Publications
= 科普文章 =
中研院訊 (Academia Sinica Newsletter), 漫步科研 【專欄】 "從基因、蛋白質、到化合物—天然物之生物合成途徑". Link
= Publications =
30. Pham, M. T., Yang, F. L., Liu, I. C., Liang, P. H., Lin, H. C.* Non-Heme Iron Enzymes Catalyze Heterobicyclic and Spirocyclic Isoquinolone Core Formation in Piperazine Alkaloid Biosynthesis. Angew. Chem. Int. Ed. 2024, e202401324. Link
29. Tseng, C. C., Chen, L. X., Lee, C. F., Tu, Z., Lin, C. H., Lin, H. C.* Characterization and catalytic investigation of fungal single-module nonribosomal peptide synthetase in terpene-amino acid meroterpenoid biosynthesis. J. Ind. Microbiol. Biotechnol. 2023, 50, kuad043. Link
28. Palla, S. R., Li, C. W., Chao, T. L., Lo, H. L., Liu, J. J., Pan, Y. C., Chiu, Y. T., Lin, W. C., Hu, C. W., Yang, C. M., Chen, Y. Y., Fang, J. T., Lin, S. W., Lin, Y. T., Lin, H. C., Kuo, C. J.,* Wang, W. C.,* Chang, S. Y.,* Liang, P. H.* Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors. Antiviral Research, 2023, 219, 105735. Link
27. Chen, T. H. and Lin, H. C.* Terpene Synthases in the Biosynthesis of Drimane-Type Sesquiterpenes Across Diverse Organisms. ChemBioChem, 2023, e202300518 (invited Concept). Link
26. Chen, T. H.,+ Chen, C. T.,+ Lee, C. F., Huang, R. J., Chen, K. L., Lu, Y. C., Liang, S. Y., Pham, M. T., Rao, Y. K., Wu, S. H., Chein, R. J., Lin, H. C.* The Biosynthetic Gene Cluster of Mushroom-Derived Antrocin Encodes Two Dual Functional Haloacid Dehalogenase-Like Terpene Cyclases. Angew. Chem. Int. Ed. 2023, 62, e202215566. Link
25. Hewage, R. T., Tseng, C. C., Liang, S. Y., Lai, C. Y., Lin, H. C.* Genome mining of cryptic bisabolenes that were biosynthesized by intramembrane terpene synthases from Antrodia cinnamomea. Phil. Trans. R. Soc. B. 2023, B378: 20220033. Link
24. Pham, M. T., Chen, S. R., Liang, S. Y., Cheng, Y. B., Lin, H. C.* Biosynthesis of Piperazine-Derived Diazabicyclic Alkaloids Involves a Nonribosomal Peptide Synthetase and Subsequent Tailoring by a Multifunctional Cytochrome P450 Enzyme. Org. Lett. 2022, 24, 22, 4064–4069. Link
23. Hewage, R. T., Huang, R. J., Lai, S. J., Lien, Y. C., Weng, S. H., Li, D., Chen, Y. J., Wu, S. H., Chein, R. J.*, Lin, H. C.* An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B. Org. Lett. 2021, 23, 5, 1904–1909. Link
22. Yan, Y., Zang, X., Jamieson, C. S., Lin, H. C., Houk, K. N., Zhou, J.*, Tang, Y.* Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance. Chem. Sci. 2020, 11, 9554-9562. Link
21. Chen, Y.R., Naresh, A., Liang, S.Y., Lin, C.H., Chein, R.J.*, Lin, H.C.* Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis. Angew. Chem. Int. Ed. 2020, 59, 13537–13541. Link
20. Chen, K. L., Lai, C. Y., Pham, M. T., Chein, R. J., Tang, Y., Lin H. C.* Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis. Org. Lett. 2020, 22, 8, 3302–3306. Link
19. Lee, C.F., Chen, L. X., Chiang, C. Y., Lai, C.Y., Lin, H. C.* Biosynthesis of norsesquiterpene aculenes requires three cytochrome P450s to catalyze a stepwise demethylation process. Angew. Chem. Int. Ed. 2019, 58, 18414–18418. Link
18. Tran, P.N., Yen, M. R., Chiang, C. Y., Lin, H. C.*, Chen, P. Y.* Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi. Appl. Microbiol. Biotechnol., 2019, doi: 10.1007/s00253-019-09708-z. Link
17. Lin, H. C.*, Hewage, R., Lu, Y. C., Chooi, Y. H. Biosynthesis of bioactive natural products from Basidiomycota. Org. Biomol. Chem., 2019, 17, 1027–1036. Link
16. Harvey, C.*, Tang, M., Schlecht, U., Horecka, J., Fischer, C., Lin, H. C., Li, J., Naughton, B., Cherry, J., Miranda, M., Li, U. F., Chu, A. M., Hennessy, J., Vandova, G., Inglis, D., Aiyar, R., Steinmetz, L., Davis, R., Medema, M., Sattely, E., Khosla, C., Onge, R., Tang, Y., Hillenmeyer, M.* HEx: A heterologous expression platform for the discovery of fungal natural products. Sci. Adv. 2018, 4(4):eaar5459. Link
15. Lai, C. Y., Lo, I. W., Hewage, R. T., Chen, Y. C., Chen, C. T., Lee, C. F., Lin, S., Tang, M. C., Lin, H. C.* Biosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines. Angew. Chem. Int. Ed. 2017, 56, 9478–9482. (MOST 105-2113-M-001-013) Link
14. Lin, H. C., McMahon T. C., Patel, A., Corsello, M., Simon, A., Xu, W., Zhao, M., Houk, K. N., Garg, N. K., Tang, Y* P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers. J. Am. Chem. Soc. 2016, 138, 4002–4005. Link
13. Zhao M., Lin, H.C., Tang, Y.* Biosynthesis of the α-Nitro-containing Cyclic Tripeptide Psychrophilin. J. Antibiot. 2016, 69, 571–573. Link
12. Tang, M. C., Lin, H. C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc. 2015, 137, 13724–13727. Link
11. Mao, X. M., Zhan, Z. J., Grayson, M. N., Tang, M. C., Xu, W., Li, Y. Q., Yin, W. B., Lin, H. C., Chooi, Y. H., Houk, K. N., Tang, Y.* Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System. J. Am. Chem. Soc. 2015, 137, 11904–11907. Link
10. Lin, H. C., Chou, G., Chooi, Y. H., McMahan, T. C., Xu, W., Garg, N. K., Tang, Y.*. Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids. Angew. Chem. Int. Ed. 2015, 54, 3004−3007 (VIP paper). Link
9. Lin, H. C., Yuta, T., Dhingra, S., Xu, W., Fukutomi, M., Chooi, Y. H., Cane, D. E., Calvo, A. M, Watanabe, K., Tang, Y.*. Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of Multifunctional Cytochrome P450 in the Fumagillin Pathway. J. Am. Chem. Soc. 2014, 136, 4426−4436. Link
8. Zabala, A. O., Chooi, Y., H.; Choi, M. S.; Lin, H. C., Tang Y.*. Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase. ACS Chem. Biol. 2014, 9(7), 576–1586.
7. Ahmed, S. 1, Lin, H. C.1, Khan, N. U.*, Lee, S. S.*. A proanthocyanidin from the Bark of Acacia leucophloea. Rec. Nat. Prod. 8:3, 2014, 294-298.
6. Lin, H. C., Chooi, Y. H., Dhingra S., Xu, W., Calvo, A. M., Tang Y.*. The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene. J. Am. Chem. Soc. 2013, 135, 4616−4619. Link
5. Dhingra, S., Lind, A. L., Lin, H. C., Tang, Y., Rokas, A. Calvo, A. M.* The Fumagillin Gene Cluster, an Example of Hundreds of Genes Under veA Control in Aspergillus fumigatus. PLoS One. 2013, Oct;8(10):e77147.
4. Lin, H. C., Lee, S. S.*. Dibenzocycloheptenes from the Leaves of Cinnamomum subavenium. J. Nat. Prod. 2012, 75, 1735−1743.
3. Lin, H. C., Tsai, S. F., Lee, S. S.*. Flavonoid Glycosides from the Leaves of Machilus philippinensis. J. Chin. Chem. Soc. 2011, 58, 555-562.
2. Lin, H. C., Lee, S. S.*. Proanthocyanidins from the Leaves of Machilus philippinensis. J. Nat. Prod. 2010, 73, 1375-1380.
1. Lee, S. S.*, Lin, H. C., Chen, C. K. Acylated Flavonol Monorhamnosides, α-Glucosidase Inhibitors, from Machilus philippinensis. Phytochemistry 2008, 12, 2347-2353.