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Current research topics
Current research topics
For details, refer our publications
Protein engineering is a powerful tool that allows the manipulation of protein structure and function for various applications. However, the vast size of the protein sequences poses significant challenges in discovering or engineering proteins with desired properties using conventional approaches. To address the current limitations, we employ reductive strategies to harness the full potential of the proteins in nature. Reductive strategies simplify the complex relationship between protein structure and function by focusing on key elements. This enables effective exploration of the infinite protein sequence space, thereby accelerating the identification of critical residues in proteins with desired properties. Specifically, short motifs, minimal functional domains, and evolutionary constraints are utilized to reduce the design space.
Targeting protein–protein interactions for therapeutic intervention by proteins/peptides
Targeting protein–protein interactions for therapeutic intervention by proteins/peptides
Development of tight binders against protein targets by screening of protein libraries
Development of tight binders against protein targets by screening of protein libraries
Establishment of cell-based protein-protein interaction assays and screening of regulators
Establishment of cell-based protein-protein interaction assays and screening of regulators
PPI study by screening motif-mediated protein interactions
PPI study by screening motif-mediated protein interactions
Identification of novel PPIs by phage display screening of proteome-scale peptide libraries
Identification of novel PPIs by phage display screening of proteome-scale peptide libraries
Cell-based phenotypic screening of peptide libraries for development of disease-relevant PPI modulators
Cell-based phenotypic screening of peptide libraries for development of disease-relevant PPI modulators
Development of highly sensitive biosensors for small molecules, natural constituents & peptides
Development of highly sensitive biosensors for small molecules, natural constituents & peptides
Engineering and optimization of protein scaffolds for recognizing small molecules, natural constitutents & peptides
Engineering and optimization of protein scaffolds for recognizing small molecules, natural constitutents & peptides
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