Past Research topics

Site-specific dual-labeling of a protein for study of protein dyanmics

I developed new tools for efficient single-molecule analysis using genetic code expansion (Seo et al. Anal Chem, 2011; Seo et al. Anal Chem, 2013). This method increases the availability of various proteins for single-molecule study to explore more complicated molecular dynamics.

Protein dynamics

Based on the experience of smFRET, I pursued investigating the relationship of the protein dynamics and molecular recognition that seems to be applied to structure-based drug design via optimizing ligand residence times to meet the desired pharmaceutical modulation (Seo et al. Nature Commun., 2014).

Molecular mechanism of glucose homeostatis

Glucokinase is one of the key enzymes for glucose homeostasis. Based on the structural data we built, I determined the detailed allosteric molecular mechanism in which glucokinase is regulated by molecular association with regulatory factors (Choi & Seo et al. PNAS, 2013). These studies help us understand blood glucose homeostasis, and also provide a new approach to anti-diabetes drugs.