I am an associate professor at the Molecular and Statistical and Biophysics group of SISSA, in Trieste (Italy).
  I am the Principal Investigator of the Small RNA in silico research group, currently funded by an ERC grant.
  This site is about my job, for something else go to the other page.

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Recent News

  • RNA folding in stop motion accepted on NAR
    Together with Sandro Bottaro and Alejandro Gil-Ley, we developed a method that can be used to construct RNA folding trajectories starting from static X-ray pictures. The idea is borrowed from Markov state models and diffusion maps, and uses a measure of structural deviation that we developed for RNA structures. We call this method stop motion modeling, in analogy with the animation technique that produces the impression of motion through juxtaposition of static pictures. Using this method, we characterized the folding pathways of common RNA tetraloops, providing results that can be compared with molecular dynamics trajectories and with experiments.

    The work has been accepted for publication on Nucleic Acids Research. A preprint is available on arXiv.
    Posted Mar 31, 2016, 3:21 AM by Giovanni Bussi
  • Role of hairpin formation in telomeric quadruplex folding
    In collaboration with the group of Jiri Sponer we performed a computational study on the folding mechanism of DNA hairpins which are participating in the formation of telomeric quadruplexes. We used molecular dynamics and extensive parallel tempering simulations. The manuscript has been accepted for publication on Nucleic Acids Research, and a preprint is available on arXiv.
    Posted Sep 22, 2015, 11:28 PM by Giovanni Bussi
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