TfReg: Calculates melting temperatures of DNA and RNA with mesoscopic models

TfReg implements the calculation of Peyrard-Bishop style Hamiltonians to obtain some physical properties of DNA and RNA duplexes. The method uses the transfer matrix technique for the calculation of the classical partition function. Also, TfReg calculates the regression of experimental versus predicted melting temperatures using the equivalent melting index.

News: version 4.0 is now available with new parameters for DNA/RNA hybrids (September 2018)

Please have a look at the Documentation for more details about what TfReg can do for you and examples of how to install and run the software.

This software is distributed under the GNU General Public License version 3 (GPLv3) and precompiled binary packages for several Linux distributions, as well as the source code, can be found at the OpenSuse Build Service or from our site.

 Download Version 4.0  September 2018
 One-click automatic install (recommended) For OpenSUSE, Fedora, CentOS and ScientificLinux
 Download documentation only Documentation (PDF file)
 Download for recompiling if you have a different Linux system Source Tar File (see documentation how to compile and install)
 Download packages binary packages for all distributions from   from
 Download packages from OpenSuse Build Service Packages for OpenSUSE, Fedora, Debian, Ubuntu, CentOS and ScientificLinux.

Please note: only OpenSuse42.3 was fully tested. If you are running into problems for your distribution please send me an email reporting your problem with as much details as possible. 

Installation: please refer to your Linux distribution documentation for installation of rpm or deb packages.

Example installation command for openSuse42.3

zypper addrepo
zypper refresh
zypper install TfReg

Example installation for Fedora 25

dnf config-manager --add-repo
dnf install TfReg

If you found this software useful, please let me know by sending an email or by adding a comment below (you may need to sign in to your Google account to add comments). It is of considerable help to show a list of users to funding agencies to guarantee continued financial support for the project.

Previous versions: download binary packages