Publications

Work at HKU since 2019 (* corresponding):

(1) Jiang H. and Y.W. Chan*. 2023. Chromatin bridges: stochastic breakage or regulated resolution? Trends in Genetics. available online:   https://doi.org/10.1016/j.tig.2023.10.004 (invited review)

(2) Zheng Y., Cheng Y., He M., Ko W.K., Chan Y.W. and A.O. Wong*. 2023. Goldfish Adiponectin: (I) Molecular Cloning, Tissue Distribution, Recombinant Protein Expression, and Novel Function as a Satiety Factor in Fish Model. Frontiers in Endocrinology. 14  https://www.frontiersin.org/articles/10.3389/fendo.2023.1283298/ 

(3) Kong N. and Y.W. Chan*. 2023. Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS-STING Activation. STAR Protocol. 4(2): 102286 https://star-protocols.cell.com/protocols/2719 

(4) Jiang H., Kong N., Liu Z., West S.C. and Y.W. Chan*. 2023. Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS-STING Activation. Advanced Science. https://doi.org/10.1002/advs.202204388 

(5) Kong N., Liu Z. and Y.W. Chan*. 2023. RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1. Cell Reports. 42(2): 112032. https://doi.org/10.1016/j.celrep.2023.112032 

(6) Benitez A., Sebald M., Kanagaraj R., Rodrigo-Brenni M. C., Chan Y. W., Liang C. C., and West S. C.* 2023. GEN1 promotes common fragile site expression. Cell Reports. 42(2): 112062. https://doi.org/10.1016/j.celrep.2023.112062 

(7) Chanboonyasitt P. and Y.W. Chan*. 2021. Regulation of mitotic chromosome architecture and resolution of ultrafine anaphase bridges by PICH. Cell Cycle. 20(20): 2077-2090. https://doi.org/10.1080/15384101.2021.1970877

Work prior to joining HKU before 2019:

1. Chan, Y.W. and S.C. West. 2018. A new class of ultrafine anaphase bridges generated by homologous recombination. Cell Cycle. 17: 2101-2109.       

2. Chan, Y.W., Fugger, K., and S.C. West. 2018. Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations. Nature Cell Biology 20, 92-103

3. Shah Punatar, R., Martin, M. J., Wyatt, H. D. M., Chan, Y. W., and West, S. C. 2017. Resolution of single and double Holliday junction recombination intermediates by GEN1. Proceedings of the National Academy of Sciences of the United States of America 114, 443–450.

4. West S.C. and Y.W. Chan. 2017. Genome instability as a consequence of defects in the resolution of recombination intermediates. Cold Spring Harbor symposia on quantitative biology. 82: 207-212.

5. Chan, Y.W. and S.C. West. 2015. GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism. Nucleic Acid Research. 43 (22): 10882-10892.

6. West S.C., M.G. Blanco, Y.W. Chan, J. Matos, S. Sarabajna and H.D.M. Wyatt. 2015. Resolution of Recombination Intermediates: Mechanism and Regulation. Cold Spring Harbor symposia on quantitative biology. 80: 103-9.

7. Chan, Y.W. and S.C. West. 2014. Spatial control of the GEN1 Holliday junction resolvase ensures genome stability. Nature Comms. 5: 5844.

8. Bock, F.J., K. Brinkmann, Y.W. Chan, and L.L. Fava. 2013. Cycling to death, in the Tyrolean Alps. Cell Death Differ.20: 1279-1280.

9. Jeyaprakash, A.A., A. Santamaria, U. Jayachandran, Y.W. Chan, C. Benda, E.A. Nigg, and E. Conti. 2012. Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface. Mol. Cell 12: 274-286.

10. Chan, Y.W., A.A. Jeyaprakash, E.A. Nigg, and A. Santamaria. 2012. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. J. Cell Biol. 196: 563-571.

11. Chan, Y.W., L.L. Fava, A. Uldschmid, M.H.A. Schmitz, D.W. Gerlich, E.A. Nigg, and A. Santamaria. 2009. Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J. Cell. Biol. 185: 859–874.

12. Chan, Y.W., Y. Chen, and R.Y.C. Poon. 2009. Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe. Oncogene 28:170–183.

13. Chan, Y.W., H.T. Ma, W. Wong, C.C. Ho, K.F. On, and R.Y.C. Poon. 2008. CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. Cell Cycle 7: 1449–1461.

14. Chan, Y.W., K.F. On, W.M. Chan, W. Wong, H.O. Siu, P.M. Hau, and R.Y.C. Poon. 2008. The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. J. Biol. Chem. 283: 15716–15723.