I am a biomedical engineer, pursuing my research career in regenerating tissues with engineered biomaterials and stem cells. Although much interest is given to stem cell differentiation, the roles of 3D and the extracellular matrix (ECM) in stem cell differentiation and soft tissue regeneration are under explored. My strong interest is to guide stem cell differentiation by engineered 3D tissue created from modular biomaterial platforms. Thus, I have developed modular platforms enabling statistical modeling and multifactorial optimization to systematically tune multiple ECMs and ECM-bound factors to promote stem cell differentiation. Such systematic approaches will guide efforts to engineer niches that harbor stem cells and engineered microenvironments, aiming to apply compositional information for solid organ fabrication.