Εργασίες & Δημοσιεύσεις

Δημοσιεύσεις σε Επιστημονικά Περιοδικά

• 2019: Kokkinopoulou I., Maratou E., Mitrou P., Boutati E., Sideris D.C., Fragoulis E.G., Christodoulou M.I. Decreased expression of microRNAs targeting type-2 diabetes susceptibility genes in peripheral blood of patients and predisposed individuals. Endocrine. 66(2):226-239.

• 2019: Christodoulou M.I., Avgeris M., Kokkinopoulou I., Maratou E., Mitrou P., Kontos C.K., Pappas E., Boutati E., Scorilas A., Fragoulis E.G. Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk. Sci Rep. 6;9(1):1512.

• 2016: Papadopoulos E.I., Petraki C., Gregorakis A., Fragoulis E.G., Scorilas A. Clinical evaluation of microRNA-145 expression in renal cell carcinoma: a promising molecular marker for discriminating and staging the clear cell histological subtype. Biol Chem. 1;397(6):529-39.

• 2015: Papadopoulos E.I., Fragoulis E.G, and Scorilas A. Human L-DOPA decarboxylase mRNA is a target of miR-145: A prediction to validation workflow. Gene. 10;554(2):174-80.

• 2015: Avgeris M., Mavridis K., Tokas T., Stravodimos K., Fragoulis E.G and Scorilas A. Uncovering the clinical utility of miR-143, miR-145 and miR-224 for predicting the survival of bladder cancer patients following treatment. Carcinogenesis. 36(5):528-37.

• 2015: Papadopoulos E.I., Petraki C., Gregorakis A, Chra E., Fragoulis E.G., Scorilas A. L-DOPA decarboxylase mRNA levels provide high diagnostic accuracy and discrimination between clear cell and non-clear cell subtypes in renal cell carcinoma. Clin Biochem. 48(9):590-5.

• 2015: Papadopoulos E.I, Petraki C., Gregorakis A., Fragoulis E.G. and Scorilas A. Clinical evaluation of microRNA-145 expression in renal cell carcinoma: a promising molecular marker for discriminating and staging the clear cell histological subtype. Biol Chem. 397(6):529-39.

• 2014: Gkratsou A.S. Fragoulis E.G. and Sideris D.C. Effect of Cytostatic Drugs on the mRNA Expression Levels of Ribonuclease κ in Breast and Ovarian Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry 14 400-408.

• 2013: Avgeris M., Stravodimos K., Fragoulis E.G. and Scorilas A. The loss of the tumor suppressor miR-145 results in the shorter disease-free survival of prostate cancer patients. . Br J Cancer. 108(12), 2573-81.

• 2013: Korbakis D., Fragoulis E.G. and Scorilas A. Quantification and study of the L-DOPA decarboxylase expression in gastric adenocarcinoma cells treated with chemotherapeutic substances. Anticancer Drugs. 24(3), 291-299. 

• 2013: Florou D., Papadopoulos I.N., Fragoulis E.G. and Scorilas A. L-Dopa decarboxylase (DDC) constitutes an emerging biomarker in predicting patients' survival with stomach adenocarcinomas. J Cancer Res Clin Oncol. 139(2), 297-306.

 • 2012: Geomela P.A., Kontos C.K., Yiotakis I., Fragoulis E.G. and Scorilas A. L.DOPA decarboxylase mRNA expression in associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study.  BMC Cancer 20(12), 484. 

• 2012: Patsis C., Glyka V., Yiotakis I., Fragoulis E.G. and Scorilas A. L-DOPA Decarboxylase (DDC) Expression Status as a Novel Molecular Tumor Marker for Diagnostic and Prognostic Purposes in Laryngeal Cancer. Transl Oncol, 5(4), 288-296.

• 2012: Kiritsi M.N., Fragoulis E.G. and Sideris D.C. Essential cysteine resitudes for Human RNase κ catalytic activity. FEBS Journal 279(7), 1318-26. 

• 2011: Chalatsa I., Fragoulis E.G. and Vassilakopoulou D. Release of Membrane-Associated L-Dopa decarboxylase from human cells. Neurochem. Res. 36, 1426-1434.

 • 2011: Rampias T.N., Fragoulis E.G. and Sideris D.C. Efficient Cloning of alternatively Polyadenylated Transcripts via Hybridization Capture PCR. Curr. Issues Mol. Biol. 14, 1-8.

 • 2011: Chalatsa I., Nikoloutsou E., Fragoulis E.G. and Vassilakopoulou D. L-Dopa decarboxylase expression profile in human cancer cells. Mol. Biol. Rep. 38, 1005-1011.

 • 2010: Kontos C.K., Papadopoulos I.N., Fragoulis E.G. and Scorilas A. Quantitative expression analysis and prognostic significance of L Dopa decarboxylase in colorectal adenocarcinoma. British Journal of Cancer 102, 1384-1390.

 • 2009: Kokkinou Ioanna, Fragoulis Emmanuel G, Vassilacopoulou Dido The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase. Journal of Neuroimmunology 2009, 216(1-2): 51-8.

 • 2009: Vassiliou Alice-Georgia, Fragoulis Emmanuel G, Vassilacopoulou Dido Detection, purification and identification of an endogenous inhibitor of L-Dopa decarboxylase activity from human placenta. Neurochemical Research 2009, 34(6): 1089-100.

 • 2009: Rampias Theodoros N, Fragoulis Emmanuel G, Sideris Diamantis C A hybrid-specific, polymerase chain reaction-based amplification approach for chromosomal walking. Analytical Biochemistry 2009, 388(2): 342-4.

 • 2009: Kokkinou Ioanna, Nikolouzou Eleftheria, Hatzimanolis Alexandros, Fragoulis Emmanuel G, Vassilacopoulou Dido Expression of enzymatically active L-DOPA decarboxylase in human peripheral leukocytes. Blood Cells, Molecules & Diseases 2009, 42(1): 92-8.

 • 2008: Rampias Theodoros N, Fragoulis Emmanuel G, Sideris Diamantis C Genomic structure and expression analysis of the RNase kappa family ortholog gene in the insect Ceratitis capitata. The FEBS Journal 2008, 275(24): 6217-27.

 • 2008: Avgeris Margaritis, Koutalellis Georgios, Fragoulis Emmanuel G, Scorilas Andreas Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer. Clinical Biochemistry 2008, 41(14-15): 1140-9.

• 2007: Economopoulou Marie-Angela I, Fragoulis Emmanouel G, Sideris Diamantis C Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. Nucleic Acids Research 2007, 35(19): 6389-98.

 • 2005: Vassiliou Alice-Georgia, Vassilacopoulou Dido, Fragoulis Emmanuel G Purification of an endogenous inhibitor of L-Dopa decarboxylase activity from human serum. Neurochemical Research 2005, 30(5): 641-9.

 • 2004: Vassilacopoulou Dido, Sideris Diamantis C, Vassiliou Alice G, Fragoulis Emmanuel G Identification and characterization of a novel form of the human L-dopa ecarboxylase mRNA. Neurochemical Research 2004, 29(10): 1817-23.

 • 2003: Rampias Theodoros N, Sideris Diamantis C, Fragoulis Emmanuel G Cc RNase: the Ceratitis capitata ortholog of a novel highly conserved protein family in metazoans. Nucleic Acids Research 2003, 31(12): 3092-100.

 • 2003: Siaterli Maria-Zaharenia, Vassilacopoulou Dido, Fragoulis Emmanuel G Cloning and expression of human placental L-Dopa decarboxylase. Neurochemical Research 2003, 28(6): 797-803.

 • 2003: Leimoni Irini D, Sideris Diamantis C, Fragoulis Emmanuel G Purification from normal human plasma and biochemical characterization of a ribonuclease specific for poly(C) and poly(U). Archives of Biochemistry and Biophysics 2003, 413(1): 83-90.

 • 2002: Poulikakos P, Vassilacopoulou Dido, Fragoulis Emmanuel G. A membrane –associated form of L-DOPA decarboxylase in the white prepuparium and adult eclosion developmental stages of the mediteranean fruit fly Ceratitis capitata. Biogenic Amines 2002, 17 (1): 15-24.

 •2001: Poulikakos P, Vassilacopoulou D, Fragoulis E G L-DOPA decarboxylase association with membranes in mouse brain. Neurochemical Research 2001, 26(5): 479-85.

 • 2000: Sideris D C, Rampias T N, Fragoulis E G Isolation and sequencing of a cDNA encoding for a ribonuclease from the insect Ceratitis capitata. Insect Biochemistry and Molecular Biology 2000, 30(2): 153-61.

 • 1998: Mantzouridis T D, Fragoulis E G Two different cDNAs code for L-DOPA decarboxylase in the white prepuparium and eclosion developmental stages of the insect Ceratitis capitata1. Biochimica et Biophysica Acta 1998, 1443(1-2): 267-73.

 • 1998: Kouyanou S, Gagou M E, Fragoulis E G Characterization of acidic ribosomal proteins from three developmental stages of the medfly Ceratitis capitata. Biochemistry and Molecular Biology International 1998, 45(3): 623-33.

 • 1997: Mantzouridis T D, Sideris D C, Fragoulis E G cDNA cloning of L-dopa decarboxylase from the eclosion stage of the insect Ceratitis capitata. Evolutionary relationship to other species decarboxylases. Gene 1997, 204(1-2): 85-9.

 • 1997: Lalioti V S, Ballesta J P, Fragoulis E G Purification and characterization of a novel poly(U), poly(C) ribonuclease from Saccharomyces cerevisiae. Biochimica et Biophysica Acta 1997, 1342(1): 62-72.

• 1996: Bossinakou K S, Matzouridis T D, Fragoulis E G. L-Dopa decarboxylase m-RNA levels are correlated with the L-Dopa Decarboxylase protein profile during the development of the Insect Ceratitis capitata Insect Biochem. Molec. Biol. 1996, 8-9: 859-865.

 • 1996: Bossinakou K S, Fragoulis E G Purification and characterisation of L-DOPA decarboxylase from pharate pupae of Ceratitis capitata. A comparison with the enzyme purified from the white prepupae. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology 1996, 113(2): 213-20. 

• 1995: Kouyanou S, Pilali M, Fragoulis E G Ribosome-associated ribonucleases from six-day larvae of the insect Ceratitis capitata. Biochemistry and Molecular Biology International 1995, 37(6):1217-27. 

• 1994: Lalioti V S, Fragoulis E G In vitro translation of an intact mRNA coding for a poly(U), poly(C) specific ribonuclease isolated from six-day-old larvae of Ceratitis capitata by a modified extraction procedure. Biochemistry and Molecular Biology International 1994, 34(1): 37-45. 

• 1992: Sideris D C, Kühn S, Fragoulis E G Preparation of monoclonal antibodies against a poly(U), poly(C) specific ribonuclease prepared from the insect Ceratitis capitata. Biochemistry International 1992, 27(1): 25-35. 

• 1992: Lalioti V S, Sideris Diamantis C, Fragoulis Emmanuel G Further characterization of a poly(U) poly (C ) ribonuclease from the insect Ceratitis capitata. Insect Biochem. Molec. Biol. 1992, 22(2): 125-135.

• 1991: Pilali M. and Fragoulis E.G. Purification of Ribosomal subunits from Ceratitis capitata and comparison of their proteins from two different developmental stages. Archives of Insect Biochemistry and Physiology 16, 55-67. 

• 1990: Mappouras D G, Stiakakis J, Fragoulis E G Purification and characterization of L-dopa decarboxylase from human kidney. Molecular and Cellular Biochemistry 1990, 94(2): 147-56. 

• 1990: Mappouras D G, Fragoulis E G L-dopa decarboxylase in Ceratitis capitata white puparia and human: a comparative study. Comparative Biochemistry and Physiology. B, Comparative Biochemistry 1990, 97(2): 301-6.

• 1989: Sideris D.C. and Fragoulis E.G. Properties of a partially purified inhibitor of protein synthesis from the post ribosomal supernatant of six day old larvae of Ceratitis capitata. Comp. Biochem. and Physiol. 93B (3), 657-664.

• 1988: Mapouras D.G. and Fragoulis E.G. Purification and Characterization of L-DOPA decarboxylase from the white puparia of Ceratitis capitata. Insect Biochem. 18 (4), 369-376. 

• 1987: Sideris D. C., Fragoulis E. G. Purification and characterization of a ribonuclease specific for poly(U) and poly(C) from the larvae of Ceratitis capitata. European Journal of Biochemistry / FEBS 1987, 164(2): 309-15. 

• 1985: Kouyanou S, Fragoulis E G Comparison of native and KCl treated 40S ribosomal subunits from the silkmoth Antherea pernyi and mammals. Comparative Biochemistry and Physiology. B, Comparative Biochemistry 1985, 82(3): 461-8. 

• 1984: Fragoulis E.G. Traub P. Inhibition of protein synthesis in a polyribosome dependent cell-free system by a specific ribonuclease prepared from the follicles of two different stages of development of the silkmoth Antherea pernyi. Roux's Arch. Dev. Biol. 1984, 194: 25-31. 

• 1983: Kouyanou S, Fragoulis E, Kafatos F C Developmental and evolutionary comparisons of proteins from purified ribosomal subunits in two silkmoths. European Journal of Biochemistry / FEBS 1983, 135(1): 1-8. 

• Εμμ. Γ. Φραγκούλης (1981) Μελέτη του ανασυνδυασμού των ριβοσωμικών υπομονάδων και της λειτουργικότητος In vitro συστημάτων μετάφρασης από αναπτυσσόμενα ωοθυλάκια του εντόμου A. pernyi. Διατριβή επί Υφηγεσία υποβληθείσα στη Φυσικομαθηματική Σχολή του Πανεπιστημίου Αθηνών

• 1978: Fragouli-Fournogeraki M.E., Fragoulis E.G. and Sekeris C.E. Protein synthesis by polysomes from the epidermis of Blowfly larvae: Dependence of formation of DOPA decarboxylase on the developmental stage. Insect Biochemistry 8, 435-411. 

• 1976: Fragoulis E G, Sekeris C E Poly(A) sequences in Insect RNA. Insect Biochemistry 1976, 6: 39-42. 

• 1976: Sekeris C.E. and Fragoulis E.G. Dependence of m-RNA concentration for DOPA decarboxylase in Epidermis tissue of Calliphora vicina R.D. on Ecdysone. Colloques internationaux C.N.R.S. Actualites Sur les Hormones D' Invertebres 251, 343-350. 

• 1975: Fragoulis E, Sekeris C E Translation of 3,4Dihydroxyphenylalanine Decarboxylase Isolated from Epidermis Tissue of Calliphora vicina R.-D. in an Heterologous System - Dependence of mRNA Concentration on the Insect Steroid Hormone Ecdysone. European Journal of Biochemistry 1975, 51(1): 305-316. 

• 1975: Fragoulis E G and Sekeris C E Translation of m-RNA for DOPA decarboxylase, isolated from epidermis of Calliphora vicina larvae, in an heterologous system: Dependence of MRNA concentration on the ecdysonetiter. Z. Physiol. Chem. 1975, 355: 24-25. 

• 1975: Fragoulis E G and Sekeris C E Purification and Characterization of DOPA decarboxylase from the integument of Calliphora vicina larvae. Archives of Biochemistry and Biophysics 1975, 168: 15-25. 

• 1975: Fragoulis E G and Sekeris C E Induction of Dopa (3,4Dihydroxyphenylalanine) Decarboxylase in Blowfly Integument by Ecdysone - A demonstration of synthesis of the enzyme de novo Biochemical Journal 1975, 146: 121-126. 

• 1974: Fragoulis E.G. Induction of DOPA decarboxylase in blowfly larvae during development. Molecular action of Ecdysone. Ph.D. Thesis in the University of Marburg. 

• 1973: Fragoulis E G and Sekeris C E Ecdysone and the Induction of DOPA decarboxylase a key enzyme of metamorphosis. Z. Physiol. Chem. 1973, 354: 190-191. 

• 1971: Marmaras V J and Fragoulis E G Studies on the metabolism of 14C-DOPA in the Hepatopancreas of Decapod Crustacean Upogebia litoralis. Comparative and General Pharmacology 1971, 2(5): 52-58. 

• 1971: Marmaras V J, Fragoulis E G and Christophoratou-Manioti A The metabolism of 14C-Dopamine in the Decapod Crustacean Upogebia litoralis. Comparative and General Pharmacology 1971, 2(8): 377-382. 

• 1970: Marmaras V J and Fragoulis E G 5-Hydroxytryptophan decarboxylase activity in the Decapod Crustacean Upogebia litoralis. Experientia 1970, 26: 359-360.

Δημοσιεύσεις σε Πρακτικά Συνεδρίων & Κεφάλαια Βιβλίων

• 2011: Florou D., Scorilas A., Vassilacopoulou D., Fragoulis E.G. DDC (dopa decarboxylase (aromatic L-amino acid decarboxylase)). Atlas Genet Cytogenet Oncol Haematol. May 2011. URL : http://AtlasGeneticsOncology.org/Genes/DDCID50590ch7p12.html

• 2005: Vasilacopoulou D. Fragoulis E.G. L-Dopa decarboxylase: from the protein to the Gene. Presented in the symposium of Biochemical – Pharmacological research from the Biochemistry of Metabolism to Molecular Biology. Biotechnology and Contemporary therapeutics. October 2004

• 1988: Sekeris C.E. Fragoulis E.G. Dopa decarboxylase. In Insects Hormonal Control and tissue specific expression In Ecdysone Ed.J.Koolman Georg Thieme Verlag.

• 1985: Sekeris C.E. Fragoulis E.G. Control of Dopa decarboxylase. In comprehensive Insect Physiology Biochemistry and Pharmacology (Ed A. Kerkut and L.Gilbert) Pergamon press. p. 147-164.