Recent Publications

A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold, Kamilia Ould Lamara, Nathan Noël, Fabien Massicot, Jean-Luc Vasse, Stéphane P. Vincent, Jean-Bernard Behr, Molecules 2025, 30, 226.

Bis-zirconocenes Generated from Weinreb 2-Allylaminoacetamides as Key Intermediates for a Diastereoselective Approach to 2- and 6-Substituted-3-Aminopiperidines, M. El Gharbi, E. Bianchi, A. Coelho, C. Kowandy, J.-B. Behr, J.-L. Vasse, J. Org. Chem. 2025, 90, 4134-4139..

Lanthanide-mediated Defluorinative Transformations of Trifluoromethylated Benzofulvenes: Access to FunctionalizedDifluoroalkenes and Mechanistic Insights, T. Kumar, Y. Yang, A. Ben Hassine, D. Mali, Y. Prajapat, P. Khandelwal, M. Bouquin, M. Taillefer, F. Massicot, S. Chevreux, J.-B. Behr, L. Maron, F. Jaroschik, Chem. Asian J., 2025, doi.org/10.1002/asia.202500071.

Synthesis, biological evaluation, ADMET studies, and molecular docking of novel coumarin–isoxazole derivatives as dual inhibitors of Hsp90 protein and acetylcholinesterase enzyme, A. Benazzouz-Touami, M. Makhloufi-Chebli, , K. Ighilarhiz, A. Chouh, N. Hadhoum,, J.-B. Behr, J. Mol. Struct., 2025, 1333, 141776.

Kinetics of strain-promoted alkyne-nitrone cycloadditions (SPANC) with unprotected carbohydrate scaffolded nitrones, N. Noël, A. Martinez, F. Massicot, J.-L. Vasse, J.-B. Behr, Org. Lett. 2024, 26, 3917-3922.

Carbohydrate-Templated Syntheses of Trifluoromethyl-Substituted MEP Analogues for the Study of the Methylerythritol Phosphate Pathway, B. Simonet, V. Herrscher, C. Witjaksono, P. Chaignon, F. Massicot, J.-L. Vasse, M. Semmann, J.-B. Behr, J. Org. Chem. 2023, 88, 15832-15843.

High-Pressure Activation to Circumvent Product Degradation in the Reaction of Unprotected Glyconitrones with Alkynes, N. Noël, G. Messire, F. Massicot, J.-L. Vasse, J.-B. Behr, Synthesis 2023, 55, 1285-1297.

Protecting-group free synthesis of glycoconjugates displaying dual fungicidal and plant defense-eliciting activities, N. Noël, S. Duchateau, G. Messire, F. Massicot, J.-L. Vasse, S. Villaume, A. Aziz, S. Dorey, J. Crouzet, J.-B. Behr, Bioorg. Chem. 2023, 141, 106829.

Irreversible inhibition of IspG, a target for the development of new antimicrobials, by a 2-vinyl analogue of its MEcPP substrate, V. Herrscher, C. Witjaksono, M. Buchotte, C. Ferret, F. Massicot, J.-L. Vasse, F. Borel, J.-B. Behr, M. Seemann, Chem. Eur. J., 2022, 28, e202200241.

Access to 5-bromopentanal and 6-bromohexanal derivatives via the bromination/hydrolysis of C,O-bis-zirconocenes generated from unsaturated Weinreb amides, A. Coelho, J.-B. Behr, J.-L. Vasse, Org. Biomol. Chem. 2022, 20, 5803-5811.

Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands, K. O. Lamara, M. Makhloufi-Chebli, A. Benazzouz-Touami, S. Terrachet-Bouaziz, A. Robert, C. Machado-Rodriguez, J.-B. Behr, J. Mol. Struct., 2022, 1252, 132153.

Dual activation of unsaturated amides with Schwartz’s reagent: a diastereoselective access to cyclopentanols and N,O-dimethylcyclopentylhydroxylamines, A. Coelho, M.-S. Souvenir Zafindrajaona, A. Vallee, J.-B. Behr, J.-L. Vasse, Chem. Eur. J., 2022, 28, e202103789.

A dansyl-derivatized phytic acid analogue as a fluorescent substrate for phytases: experimental and computational approach, C. Dussouy, E. Dubreucq, P. Chemardin, V. Perrier, J. Abadie, H. Quiquampoix, C. Plassard, J.-B. Behr, Bioorg. Chem., 2021, 110, 104810.

Convergent Evolution of Diastereomeric Mixtures of 5-Methoxy-pentylzirconocenes toward Trans-1,2-substituted Cyclopentanes, A. Coelho, C. Machado-Rodrigues, J.-B. Behr, J.-L. Vasse, Org. Letters, 2021, 23, 772-776.

Tuning the Regioselective Functionalization of Trifluoromethylated Dienes via Lanthanum-Mediated Single CF Bond Activation, T. Kumar, Y. Yang, S. Sghaier, Y. Zaid, X. F. Le Goff, E. Rousset, F. Massicot, D. Harakat, A. Martinez, M. Taillefer, L. Maron, J.-B. Behr, F. Jaroschik, Chem. Eur. J., 2021, 27, 4016-4021.

Selectivity control in the reaction between 2-hydroxyarylaldehydes and 4-hydroxycoumarin. Antioxidant activities and computational studies of the formed products, K. O. Lamara, M. Makhloufi-Chebli, A. Benazzouz-Touami, S. Terrachet-Bouaziz, N. Hamdi, A. M. S. Silva, J.-B. Behr, J. Mol. Struct., 2021, 1231, 129936.

Broadening the reaction scope of unprotected aldoses via their corresponding nitrones: 1,​3-​dipolar cycloaddition with alkenes, Messire, G.; Massicot, F.; Pascual, L.; Riguet, E.; Vasse, J.-L., Behr, J.-B, Org. Biomol. Chem. 2020, 18, 5708-5728.

Homoallylic amines as efficient chiral inducing framework in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines, A. Coelho, J. Rogier, L. Anani, F. Massicot, C. Machado, J.-B. Behr, J.-L. Vasse, Org. Biomol. Chem. 2020, 18, 2632-2636.

Regiospecific formation of sugar-derived ketonitrone towards unconventional C-branched pyrrolizidines and indolizidines, Massicot, F.; Messire, G.; Vasse, J.-L.; Py, S.; Behr, J.-B., Org. Biomol. Chem. 2019, 17, 7066-7077.

 Spiro Iminosugars: structural diversity and synthetic strategies, Hazelard, D.; Hensienne, R.; Behr, J.-B.; Compain, P., Top. Heterocycl. Chem. 2019, L. Somsak Ed., Springer Nature Switzerland.

Aza-Henry reaction with nitrones, an under-explored transformation, Messire, G.; Massicot, F.; Vasse, J.-L., Behr, J.-B., Eur. J. Org. Chem. 2019, 1659-1668.

 Synthesis of 1,​3-​disubstituted cyclohexenes from dienylethers via sequential hydrozirconation​/deoxygenative cyclisation, Payet, A.; Blondeau, B.; Behr, J.-B.; Vasse, J.-L, Org. Biomol. Chem. 2019, 17, 798-802.