Are TUS effects are target-specific? Using behavioural measures and EEG we compare the effects of pulvinar stimulation (visual attention, alpha activity) against globus pallidus stimulation (motor control, beta activity).
TUS can non-invasively stimulate deep structures in the brain with high focality, and are these effects replicable?
Can we also reliably modulate thalamic nuclei at rest and during a decision making task?
European collaborative project developing TUS systems and software for closed-loop stimulation, using MR-ARFI feedback to precisely target deep brain structures.
How does cortical excitability change after stroke in patients with upper limb impairments?
Can dose-controlled non-invasive brain stimulation reliably modulate cortical excitability?
Electric field modelling shows large inter-individual variability in electric field reaching the brain and target region when applying transcranial direct or alternating current stimulation (tDCS/tACS).
This research provides ways to individualise stimulation protocol to vastly reduce electric field variability, which may result in more reliable effects.