Recent publications

2022

Campos ML, Fernandes MF, Castro MB, Campos AD, Pires PP, Oliveira IM, Silva AM, Sabarense, CM, Andreazzi AE, Andrade RO, Castanon MCMN, Scio E. A pharmaceutical formulation containing Cecropia pachystachya alleviates metabolic alterations caused by a hypercaloric diet obesity model in Swiss mice. Biocatal. Agric. Biotechnol. 2022.

Costa KA, Lacerda DR, Silveira ALM, Martins LB, Oliveira MC, Rezende BM, Menezes-Garcia Z, Mügge FLB, Silva AM, Teixeira MM, Rouault C, Pinho V, Marcelin G, Clément K, Ferreira AVM. PAF signaling plays a role in obesity-induced adipose tissue remodeling. Int J Obes (Lond). 2022 Jan;46(1):68-76. doi: 10.1038/s41366-021-00961-9. Epub 2021 Sep 7. PMID: 34493775.

2021

da Silva MCM, Gomes GF, de Barros Fernandes H, Silva AM, Teixeira AL, Moreira FA, de Miranda AS, de Oliveira ACP. Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine. Scientific Reports. 2021 Aug 6;11(1):15989. doi: 10.1038/s41598-021-95059-7. PMID: 34362959; PMCID: PMC8346567.

Campos ML, Castro MB, Campos AD, Fernandes MF, Conegundes JLM, Rodrigues MN, Mügge FLB, Silva AM, Sabarense CM, Castañon MCMN, Andreazzi AE, Scio E. Antiobesity, hepatoprotective and anti-hyperglycemic effects of a pharmaceutical formulation containing Cecropia pachystachya Trécul in mice fed with a hypercaloric diet. Journal of Ethnopharmacology. 2021 Jul 13;280:114418. doi: 10.1016/j.jep.2021.114418. Epub ahead of print. PMID: 34271111.

Silva AM and Postler T. Charting protein dephosphorylation triggered by Toll like receptor (TLR) signalling in macrophages and their role in health and disease. International Review of Cell and Molecular Biology. Signal Transduction in Cancer and Immunity, Volume 361, First Published: 2021 Hardcover: 978-0-12-823757-1

Mugge FLB, Prates SMS, Andrade APS, Melo JC, Silva, Aristóbolo M, Araujo RLB, Labanca RA, Brandao, MG. L. Proliferative effect of food plant species from Brazil’s Cerrado on cultured fibroblasts. Journal of Medicinal Food, 2021.

2020

Costa MC, de Barros Fernandes H, Gonçalves GKN, Santos APN, Ferreira GF, de Freitas GJC, do Carmo PHF, Hubner J, Emídio ECP, Santos JRA, Dos Santos JL, Dos Reis AM, Fagundes CT, da Silva AM, Santos DA. 17-β-Estradiol increases macrophage activity through activation of the G-protein-coupled estrogen receptor and improves the response of female mice to Cryptococcus gattii. Cell Microbiol. 2020 Jun;22(6):e13179. doi: 10.1111/cmi.13179. Epub 2020 Feb 20. PMID: 32017324.

Lima-Batista, E.M., Gómez-Mendoza, Paola, D, Moysés, M.N., De-Souza-Gomes, K.; De-Lima, M.E., Souza-Fagundes, E.M., Silva, Aristóbolo M., Kjeldsen, F., Verano-Braga, T., Pimenta, A.M.C. Proteomic and phosphoproteomic analyses in HL60 cells treated with the scorpion-derived peptide Lunatin-1. Toxicon, v. 177, p. S39, 2020. https://doi.org/10.1016/j.toxicon.2019.12.064

Leão FB, Vaughn LS, Bhatt D, Liao W, Maloney D, Carvalho BC, Oliveira L, Ghosh S, Silva AM. Toll-like Receptor (TLR)-induced Rasgef1b expression in macrophages is regulated by NF-κB through its proximal promoter. Int J Biochem Cell Biol. 2020 Oct;127:105840. doi: 10.1016/j.biocel.2020.105840. Epub 2020 Aug 28. PMID: 32866686.

Rocha-Resende C, da Silva AM, Prado MAM, Guatimosim S. Protective and anti-inflammatory effects of acetylcholine in the heart. Am J Physiol Cell Physiol. 2020 Dec 2. doi: 10.1152/ajpcell.00315.2020. Epub ahead of print. PMID: 33264077.

2019

Carvalho, B.C., Oliveira, L.C., Rocha, C.D., Fernandes, H.B., Oliveira, I.M., Leão, F.B., Valverde, T.M., Rego, I.M.G., Ghosh, S., Silva, A.M. Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-κB activity and inflammatory gene expression. Molecular Immunology, 2019. doi: org/10.1016/ j.molimm.2019.02.015

Carvalho, B.C., Oliveira, L.C., Rocha, C.D., Fernandes, H.B., Oliveira, I.M., Leão, F.B., Valverde, T.M., Rego, I.M.G., Ghosh, S., Silva, A.M. Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation. Data in Brief, 2019.

2018

Araujo, A.M., Antunes, M.M., Mattos M.S., Diniz, A.B., Alvarenga, D.M., Nakagaki, B.N., Carvalho, E., Lacerda, V., Carvalho-Gontijo, R., Goulart, J., Mafra, K., Freitas-Lopes, M.A., Castro Oliveira, H.M., Dutra, C.M., David, B.A., Silva, Aristóbolo M., Quesniaux, V., Ryfell, B., Oliveira, S.C., Barber, G.N., Mansur, D.S., Cunha, T.M., Rezende, R.M., Oliveira, A.G., and Menezes, G.B. Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose. Cells, v.7:88, 2018.

Santos, C.M.A., Pires, M.C.V., Leão, T.L., Silva, A.K.S., Miranda, L.S., Martins, F.S., Silva, Aristóbolo, M., Nicoli, J.R. Anti-inflammatory effect of two Lactobacillus strains during infection with Gardnerella vaginalis and Candida albicans in HeLa cell culture model. Microbiology, v. 164, p. 349-358, 2018. doi: 10.1099/mic.0.000608

2017

Mugge, F.L.B.; Silva, Aristóbolo M. Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6α and downstream target genes. Scientific Reports, 7:9190, 2017. doi:10.1038/s41598-017-09500-x

2016

Vilas Boas, F.; Silva, Aristóbolo M.; Lima, K. M.; Estanislau, A.; Bittencourt, L.; Vilela, M. C.; Gomes, DA; Souza, LP; Teixeira, M. M.; Barcelos, L. S. Impairment of stress granule assembly via inhibition of the eIF2alpha phosphorylation sensitizes glioma cells to chemotherapeutic agents. Journal of Neurooncology, v.127, p.253-260, 2016. doi.org/10.1007/s11060-015-2043-3

Samudio, R; Pereira, L.; Rocha, C. D.; Berg, D.; Muniz-Queiroz, T; Santanna, H. P.; Cabrera, L; Combe, J. M.; Herrera, P; Jahuira, M; Leão, F.B.; Lyon, F; Prado, W. A.; Rodrigues, M. R.; Rodrigues-Soares, F.; Santolalla, M. L.; Zolini, C.; Silva, Aristóbolo M.; Gilman, R.H.; Tarazona-Santos, E.; Kehdy, F. S. Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry. Digestive Diseases and Sciences, v.61, p.107-116, 2016. doi.org/10.1007/s10620-015-3859-6

2015

Mugge, F.L.B.; Silva, Aristóbolo M. Endoplasmic reticulum stress response in the roadway for the effects of non-steroidal anti-inflammatory drugs. Cell Pathology, v.2, p.1-17, 2015. doi.org/10.1515/ersc-2015-0001

2014

Barreto-de-Souza, V; Ferreira, P. L.; Vivarini, AC; Calegari-Silva, T. C.; Soares, DC; Regis, E. G.; Pereira, RM; Silva, Aristóbolo M.; Saraiva, EM; Lopes, UG; Bou-Habib, DC . IL-27 enhances Leishmania amazonensis infection via ds-RNA dependent kinase (PKR) and IL-10 signaling. Immunobiology, v.?, p.231-239, 2014. doi.org/10.1016/j.imbio.2014.11.006

2013

Hissa, B.; Pontes, B.; Roma, P. M. S.; Alves, A. P.; Rocha, C. D.; Valverde, T. M.; Aguiar, P. H. N.; Almeida, F. P.; Guimaraes, A. J.; Guatimosim, C.; Silva, Aristóbolo M.; Fernandes, M. C.; Andrews, N. W.; Viana, N. B.; Mesquita, O. N.; Ajero, U.; Andrade, L. O. Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes. Plos One, v.8, p.1-17, 2013. doi.org/10.1371/journal.pone.0082988

Almeida, LA; Macedo, GC; Marinho, F.; Gomes, M. T.; Corsetti, P.; Silva, Aristóbolo M.; Cassataro, J.; Giambartolomei, G.; Oliveira, SC . TLR6 plays an important role in host innate resistance to Brucella abortus infection in mice. Infection and Immunity (Print), v.81, p.1654-1662, 2013. doi:10.1128/IAI.01356-12

Lourenço, M. V.; Clarke, J. R.; Frozza, R. L.; Bomfim, T. R.; Forny-Germano, L.; Batista, A. F.; Sathler, L. B.; Brito-Moreira, J.; Amaral, O. B.; Silva, C. A.; Freitas-Correa, L.; Espírito-Santo, S.; Campello-Costa, P.; Houzel, J.; Klein, W. L.; Holscher, C.; Carvalheira, J. B.; Silva, A. M.; Veloso, L. A.; Munoz, D. P.; Ferreira, S. T.; De Felice, F. G. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta amyloid oligomers in mice and monkeys. Cell Metabolism, v.18, p.831-843, 2013. dx.doi.org/10.1016/j.cmet.2013.11.002