Bacteriophages are viruses that specifically target and kill bacteria. Our research leverages this unique characteristic to develop effective methods for detecting and eliminating foodborne pathogens.

The rise of antimicrobial-resistant bacteria (AMR) poses a significant global health threat. In 2019, AMR bacteria caused 1.27 million deaths annually, surpassing deaths from HIV (863,837) and malaria (643,381), making them the leading cause of infectious disease-related mortality. Our research team is developing precision antimicrobials using phage-derived proteins to tackle this critical issue. 

Detection: Our research utilizes phage-derived proteins, such as the cell wall-binding domains of endolysins or tail fiber proteins, which can be engineered to specifically bind to harmful bacteria. This binding triggers a detectable signal that indicates the presence of these bacteria in foods.

Control: These proteins also have the ability to break down bacterial cell walls, effectively killing the pathogens. This approach is safe, environmentally friendly, and selectively targets harmful bacteria without affecting beneficial ones.

Our research focuses on developing a beneficial compound delivery system using probiotic membrane vesicles. These vesicles, secreted by probiotic bacteria, can carry bioactive molecules such as proteins, lipids, and nucleic acids. By utilizing these vesicles, we aim to enhance the stability, bioavailability, and targeted delivery of health-promoting compounds. This technology has potential applications in functional foods, and pharmaceuticals.