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Current work:
Process Chemistry · cGMP manufacturing · Organic Synthesis · Team Leadership
Route scouting, process development and optimization of small molecule drugs, high-potent APIs, oligonucleotides and drug conjugates following cGMP guidelines
Demonstration-scale synthesis of final API/drug substance, Master Batch Record (MBR), process hazard analysis (PHA) documents, technology transfer and supervision of the kilo lab campaign.
Synthesis of high-potent drug (payload) and linkers and scaled up.
New impurities syntheses and "fate and purge" study of the final API.
Work at Abzena:
Following topics were my main focus at Abzena:
Antibody drug conjugates (ADCs):
ADCs made from novel payloads specific for infectious disease-related targets and methods of use to inhibit bacterial growth and treat bacterial infections.
Development of novel linkers for improvement of the conjugation techniques
Synthesis of derivatives of cytotoxic/potent natural product based compounds
Multi-step synthesis of novel drug like molecules
Early and late stage route design and execution for process development
Postdoctoral Work:
My postdoctoral research at NIH was focused on three different topics:
syntheses of Wip1 phosphatase inhibitors
small molecule anti-HIV drug synthesis (NCp7 inactivators)
synthesis and studies on peptides and peptide nucleic acids (PNAs)
Doctoral Work:
My graduate research at Oregon State University was broadly focused on the development of unifying strategies towards the synthesis of multiple sub-families of the Lycopodium alkaloids. This family have shown wide-ranging and significant biological activity including being implicated as the active ingredient in the herbal remedies. I targeted the C10-functionalized Lycopodium alkaloids such as 10-hydroxylycopodine, deacetylpaniculine, paniculine, lycopecurine, inundatine and fastigiatine. I also worked towards quinolizidine containing natural products such as cermizine C and cermizine D.
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