones, an under-explored transformation, Messire, G.; Massicot, F.; Vasse, J.-L., Behr, J.-B., Eur. J. Org. Chem. 2019, 1659-1668.

  14. Synthesis of 1,​3-​disubstituted cyclohexenes from dienylethers via sequential hydrozirconation​/deoxygenative cyclisation, Payet, A.; Blondeau, B.; Behr, J.-B.; Vasse, J.-L, Org. Biomol. Chem. 2019, 17, 798-802.

  15. Synthesis and glycosidase inhibition potency of all-​trans substituted 1-​C-​perfluoroalkyl iminosugars, Massicot, F.; Plantier-Royon, R.; Vasse, J.-L.; Behr, J.-B., Carbohydr. Res. 2018, 464, 2-7.

  16. Short synthesis, X-​ray and conformational analysis of a cyclic peracetylated l-​sorbose-​derived nitrone, a useful intermediate towards N-​O-​containing D-​gluco-​iminosugars Tangara, S.; Kanazawa, A.; Fayolle, M.; Philouze, C.; Poisson, J.-F.; Behr, J.-B.; Py, Sandrine, New J. Chem., 2018, 42, 16735-16743.

  17. Ring-​Junction-​Substituted Polyhydroxylated Pyrrolizidines and Indolizidines from Ketonitrone Cycloadditions, Lieou Kui, E.; Kanazawa, A.; Behr, J.-B.; Py, S., Eur. J. Org. Chem., 2018, 2178-2192.

  18. Application of elemental lanthanides in the selective C-F activation of trifluoromethylated benzofulvenes providing access to various difluoroalkenes, Kumar, T.; Jaroschik, F.; Ben Hassine, A.; Martinez, A.; Harakat, D.; Chevreux, S.; Massicot, F.; Behr, J.-B.; Vasse, J.-L.; Taillefer, M. JoVE (J. of visualized Exp.) 2018, 137.

  19. Generation of ε,ε-difluorinated metal-pentadienyl species through lanthanide-mediated C-F activation, T. Kumar, F. Massicot, D. Harakat, S. Chevreux, A. Martinez, K. Bordolinska, P. Preethalayam, R. Kokkuvayil Vasu, J.-B. Behr, J.-L. Vasse, F. Jaroschik, Chem. Eur. J. 2017, 23, 16460-16465

  20. Single or synergistic kinetic resolutions of chiral allylalanes: two complementary routes for the asymmetric synthesis of syn homoallylamines, M. Coffinet, J.-B. Behr, F. Jaroschik, J.-L. Vasse, Org. Lett., 2017, 19, 6728-6731.

  21. (+)​-​Camphor-​mediated kinetic resolution of allylalanes: a strategy towards enantio-​enriched cyclohex-​2-​en-​1-​ylalane, M. Coffinet, F. Massicot, J. Joseph, J.-B. Behr, F. Jaroschik, J.-L. Vasse, Chem. Commun. 2017, 53, 111-114.

  22. Polyhydroxylated quinolizidine iminosugars as nanomolar selective inhibitors of α-glucosidases, A. Vieira Da Cruz, A. Kanazawa, J.-F. Poisson, J.-B. Behr, S. Py, J. Org. Chem., 2017, 9866–9872.

  23. Tetramethylammonium Fluoride, F. Massicot, J.-B. Behr, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2017.

  24. Biological activities of triterpenoids from Poraqueiba sericea stems, I. Zebiri, M. Haddad, L. Duca, M. Sauvain, L. Paloque, B. Cabanillas, E. Rengifo, J.-B. Behr, L. Voutquenne-Nazabadioko, Natural Prod. Res., 2017, 31, 1331-1338.

  25. Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers, A. Hottin, D. W. Wright, E. Moreno-Clavijo, A. J. Moreno-Vargas, G. J. Davies, J.-B. Behr, Org. Biomol. Chem. 2016, 14, 4718-4727.

  26. Determination of the relative configuration and conformational analysis of five–membered N-Acyl-iminosugars by relevant 3J coupling constants, D. LeNouen, J.-B. Behr, A. Defoin, Chem. Select 2016, 1, 1256-1267.

  27. Expanding the library of divalent fucosidase inhibitors with polyamino and triazole-benzyl bridged bispyrrolidines, A. Hottin, S. Carrion-Jimenez, E. Moreno-Clavijo, A. J. Moreno-Vargas, A. T. Carmona, I. Robina, J.-B. Behr, Org. Biomol. Chem. 2016, 14, 3212-3220.

  28. A second-generation ferrocene-iminosugar hybrid with improved fucosidase binding properties, A. Hottin, A. Scandolera, L. Duca, D. W. Wright, G. J. Davies, J.-B. Behr, Bioorg. Med. Chem. Lett. 2016, 26, 1546-1549.