Armindo Salvador CV
Ph. D., Theoretical Biochemistry (The University of Lisbon, Portugal, 1997)
2005- Group leader, Computational & Systems Biology, Center for Neuroscience and Cell Biology, Portugal
2011-2013 Invited Professor, The University of Coimbra, Portugal
2002-2005 Post-doctoral fellow, Molecular Systems Biology, The University of Coimbra, Portugal
2002 Visiting scholar, Molecular Systems Biology, University of California - Davis, U.S.A.
2000-2002 Research fellow, Molecular Systems Biology, Pfizer Global Research & Development/The University of Michigan, U.S.A.
1998-2000 Post-doctoral fellow, Computational Systems Biology, The University of Michigan, U.S.A.
1997-1998 Post-doctoral fellow, Membrane biophysics, Institute for Chemical and Biological Technology, Portugal
Main research interests
Organization principles of biochemical systems
Redox signaling
Metabolism
Other activities
Editorial Board, Journal of theoretical Biology
Directive Board, Portuguese Society of Biophysics
Coordinator, Summer School in Computational Biology - from molecules to tissues
Representative publications
Peskin, A.V., Meotti, F.C.; Sousa, L.F., Anderson, R.F., Winterbourn, C.C., Salvador, A. (2020). "Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2". Free Radical Biology and Medicine (in press) DOI:10.1016/j.freeradbiomed.2020.07.007 [Full text]
Filipe, H. A. L., Javanainen, M., Salvador, A., Galvão, A. M., Vattulainen, I., Loura, L. M. S., Moreno, M. J. (2018) "Quantitative assessment of methods used to obtain rate constants from molecular dynamics simulations – translocation of cholesterol across lipid bilayers". J. Chem. Theory Comput. 14:3840–3848. DOI: 10.1021/acs.jctc.8b00150.
Selvaggio, G., Coelho, P.M.B.M., Salvador, A. (2018) "Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin - thioredoxin system. 1. Understanding commonalities and differences among cell types". Redox Biology 15:297-315. DOI:10.1016/j.redox.2017.12.008 [Full text]
Travasso, R.D.M., Sampaio dos Aidos, F., Bayani, A., Abranches, P., Salvador, A. (2017). "Localized Redox Relays as a Privileged Mode of Cytoplasmic Hydrogen Peroxide Signaling". Redox Biology 12:233–245. DOI:10.1016/j.redox.2017.01.003. [PDF]
Miranda-Santos, I., Gramacho, S., Pineiro, M., Martinez-Gomez, K., Fritz, M., Hollemeyer, K., Salvador, A., Heinzle, E. (2015). "Mass isotopomer analysis of nucleosides isolated from RNA and DNA using GC-MS" Anal. Chem. 87, 617-623.
Benfeitas, R., Selvaggio, G., Antunes, F., Coelho, P. M. B. M., Salvador, A. (2014). "Hydrogen peroxide metabolism and sensing in human erythrocytes: a validated kinetic model and reappraisal of the role of peroxiredoxin II." Free Radic. Biol. Med. 74:35-49. [PDF]
Filipe, H., Salvador, A., Silvestre, J., Vaz, W., Moreno, M.J. (2014). "Beyond Overton’s rule - Quantitative Modeling of Passive Permeation Through Tight Cell Monolayers" Molec. Pharmaceut. 11:3696-706.
Estronca, L. M. B. B., Filipe, H. A. L., Salvador, A., Moreno, M. J., & Vaz, W. L. C. (2014). "Homeostasis of Free Cholesterol in the Blood - a Preliminary Evaluation and Modeling of Its Passive Transport." J. Lipid Res. 55:1033-1043. [Abstract][PDF]
Dehmer, M., Emmert-Streib, F., Graber, A., Salvador, A. (Ed.s) (2011) “Applied Statistics for Network Biology”, Weinheim: Wiley.
Coelho, P. M. B. M., Salvador, A., Savageau, M. A. (2010). “Relating Mutant Genotype to Phenotype via Quantitative Behavior of the NADPH Redox Cycle in Human Erythrocytes” PLoS ONE 5:e13031 [Full text] [PDF]
Savageau, M.A., Coelho, P.M.B.M., Fasani, R.A., Tolla, D.A., Salvador, A. (2009). Phenotypes and tolerances in the design space of biochemical systems. Proc. Natl. Acad. Sci. USA 106: doi:10.1073/pnas.0809869106 [Abstract] [PDF]
Coelho, P. M. B. M., Salvador, A., Savageau, M. A. (2009). "Quantifying Global Tolerance of Biochemical Systems: Design Implications for Moiety-Transfer Cycles." PLoS Comp. Biol. 5:e1000319. [Abstract] [PDF] [PLoS Comput. Biol.]
Salvador, A. (2008). “Book review: Uri Alon (2008). ‘An introduction to systems biology: design principles of biological circuits’ London: Chapman & Hall/CRC”, Math. Biosci. 215:193-195. [Math. Biosci.]
Alves, R., Antunes, F., Salvador, A. (2006). Tools for kinetic modeling of biochemical systems, Nature Biotechnol. 24:667-672. [Abstract] [PDF] [Nature Biotechnology]
Gardner, R., Moradas-Ferreira, P., Salvador, A. (2006). Why does superoxide dismutase overexpression often increase hydrogen peroxide concentrations? An alternative explanation, J. Theor. Biol. 242:798-800. [PDF] [J. Theor. Biol.]
Salvador, A., Savageau, M. (2006) Evolution of enzymes in a series is driven by dissimilar functional demands. Proc. Natl. Acad. Sci. USA 103:2226-2231. [Abstract] [PDF] [PNAS]
Salvador, A. and Savageau, M. A. (2003). Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes. Proc. Natl. Acad. Sci. USA 100:14463-14468. [Abstract] [PDF]
Gardner, R., Salvador, A., and Moradas-Ferreira, P. (2002). Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation. Free Radic. Biol. Med. 32:1351-1357. [Abstract] [PDF]
Salvador, A., Sousa, J., and Pinto, R. E. (2001). Hydroperoxyl, superoxide and pH gradients in the mitochondrial matrix: a theoretical assessment. Free Radic. Biol. Med. 31:1208-1215. [Abstract] [PDF]
Salvador, A. (2000). Synergism analysis of metabolic processes: I. Conceptual framework. Math. Biosci. 163:105-129. [Abstract] [PDF]
Salvador, A. (2000). Synergism analysis of metabolic processes: II. Tensor formulation and treatment of stoichiometric constraints. Math. Biosci. 163:131-158. [Abstract] [PDF]
Antunes, F., Salvador, A., Marinho, H. S., Alves, R., and Pinto, R. E. (1996). Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model. Free Radic. Biol. Med. 21:917-943. [Abstract] [PDF]
Antunes, F., Salvador, A., and Pinto, R. E. (1995). PHGPx and phospholipase A2/GPx: comparative importance on the reduction of hydroperoxides in rat liver mitochondria. Free Radic. Biol. Med. 19:669-677. [Abstract] [PDF]
Salvador, A., Antunes, F., and Pinto, R. E. (1995). Kinetic modelling of in vitro lipid peroxidation experiments -- 'low level' validation of a model of in vivo lipid peroxidation. Free Radic. Res. 23:151-172. [Abstract] [preprint]