Emmanuel A Stamatakis

eas46 at cam.ac.uk

My research focuses on elucidating the neural mechanisms underlying a wide range of altered states of consciousness in healthy individuals (induced by anaesthetics or psychedelics), and patients who have sustained brain injuries that result in Disorders of Consciousness (DoC) (e.g. minimally conscious state or coma). Employing an integrative and interdisciplinary approach, I combine behavioural paradigms with advanced multimodal brain imaging techniques, including structural and functional MRI, PET, and EEG. Moreover, I utilise computational neuroimaging methods, incorporating mathematical models, network science and information theory to investigate the functional organisation of the human brain. 

I am also interested in the potential of functional magnetic resonance imaging (fMRI) to predict long-term cognitive and affective symptoms following concussion and I utilise pharmacological fMRI to examine therapeutic interventions in patients with traumatic brain injury. My previous research at the Centre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, focused on the neural substrates of semantic processing and language comprehension. 

Further, I develop analytical tools for neuroimaging data, which I share with collaborators and the broader neuroscience community. Recent methodological approaches include bridging micro- and macroscopic levels in neuroscience by exploring the relationships between brain network connectivity and gene expression, examining the impact of brainstem neurotransmitter and neuromodulator systems on cortical and subcortical networks, and applying machine learning to the study (un)consciousness.

Key Publications

RE Woodrow, J Grossac, YT Hong, S Winzeck, T Geeraerts, SA Shah, ARD Peattie, AE Manktelow, JG Outtrim, NA Karakatsanis, ND Schiff, TD Fryer, DK Menon, JP Coles & EA Stamatakis. Selective Thalamic Neuronal Loss in Chronic Traumatic Brain Injury: Outcome Associations and Mechanisms. JAMA Network Open. Accepted.

RE Woodrow, CENTER-TBI MRI Sub-study Participants and Investigators, DK Menon & EA Stamatakis. Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans. Brain Communications. Accepted.

AI Luppi, HM Gellersen, Z-Q Liu, ARD Peattie, AE Manktelow, R Adapa, AM Owen, L Naci, DK Menon, SI Dimitriadis, EA Stamatakis. Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics. Nature Communications.  Accepted.

C Rua, B Raman, CT Rodgers, VFJ Newcombe, A Manktelow, DA Chatfield, SJ Sawcer, JG Outtrim, VC Lupson, EA Stamatakis, GB William, WT Clarke, L Qiu, M Ezra, R  McDonald, S Clare, M Cassar, S Neubauer, KD Ersche, ET Bullmore, DK Menon, K Pattinson, JB Rowe, on behalf of the Cambridge NeuroCOVID group and the CITIID-NIHR COVID-19 BioResource Collaboration and the Oxford CMORE-NEURO group. Quantitative susceptibility mapping at 7 Tesla in COVID-19:  mechanistic and outcome associations. Brain. Accepted.

AI Luppi, FE Rosas, PAM Mediano, A Demertzi, DK Menon & EA Stamatakis. Unraveling consciousness and brain function through the lens of time, space, and information. Trends in Neurosciences.  Accepted.

AI Luppi, FE Rosas, PAM Mediano, DK Menon, EA Stamatakis. Information decomposition and the informational architecture of the brain. Trends in Cognitive Sciences. Accepted.

ARD Peattie, AE Manktelow, BJ Sahakian, DK Menon, EA Stamatakis. Methylphenidate ameliorates behavioural and neurobiological deficits in executive function for patients with chronic Traumatic Brain Injury.  Journal of Clinical Medicine. 2024, 13, 771. https://doi.org/10.3390/jcm13030771.

I Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C T immermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB. de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis. In Vivo Mapping of Pharmacologically-induced Functional Reorganisation onto the  Human Brain’s Neurotransmitter Landscape. Science Advances. 16;9(24):eadf8332. doi: 10.1126/sciadv.adf8332.

RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Sub-study Participants and Investigators, DK Menon, EA Stamatakis. Thalamic connectivity as an acute marker of chronic postconcussive symptoms after mild TBI: prognostic and treatment implications. Brain. 2023, 146(8):3484-3499. [Top 10 trending articles published in Brain] 

D Lyu, S Naik, DK Menon, EA Stamatakis. Intrinsic brain dynamics in the Default Mode Network predict involuntary fluctuations of visual awareness. Nature Communications. 13, 6923 (2022).AI Luppi, PAM Mediano, FE Rosas, N Holland, TD Fryer, JT O’Brien, JB Rowe, DK Menon, D Bor & EA Stamatakis. A synergistic core for human brain evolution and cognition. Nature Neuroscience. 25, 771–782 (2022). 

G Northoff, D Vatansever, A Scalabrini and EA Stamatakis. Ongoing brain activity and its role in cognition – Dual vs baseline models. The Neuroscientist (2022).   doi: 10.1177/10738584221081752.

LRB Spindler, AI Luppi, R Adapa, MC Craig, P Coppola, ARD Peattie, AJ Manktelow, P Finoia, BJ Sahakian, GB Williams, J Allanson, JD Pickard, DK Menon and EA Stamatakis. Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation. PNAS. 118 (30) e2026289118 (2021). [Commentary written for this article by Brian L. Edlow].

D Lyu, I Pappas, DK Menon, EA Stamatakis. A Precuneal Causal Loop Mediates External and Internal Information Integration in the Human Brain. Journal of Neuroscience. Accepted.

AI Luppi*, J Cain*, LRB  Spindler*,  UJGórska*,  D Toker,  AE  Hudson,  EN  Brown,  MN  Diringer,  RD  Stevens,  M  Massimini,  MM Monti,  EA Stamatakis**,  M Boly**,  the  Curing  Coma  Campaign  and  its  contributing  collaborators.  Mechanisms Underlying Disorders of Consciousness:  Bridging Gaps to Move Towards an Integrated Translational Science. Neurocritical Care. 35 (1), 37-54 (2021).  *co-first authors **co-senior authors.

MM Craig, B Misic, I Pappas, RM Adapa, DK Menon, EA Stamatakis. Propofol-induced alterations in brain connectivity reflect parvalbumin interneuron distribution in the human cortex.  British Journal of Anaesthesia. 126(4):835-844 (2021). 

AI Luppi, RL Carhart-Harris, L Roseman, I Pappas, DK Menon, EA Stamatakis. LSD alters dynamic integration and segregation in the human brain. NeuroImage. 227 (2021) 117653.  

TF Varley, R Carhart-Harris, Leor Roseman, David K Menon, EA Stamatakis. Serotonergic Psychedelics LSD and Psilocybin Increase the Fractal Dimension of Cortical Brain Activity in Spatial and Temporal Domains. NeuroImage 220 117049 (2020).

I Pappas, MM Craig, DK Menon, EA Stamatakis. Structural optimality and neurogenetic expression mediate functional dynamics in the human brain. Human Brain Mapping. 41(8):2229-2243 (2020). 

TF Varley†, A Luppi†, I Pappas, R Adapa, A Owen, L Naci, DK Menon, EA Stamatakis. Consciousness & Brain Functional Complexity in Propofol Anaesthesia. Scientific Reports, 10, 1018 (2020). †Contributed equally to this work.

AI Luppi, MM Craig, I Pappas, P Finoia, GB Williams, J Allanson, JD Pickard, AM Owen, L Naci, DK Menon & EA Stamatakis. Consciousness-specific dynamic interactions of brain integration and functional diversity. Nature Communications. 10(1):4616 (2019).

I Pappas†, L Cornelissen†, DK Menon, CB Berde, EA Stamatakis. Delta oscillation correlates of anesthesia-induced unconsciousness in large-scale brain networks of human infants. Anesthesiology, 131(6):1239–1253 (2019). †Contributed equally to this work.  [Editorial written for this article by MP Puglia & GA Mashour]

I Pappas, RM Adapa, DK Menon, EA Stamatakis. Brain network disintegration during sedation is mediated by the complexity of sparsely connected regions. Neuroimage, 186:221-233 (2019).

D Vatansever, DK Menon, EA Stamatakis. Default mode contributions to automated information processing. PNAS, 114:12821-12826 (2017).

AE Manktelow, DK Menon, BJ Sahakian and EA Stamatakis. Working memory after traumatic brain injury: the neural basis of improved performance with methylphenidate. Frontiers in Behavioral Neuroscience, 11:58. doi: 10.3389/fnbeh.2017.00058 (2017).

D Vatansever, AE Manktelow, BJ Sahakian, DK Menon, EA Stamatakis. Cognitive Flexibility: A Default Network and Basal Ganglia Connectivity Perspective. Brain Connectivity, 6(3):201-207 (2016).

D Vatansever, DK Menon, AE Manktelow, BJ Sahakian, EA Stamatakis (2015), “Default mode dynamics for global functional integration” Journal of Neuroscience 18;35(46):15254-62.

LK Tyler, WD Marslen-Wilson, B Randall, P Wright, BJ Devereux, J Zhuang, M Papoutsi, EA Stamatakis. Left inferior frontal cortex and syntax: Function, structure and behaviour in left-hemisphere damaged patients. Brain, 134(2): 415-431 (2011). 

EA Stamatakis, RM Adapa, AR Absalom, DK Menon. Changes in resting neural connectivity during propofol sedation. PLoS One, 5(12):e14224 (2010). 

LK Tyler, P Wright, B Randall, WD Marslen-Wilson, EA Stamatakis. Reorganization of syntactic processing following left-hemisphere brain damage: does right-hemisphere activity preserve function? Brain, 133(11):3396-408 (2010).

M Kasahara, DK Menon, CH Salmond, JG Outtrim, JV Taylor Tavares, TA Carpenter, JD Pickard, BJ Sahakian, EA Stamatakis. Altered functional connectivity in the motor network after traumatic brain injury. Neurology, 75(2):168-76 (2010).

LK Tyler, MA Shafto, B Randall, P Wright, WD Marslen-Wilson, EA Stamatakis. Preserving Syntactic Processing across the Adult Life Span: The Modulation of the Frontotemporal Language System in the Context of Age-Related Atrophy. Cerebral Cortex, 20(2):352-64 (2009).

EA Stamatakis, WD Marslen-Wilson, LK Tyler, PC Fletcher. Cingulate control of fronto-temporal integration is dependent upon linguistic demands: a three-way interaction in functional connectivity identified using fMRI. NeuroImage, 28:115-121 (2005).