Recombination and Chromosome Segregation Laboratory

We aim at understanding:

Interplay between DNA repair, chromosome segregation and genome instability
How the formation and resolution of anaphase bridges influence genome stability in normal and cancer cells
Mechanism of nucleases involved in DNA repair and segregation

Cell unable to complete homologous recombination undergoes abnormal chromosome segregation.

News:

Our preview article entitled "Rare-variant association study unveils the Achilles’ heel for HCC" is available online (May 8, 2024) in Cell Genomics. https://doi.org/10.1016/j.xgen.2024.100558
Congratulations to Prof Gary Chan on receiving the HKU Early Career Teaching Award. https://www.scifac.hku.hk/award-achievement/early-career-teaching-award-2023
Our invited review article entitled "Chromatin bridges: stochastic breakage or regulated resolution?" is available online (October 26, 2023) in Trends in Genetics. https://doi.org/10.1016/j.tig.2023.10.004