Work Experience
Project Title: Emergence of high-grade and treatment-resistant pancreatic neuroendocrine tumor subclones
Designation: Senior Research Scientist
Organization: Memorial Sloan Kettering Cancer Center, New York, US
Duration: March 15, 2022 - present
Responsibilities
Analysis of Whole Exome Analysis networks in cancer and normal tissues
Constructing metastatic seeding patterns in human cancer
Designing and implementing protocols to ease the analysis.
Project Title: Comparative evaluation of regulatory networks in normal and cancer tissues
Designation: Postdoctoral Research Scientist
Organization: Columbia University, Irving Medical Center, New York, US
Duration: March 15, 2021 - March 14, 2022
Responsibilities
Analysis of regulatory networks in cancer and normal tissues
Development of various scripts/work-flows related to genome sequencing data analysis
Designing and implement protocols to ease the analysis.
Project Title: Identification of Epromoter-like associated clusters in different stress conditions
Designation: Post Doctoral Fellow
Organization: TAGC, INSERM-U1090, Aix Marseille University, Marseille, France
Duration: Oct 28, 2018 - Feb 28, 2021
Responsibilities
Analysis of NGS dataset: RNA-Seq, ChIP-Seq, PRO-Seq/GRO-Seq, Motif Enrichment, Gene Clustering by TSS distance etc.
Development of various scripts/work-flows related to genome sequencing data analysis
Designing and implement protocols to ease the analysis.
To explore effect of promoter variants in gene regulations.
Project Title: Physiological regulations under hypobaric hypoxia environment of high altitude
Designation: Research Associate
Organization: Genomics & Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology, Delhi, India
Duration: Nov 11, 2016-July 27, 2018
Responsibilities
Analysis of NGS data analysis: (Bisulfite Seq, RNA-Seq, Chip-Seq, Genome Assembly etc.)
Development of various scripts/pipe-lines related to genome sequencing data analysis
Designing and implement protocols to ease the analysis.
Analysis of variants to find pathogenicity.
Interaction of TF and its DNA binding sites by Molecular Dynamics Simulations
Biological Data Analysis using Machine Learning Approaches and Meta-analysis
Developing various pipelines and writing Research Articles, Grants & Scientific Reports
Project Title: Identification of genes containing DNA-triplex forming large (purine) repeats in human genome and their application as therapeutic targets in various disorders.
Designation: Research Scholar
Organization: All India Institute of Medical Sciences, New Delhi, India
Duration: Sept 2011- Nov 2016
Summary: The Research work was focused on the human genome analysis to identify purine repeats and find its role in the genome integrity as well as disease pathogenesis. Further, various ligands were investigated for their capacity to destabilize DNA-triplex. DNA-triplex with triplets (G*GC) and (A*AT) were modeled in-silico and performed docking study to screen the best drug candidate which was further validated by biophysical approaches. In addition, we developed the software entitled “nTrackAnnotator” to identify and annotate low complexity regions present in the genome.
PHD Details
Title: Identification of genes containing DNA-triplex forming large (purine) repeats in human genome and their application as therapeutic targets in various disorders.
Date of PhD Registration: 20/09/2013
Thesis submission date: 09/05/2016
Date of Completion: 27/12/2016
PRE-PHD RESEARCH
M.Tech. (Bioinformatics) Projects
CGPA: 8.96; 1981/2600 (76.19%)
1. Worked on six months, project entitled “Comparison of Binding Sites to identify consensus binding site using automated different Binding Site Identification Software” under the supervision of Dr. N. Subbarao, Assoct. Prof., at Jawaharlal Nehru University, New Delhi, India.
2. Worked on four months, project entitled “Petrol fumes exposure and health hazard: A case study with petrol pump workers” under supervision of Dr. Aseem Bhatnagar, Scientist F, INMAS, DRDO, Delhi, India during .
B.Tech. (Biotechnology) Projects
2471/3200 (77.21 %)
1. Worked on four months on Industrial Project on “Quality Control Microbial Tests for the pharmaceutical Industries” at Aglowmed Pvt. Ltd., Roorkee, Uttarakhand, India.
2. Worked on one month project entitled “Plant Tissue Culture on Agro-bacterium mediated Genetic Transformation”, under supervision of Dr. Vishnu Bhat, Associate Professor, University of Delhi, Delhi, India.
3. One month project training during 05-09-2006 to 04-10-2006 from Institute of Bio-Engineering & Biological Sciences, Varanasi.
4. One month project training in the Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi. From 02.1.2007 to 24.01.2007.