Publications

*corresponding author, §joint first author

PRIMARY PUBLICATIONS

Prokopidis K, Giannos P, Isanejad M, Wright HL*.  Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants. BMC Gastroenterology 22:533 https://doi.org/10.1186/s12876-022-02613-2

Cross A, Hawkes J, Frankland H, Mediana A, Wright H, Goodson N, Edwards SW, Moots R. Neutrophils in patients with psoriatic arthritis treated with secukinumab: altered cytokine signalling, but host defence preserved. Rheumatology (Oxford) https://doi.org/10.1093/rheumatology/kead007   

Banka S, Shalev S, Park SM, Wood KA, Thomas HB, Wright HL, Alyahya M, Bankier S, Alimi O, Chervinsky E, Zeef LAH, O’Keefe RT. Bi-allelic FRA10AC1 variants in a multisystem human syndrome. Brain 2022 145(10), e86-e89 https://doi.org/10.1093/brain/awac262  

Chokesuwattanaskul S, Fresneda Alarcon M, Mangalakumaran S, Grosman R, Cross AL, Chapman EA, Mason D, Moots RJ, Phelan M, Wright HL*. Metabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition. Metabolites 2022, 12(7); 650 https://doi.org/10.3390/metabo12070650

Saithong S, Saisorn W, Tovichayathamrong P, Filbertine G, Torvorapanit P, Wright HL, Edwards SW, Leelahavanichkul A, Hirankarn N,  Chiewchengchol D. Anti-inflammatory Effects and Decreased Formation of Neutrophil Extracellular Traps by Enoxaparin in COVID-19 Patients. International Journal of Molecular Sciences 2021, 23(9), 4805; doi: https://doi.org/10.3390/ijms23094805

Shaayau S, Cross AL, Wright HL, Edwards SW. An improved culture protocol for the differentiation and survival of human promyelocytic leukaemia PLB-985 cell-line into mature neutrophil-like granulocytes. BioRxiv 2021, doi: https://doi.org/10.1101/2021. 09.14.460267

Wilkinson DJ, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, del Carmen Arques M, Janciauskiene S, Refaie R, Rankin KS, Young DA, Rowan AD. Matrix metalloproteinase-13 is fully activated by neutrophil elastase, and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. FEBS Journal 2021, doi: https://doi.org/10.1111/febs.16127

Zhan D, Cross A, Wright HL, Moots RJ, Edwards SW, Honsawek S. Internalisation of neutrophil-derived microvesicles modulates TNFa-stimulated proinflammatory cytokine production in human fibroblast-like synoviocytes. International Journal of Molecular Science 2021, 22(14): 7409.

Wright HL*, Lyon M, Chapman EA, Moots RJ, Edwards SW. Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species and neutrophil extracellular traps. Frontiers in Immunology 2021, doi: https://doi.org/10.3389/fimmu.2020.584116 

Glennon-Alty L, Moots RJ, Edwards SW, Wright HL*. Type-I interferon regulates cytokine-delayed neutrophil apoptosis, reactive oxygen species production and chemokine expression via activation of p38 MAPK. Clinical and Experimental Immunology doi: 10.1111/cei.13525 Editor’s choice article for February 2021 

de Bont CM, Stokman M, Faas P, Thurlings, RM, Boelens W, Wright HL, Pruijn G. Autoantibodies to neutrophil extracellular traps represent a potential serological biomarker in rheumatoid arthritis Journal of Autoimmunity 2020 doi: 10.1016/j.jaut.2020.102484

Sae-Khow K, Tachaboon S, Wright HL, Edwards SW, Srisawat B, Leelahavanichkul A, Chiewchengchol D. Defective neutrophil function in patients with sepsis is mostly restored by ex vivo ascorbate incubation. Journal of Inflammation Research 2020, 13:263:274 doi:10.2147/JIR.S252433

Cross AL, Hawkes J, Wright HL, Moots RJ, Edwards SW. APPA (Apocynin and Paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNFα expression and signalling. Inflammopharmacology 2020, doi.org/10.1007/s10787-020-00715-5

Salao K, Spofford EM, Price C, Mairiang E, Suttiprapa S, Wright HL, Sripa B, Edwards SW. Enhanced neutrophil functions during Opisthorchis viverrini infections and correlation with advanced periductal fibrosis. International Journal for Parasitology 2020 doi:10.1016/j.ijpara.2019.11.007

Chapman E, Lyon M, Simpson DM, Mason DN, Beynon RJ, Moots RJ, Wright HL*. Caught in a Trap? Proteomics analysis of neutrophil extracellular traps in rheumatoid arthritis and systemic lupus erythematosus. Frontiers in Immunology 2019 10:423doi:10.3389/fimmu.2019.00423

Rodsaward O, Chottawornsak N, Suwannachoat S, Rachayon M, Deekajorndech T, Wright HL, Edwards SW, Beresford MW, Rerknimitr P, Chiewchengchol D. The clinical significance of antinuclear antibodies (ANA) staining patterns and number of patterns in juvenile and adult systemic lupus erythematosus. Asian Pacific Journal of Allergy and Immunology 2019 doi: 10.12932/AP-211218-0465

Tammasia N, Arrunda-Silva, Wright HL, Moots RJ, Gardiman E, Bianchetto-Aguilera F, Gasperini S, Capone M, Maggi L, Annunziato F, Edwards SW, Cassatella M. Human neutrophils activated via TLR8 promote Th17 polarisation through IL-23. Journal of Leukocyte Biology 2019 105(6) 1155-1165 doi: 10.1002/JLB.MA0818-308R

Chokesuwattanaskul S, Phelan MM, Edwards SW, Wright HL*. A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling. PLoS One 2018 13(12): e0209270

Anderson JR, Chokesuwattanaskul S, Phelan MM, Welting TJ, Peffers MP, Wright HL*. Application of 1H nuclear magnetic resonance spectroscopy to identify underlying pathology in osteoarthritis and rheumatoid arthritis synovial joints. Journal of Proteome Research 2018 17(11) 3780-3790 doi: 10.1021/acs.jproteome.8b00455

Phoomvuthisarn P, Cross A, Glennon-Alty L, Wright HL, Edwards SW. The CDK inhibitor Purvalanol A Induces Neutrophil Apoptosis and Increases the Turnover Rate of Mcl-1: Potential role of p38-MAPK in Regulation of Mcl-1 Turnover. Clinical and Experimental Immunology 2018 192(2) 171-180

Ramanathan K, Glaser A, Lythgoe H, Ong J, Beresford M, Midgley A§*, Wright HL§*. Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low density granulocytes. Rheumatology 2018 57(3) 488-498

Mitchell T, Moots RJ, Wright HL*. JAK inhibition prevents migration of rheumatoid arthritis neutrophils towards interleukin-8, but does not inhibit priming of the respiratory burst or ROS production. Clinical and Experimental Immunology 2017; 189(2) 250-258 doi:10.1111/cei.12970

Wright HL*, Cox T, Moots RJ, Edwards SW. Neutrophil biomarkers predict response to therapy with tumour necrosis factor inhibitors in patients with rheumatoid arthritis. Journal of Leukocyte Biology 2017; 101 785-795 doi: 10.1189/jlb.5A0616-258R

Wright HL*, Makki F, Moots RJ, Edwards SW. Low density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling. Journal of Leukocyte Biology 2017; 101 599-611 doi: 10.1189/jlb.5A0116-022R

Thomas HB, Moots RJ, Edwards SW, Wright HL*. Whose gene is it anyway? The effect of preparation purity on neutrophil transcriptome studies. PLoS One 2015;10(9):e0138982

Wright HL, Mewar D, Bucknall RC, Edwards, SW, Moots RJ. Synovial fluid interleukin-6 concentrations associated with dramatic response to Tocilizumab in an RA patient with failed response to anti-TNF and Rituximab. Rheumatology 2015; 54(4) 743-744 doi: 10.1093/rheumatology/keu488

Wright HL, Thomas HB, Edwards SW, Moots RJ. Interferon gene expression signature in RA neutrophils correlates with a good response to TNFi therapy. Rheumatology 2015; 54(1) 188-193 doi: 10.1093/rheumatology/keu299

Chiewchengchol D, Wright HL, Thomas HB, Lam C, Roberts K, Hirankarn N, Beresford M, Moots R, Edwards SW. Differential Changes in Gene Expression in Human Neutrophils following TNF-α Stimulation: Up-Regulation of Anti-Apoptotic Proteins and Down-Regulation of Proteins involved in Death Receptor Signalling Immunity Inflammation & Disease 2015; 4(1):35-44.

Flanagan PK, Chiewchengchol D, Wright HL, Edwards SW, Alswied A, Satsangi J, Subramanian S, Rhodes JM, Campbell BJ. Killing of Escherichia coli by Crohn’s disease monocyte-derived macrophages and its enhancement by hydroxychloroquine and Vitamin D. Inflammatory Bowel Disease 2015; 21(7):1499-510.

Tamarozzi F, Wright HL, Thomas HB, Edwards SW, Taylor MJ. A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry. Immunology Letters 2014; 162(2B) 194-198.

Tamarozzi F, Wright HL, Johnston K, Edwards SW, Turner JD, Taylor M.J. Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro. Parasite Immunology 2014; 36(10) 494-502

Wright HL§, Cross AL§ Edwards SW, Moots RJ. Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatology 2014 53(7) 1321-31

Chokdeemeeboon C, Ammarinthnukrowh P, Tongkobpetch S, Srichomtong C, Deekajorndech T, Rianthavorn P, Kingwattanakul P, Avihingsanon Y, Wright HL, Akkahat P, Hoven VP, Mekboonsonglarp W, Edwards SW, Hirankarn N, Suphapeetiporn K, Shotelersuk V. DcR3 Mutations in Patients with Juvenile-onset Systemic Lupus Erythematosus Lead to Enhanced Lymphocyte Proliferation. Journal of Rheumatology2013; 40(8), 1316-26.

Wright HL§, Thomas HB§, Moots RJ, Edwards SW. RNA-Seq reveals activation of both common and cytokine-specific pathways following neutrophil priming. PLoS One 2013; 8(3) e58598.

Wright HL, Bucknall RC, Moots RJ, Edwards SW. Analysis of synovial fluid and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. Rheumatology 2011; 51(3), 451-459.

Wright HL, Chikura B, Bucknall RC, Moots RJ, Edwards SW. Change in expression of membrane TNF, NFkappaB activation and neutrophil apoptosis during active and resolved inflammation. Annals of the Rheumatic Diseases 2010; 70(3), 537-43

REVIEW ARTICLES

Fresneda Alarcon M, McLaren Z, Wright HL*. Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different M.O. Frontiers in immunology 2021 doi: 10.3389/fimmu.2021.649693

Glennon-Alty L, Hackett AP, Chapman EA, Wright HL*. Neutrophils and redox stress in the pathogenesis of autoimmune disease. Free Radical Biology and Medicine 2018 125, 25-35 pii: S0891-5849(18)30159-X. doi: 10.1016/j.freeradbiomed.2018.03.049. 

Edwards SW, Spofford EM, Price C, Wright HL, Salao S, Suttiprapa S, Sripa B. Opisthorchiasis-induced cholangiocarcinoma: How innate immunity may cause cancer. Advances in Parasitology 2018 doi: 10.1016/bs.apar.2018.05.006

Suwanchote S, Rachayon M, Rodsaward P, Wongpiyabovorn J, Deekajorndech T, Wright HL, Edwards SW, Beresford MW, Rerknimitr P, Chiewchengchol D. Antineutrophil cytoplasmic antibodies and their clinical significances. Clinical Rheumatology 2018 https://doi.org/10.1007/s10067-018-4062-x

Thieblemont N§, Wright HL§, Edwards SW, Witko-Sarsat V. Human neutrophils in auto-immunity. Seminars in Immunology 2016; 28(2):159-173.

Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis.  Nature Reviews Rheumatology 2014; 10(10) 593-601.

Wright HL, Moots RJ, Bucknall RC, Edwards SW. Neutrophil function in inflammation and inflammatory disease. Rheumatology 2010; 49(9), 1618-31.

Shervington A, Cruikshanks N, Wright H, Atkinson-Dell R, Lea R, Roberts G, Shervington L. 2006. Glioma: what is the role of c-Myc, hsp90 and telomerase? Molecular and Cellular Biochemistry 2006; 283(1-2), 1-9