Emmanuel A Stamatakis

eas46 at cam.ac.uk

My research seeks to determine how cognitive function arises from the topographical organization and complex dynamics in the brain. My integrative, interdisciplinary approach combines behavioural paradigms with state-of-the-art multimodal brain imaging (structural/functional MRI, PET and EEG) and computational neuroimaging approaches using mathematical models, network science and information theory to investigate functional organisation in the human brain. Accordingly, I develop tools for the analysis of neuroimaging data which I share with collaborators and the broader neuroscience community. More recent research directions include: attempting to bridge micro- and macroscopic levels in neuroscience by investigating associations between brain network connectivity and gene expression; studying the influence of brainstem neurotransmitter/neuromodulator systems on cortical/subcortical networks and the use of deep graph convolutional neural networks to identify patients with disorders of consciousness with covert cognitive capacity.

My current work focuses on understanding the neural mechanisms underlying a broad spectrum of altered states of consciousness in healthy volunteers (induced by anaesthetics or psychedelics), and patients who have sustained brain injuries that result in disorders of consciousness (e.g. minimally conscious state, coma). This work is underpinned by fundamental neuroscience questions on the role of the default mode network (DMN) in cognition (the DMN has been implicated in conscious processing), as well as broader cognitive architecture questions. I also use pharmacological fMRI to understand the effects of cognitive enhancers on traumatic brain injury (TBI) survivors who suffer from long term cognitive and affective disorders. This works aims to describe residual capacity and the limits of plasticity in the injured brain. My earlier work at the Centre for Speech, Language and the Brain, Department of Psychology, focused on the neural substrates of semantic processing and language comprehension.

Key Publications

LRB Spindler, AI Luppi, R Adapa, MC Craig, P Coppola, ARD Peattie, AJ Manktelow, P Finoia, BJ Sahakian, GB Williams, J Allanson, JD Pickard, DK Menon and EA Stamatakis. Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation. PNAS. 118 (30) e2026289118 (2021). [Commentary written for this article by Brian L. Edlow].

D Lyu, I Pappas, DK Menon, EA Stamatakis. A Precuneal Causal Loop Mediates External and Internal Information Integration in the Human Brain. Journal of Neuroscience. Accepted.

AI Luppi*, J Cain*, LRB Spindler*, UJGórska*, D Toker, AE Hudson, EN Brown, MN Diringer, RD Stevens, M Massimini, MM Monti, EA Stamatakis**, M Boly**, the Curing Coma Campaign and its contributing collaborators. Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Towards an Integrated Translational Science. Neurocritical Care. 35 (1), 37-54 (2021). *co-first authors **co-senior authors.

MM Craig, B Misic, I Pappas, RM Adapa, DK Menon, EA Stamatakis. Propofol-induced alterations in brain connectivity reflect parvalbumin interneuron distribution in the human cortex. British Journal of Anaesthesia. 126(4):835-844 (2021).

AI Luppi, RL Carhart-Harris, L Roseman, I Pappas, DK Menon, EA Stamatakis. LSD alters dynamic integration and segregation in the human brain. NeuroImage. 227 (2021) 117653.

TF Varley, R Carhart-Harris, Leor Roseman, David K Menon, EA Stamatakis. Serotonergic Psychedelics LSD and Psilocybin Increase the Fractal Dimension of Cortical Brain Activity in Spatial and Temporal Domains. NeuroImage 220 117049 (2020).

I Pappas, MM Craig, DK Menon, EA Stamatakis. Structural optimality and neurogenetic expression mediate functional dynamics in the human brain. Human Brain Mapping. 41(8):2229-2243 (2020).

TF Varley†, A Luppi†, I Pappas, R Adapa, A Owen, L Naci, DK Menon, EA Stamatakis. Consciousness & Brain Functional Complexity in Propofol Anaesthesia. Scientific Reports, 10, 1018 (2020). †Contributed equally to this work.

AI Luppi, MM Craig, I Pappas, P Finoia, GB Williams, J Allanson, JD Pickard, AM Owen, L Naci, DK Menon & EA Stamatakis. Consciousness-specific dynamic interactions of brain integration and functional diversity. Nature Communications. 10(1):4616 (2019).

I Pappas†, L Cornelissen†, DK Menon, CB Berde, EA Stamatakis. Delta oscillation correlates of anesthesia-induced unconsciousness in large-scale brain networks of human infants. Anesthesiology, 131(6):1239–1253 (2019). †Contributed equally to this work. [Editorial written for this article by MP Puglia & GA Mashour]

I Pappas, RM Adapa, DK Menon, EA Stamatakis. Brain network disintegration during sedation is mediated by the complexity of sparsely connected regions. Neuroimage, 186:221-233 (2019).

D Vatansever, DK Menon, EA Stamatakis. Default mode contributions to automated information processing. PNAS, 114:12821-12826 (2017).

AE Manktelow, DK Menon, BJ Sahakian and EA Stamatakis. Working memory after traumatic brain injury: the neural basis of improved performance with methylphenidate. Frontiers in Behavioral Neuroscience, 11:58. doi: 10.3389/fnbeh.2017.00058 (2017).

D Vatansever, AE Manktelow, BJ Sahakian, DK Menon, EA Stamatakis. Cognitive Flexibility: A Default Network and Basal Ganglia Connectivity Perspective. Brain Connectivity, 6(3):201-207 (2016).

D Vatansever, DK Menon, AE Manktelow, BJ Sahakian, EA Stamatakis (2015), “Default mode dynamics for global functional integration” Journal of Neuroscience 18;35(46):15254-62.

LK Tyler, WD Marslen-Wilson, B Randall, P Wright, BJ Devereux, J Zhuang, M Papoutsi, EA Stamatakis. Left inferior frontal cortex and syntax: Function, structure and behaviour in left-hemisphere damaged patients. Brain, 134(2): 415-431 (2011).

EA Stamatakis, RM Adapa, AR Absalom, DK Menon. Changes in resting neural connectivity during propofol sedation. PLoS One, 5(12):e14224 (2010).

LK Tyler, P Wright, B Randall, WD Marslen-Wilson, EA Stamatakis. Reorganization of syntactic processing following left-hemisphere brain damage: does right-hemisphere activity preserve function? Brain, 133(11):3396-408 (2010).

M Kasahara, DK Menon, CH Salmond, JG Outtrim, JV Taylor Tavares, TA Carpenter, JD Pickard, BJ Sahakian, EA Stamatakis. Altered functional connectivity in the motor network after traumatic brain injury. Neurology, 75(2):168-76 (2010).

LK Tyler, MA Shafto, B Randall, P Wright, WD Marslen-Wilson, EA Stamatakis. Preserving Syntactic Processing across the Adult Life Span: The Modulation of the Frontotemporal Language System in the Context of Age-Related Atrophy. Cerebral Cortex, 20(2):352-64 (2009).

EA Stamatakis, WD Marslen-Wilson, LK Tyler, PC Fletcher. Cingulate control of fronto-temporal integration is dependent upon linguistic demands: a three-way interaction in functional connectivity identified using fMRI. NeuroImage, 28:115-121 (2005).