Publications

Jenny J. Hung, Tina W. Shih, Alice P. Du, Ethan I. Lan*, 2026. Biosynthesis of 3-Hydroxy-3-methylbutyrate by Probiotic Escherichia coli Nissle 1917. Journal of Agricultural and Food Chemistry, in press. Link

Arvin Y. Chen, Jenny J. Hung, Ethan I. Lan*, 2026. Biosynthesis of isoprene glycol from glucose by metabolically engineered Escherichia coli. Bioresource Technology, 462, 135539. Link 

Hung, Jenny Ji-Chan, Teresa Pei-Ju Tsai, Ethan I Lan*, 2026. Escherichia coli Nissle 1917 as a Probiotic Microbial Cell Factory: From Genetic Engineering to Fermentation. Fermentation 12, no. 6: 265. Link

Sally J. Huang, Martin J. Lai, Arvin Y. Chen, Ethan I. Lan*, 2024. De novo biosynthesis of 3-hydroxy-3-methylbutyrate as anti-catabolic supplement by metabolically engineered Escherichia coli, Metabolic Engineering, Volume 84, 2024, Pages 48-58. Link.

Jemmy C. Tsai, Martin J. Lai, Ethan I. Lan*, 2023. Expression of Weimberg xylose utilization pathway for succinate production by cyanobacteria under diurnal condition. Journal of the Taiwan Institute of Chemical Engineers. Link

Martin J. Lai, Jemmy C. Tsai, Ethan I. Lan*, 2022. CRISPRi-enhanced direct photosynthetic conversion of carbon dioxide to succinic acid by metabolically engineered cyanobacteria. Bioresource Technology, 366.  Link

Jason T. Ku, Arvin Y. Chen, Ethan I. Lan*, 2022. Metabolic engineering of Escherichia coli for efficient biosynthesis of butyl acetate. Microbial Cell Factories, 21, 28. Link 

Jason T. Ku, Arvin Y. Chen, Ethan I. Lan*,  2020. Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux. Metabolites, 10, 166. Link

Arvin Y. Chen, Ethan I. Lan*, 2020. Chemical Production from Methanol Using Natural and Synthetic Methylotrophs. Biotechnology Journal, 1900356. Link 

Martin J Lai, Ethan I Lan*, 2019. Photoautotrophic synthesis of butyrate by metabolically engineered cyanobacteria. Biotechnology and Bioengineering, 116:893–903 . Link

Sammy Pontrelli, Tsan-Yu Chiu, Ethan I. Lan, Frederic Y.-H. Chen, Peiching Chang, James C. Liao, 2018. Escherichia coli as a host for metabolic engineering. Metabolic Engineering 50, 16-46. Link

Jason T. Ku, Ethan I. Lan*, 2018. A balanced ATP driving force module for enhancing photosynthetic biosynthesis of 3-hydroxybutyrate from CO2. Metabolic Engineering, 46, 35-42. Link 

Jason T. Ku, Wiwik Simanjuntak, Ethan I. Lan*, 2017. Renewable synthesis of n-butyraldehyde from glucose by engineered Escherichia coli. Biotechnology for Biofuels, 10:291. Link 

Ethan I. Lan*, Crystal T. Wei, 2016. Metabolic engineering of cyanobacteria for the photosynthetic production of succinate. Metabolic Engineering 38, 483-493. Link 

Shingo Noguchi, Sastia P. Putri, Ethan I. Lan, Walter A. Laviña, Yudai Dempo, Takeshi Bamba, James C. Liao, Eiichiro Fukusaki, 2016. Quantitative target analysis and kinetic profiling of acyl-CoAs reveal the rate-limiting step in cyanobacterial 1-butanol production. Metabolomics 12, 26. Link 

Martin C. Lai, Ethan I. Lan*, 2015. Advances in Metabolic Engineering of Cyanobacteria for Photosynthetic Biochemical Production. Metabolites 5, 636-658. Link 

Ethan I. Lan, Derrick S. Chuang, Claire R. Shen, Annabel M. Lee, Soo Y. Ro, James C. Liao, 2015. Metabolic engineering of cyanobacteria for photosynthetic 3-hydroxypropionic acid production from CO2 using Synechococcus elongatus PCC 7942. Metabolic Engineering 31, 163-170. Link 

Ethan I. Lan, Soo Y. Ro, James C. Liao, 2013. Oxygen-tolerant Coenzyme A-acylating aldehyde dehydrogenase facilitates efficient photosynthetic n-butanol biosynthesis in cyanobacteria. Energy & environmental science. 6, 2672-2681. Link 

Ethan I. Lan, Yasumasa Dekishima, Derrick S. Chuang, James C. Liao, 2013. Metabolic engineering of 2-pentanone synthesis in Escherichia coli. AICHE Journal. 59, 3167-3175. Link 

Ethan I. Lan, James C. Liao, 2012. Microbial synthesis of n-butanol, isobutanol, and other higher alcohols from diverse resources. Bioresource Technology., 135, 339-349.  Link 

Hidevaldo B. Machado, Yasumasa Dekishima, Hao Luo, Ethan I. Lan, James C. Liao, 2012. A selection platform for carbon chain elongation using the CoA-dependent pathway to produce linear higher alcohols. Metabolic Engineering 14, 504-511. Link 

Ethan I. Lan and James C. Liao. ATP drives direct photosynthetic production of 1-butanol in cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America 109, 6018-6023. Link 

Yasumasa Dekishima, Ethan I. Lan, Claire R. Shen, Kwang Myung Cho, James C. Liao, 2011. Extending Carbon Chain Length of 1-Butanol Pathway for 1-Hexanol Synthesis from Glucose by Engineered Escherichia coli. Journal of the American Chemical Society. 133, 11399-11401. Link 

Ethan I. Lan and James C. Liao, 2011. Metabolic engineering of cyanobacteria for 1-butanol production from carbon dioxide. Metabolic Engineering. 13, 353-363. Link 

Claire R. Shen, Ethan I. Lan, Yasumasa Dekishima, Antonino Baez, Kwang Myung Cho, James C. Liao, 2011. Driving forces enable high-titer anaerobic 1-butanol synthesis in Escherichia coli. Applied and Environmental Microbiology. 77, 2905-2915. Link 

Arvin Y. Chen, Jason T. Ku, Teresa P. Tsai, Jenny J. Hung, Billy C. Hung & Ethan I. Lan* (2023). Metabolic Engineering Design Strategies for Increasing Carbon Fluxes Relevant for Biosynthesis in Cyanobacteria. In: Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2023_218. Link

Ku J.T., Lan E.I.*. Design Principles for Engineering Metabolic Pathways in Cyanobacteria. Cyanobacteria Biotechnology (ISBN: 9783527347148 ). WILEY‐VCH GmbH. Apr, 2021: 121-166. Link

Ku J.T., Lan E.I.*. Photosynthesis and Its Metabolic Engineering Applications. Engineering Microbial Metabolism For Chemical Synthesis: Reviews And Perspectives (ISBN: 978-1-78634-429-8). World Scientific Publishing Europe Ltd. Feb, 2018: 121-166. Link