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Profile
- Biopharmaceutical industry professional with ~14 years of management, research & development, team building & project management experience in interdisciplinary sciences: protein biochemistry, peptide chemistry, analytical science, molecular biology, computational biology, and bio-organic chemistry
- ~5 years of GMP experience at SGS Canada, a global testing/certification organization.
- Leading operational activities including day-to-day management, support as SMEs, training including OJT, developing & monitoring KPIs, and coaching the team of 18 professional biotech analysts including 2 Scientists and 14 direct reports
- Extensive experience (SME) in Method Development (MD), Method Qualification/Validation (MQ/MV), Supplemental Qualification (SQ) and Method Transfer (MT) following ICH Q2 (R1) and FDA guidelines recommended by CDER and CBER to support Release, Stability and PPQ testing of Drug Substance (DS) and Drug Products (DP)
- Strong experience and understanding of Quality Management System (QMS) including DMS, TMS, change control request (CCR) to update SOPs for operations activities, Quality Events (QEs), performing Root Cause Analysis (RCA), leading Investigations (OOX, OOS, OOTs), and implementing Corrective and Preventative Actions (CAPAs)
- Strong experience with multiple client interactions, rapid troubleshooting, support as Subject Matter Experts (SMEs), resource management, invoicing, and driving projects with tight timelines successfully to completion.
- Strong communication skills with Quality Assurance (QA) and Quality Control (QC) to establish the smooth and efficient operation activities
- 2+ years of experience in setting a new lab and generating scientific data to establish the novel commercialized idea for support of a product in the non-traditional life science industry.
- 6.5+ years of work-experience/Post-Doctoral work in the field of Chemical Biology and Molecular Biology.
- 5.5+ years of work-experience/Doctoral thesis work in the field of bioorganic/biophysics chemistry.
- Excellent verbal/written communication skills with competent 20+ international publication records, 30+ conference presentations, national and international fellowship awards.
- Strong leadership skills and networking abilities; organized multiple events.
- Trained and certified Workplace Hazardous Materials Information System (WHIMS) professional with experience in CRYSTAL reporting to establish the health and safety behaviors and policies of the employees
Research Interests
Biologics, Biosimilar, Cell and Gene Therapy, Chemical Biology, Drug Design and Discovery, Biochemistry, Medicinal Chemistry, Organic Chemistry, Optogenetic Tools, Peptide-based drugs, Analytical chemistry, Molecular Biophysics, Molecular Biology
Education
1. Doctor of Philosophy from Indian Institute of Technology Bombay (IIT Bombay), India in Jul. 2003 - Jan. 2009
Thesis: "Stereochemistry: Studies of its role in Protein Folding and scope in De novo design"
Thesis Supervisor: Prof. Susheel Durani
2. Master of Science from University of Delhi (DU) in Jul. 2000 - Jul. 2002
Specialisation: Organic Chemistry
Post Ph.D. Work Experiences
7. Senior Organic Chemist | Pigment Production Engineer, SPOT MYUV, J&J Lab, MARS, Toronto, Canada in 2017
6. Research Scientist, OS&B, Oakville, Canada in 2016 - 2018
5. Postdoctoral Fellow from University of Toronto, Canada in 2014 - 2016
4. CIHR Postdoctoral Fellow from CIHR Training Program in Protein Folding, Canada in 2012 - 2014
3. Postdoctoral Fellow from University of Toronto (UofT), Canada in 2010 - 2012
2. Postdoctoral Fellow from Washington University in St. Louis (WUSTL), USA in 2009 - 2010
1. Research Associate from Indian Institute of Technology Bombay (IIT Bombay), India in Jan. 2009 - Nov. 2009
Skills and Key Competencies
Experimental Skills
o Molecular biology: plasmid preparation, cloning, transformation, DNA extraction from bacterial cells, PCR, agarose gel electrophoresis, site-directed mutagenesis, bacterial (E.coli) protein expression, expression of isotopically labelled (15N, 13C, 19F) proteins
o Protein/peptide purification: FPLC (SEC), RP-HPLC and other chromatographic techniques; Ni-affinity chromatography, dialysis, lyophilization, centrifugation, SDS-PAGE and native PAGE
o Biophysical characterization: multidimensional solution NMR, UV-Vis spectroscopy, fluorescence spectroscopy, differential scanning calorimetry (DSC), isothermal titration calorimetry (ITC), MALDI-MS, analytical ultracentrifugation (AUC), IR, LC-MS
o Synthesis: Solid-phase peptide synthesis (SPPS) using Fmoc-chemistry, general organic synthesis
Computational Skills
o Molecular modelling suite: Accelrys Discovery Studio 2.5, CAPM (Computer Aided Peptide Modeler), PDBmake (in-house program)
o Molecular dynamics simulation suite: GROMACS, Simulated Annealing Molecular Dynamics (SAMD)
o Visualisation tools: DSViewer Pro, Pymol, Rasmol, MOLMOL, VMD, Molscript, Swiss-PDB, WebLab viewer
o Science search engines: SciFinder scholar, ISI web knowledge of science, Scopus, Pubmed, Endnote, Reference Manager
o Data analysis tools: MestReNova, NMRViewJ, NMRPipe, NMR structure modeling tools DYANA, CYANA, DelPhi (electrostatic energy calculation), Ribosome (Peptide Modeler), NACESS (solvent accessible surface area calculation), DelPhi (Electrostatic Calculation), Inverse protein sequence design with Dead End Elimination (DEE), IGOR Pro 6 (Data analysis software tool)
o Molecular editor: ChemDraw
o Graphics editor: CorelDraw, Adobe Photoshop
o Microsoft Office Suite: Word, Outlook, Excel, PowerPoint
o Operating systems: Macintosh, Windows, Linux, UNIX, Linux clusters
Honors, Awards, Recognition
• Invited for participation to Young Investigators' Meeting (YIM-2016), Gurgaon, India 2016
• Travel Award, CIHR Training in protein folding to attend 28th The Protein Society Meeting, San Diego, USA 2014
• CIHR Postdoctoral Fellow, CIHR Training in protein folding, University of Toronto, Canada, 2012- 2014
• Postdoctoral Fellow, University of Toronto, Canada, 2010-2011, 2014-2015
• Proposal accepted for Chemistry Teaching Fellow Program (CTFP), Department of Chemistry, University of Toronto, Canada - 2012
• Postdoctoral Fellow, Washington University in St. Louis, USA 2009-10
• Senior Research Fellowship, Council of Scientific and Industrial Research-University Grant Commission (CSIR-UGC), India, 2005-08
• Junior Research Fellowship, Council of Scientific and Industrial Research-University Grant Commission (CSIR-UGC), India, 2003-05
• 1st position in "Idea-Research-Innovation", A symposium on Global Warming and Youthful Innovation, IIT Bombay, India, 2007
• Awarded Travel Support from Indian Biophysical Society (IBS)-2007(National Symposium on Biophysics: Trends in Biomedical Research) to be held in New Delhi on February 13-15, 2007.
• Awarded Grant from Dept. of Chemistry, IIT Bombay for attending Joint International Conference on Building Bridges, Forging Bonds for 21st Century Organic Chemistry and Chemical Biology, Jointly organised by ACS and CSIR 2006. National Chemical Laboratory, Pune, India.
• Awarded Grant from Dept. of Chemistry, IIT Bombay for attending IBS-2007 to be held at New Delhi, India on February 13- 15, 2007.
• Awarded Grant from Dept. of Chemistry, IIT Bombay for attending InCoB-2006 to be held at New Delhi, India on December 18-20, 2006.
"Education is a progressive discovery of our ignorance"
- Will Durant
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