Andrea Luppi

al857 at cam.ac.uk

Coming from a background in philosophy and cognitive science, I am interested in the relation between mind and (grey) matter. Specifically, my PhD work aims to characterise how the capacity for cognition and consciousness arises from the complex interactions between brain systems, viewed as a dynamic network. To this end, I combine tools from information theory, network science and whole-brain computational modelling to study the cortical dynamics and connectivity of the brain across multiple scales and modalities (functional MRI, DTI) throughout a variety of states of altered consciousness – such as anaesthesia and disorders of consciousness, but also sleep and psychedelics. Ultimately, I aim to develop a landscape of altered states of consciousness, and a unified theoretical understanding of how consciousness is lost, and how we can promote its recovery in patients.

Publications

AI Luppi, LRB Spindler, DK Menon, EA Stamatakis. The Inert Brain: Explaining Neural Inertia as Post-Anaesthetic Sleep Inertia. Frontiers in Neuroscience, section Sleep and Circadian Rhythms. Accepted.

AI Luppi, RL Carhart-Harris, L Roseman, I Pappas, DK Menon, EA Stamatakis. LSD alters dynamic integration and segregation in the human brain. NeuroImage. 227 (2021) 117653.

AI Luppi & EA Stamatakis. Combining Network Topology and Information Theory to Construct Representative Brain Networks. Network Neuroscience. Accepted.

TF Varley†, A Luppi†, I Pappas, R Adapa, A Owen, L Naci, DK Menon, EA Stamatakis. Consciousness & Brain Functional Complexity in Propofol Anaesthesia. Scientific Reports, 10, 1018 (2020). †Contributed equally to this work.

AI Luppi, MM Craig, I Pappas, P Finoia, GB Williams, J Allanson, JD Pickard, AM Owen, L Naci, DK Menon & EA Stamatakis. Consciousness-specific dynamic interactions of brain integration and functional diversity. Nature Communications. 10(1):4616 (2019).

Y Wang, A Luppi, J Fawcett, MC Anderson.Reconsidering unconscious persistence: Suppressing unwanted memories reduces their indirect expression in later thoughts. Cognition. 187:78-94 (2019).