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For patients with a first episode of DVT who have documented deficiency of Protein C or Protein S, deficiency of antithrombin, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels, treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis. Grapefruit juice, cranberry juice, noni juice, and pomegranate juice may interact with warfarin and lead to unwanted side effects. Avoid the use of these juice products while taking warfarin. Avoid making any changes in your diet without first talking to your doctor. Foods that are high in vitamin K (liver, leafy green vegetables, or vegetable oils) can make warfarin less effective. If these foods are part of your diet, eat a consistent amount on a weekly basis. There are two main types of blood thinners. Anticoagulants, such as heparin or warfarin (also called Coumadin), work on chemical reactions in your body to lengthen the time it takes to form a blood clot. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot. Many drugs can cause serious medical problems when used with warfarin. Tell your doctor about all medicines you have recently used. Although commonly used to treat blood clots, warfarin (Coumadin, Jantoven) can have dangerous side effects or interactions that can place you at risk of bleeding. Here are precautions to take to avoid warfarin side effects. ... But you may not realize how serious warfarin side effects can be. if you undergo a spinal tap or spinal anesthesia (epidural). You should not take warfarin if you cannot be reliable in using it because of alcoholism, psychiatric problems, dementia, or similar conditions. Warfarin can make you bleed more easily, especially if you have: a history of bleeding problems; high blood pressure or severe heart disease; kidney or liver disease; cancer; a disease affecting the blood vessels in your brain; a history of stomach or intestinal bleeding; a surgery or medical emergency, or if you receive any type of injection (shot); if you are 65 or older; or if you are severely ill or debilitated. How should I take warfarin? Take warfarin exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take warfarin in larger or smaller amounts or for longer than your doctor tells you to. Take warfarin at the same time every day. Never take a double dose. The duration of anticoagulant therapy following tissue heart valve replacement surgery is usually 6 to 12 weeks. The duration of therapy may be longer in patients with a tissue valve in the mitral location, particularly in the presence of a large left atrium and/or atrial fibrillation. In patients who receive a mechanical heart valve, lifelong anticoagulant therapy is usually needed and low dose aspirin (80 to 100 mg/day) may be added in higher risk patients. The duration of anticoagulant therapy for a first-time deep venous thrombosis is usually 3 to 12 months, depending on the reversibility of the condition which may have predisposed this patient to thrombosis. For patients with a first episode of DVT secondary to a reversible risk factor, 3 months of warfarin therapy is recommended. For patients with a first episode of idiopathic DVT, at least 6 to 12 months of treatment is recommended. For patients with two or more episodes of documented DVT, indefinite treatment with warfarin is recommended. For patients with a first episode of DVT who have documented antiphospholipid antibodies or who have two or more thrombophilic conditions, treatment for 12 months is recommended and indefinite therapy is suggested. For patients with a first episode of DVT who have documented deficiency of Protein C or Protein S, deficiency of antithrombin, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels, treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis. So, in addition totaking steps to prevent bleeding, it's also important to recognize the warning signs of this potentially serious side effect: Excessive menstrual bleeding. Coughing up anything red in color. Severe headache or stomachache. Dizziness or weakness. Blood in the urine or bowel movements. 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Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. You may still bleed more easily for several days after you stop taking warfarin. Avoid drinking alcohol. You should not take warfarin if you have a bleeding disorder, a blood cell disorder, blood in your urine or stools, stomach bleeding, very high blood pressure, an infection of the lining of your heart, bleeding in your brain, recent or upcoming surgery, or if you need a spinal tap or epidural. Do not take warfarin if you cannot take it on time every day. Ask your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes acetaminophen (Tylenol), aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. These medicines may affect blood clotting and may also increase your risk of stomach bleeding. Do not take warfarin if you are pregnant, unless your doctor tells you to. Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. You may be able to take warfarin during pregnancy if you have a mechanical heart valve. Use effective birth control to prevent pregnancy while using this medicine and for at least 1 month after your last dose. Tell your doctor right away if you become pregnant. Tell your doctor if you are sick with diarrhea, fever, chills, or flu symptoms, or if your body weight changes. You may need to stop taking warfarin 5 to 7 days before having any surgery or dental work. Call your doctor for instructions. You may also need to stop taking this medicine if you need to take antibiotics, or if you have a spinal tap or spinal anesthesia (epidural). Wear a medical alert tag or carry an ID card stating that you take warfarin. Any medical care provider who treats you should know that you are taking this medicine. Store at room temperature away from heat, moisture, and light. To make sure warfarin is safe for you, tell your doctor if you have: celiac sprue (an intestinal disorder); diabetes; congestive heart failure; overactive thyroid; a connective tissue disorder such as Marfan Syndrome, Sjögren syndrome, scleroderma, rheumatoid arthritis, or lupus; a hereditary clotting deficiency (warfarin may make your symptoms worse at first); if you use a catheter; or if you have ever had low blood platelets after receiving heparin. It is not known whether warfarin passes into breast milk. Tell your doctor if you are breast-feeding a baby. Watch for signs of bruising or bleeding in the baby if you take warfarin while you are nursing. You may take warfarin with or without food. While taking warfarin, you will need frequent "INR" or prothrombin time tests (to measure how long it takes your blood to clot). Your blood work will help your doctor determine the best dose for you. You must remain under the care of a doctor while taking this medicine. If you have received warfarin in a hospital, call or visit your doctor 3 to 7 days after you leave the hospital. Your INR will need to be tested at that time. Do not miss any follow-up appointments. Atrial Fibrillation - Stroke Prevention Guidelines & Treatment Options Do not take this medicine if you are pregnant, unless your doctor tells you to. Warfarin increases your risk of bleeding, which can be severe or life-threatening. You will need frequent tests to measure your blood-clotting time. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
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