Variance (or heritability) explained by genetic variants

This page includes programs and R scripts to calculate the variance in liability explained (i.e. heritability explained) (Vg) by individual genetic variants. Please cite the following paper if you use the programs:

So H.C., Gui A.H.S., Cherny S.S. and Sham P.C. (2011) Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genetic Epidemiology. Published online 3 Mar 2011.

VarExplained program

• • Web interface to calculate the variance explained for bi-allelic markers (i.e. 3 genotypes) [Courtesy to Dr. Johnny Kwan for building up this web interface]

  • R program to calculate the variance explained for bi-allelic markers Download

  • Program to calculate Vg for any number of strata (including haplotypes, multi-allelic markers and interactions) [zipped file; program in exe]

  • Download