SESSION 3

7. Spik-ChIP: a case of study

• Open the following UCSC session with the tracks of H3K79me2 ChIP-seq performed in REFERENCE 1 analyzed also in REFERENCE2

• Configure each collection of tracks (TRADITIONAL, SPIK-CHIP and CHIP-RX) to show each subtrack in a separate line of the image by setting Merge method: none

• Compare now how the degree of amount of histone is correctly reported at each sample by spike-in correction methods, while it is more abruptly shown in the traditional sequencing depth normalization

REFERENCES:

FIGURE 1 and 2 - ChIP-seq samples and ChIP-Rx approach at [PMID: 25437568] 

FIGURE 3 - spikChIP approach at [PMID: 34327329] and [PMID: 36723809]

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