Embedded Files
2025
2025
E. Figuerola-Bou, C. Rios-Astorch, E. Blanco, M. Sánchez-Jiménez, P. Táboas, G. Fernández, S. Gómez, Oscar Muñoz, P. Castellano-Escuder, S. Pérez-Jaume, M. García, E. Prada, S. Mateo-Lozano, N. Riggi, A. Avgustinova, C. Lavarino, L. Di Croce, S. Sánchez-Molina and J. Mora. KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma. Cancer Research (in press). [PMID:]
I. Mocavini*, A. Mallol*, A. Gutierrez, P. Chammas, A. Carretero, A. Dias, E. Blanco, I. Rodriguez Arce, M. Mallo, L. Di Croce and B. Payer. The PRC2-associated factor EPOP is required for Hox gene regulation during axial development in mice. Developmental Biology 527:250-259 . [PMID: 40834979]
2024
2024
M. Barrero, A. Lazarenkov, E. Blanco, L.G. Palma, A. López-Rubio, M. Bauer, A. Bigas, L. Di Croce, J. L. Sardina and B. Payer. The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC Reprogramming. Science Advances 10:eadj8862. [PMID:39110794]
N. Arecco N, I. Mocavini, E. Blanco, C. Ballaré, E. Libman, S. Bonnal, M. Irimia and L. Di Croce. Alternative splicing decouples local from global PRC2 activity. Molecular Cell. 84:1049-1061.e8. [PMID:38452766]
G. Serra-Bardenys, E. Blanco, C. Escudero-Iriarte, Q. Serra-Camprubi, J. Querol, L. Pascual-Reguant, B. Morancho, M. Escorihuela, A. Sabe, L. Martin, S. Segura-Bayona, G. Verde, R. Aiese Cigliano, A. Millanes-Romero, C. Jeronimo, J. P. Cebria-Costa, P. Nuciforo, S. Simoneti, C. Viaplana, R. Dienstmann, M. Oliveira, V. Peg, T. Stracker, J. Arribas, F. Canals, J. Villanueva, L. Di Croce, A. Garcia de Herreros, T. Tian and S. Peiro. LOXL2-mediated chromatin compaction is required to maintain the oncogenic properties of triple-negative breast cancer cells. The FEBS Journal 291(11):2423-2448. [PMID:38451841]
2023
2023
A. Llorente, M. T. Blasco, I. Espuny, C. Ballaré, E. Blanco, A. Caballé, A. Bellmunt, F. Salvador, M. Guiu, M. Nuñez, G. Loren, C. Figueras-Puig, P. Gibler, A. Riera, I. Holen, A. Avgustinova, L. Di Croce, R. R. Gomis. MAF Amplification licenses Estrogen Receptor a to Drive Breast Cancer Metastasis. Nature Cell Biology 25:1833-1847. [PMID:37945904]
S. Basu, O. Shukron, D. Hall, P. Parutto, A. Ponjavic, D. Shah , W. Boucher, D. Lando, W. Zhang, N. Reynolds, L. H. Sober, A. Jartseva, R. Ragheb, X. Ma, J. Cramard, R. Floyd, J. Balmer, T. A. Drury, A. R. Carr, L.-M. Needham , A. Aubert, G. Communie, K. Gor, M. Steindel, L. Morey, E. Blanco, T. Bartke , L. Di Croce, I. Berger, C. Schaffitzel, S. F. Lee, T. J. Stevens, D. Klenerman, B. D. Hendrich*, D. Holcman, E. D. Laue. Live-cell 3D single-molecule tracking reveals modulation of enhancer 24 dynamics by NuRD. Nature Structural & Molecular Biology 30:1628-1639. [PMID:37770717]
S. Aranda*, A. Alcaine-Colet, C. Ballaré, E. Blanco, I. Mocavini, A. Sparavier, P. Vizán, E. Borràs, E. Sabidó, L. Di Croce*. Thymine DNA glycosylase (TDG) regulates cell cycle–driven p53 transcriptional control in pluripotent cells. Molecular Cell 83:2673-2691. [PMID: 37506700]
P. Solá*, E. Mereu*, J. Bonjoch† , M. Casado-Pelaez† , N. Prats, M. Aguilera , O. Reina , E. Blanco , M. Esteller, L. Di Croce, H. Heyn, G. Solanas and S. Aznar Benitah. Targeting lymphoid-derived IL-17 Signalling to Delay Skin Aging. Nature Aging 3:688-704. [PMID: 37291218]
M. González-Ramírez*, E. Blanco and L. Di Croce**. A computational pipeline to learn gene expression predictive models from epigenetic information at enhancers or promoters. STAR Protocols 4: 101948. [PMID: 36583961]
E. Blanco, C. Ballaré, L. Di Croce, and S. Aranda. Quantitative comparison of multiple chromatin immunoprecipitation-sequencing (ChIP-seq) experiments with spikChIP. Computational Epigenomics and Epitranscriptomics. Methods in Molecular Biology (Humana, NY.) 2624: 55-72. [PMID: 36723809]
2022
2022
G. Mas, F. Santoro, E. Blanco, G. P. Gamarra Figueroa, F. Le Dily, G. Frigè, E. Vidal, F. Mugianesi, C. Ballaré, A. Gutierrez, A. Sparavier, M. A. Marti-Renom, S. Minucci and L. Di Croce. In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation. Genes & Development 36:451-467. [PMID: 35450883]
2021
2021
E. Blanco, M. Gonzalez-Ramirez and L. Di Croce. Productive visualization of high-throughput sequencing data using the SeqCode open portable platform. Scientific Reports 11:19545. [PMID: 34599234]
M. Gonzalez-Ramirez, C. Ballare, F. Mugianesi, M. Beringer, A. Santanach, E. Blanco and L. Di Croce. Differential contribution to gene expression prediction of histone modifications at enhancers or promoters. PLoS Computational Biology 17:e1009368. [PMID: 34473698]
E. Blanco, L. Di Croce and S. Aranda. SpikChIP: a novel computational methodology to compare multiple ChIP-seq using spike-in chromatin. NAR Genomics and Bioinformatics 3:lqab064. [PMID: 34327329]
M. García-Montolio, C. Ballaré, E. Blanco, A. Gutiérrez, S. Aranda, A. Gomez, C.H. Kok, D. Yeung, T.P. Hughes, P. Vizán and L. Di Croce. Polycomb factor Phf19 controls cell growth and differentiation towards erythroid pathway in chronic myeloid leukemia cells. Frontiers in Cell and Developmental Biology 9:655201. [PMID: 33996816]
R. Alcalá-Vida*, M. Garcia-Forn*, C. Castany-Pladevall, J. Creus-Muncunill, Y. Ito, E. Blanco, A. Golbano, K. Crespí-Vázquez, A. Parry, G. Slater, S. Samarajiwa, S. Peiró, L. Di Croce, M. Narita and E. Pérez-Navarro. Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease. EMBO Molecular Medicine 13:e12105. [PMID: 33369245]
2020
2020
S. Sanchez-Molina, E. Figuerola-Bou, E. Blanco, M. Sanchez-Jimenez, P. Taboas, S. Gomez, C. Ballare, D.J. Garcia-Dominguez, E. Prada, L. Hontecillas-Prieto, A. Montero-Carcaboso, O. Tirado, I. Hernandez-Muñoz, E. de Alava, C. Lavarino, L. Di Croce and J. Mora. RING1B recruits EWSR1-1 FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis. Science Advances 6: eaba3058. [PMID: 33097530]
P. Vizán*, A. Gutiérrez*, I. Espejo, M. García-Montolio, M. Lange, A. Carretero, A. Lafzi, L. de Andrés-Aguayo, E. Blanco, R. Thambyrajah, T. Graf, H. Heyn, A. Bigas, L. Di Croce. The Polycomb-Associated Factor Phf19 Controls Hematopoietic Stem Cell State and Differentiation. Science Advances 6:eabb2745. [PMID: 32821835]
J. Martone, M. Lisi, F. Castagnetti, A. Rosa, V. Di Carlo, E. Blanco, A. Setti,D. Mariani, A. Colantoni, T. Santini, L. Di Croce and I. Bozzoni. Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy. EMBO Molecular Medicine e12063. [PMID: 32596946]
P. Jain, C. Ballare, E, Blanco, P. Vizan and L. Di Croce. PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. Elife 9:e51373. [PMID: 32155117]
E. Blanco, M. González-Ramírez, A. Alcaine-Colet, S. Aranda and L. Di Croce. The Bivalent Genome: Characterization, Structure, and Regulation. Trends in Genetics 36: 118-131. [PMID: 31818514]
2019
2019
J. Castaño, S. Aranda, C. Bueno, F.J. Calero-Nieto, E. Mejia-Ramirez, J.L. Mosquera, E. Blanco, X. Wang, C. Prieto, L. Zabaleta, E. Mereu, M. Rovira, S. Jimenez-Delgado, D.R. Matson, H. Heyn, E.H. Bresnick, B. Gottgens, L. Di Croce, P. Menendez, A. Raya and A. Giorgetti. GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm. Stem Cell Reports 13: 515-529. [PMID: 31402335]
S. Aranda, A. Alcaine-Colet, E. Blanco, E. Borràs, C. Caillot, E. Sabidó and Luciano Di Croce. Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation. Science Advances 5: 3. [PMID: 30854431]
2018
2018
G. Mas, E. Blanco, C. Ballare, M. Sanso, Y. Spill, D. Hu, Y. Aoi, F. Le Dily, A. Shilatifard, M. A. Marti-Renom and L. Di Croce. Promoter bivalency favors an open chromatin architecture in embryonic stem cells. Nature Genetics 50: 1452–1462. [PMID: 30224650]
L. Pascual-Reguant, E. Blanco, S. Galan, F. Le Dily, Y. Cuartero, G. Serra-Bardenys, V. Di Carlo, A. Iturbide, J.P. Cebrià-Costa, L. Nonell, A. Garcia de Herreros, L. Di Croce, M. Marti-Renom and S. Peiro. Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains. Nature Communications 9: 3420. [PMID: 30143639]
T. Alioto, E. Blanco, G. Parra and R. Guigo. Using geneid to Identify Genes. Current Protocols in Bioinformatics 64:e56. John Wiley & Sons Inc., New York. ISBN: 978-0-471-25093-7. [PMID: 30332532]
2017
2017
A. Santanach, E. Blanco, H. Jiang, K.R. Molloy, M. Sansó, J. LaCava, L. Morey and Luciano Di Croce. The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity. Nature Communications 8: 1235 [PMID: 29089522]
T.J. Stevens, D. Lando, S. Basu, L.P. Atkinson, Y. Cao, S.F. Lee, M. Leeb, K.J. Wohlfahrt, W. Boucher, A. O’Shaughnessy-Kirwan, J. Cramard, A.J. Faure, M. Ralser, E. Blanco, L. Morey, M. Sansó, M.G.S. Palayret, B. Lehner, L. Di Croce, A. Wutz, B. Hendrich, D. Klenerman and E.D. Laue. 3D structures of individual mammalian genomes studied by single-cell Hi-C. Nature 544: 59-64. [PMID: 28289288]
2016
2016
M. Beringer*, P. Pisano*, V. Di Carlo*, E. Blanco, Paul Chammas, P. Vizan, A. Gutiérrez, S. Aranda, B. Payer, M. Wierer and L. Di Croce. EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells. Molecular Cell 64:645-658. [PMID: 27863225]
L. Rinaldi, D. Datta, J. Serrat, L. Morey, G. Solanas, A. Avgustinova, E. Blanco, J. Ignacio Pons, D. Matallanas, A. Von Kriegsheim, L. Di Croce and S. Aznar Benitah. Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis. Cell Stem Cell 19:491-501. [PMID: 27476967]
2015
2015
S. Perez-Lluch*, E. Blanco*, H. Tilgner*, J. Curado*, M. Ruiz-Romero, M. Corominas and R. Guigo. Absence of canonical marks of active chromatin in developmentally regulated genes. Nature Genetics 47:1158-1167. [PMID: 26280901]
L. Morey, A. Santanach*, E. Blanco*, L. Aloia, E. Nora, B. Bruneau and L. Di Croce. Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms. Cell Stem Cell 17:300-315. [PMID: 26340528]
M. Ruiz‐Romero, E. Blanco, N. Paricio, F. Serras and M. Corominas Cabut/dTIEG associates with the transcription factor Yorkie for growth control. EMBO reports 16: 362–369. [PMID: 25572844]
C. Alvarez-Fernández, S. Tamirisa, F. Prada, A. Chernomoretz, O. Podhajcer, E. Blanco and E. Martin-Blanco. Identification and Functional Analysis of Healing Regulators in Drosophila. PLoS Genet 11(2): e1004965. [PMID: 25647511]
2014
2014
E. Blanco, J.F. Abril and R. Guigo (contributors). Concise Encyclopaedia of Bioinformatics and Computational Biology, 2nd Edition. Marketa J. Zvelebil, John M. Hancock editors. Wiley-Blackwell. ISBN: 978-0-470-97871-9. [BOOK CHAPTER]
E. Blanco. Metadata and ontologies for bioinformatics. In Miguel-angel Sicilia (Editor): Handbook of Metadata, Semantics and Ontologies. World Scientific Publishing Company. ISBN: 978-9812836298. [BOOK CHAPTER]
2013
2013
N. Turkel, V. Sahota, J. Bolden, K. Goulding, K. Doggett, L. Willoughby, E. Blanco, E. Martin-Blanco, M. Corominas, J. Ellul, T. Aigaki, H. Richardson and A. Brumby. The BTB-zinc finger transcription factor Abrupt acts as an epithelial oncogene in Drosophila through maintaining a progenitor-like cell state. PLoS Genetics 9(7): e1003627. [PMID: 23874226]
N. Doumpas, M. Ruiz-Romero, E. Blanco, B. Edgar, M. Corominas and A. Teleman. Brk regulates wing disc growth in part via repression of Myc expression. EMBO reports 14:261-268. [PMID: 23337628]
E. Blanco. Genomica Computacional (spanish, 248 pages). Editorial UOC. ISBN: 978-84-9029-910-4. [BOOK]
2012
2012
E. Blanco and M. Corominas. CBS: an open platform that integrates predictive methods and epigenetics information to characterize conserved regulatory features in multiple Drosophila genomes . BMC Genomics 13:688. [PMID: 23228284]
I. Erb, Juan R. Gonzalez-Vallinas, G. Bussotti, E. Blanco, E. Eyras and C. Notredame. Use of ChIP-Seq data for the design of a multiple promoter-alignment method. Nucleic Acids Research 40:e52. [PMID: 22230796]
S. Gonzalez, B. Montserrat-Sentis, F. Sanchez, M. Puiggros, E. Blanco, A. Ramirez and D. Torrents. ReLA, a local alignment search tool for the identification of distal and proximal gene regulatory regions and their conserved transcription factor binding sites. Bioinformatics 28:763-770. [PMID: 22253291]
N. Fernandez-Castillo, M. Orejarena, M. Ribases, E. Blanco, M. Casas, P. Robledo, R. Maldonado and B. Cormand. Active and passive MDMA ('ecstasy') intake induces differential transcriptional changes in the mouse brain. Genes, Brain and Behavior 11:38-51. [PMID: 21951708]
E. Blanco. Fundamentos de Informatica en Entornos Bioinformaticos (spanish, 242 pages). Editorial UOC. ISBN: 978-84-9029-998-2. [BOOK]
2011
2011
S. Perez-Lluch, E. Blanco, A. Carbonell, D. Raha, M. Snyder, F. Serras and M. Corominas. Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing. Nucleic Acids Research 39:4628-4639. [PMID: 21310711]
2010
2010
E. Blanco, M. Ruiz-Romero, S. Beltran, M. Bosch, A. Punset, F. Serras and M. Corominas. Gene expression following induction of regeneration in Drosophila wing imaginal discs. BMC Developmental Biology 10:94. [PMID: 20813047]
E. Blanco. Computational characterization of regulatory regions. In Mourad Elloumi and Albert Y. Zomaya (editors): Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications. Wiley-Blackwell (John Wiley & Sons Ltd). ISBN-13: 978-0470505199. [BOOK CHAPTER]
2009
2009
J.M. Servitja, M. Pignatelli, M. Maestro, C. Cardalda, S.F. Boj, J. Lozano, E. Blanco, A. Lafuente, M.I. McCarthy, L. Sumoy, R. Guigo and J. Ferrer. Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Molecular and Cellular Biology 29: 2945-2959. [PMID: 19289501]
E. Blanco and J.F. Abril. Computational Gene Annotation in New Genome Assemblies Using GeneID. In D. Posada, chief editor: Bioinformatics for DNA Sequence Analysis. Methods in Molecular Biology 537:243-261. Humana Press (Springer). ISBN: 978-1-59745-251-9 [PMID: 19378148]. [BOOK CHAPTER]
2008
2008
M. Morey, S.K. Yee, T. Herman, A. Nern, E. Blanco and S.L. Zipursky. Coordinate Control of Synaptic Layer Specificity and Rhodopsins in Photoreceptor Neurons. Nature 456:795-799. [PMID: 18978774]
E. Blanco*, M. Pignatelli*, S.Beltran, A. Punset, S. Perez-Lluch, F. Serras, R. Guigo and M. Corominas. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Genome Biology 9:R134. [PMID: 18783608]
The Open Regulatory Annotation Consortium (including Enrique Blanco). ORegAnno: an open-access community-driven resource for regulatory annotation. Nucleic Acids Research 36:D107-D113. [PMID: 18006570]
2007
2007
Drosophila 12 Genomes Consortium (including Enrique Blanco). Evolution of genes and genomes on the Drosophila phylogeny. Nature 450:203-218. [PMID: 17994087]
E. Blanco, R. Guigo and X. Messeguer. Multiple Non-Collinear TF-map Alignments of Promoter Regions. BMC Bioinformatics 8:138. [PMID: 17456238]
E. Blanco, G. Parra and R. Guigo. Using geneid to Identify Genes. In A. D. Baxevanis, G.A. Petsko, L.D. Stein, and G.D. Stormo, chief editors: Current Protocols in Bioinformatics. Volume 1, Unit 4.3 (revised) (pgs 1-28). John Wiley & Sons Inc., New York. ISBN: 978-0-471-25093-7. [PMID: 18428791]
2006
2006
E. Blanco, X. Messeguer, T.F. Smith and R. Guigo. Transcription Factor Map Alignment of Promoter Regions. PLoS Computational Biology 2(5): e49. [PMID: 16733547]
E. Blanco, D. Farre, M. Alba, X. Messeguer and R. Guigo. ABS: a database of Annotated regulatory Binding Sites from orthologous promoters. Nucleic Acids Research 34:D63-D67. [PMID: 16381947] [WEB]
E. Blanco. Meta-alignment of Biological Sequences (PhD thesis). Supervised by Xavier Messeguer and Roderic Guigo. Universitat Politecnica de Catalunya (UPC). [TDX]
2005
2005
E. Blanco and R. Guigo. Predictive Methods Using DNA Sequences. In A. D. Baxevanis and B. F. Francis Ouellette, chief editors: Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Third Edition (pgs 115-142). John Wiley & Sons Inc., New York. ISBN: 0-471-47878-4. [BOOK CHAPTER]
2004
2004
S. Castellano, S.V. Novoselov, G.V. Kryukov, A. Lescure, E. Blanco, A. Krol. V.N. Gladyshev and R. Guigo. Reconsidering the evolution of eukaryotic selenoproteins: a novel non-mammalian family with scattered phylogenetic distribution. EMBO reports, 5(1):71-77. [PMID: 14710190]
2003
2003
S. Beltran, E. Blanco, F. Serras, B. Perez-Villamil, R. Guigo, S. Artavanis-Tsakonas and M. Corominas. Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster. PNAS 100(6):3293-3298. [PMID: 12626737]
2002
2002
E. Blanco, G. Parra and R. Guigo. Using geneid to Identify Genes. In A. D. Baxevanis and D. B. Davison, chief editors: Current Protocols in Bioinformatics. Volume 1, Unit 4.3 (pgs 1-26). John Wiley & Sons Inc., New York. ISBN: 0-471-25093-7. [BOOK CHAPTER]
2000
2000
G. Parra, E. Blanco, and R. Guigo. Geneid in Drosophila. Genome Research 10(4):511-515. [PMID: 10779490]
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