We aim at understanding:

• Interplay between DNA repair, chromosome segregation and genome instability

• How the formation and resolution of anaphase bridges influence genome stability in normal and cancer cells

• Mechanism of nucleases involved in DNA repair and segregation

News: 

1. Our research article entitled "The interplay of the translocase activity and protein recruitment function of PICH in ultrafine anaphase bridge resolution and genomic stability" is published (Dec 19, 2024) in Nucleic Acids Research. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1249/7929369 

2. Our research article entitled "FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition" is published (July 9, 2024) in Cell Reports. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00793-9 

3. Our preview article entitled "Rare-variant association study unveils the Achilles’ heel for HCC" is available online (May 8, 2024) in Cell Genomics. https://doi.org/10.1016/j.xgen.2024.100558