Publications

Widlansky ME, Hill RB. Mitochondrial regulation of diabetic vascular disease: an emerging opportunity. Transl Res. 2018;202:83–98. doi:10.1016/j.trsl.2018.07.015

Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB. Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. J Biol Chem. 2018 Sep 21;293(38):14891-14904. doi: 10.1074/jbc.RA117.001469. Epub 2018 Aug 7. PMID: 30087121; PMCID: PMC6153299.

Harwig MC, Viana MP, Egner JM, Harwig JJ, Widlansky ME, Rafelski SM, Hill RB. Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph. Anal Biochem. 2018 Jul 1;552:81-99. doi: 10.1016/j.ab.2018.02.022. Epub 2018 Mar 2. PMID: 29505779; PMCID: PMC6322684.

Ma C, Beyer AM, Durand M, Clough AV, Zhu D, Norwood Toro L, Terashvili M, Ebben JD, Hill RB, Audi SH, Medhora M, Jacobs ER. Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):622-635. doi: 10.1161/ATVBAHA.117.310605. Epub 2018 Feb 1. PMID: 29419407; PMCID: PMC5823793.

Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB. Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy. Chembiochem. 2018 Mar 2;19(5):448-458. doi: 10.1002/cbic.201700386. Epub 2018 Jan 25. PMID: 29239081; PMCID: PMC5844354.

Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM. SRCP1 Conveys Resistance to Polyglutamine Aggregation. Mol Cell. 2018 Jul 19;71(2):216-228.e7. doi: 10.1016/j.molcel.2018.07.008. PMID: 30029002; PMCID: PMC6091221.

Bakkum AL, Hill RB. Removal of a consensus proline is not sufficient to allow tetratricopeptide repeat oligomerization. Protein Sci. 2017 Oct;26(10):1974-1983. doi: 10.1002/pro.3234. Epub 2017 Jul 25. PMID: 28707340; PMCID: PMC5606541.

Lee MW, Lee EY, Lai GH, Kennedy NW, Posey AE, Xian W, Ferguson AL, Hill RB, Wong GCL. Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission. ACS Cent Sci. 2017 Nov 22;3(11):1156-1167. doi: 10.1021/acscentsci.7b00338. Epub 2017 Nov 8. PMID: 29202017; PMCID: PMC5704292.

Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM (2017), The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species., Dev Cell. Mar 27;40(6):583-594, doi: 10.1016/j.devcel.2017.02.020.

Koppenol-Raab, M., Harwig, M. C., Posey, A. E., Egner, J. M., MacKenzie, K. R., & Hill, R. B. (2016). A Targeted Mutation Identified Through pKa Measurements Indicates a Post-recruitment Role for Fis1 in Yeast Mitochondrial Fission. The Journal of Biological Chemistry, jbc.M116.724005. http://doi.org/10.1074/jbc.M116.724005\

Cahill, T. J., Leo, V., Kelly, M., Stockenhuber, A., Kennedy, N. W., Bao, L., et al. (2015). Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure. The Journal of Biological Chemistry, 290(43), 25907–25919. http://doi.org/10.1074/jbc.M115.665695

Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G. A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.Viruses. 2016 6;8(6). pii: E158. doi: 10.3390/v8060158.

Hill, R. B., MacKenzie, K. R., & Harwig, M. C. (2015). The Tail-End Is Only the Beginning: NMR Study Reveals a Membrane-Bound State of BCL-XL. Journal of Molecular Biology, 427(13), 2257–2261. http://doi.org/10.1016/j.jmb.2015.04.005

Diers AR, Broniowska KA, Chang CF, Hill RB, Hogg N. S-Nitrosation of monocarboxylate transporter 1: inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells. Free Radic Biol Med. 2014 Apr;69:229-38. doi: 10.1016/j.freeradbiomed.2014.01.031. Epub 2014 Jan 30.

Lees JP, Manlandro CM, Picton LK, Tan AZ, Casares S, Flanagan JM, Fleming KG, Hill RB. A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. J Mol Biol. 2012 Oct 19;423(2):143-58. doi: 10.1016/j.jmb.2012.06.042. Epub 2012 Jul 9.

Tooley JE, Khangulov V, Lees JPB, Schlessman JL, Bewley MC, Heroux A, Bosch J, Hill RB. The 1.75 A resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain. Acta Cryst. 2011 F67:1310–1315. doi:10.1107/S1744309111029368

Wells RC and Hill RB. The Fis1 cytosolic domain binds and reversibly clusters lipid vesicles. PLoS One. 2011;6(6):e21384. Epub 2011 Jun 28.

Jeyaraju DV, McBride HM, Hill RB*, Pellegrini L*. Structural and mechanistic basis of Parl activity and regulation. Cell Death Differ. 2011 Sep;18(9):1531-9. doi: 10.1038/cdd.2011.22. Epub 2011 Mar 18.

Tan FJ, Zuckerman JE, Wells RC, Hill RB. The C. elegans b-cell lymphoma 2 (bcl-2) homolog cell death abnormal 9 (ced-9) associates with and remodels lipid membranes. Protein Sci. 2011 Jan;20(1):62-74. Epub 2010 Oct 28. PubMed PMID: 21031486.

Chang CR, Manlandro CM, Arnoult D, Stadler J, Posey AE, Hill RB, Blackstone C. A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher-order assembly and mitochondrial division. J Biol Chem. 2010 Oct 15;285(42):32494-503. Epub 2010 Aug 9. PubMed PMID: 20696759.

Hill RB, Pellegrini L. The PARL family of mitochondrial rhomboid proteases. Semin Cell Dev Biol. 2010 Aug;21(6):582-92. Epub 2010 Jan 4. PubMed PMID: 20045481.

Picton LK, Casares S, Monahan AC, Majumdar A, Hill RB. Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae. Biochemistry. 2009 Jul 21;48(28):6598-609. PubMed PMID: 19522466.

Parrott MM, Sitarski SA, Arnold RJ, Picton LK, Hill RB, Mukhopadhyay S. Role of conserved cysteines in the alphavirus E3 protein. J Virol. 2009 Mar;83(6):2584-91. Epub 2008 Dec 24. PubMed PMID: 19109378; PubMed Central PMCID: PMC2648270.

Tan FJ, Husain M, Manlandro CM, Koppenol M, Fire AZ, Hill RB. CED-9 and mitochondrial homeostasis in C. elegans muscle. J Cell Sci. 2008 Oct 15;121(Pt 20):3373-82. Epub 2008 Sep 30. PubMed PMID: 18827010.

De Cotiis DA, Woll MP, Fox TE, Hill RB, Levenson R, Flanagan JM. Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. Protein Expr Purif. 2008 Oct;61(2):103-12. Epub 2008 Jun 25. PubMed PMID: 18634883.

Siskind LJ, Feinstein L, Yu T, Davis JS, Jones D, Choi J, Zuckerman JE, Tan W, Hill RB, Hardwick JM, Colombini M. Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels. J Biol Chem. 2008 Mar 14;283(11):6622-30. Epub 2008 Jan 2. PubMed PMID: 18171672; PubMed Central PMCID: PMC2713582.

Wells RC, Picton LK, Williams SC, Tan FJ, Hill RB. Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm. J Biol Chem. 2007 Nov 16;282(46):33769-75. Epub 2007 Sep 20. PubMed PMID: 17884824.

Tan FJ, Fire AZ, Hill RB. Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain. Cell Death Differ. 2007 Nov;14(11):1925-35. Epub 2007 Aug 17. PubMed PMID: 17703231.

Thuduppathy GR, Terrones O, Craig JW, Basañez G, Hill RB. The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner. Biochemistry. 2006 Dec 5;45(48):14533-42. PubMed PMID: 17128992; PubMed Central PMCID: PMC1764622.

Thuduppathy GR, Craig JW, Kholodenko V, Schon A, Hill RB. Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism. J Mol Biol. 2006 Jun 16;359(4):1045-58. Epub 2006 Apr 6. PubMed PMID: 16650855; PubMed Central PMCID: PMC1785297.

Thuduppathy GR, Hill RB. Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes. Protein Sci. 2006 Feb;15(2):248-57. Epub 2005 Dec 29. PubMed PMID: 16385002; PubMed Central PMCID: PMC1752203.

Fannjiang Y, Cheng WC, Lee SJ, Qi B, Pevsner J, McCaffery JM, Hill RB, Basañez G, Hardwick JM. Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev. 2004 Nov 15;18(22):2785-97. Epub 2004 Nov 1. PubMed PMID: 15520274; PubMed Central PMCID: PMC528898.

Thuduppathy GR, Hill RB. Applications of NMR spin relaxation methods for measuring biological motions. Methods Enzymol. 2004;384:243-64. PubMed PMID: 15081691.

Dohm JA, Lee SJ, Hardwick JM, Hill RB, Gittis AG. Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. Proteins. 2004 Jan 1;54(1):153-6. PubMed PMID: 14705031.