CASS is an easy-to-use program for combining several phylogenetic trees into a single phylogenetic network. This website explains how you can use CASS to construct phylogenetic networks. Theoretical properties and performance in practice are described in the following paper:

Leo van Iersel, Steven Kelk, Regula Rupp and Daniel Huson, Phylogenetic Networks Do not Need to Be Complex: Using Fewer Reticulations to Represent Conflicting Clusters, Bioinformatics, 26:i124-i131 (2010).

Please cite this paper if you use CASS for a publication.

Thanks to the Allan Wilson Centre for Molecular Ecology and Evolution, The Netherlands Organisation for Scientific Research (NWO, Computational Life Sciences grant) and the Deutsche Forschungsgemeinschaft (PhyloNet project) for helping to fund this work. Thanks to Mike Steel for organizing the Cass workshop in the Cass Field Station in February 2009, where we started this work, and after which we named the algorithm.

If you have any question, just send an email to: