Research articles

1) B. Calvignac, O. Boutin, The impinging jets techology: A contacting device using SAS process type, Journal of PowderTechnology, 191, p. 200-205, 2009

2) B. Calvignac, E. Rodier, J.-J. Letourneau, J. Fages, Development of characterization techniques of thermodynamic and physical properties applied to the CO2-DMSO mixture, International Journal of Chemical Reactor Engineering, vol. 7, article A46, 2009

3) B. Calvignac, E. Rodier, J.-J. Letourneau, J. Fages, Cocoa butter saturated with supercritical carbon dioxide: measurements and modelling of solubility, volumetric expansion, density and viscosity, International Journal of Chemical Reactor Engineering, vol. 8, article A73, 2010

4) B. Calvignac, P. Vitoux, E. Rodier, J.-J. Letourneau, C. Aymonier, J. Fages, Developement of an improved falling ball viscometer for high pressure measurements with supercritical CO2, Journal of Supercritical Fluids, 55, p. 96-106, 2010

5) T. Beuvier, B. Calvignac, G.J.-R. Delcroix, N. Delorme, J.-F. Bardeau, A. Gibaud, F. Boury, Synthesis of hollow vaterite CaCO3 microspheres insupercritical carbon dioxide, Journal of Material Chemistry, vol. 21, p. 9757, 2011

6) E. A. Chavez Panduro, T. Beuvier, M. Fernández Martínez, L. Hassani, B. Calvignac, F. Boury and A. Gibaud, Small-angle X-ray scattering analysis of porous powders of CaCO3, Journal of Applied Crystallography, Volume 45, Part 5, 2012

7) T. Beuvier, J.-F. Bardeau, B. Calvignac, H. Phan Ngoc Minh, G. Corbel, J.-M. Grenèche, F. Boury, A. Gibaud, Phase transformations in CaCO3/iron oxide composite induced by thermal treatment and laser irradiation, Journal of Raman spectroscopy, 2012

8) G. Rethore, C. Boyer, B. Calvignac, F. Xie, J. Guicheux, JF. Tassin, F. Boury, P. Weiss, Si-HPMC hydrogels for tissueengineering, Journal of tissue engineering and regenerative medicine, vol. 6, p. 239, 2012

9) M-K. Tran, L.N. Hassani, B. Calvignac, T. Beuvier, F. Hindré, F. Boury, Lysozyme Encapsulation Within PLGA and CaCO3 Microparticles using Supercritical CO2 Medium, Journal of Supercritical Fluids, vol 19. p. 159-169, 2013

10) L. N. Hassani, F. Hindre, T. Beuvier, B. Calvignac, N. Lautram, A. Gibaud and F. Boury, Lysozyme encapsulation into nanostructured CaCO3 microparticles using supercritical CO2 process andcomparison with the normal route, J. Mater. Chem. B, 2013

11) A. Favrelle, C. Boyère, M.K.Kien, D. Alaimo, B. Calvignac, M. Paquot, F. Boury, C. Jérôme, Surface Activity of a Fluorinated Carbohydrate Ester in Water/CarbonDioxide Emulsions, J. Colloid Interface Sci., 398, 273–275, 2013

12) V. E. Bosio, M. Cacicedo, B. Calvignac, I. Icon, T. Beuvier, F. Boury, G. R. Castro, Synthesis and characterization of CaCO3-biopolymer hybrid nanoporous microparticles for controlled release of doxorubicin, Colloids and surfaces B: Biointerfaces, vol.23, 158–169, 2014

13) T. Beuvier, B. Calvignac, J.-F. Bardeau, A. Bulou, F. Boury, A. Gibaud, Quantification of the Dissolved Inorganic Carbon Species and of the pH of Alkaline Solutions Exposed to CO2 under Pressure: A Novel Approach by Raman Scattering, Analytical chemistry, 86 (19), pp 9895–9900, 2014

14) M-K. Tran, A.Swed, B. Calvignac, T. Beuvier, K-N. Dang, L.N. Hassani, T. D. Cordonnier, F. Boury, Preparation of polymeric particles in CO2 medium using non-toxic solvents: Discussions on the mechanism of particle formation, J. Mater. Chem. B, vol.3, p. 1573-1582, 2014

15) T. Beuvier, E. A. Chavez Panduro, P. Kwaśniewski, S. Marre, C. Lecoutre, Y. Garrabos, C. Aymonier, B. Calvignac, and Alain Gibaud, Implementation of in situ SAXS/WAXS characterization into silicon/glass microreactors, J. Lab on chip, vol. 15, p. 2002-2009, 2015

16) Y. Z. Ergul, A. Debuigne, B. Calvignac, F. Boury, C. Jerome, Double Hydrophilic Polyphosphoester Containing Copolymers as Efficient Templating Agents for Calcium Carbonate Microparticles, J. Mater. Chem. B, vol.3, p. 7227-7236, 2015

17) Y. Z. Ergul, T. Cordonnier, A. Debuigne, B. Calvignac, F. Boury, C. Jerome, Protein encapsulation and release from PEO-b-polyphosphoester templated calcium carbonate particles, International Journal of Pharmaceutics, Volume 513, 1–2,p. 130–137, 2016

18) G. Lefebvre, , J. Riou, G. Bastiat, E. Roger, K. Frombach, J-C. Gimel, P. Saulnier, B. Calvignac, Spontaneous nano-emulsification: Process optimization and modeling for the prediction of the nanoemulsion’s size and polydispersity, International Journal of Pharmaceutics, Volume 534, Issues 1–2, 20 December 2017, p.220–228

19) S. Gay, G. Lefebvre, M. Bonnin, B. Nottelet, F. Boury, A. Gibaud, B. Calvignac, PLA scaffolds production from Thermally Induced Phase Separation: Effect of process parameters and development of an environmentally improved route assisted by supercritical carbon dioxide, J. of Supercritical Fluids, Volume 136, June 2018, Pages 123-135

20) S. Gay, B. Calvignac, L. Ouanssy Kamtcheu, T. Beuvier, E. Boller, M. Sauceau, S. Del Confetto, F. Boury and A. Gibaud, Synchrotron X-ray In situ Tomography of Thermally Induced Phase Separation of PolyLactic Acid in 1,4 Dioxane solution, ACS Crystal growth and Design, 8 (12), pp 7496–7503, 2018

21) L. Guyon, E. Lepeltier, J-C Gimel, B. Calvignac, F. Franconi, N. Lautram, A. Dupont, C. Bourgaux, P. Pigeon, P. Saulnier, G. Jaouen, C. Passirani, Importance of Combining Advanced Particle Size Analysis Techniques To Characterize Cell-Penetrating Peptide–Ferrocifen Self-Assemblies, J. Phys. Chem. Lett., pp. 6613-6620, 2019

22) P. Legout, O. Colombani, G. Lefebvre, M. Bonnin, J.C. Gimel, L. Benyahia, P. Saulnier, B. Calvignac, Synthesis of PDMS-b-POEGMA Diblock Copolymers and Their Application for the Thermoresponsive Stabilization of Water-Supercritical Carbon Dioxide Emulsions, Langmuir, 2020

23) K. Matha, B. Calvignac, J.-P. Gangneux, J.-P. Benoit, The advantages of nanomedicine in the treatment of visceral Leishmaniasis: between sound arguments and wishful thinking, Expert Opinion on drug delivery, 2020

24) S. Raffy, E. Palleau, B. Calvignac, G. Brotons, G. Lefebvre, N. Rolley, S. Teychene, B. Viguer, S. Castaño Cerezo, G. Truan, L. Ressier, “All in one” resealable epoxy-based microfluidic chips at your fingertips, ACS Applied Polymer Materials, 2021

25) N. Rolley, M. Bonnin, G. Lefebvre, S. Verron, S. Bargiel, J.-C. Gimel, J.-P. Benoit, G. Brotons, B. Calvignac, Galenic Lab-on-a-Chip concept for lipid nanocapsules production, Nanoscale, 2021, 13, 11899-11912

26) A. Fabien, G. Lefebvre, B. Calvignac, P. Legout, E. Badens, C. Crampon, Interfacial tension of ethanol, water, and their mixtures in high pressure carbon dioxide: Measurements and modeling, Journal of Colloid and Interface Science, 2022, 613, 847-856

27) P. Legout, G. Lefebvre, M. Bonnin, J.C. Gimel, L. Benyahia, A. Gibaud, S. Marre, C. Simonsson, S. Wang, O. Colombani, B. Calvignac, Reactive precipitation of vaterite calcium carbonate microspheres in supercritical carbon dioxide/water dispersion by microfluidics, J. of Supercritical Fluids, 2022, 188, 105678

28) K. Matha, J.-P. Benoit, J.-C. Gimel, J.-P. Gangneux, B. Calvignac, Development and evaluation of hyaluronic acid and polyarginine nanocomplexes associating pentamidine to treat visceral leishmaniasis, Nanomedicine: Nanotechnology, Biology and Medicine, 2021, in preparation

29) K. Matha, J-P. Benoit, J-C. Gimel, N. Lautram, C. Manuel, J-P. Gangneux, B. Calvignac, Microfluidic formulation of intravenously injectable Miltefosine-loaded lipid nanocapsules formulation to treat visceral leishmaniasis, in preparation

PhD Thesis

B. Calvignac, Mise au point de méthodes de caractérisation de binaires en milieu supercritique et modélisation des propriétés physiques et thermodynamiques mesurées, Ecole Nationale Supérieure des Mines de Paris, 2009

Communications

INVITED CONFERENCES / SEMINars

CI1 – B. Calvignac, Formulation de biomatériaux micro- et nano structurés par technologie CO2 supercritique, IFS days, 14-15 décembre 2017, Pornic

CI2 – B. Calvignac, Elaboration de matrices microcellulaires de PLA par la technologie du CO2 supercritiique, Colloque régional MATIERES, 30 janvier 2018, Nantes

CI3 – B. Calvignac, Ingénierie des micro et nanotechnologies appliquées au développement de systèmes de délivrance de médicaments, Midis de la recherche du Pôle Santé de l’Université d’Angers, 29 janvier 2019, Angers

CI4 – B. Calvignac, Les Nanomédicaments, Conférence santé et environnement du CHU de Rennes, 13 juin 2019, Marseille (visioconférence)

CI5 – B. Calvignac, Ingénierie des micro et nanotechnologies appliquées au développement de systèmes de délivrance de médicaments, Séminaire scientifique du laboratoire IMRCP UMRS 5623, 6 novembre 2019, Toulouse

CI6 – B. Calvignac, Les Nanomédicaments, Conférence scientifique pour les étdudiants et personnels d’Aix-Marseille Université, Mars 2021, Rennes

CI7 – B. Calvignac, Les technologies Fluides supercritiques appliquées aux produits de santé, Conférence grand-public à l’Ecole des Mines d’Albi, 4 juin 2021, Albi

with PEER-reviewed proceedings / abstracts

C-ACS1 – O. Boutin, T. Petit-Gas, B. Calvignac, E. Badens, Etude et mise au point de nouveaux dispositifs d’injection pour les procédés de génération de particules en milieu supercritique, Récents Progrès en Génie des Procédés, N° 96-2007, 11ème Congrès de la Société Française de Génie des Procédés, 9-11 octobre 2007, Saint-Etienne, France (Communication affichée).

C-ACS2 – B. Calvignac, P. Vitoux, E. Rodier, J-J. Letourneau, C. Aymonier, J. Fages, Development of a falling body viscosimeter for high pressure measurements, Proceedings of 9th International Symposium on Supercritical Fluids (ISSCF), 18-20 mai 2009, Arcachon, France (Communication orale).

C-ACS3 – B. Calvignac, E. Rodier, J-J. Letourneau, J. Fages, Characterization of high pressure thermophysical properties of supercritical CO2-DMSO for process design and modelling, Récents Progrès en Génie des Procédés, N° 96-2007, 12ème Congrès de la Société Française de Génie des Procédés, 14-16 octobre 2009, Marseille, France (Communication orale).

C-ACS4 – B. Calvignac, T. Beuvier, G. Delcroix, J.-F. Bardeau, A. Gibaud, F. Boury, Elaboration of composite calcium carbonate microparticles in supercritical CO2, Second International Conference on Multifunctional, Hybrid and Nanomaterials (HYMA 2011), 6-10 mars 2011, Strasbourg, France (Communication affichée).

C-ACS5 – M.K. Tran, B. Calvignac, F. Boury, A Novel Preparation Method For PLGA Microspheres Using Non Toxic Solvent Emulsified In Supercritical CO2, 13th European Meeting on Supercritical Fluids, 9-12 Octobre 2011, La Hague, Pays Bas (Communication orale).

C-ACS6 – L. N. Hassani, B. Calvignac, G. Delcroix, M.K. Tran, T. Beuvier, F. Hindré, A. Gibaud, F. Boury, Microencapsulation of proteins within CaCO3 microspheres using supercritical CO2 media, 13th European Meeting on Supercritical Fluids, 9-12 Octobre 2011, La Hague, Pays Bas (Communication orale).

C-ACS7 – B. Calvignac, T. Beuvier, L. N. Hassani, F. Hindré, A. Gibaud, F. Boury, Développement d’un procédé de génération de particules de carbonate de calcium en milieu CO2 supercritique pour applications biomédicales, Journées supercritiques (JSC2012), 15 et 16 mars 2012, Albi, France (Communication orale).

C-ACS8 – T. Beuvier, B. Calvignac, L. N. Hassani, J.-F. Bardeau, A. Gibaud, F. Boury, Etude in-situ de la précipitation du carbonate de calcium en milieu CO2 supercritique, Journées Nationales Supercritiques (JNSC2012), 15 et 16 mars 2012, Albi, France (Communication orale).

C-ACS9 – M.K. Tran, L. N. Hassani, B. Calvignac, T. Beuvier, F. Hindré, A. Gibaud, F. Boury, Microencapsulation Of Proteins Within Polymeric and Inorganic Particles Using Supercritical CO2 Media, Proceedings of 10th International Symposium on Supercritical Fluids (ISSCF), 13-26 mai 2012, San Francisco, USA (Communication orale).

C-ACS10 – B. Calvignac, T. Beuvier, L. N. Hassani, F. Hindré, A. Gibaud, F. Boury, Development of a supercritical precipitation process of calcium carbonate for biomedical applications, Proceedings of 10th International Symposium on Supercritical Fluids (ISSCF), 13-26 mai 2012, San Francisco, USA (Communication orale).

C-ACS11 – L. N. Hassani, B. Calvignac, T. Beuvier, F. Hindré, A. Gibaud, F. Boury, Supercritical CO2 as highly efficient innovative process for proteins encapsulation, 20th International Conference on Bioencapsulation, 21-24 September 2012, Orillia, Canada (Communication orale).

C-ACS12 – V.E. Bosio, M. Cacicedo, I. Leon, T. Beuvier, B. Calvignac, F. Boury, R. Castro, Synthesis and characterization of CaCO3 C biopolymers hybrid nanoporous microparticles for cancer damaged bone therapy, 11th Internation conference on nanostructured materials, 26-31 August 2012, Rhodes, Greece (Communication orale).

C-ACS13 – L. N. Hassani, B. Calvignac, F. Hindré, T. Beuvier, A. Gibaud, F. Boury, Supercritical CO2 as highly efficient innovative process for protein encapsulation, In proceeding of International conference on bioencapsulation, 2013 (Communication orale).

C-ACS14 – S. Gay, F. Boury, A. Gibaud, B. Calvignac, Elaboration of polymers biobased foams using supercritical carbone dioxide, Biopolymers 2015, 14-16 December 2015, Nantes, France (Communication orale)

C-ACS15 – S. Gay, F. Boury, S. Del Confetto, M. Sauceau, A. Gibaud, B. Calvignac, Elaboration de mousses polymères biosourcées et biocomposites en milieu CO2 supercritique, Journées Nationales Supercritiques (JNSC2016), 9-10 juin 2016, Nordeaux, France (Communication orale)

C-ACS16 – S. Gay, G. Lefebvre, M. Bonnin, B. Nottelet, F. Boury, A. Gibaud, B. Calvignac, Development of an eco-friendly Thermal Induced Phase Separation (TIPS) process assisted by supercritical CO2 for the production of PLA scaffolds with tunable structural and mechanical properties, 16th European Meeting on Supercritical Fluids, 25-28 April 2017, Lisbonne, Portugal (Communication orale).

C-ACS17 – G. Lefebvre, J. Riou, G. Bastiat, E. Roger, K. Frombach, J-C. Gimel, P. Saulnier, B. Calvignac, Spontaneous nano-emulsification: Process optimization and modeling for the prediction of the nanoemulsion’s size and polydispersity, 4ème congrès SFNano, 5-7 décembre 2017, Bordeaux (Communication affichée).

C-ACS18 – P. Legout, O. Colombani, G. Lefebvre, M. Bonnin, D. Lefevre, B. Calvignac, Synthèse de copolymères fonctionnels amphiphiles appliqués à la cristallisation de particules de carbonate de calcium en milieu CO2 supercritique par un procédé d’émulsification continu et éco-responsable, journées annuelles du GFP Grand Ouest et du réseau SPEED, 24 et 25 mai 2018, Le Mans, France (Communication orale)

C-ACS19 - J.-Y.Rolland, Alexei Lozinski, Jean-Christophe Gimel, Florence Franconi, Laurent Lemaire, B. Calvignac, Fluid-poroelastic interface modelling for an implantable medical device: Application to brain tumours treatment, 3rd edition of Mathematical Biologogy Modelling days, 19-22 Juin 2018, Besançon

C-ACS20 - J.-Y.Rolland, Alexei Lozinski, Jean-Christophe Gimel, Florence Franconi, Laurent Lemaire, B. Calvignac, Fluid-poroelastic interface modelling for an implantable medical device: Application to brain tumours treatment, 14ème journées d'étude des milieux poreux (JEMP), 10 Octobre 2018, Nantes.

C-ACS21 - L. Guyon, E. Lepeltier, B. Calvignac, N. Lautram, B. Lelievre, D. Chrétien, J.C. Gimel, C. Bourgaux, G. Jaouen, P. Pigeon, C. Passirani, Nanoassemblies formed by polyarginine-ferrocifene conjugates for lung cancer treatment, 5ème congrès SFNano, 3-5 décembre 2018, Montpellier (Communication orale).

C-ACS22 – N. Rolley, M. Bonnin, G. Lefebvre, S. Verron, S. Bargiel, J.-C. Gimel, J.-P. Benoit, G. Brotons, B. Calvignac, How additive manufacturing and microfabrication techniques could be complementary and applied to the development of the Galenic-on-chip concept? Flowmat 2019, 26-27 Juin 2019

C-ACS23 – K. Matha, J.-P. Benoit, J.-C. Gimel, J.-P. Gangneux, B. Calvignac, Transposition from a batch to continuous formulation process of sterile pentamidine-loaded nanopolyplexes to treat Leishmaniasis, Flowmat 2019, 26-27 Juin 2019

C-ACS24 – P. Legout, O. Colombani, G. Lefebvre, M. Bonnin, J.C. Gimel, B. Maxit, L. Benyahia, Sylvain Boj, P. Saulnier, B. Calvignac, Caractérisation de l’activité interfaciale et du comportement auto-associatif de copolymères à blocs amphiphiles : application à la formulation d’émulsions Eau/CO2 supercritique pour la précipitation réactive de CaCO3, 17ème Congrès de la Société Française de Génie des Procédés, 15-17 octobre 2019, Nantes, France (Communication orale).

C-ACS25 – M. Weitten, L. Lemaire, F. Franconi, F. Letournel, .C. Gimel, B. Maxit, L. Benyahia, Sylvain Boj, P. Saulnier, B. Calvignac, Development of a 3D printed microfluidic medical device for locoregional treatments of Glioblastoma, CRS Annual meeting & exposition, Las Vegas (USA), Juillet 2020 (Communication orale).

C-ACS26 – N. Rolley, K. Matha, M. Bonnin, G. Lefebvre, S. Verron, J.C. Gimel, N. Lautram, S. Bargiel, J.-P. Gangneux, J.-P. Benoit, G. Brotons, B. Calvignac, Galenic-on-chip concept for development and production of Lipid NanoEmulsions encapsulated Miltefosine for Leishmaniasis treatment, CRS Annual meeting & exposition, Las Vegas (Etats-Unis), Juillet 2020 (Communication orale).

without PEER-reviewed proceedings / abstracts

C1 – B. Calvignac, E. Rodier, J-J. Letourneau, J. Fages, Characterization of high pressure thermophysical properties of binary system: supercritical CO2-saturated cocoa butter, First workshop Tohoku University-EMAC-INSA, 1&2 décembre 2008, Albi, France (Communication affichée).

C2 – G.J-R. Delcroix, B. Calvignac, F. Hindré, F. Boury, Calcium carbonate multifunctional particles formulated in supercritical CO2: Application to controlled release of therapeutic proteins for tissue engineering, Journées de l’IFR 132, Avril 2010, Angers (Communication orale).

C3 – F. Boury, C. Montero-Menei, B. Calvignac, T. Beuvier, A. Gibaud, J.P. Benoit, Nanomedecine et ingénierie tissulaire du cartilage, 6ème journée du Pôle Lorrain d'Ingénierie du Cartilage, Nancy, France, 12-13 Octobre 2011 (Communication orale).

C4 – S. Gay, T. Beuvier, F. Boury, A. Gibaud and B. Calvignac, Elaboration de mousses de polymères biosourcés par CO2 supercritique, Journées Scientifiques de l’Université de Nantes, 12 juin 2015, Nantes, France (Communication affichée et Communication orale)

C5 – C. Simonsson and B. Calvignac, Développement d’un labopuce de galénique utilisant la technologie CO2 supercritique, Colloque du défi « Instrumentation aux limites » du CNRS, Paris, France, 4 Mai 2017 (Communication affichée).