Research

Real-time and Non-invasive Impedimetric Monitoring of Cell Proliferation and Chemosensitivity in a Perfusion 3D Cell Culture Microfluidic Chip

Cellular responses including proliferation and chemosensitivity in 3D culture construct under perfusion of tested substance can be monitored by impedimetric technique in a real-time and non-invasive manner. For interested reader, please refer to the article published in Biosensors and Bioelectronics 51 (2014) 16-21.

Impedimetric Quantification of the Formation Process and the Chemosensitivity of Cancer Cell Colonies Suspended in 3D Environment

The colony formation process could be quantitatively represented by indexes calculated from electrical impedance measured by a biosensor. For interested reader, please refer to the article published in Biosensors and Bioelectronics 74 (2015) 878-885.

Quantitative Impedimetric Monitoring of Cell Migration under the Stimulation of Cytokine or Anti-cancer Drug in a Microfluidic Chip

A microfluidic chip embedded with measurement electrodes has been developed to quantitatively monitor the cell migration activity based on the impedimetric measurement technique. For interested reader, please refer to the article published in Biomicrofluidics 9 (2015) 034109.

Paper-based Microreactor Integrating Cell Culture and Subsequent Immunoassay for the Investigation of Cellular Phosphorylation

Study of the activation level of phosphorylated Stat3 of liver cancer cells stimulated by IL-6 cytokine was demonstrated by the paper-based microreactor integrating cell culture and subsequent immunoassay. For interested reader, please refer to the article published in ACS Applied Materials & Interfaces 6 (2014) 22423-22429.

Paper-based Enzyme-free Immunoassay for Rapid Detection and Subtyping of Influenza A H1N1 and H3N2 Viruses

Based on the internal structural protein, i.e., nucleoprotein (NP), and outer surface glycoproteins, i.e., H1 and H3, of the influenza viruses, detection and subtyping of influenza A H1N1 and H3N2 viruses found in people were demonstrated by colorimetric paper-based sandwich immunoassay platform. For interested reader, please refer to the article published in Analytica Chimica Acta 883 (2015) 37-44.

Paper-based Microfluidic Sensing Device for Label-free Immunoassay Demonstrated by Biotin-Avidin Binding Interaction

A fabrication method for depositing carbon nanotube bundles has been successfully developed for realization of functional paper-based microfluidic sensing device. Quantitative detection of label-free immunoassay, i.e., biotin-avidin binding interaction, was demonstrated by direct measurement of the current change of the biosensor after single application of the target analyte. For interested reader, please refer to the article published in Talanta 134 (2015) 264-270.

Successful Differentiation of Neural Stem/Progenitor Cells Cultured on Electrically Adjustable Indium Tin Oxide (ITO) Surface

The differentiation behavior of neural stem/progenitor cells (NSPCs) cultured on indium tin oxide surface was found to be strongly controlled by the electrical stimulation.  With the optimal stimulation condition, i.e., 80 mV, NSPCs could develop long processes and large amounts of functional neurons were gathered. For interested reader, please refer to the article published in Langmuir 30 (2014) 14241-14249.

A Flexible PDMS Capacitive Tactile Sensor with Adjustable Measurement Range for Plantar Pressure Measurement

A flexible capacitive tactile sensor with adjustable characteristics, i.e., measurement range and sensitivity, has been developed for large pressure measurement. Polydimethylsilxane (PDMS) material was selected as the material of the dielectric layer between the parallel plate electrodes of the sensor because the elasticity of the PDMS material can be adjusted by the mixing ratio of PDMS pre-polymer and curing agent during formation. For interested reader, please refer to the article published in Microsystem Technologies 20 (2014) 1351-1358.