Most relevant publications (Last 10 years)
2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | Book & Book Chapters
- J. Magalhaes, M. Pinheiro, B. Drasler, D. Septiadi, A. Petri-Fink, S.G. Santos, B. Rothen-Rutishauser, S. Reis
Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model.
Nanomedicine. (2019) [Epub ahead of print]
- A.I. Barbosa, A.J. Coutinho, S.A.C. Lima, S. Reis
Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field.
Mar Drugs. 17(12) (2019) pii: E654
[DOI: 10.3390/md17120654]
- D. Araujo, V.D. Alves, S.A.C. Lima, S. Reis, F. Freitas, M.A.M. Reis
Novel hydrogels based on yeast chitin-glucan complex: Characterization and safety assessment.
Int J Biol Macromol. (2019) [Epub ahead of print]
[DOI: 10.1016/j.ijbiomac.2019.11.141]
- V.M. Gouveia, L. Rizzello, C. Nunes, A. Poma, L. Ruiz-Perez, A. Oliveira, S. Reis, G. Battaglia
Macrophage Targeting pH Responsive Polymersomes for Glucocorticoid Therapy.
Pharmaceutics. 11 (11) (2019) pii:E614
[DOI: 10.3390/pharmaceutics11110614]
- L. Farkuh, P.T. Hennies, C. Nunes, S. Reis, L. Barreiros, M.A. Segundo, P.L. Oseliero Filho, C.L.P. Oliveira, A. Cassago, R.V. Portugal, R.A. Muramoto, G.P.B. Carretero, S. Schreier, H. Chaimovich, I.M. Cuccovia
Characterization of phospholipid vesicles containing lauric acid: physicochemical basis for process and product development.
Heliyon. 5 (10) (2019) e02648
[DOI: 10.1016/j.heliyon.2019.e02648]
- M. Pinheiro, H. Amenitsch, S. Reis
Antituberculosis Drug Interactions with Membranes: A Biophysical Approach Applied to Bedaquiline.
Membranes (Basel). 9 (11) (2019) pii:E141
[DOI: 10.3390/membranes9110141]
- A.C. Santos, I. Pereira, S. Reis, F. Veiga, M. Saleh, Y. Lvov
Biomedical potential of clay nanotube formulations and their toxicity assessment.
Expert Opin Drug Deliv. 16 (11) (2019) 1169-1182
[DOI: 10.1080/17425247.2019.1665020]
- A. Essaghraoui, A. Belfkira, B. Hamdaoui, C. Nunes, S.A.C. Lima, S. Reis
Improved Dermal Delivery of Cyclosporine A Loaded in Solid Lipid Nanoparticles.
Nanomaterials (Basel). 9 (9) (2019) pii:E1204
[DOI: 10.3390/nano9091204]
- R.M. Pinto, D. Lopes-de-Campos, M.C.L. Martins, P. Van Dijck, C. Nunes, S. Reis.
Impact of nanosystems in Staphylococcus aureus biofilms treatment.
FEMS Microbiology Reviews. (2019) fuz021.
[DOI: 10.1093/femsre/fuz021]
- A. Júlio, R. Caparica, S.A.C. Lima, A.S. Fernandes, C. Rosado, D.M.F. Prazeres, S. Reis, T.S. Almeida, P. Fonte.
Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs.
Nanomaterials (Basel). 9(8)(2019) pii:E1148
[DOI: 10.3390/nano9081148]
- M. Pinheiro, J. Magalhães, S. Reis.
Antibiotic interactions using liposomes as model lipid membranes.
Chemistry and Physics of Lipids. 222 (2019) 36-46.
[DOI: 10.1016/j.chemphyslip.2019.05.002]
- Z. Shakel, C. Nunes, S.A.C. Lima, S. Reis.
Development of a novel human stratum corneum model, as a tool in the optimization of drug formulations.
International Journal of Pharmaceutics. 569 (2019) 118571.
[DOI: 10.1016/j.iipharm.2019.118571]
- A. Júlio, S.A.C. Lima, S. Reis, T.S. Almeida, P. Fonte.
Development of ionic liquid-polymer nanoparticle hybrid systems for delivery of poorly soluble drugs.
Journal of Drug Delivery Science and Technology. (2019) In Press
[DOI: 10.1016/j.jddst.2019.01.030]
- J.C. Campos, D.C. Ferreira, S.A.C. Lima, S. Reis, P.J. Costa.
Swellable polymeric particles for the local delivery of budesonide in oral mucositis.
International Journal of Pharmaceutics. 566 (2019) 126-140.
[DOI: 10.1016/j.iipharm.2019.05.057]
- D. Lopes-de-Campos, R.M. Pinto, S.A.C. Lima, T. Santos, B. Sarmento, C. Nunes, S. Reis.
Delivering amoxicillin at the infection site – a rational design through lipid nanoparticles.
International Journal of Nanomedicine. 14 (2019) 2781–2795.
[DOI: 10.2147/IJN.S193992]
- A.I. Barbosa, S.A.C. Lima, S. Reis
Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation.
International Journal of Biological Macromolecules. 124(2019) 1115-1122.
[DOI: 10.1016/j.ijbiomac.2018.12.014]
- C. Pereira-Leite, D. Lopes-de-Campos, P. Fontaine, I.M. Cuccovia, C. Nunes, S. Reis
Licofelone-DPPC Interactions: Putting Membrane Lipids on the Radar of Drug Development.
Molecules. 24(3) (2019).
[DOI: 10.3390/molecules24030516]
- A. Alves, M. Correia-da-Silva, C. Nunes, J. Campos, E. Sousa, P.M. Silva, H. Bousbaa, F. Rodrigues, D. Ferreira, P. Costa, M.Pinto
Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations.
Molecules. 24(3) (2019).
[DOI: 10.3390/molecules24030409 ]
- A.I. Barbosa, S.A.C. Lima, S. Reis
Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery.
Molecules. 24(2) (2019).
[DOI: 10.3390/molecules24020346]
- C. Pereira-Leite, C. Nunes, J.C. Bozelli, Jr., S. Schreier, C.S. Kamma-Lorger, I.M. Cuccovia, S. Reis
Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?
Colloids Surf B Biointerfaces. 169 (2018) 375-383.
[DOI: 10.1016/j.colsurfb.2018.05.019]
- S.M.T. Cavalcanti, S.M.T., C. Nunes, S.A.C. Lima, J.L. Soares-Sobrinho, S. Reis
Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method.
European Journal of Pharmaceutical Sciences. 122(2018) 22-30.
[DOI: 10.1016/j.ejps.2018.06.017]
- L.L. Chaves, L.L., S. Lima, A.C.C. Vieira, D. Ferreira, B. Sarmento, S. Reis
Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles.
Journal of the Royal Society Interface. 15(139) (2018).
[DOI: 10.1098/rsif.2017.0932]
- L.L. Chaves, S.A.C. Lima, A.C.C. Vieira, L. Barreiros, M.A. Segundo, D. Ferreira, B. Sarmento, S. Reis
Nanosystems as modulators of intestinal dapsone and clofazimine delivery.
Biomedicine & Pharmacotherapy. 103(2018) 1392-1396.
[DOI: 10.1016/j.biopha.2018.04.195]
- J. Lopes-de-Araujo, S. Reis, C. Nunes
Topotecan effect on the structure of normal and cancer plasma membrane lipid models: A multi-model approach.
European Journal of Pharmaceutical Sciences. 123(2018) 515-523.
[DOI: 10.1016/j.ejps.2018.08.006]
- D.R.P. Loureiro, J.X. Soares, D. Lopes, T. Macedo, D. Yordanova, S. Jakobtorweihen, C. Nunes, S. Reis, M.M. Pinto, C.M. Afonso
Accessing lipophilicity of drugs with biomimetic models: A comparative study using liposomes and micelles.
European Journal of Pharmaceutical Sciences. 115(2018) 369-380.
[DOI: 10.1016/j.ejps.2018.01.029]
- S. Machado, S.R. Fernandes, L.L. Chaves, S.A.C. Lima, E.M.P. Silva, L. Barreiros, S. Reis, M.A. Segundo
Chromatographic method for the simultaneous quantification of dapsone and clofazimine in nanoformulations.
Journal of Separation Science. 41(17) (2018)-
[DOI: 10.1002/jssc.201800427]
- C.M. Morais, A.M. Cardoso, P.P. Cunha, L. Aguiar, N. Vale, E. Lage, M. Pinheiro, C. Nunes, P. Gomes, S. Reis, M.M.C.A. Castro, M.C.P. de Lima, A.S. Jurado
Acylation of the S4(13)-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions.
Biochimica Et Biophysica Acta-Biomembranes. 1860(12) (2018) 2619-2634.
[DOI: 10.1016/j.bbamem.2011.12.022]
- C.L. Seabra, C.L., C. Nunes, M. Bras, M. Gomez-Lazaro, C.A. Reis, I.C. Goncalves, S. Reis, M.C.L. Martins
Lipid nanoparticles to counteract gastric infection without affecting gut microbiota.
European Journal of Pharmaceutics and Biopharmaceutics. 127(2018) 378-386.
[DOI: 10.1016/j.ejpb.2018.02.030]
- A.C.C. Vieira, L.L. Chaves, M. Pinheiro, S.A.C. Lima, D. Ferreira, B. Sarmento, S. Reis
Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages.
Artificial Cells Nanomedicine and Biotechnology. 46(2018) S653-S663.
[DOI: 10.1080/21691401.2018.1434186]
- Lopes-de-Campos, D., C. Nunes, B. Sarmento, S. Jakobtorweihen, S. Reis
Metronidazole within phosphatidylcholine lipid membranes: new insights to improve the design of imidazole derivatives.
Eur J Pharm Biopharm, (2018)
[DOI: 10.1016/j.ejpb.2018.05.036]
- Pereira-Leite, C., C. Nunes, D. Grahl, J.C. Bozelli, S. Schreier, C.S. Kamma-Lorger, I.M. Cuccovia, S. Reis
Acemetacin-phosphatidylcholine interactions are determined by the drug ionization state.
Phys Chem Chem Phys. 20(21) (2018) 14398-14409.
[DOI: 10.1039/c8cp01698d]
- Gouveia, V.M., J. Lopes-de-Araujo, S.A. Costa Lima, C. Nunes, S. Reis
Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy.
Nanomedicine (Lond). 13(9) (2018) 1037-1049.
[DOI: 10.2217/nnm-2017-0377]
- Lage, E.V., J. Magalhaes, M. Pinheiro, S. Reis
Effect of the alkyl group in the piperazine N-substitution on the therapeutic action of rifamycins: A drug-membrane interaction study.
Chem Biol Interact. 289 (2018) 75-80.
[DOI: 10.1016/j.cbi.2018.04.027]
- Vieira A.C.C., L.L. Chaves, S. Pinheiro, S. Pinto, M. Pinheiro, S.C. Lima, D. Ferreira, B. Sarmento, S. Reis
Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis.
International Journal of Pharmaceutics. 536(1) (2018) 478-485.
[DOI:10.1016/j.ijpharm.2017.11.071]
- Santos A., J.X. Soares, S. Cravo, M.E. Tiritan, S. Reis, C. Afonso, C. Fernandes, M.M.M. Pinto
Lipophilicity assessement in drug discovery: Experimental and theoretical methods applied to xanthone derivatives.
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 1072(2018) 182-192.
[DOI:10.1016/j.jchromb.2017.10.018]
- Chaves L.L., S.A.C. Lima, A.C.C. Vieira, L. Barreiros, M.A. Segundo, D. Ferreira, B. Sarmento, S. Reis
Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability.
European Journal of Pharmaceutical Sciences. 112(2018) 28-37.
[DOI:10.1016/j.ejps.2017.11.004]
- M. Moskvin, M. Babič, S. Reis, M.M. Cruz, L.P. Ferreira, M.D. Carvalho, S.A.C. Lima, D. Horák
Biological evaluation of surface-modified magnetic nanoparticles as a platform for colon cancer cell theranostics.
Colloids Surf B - Biointerfaces (2017).
[DOI: 10.1016/j.colsurfb.2017.10.034]
- J.C. Campos, J.D. Cunha, D.C. Ferreira, S. Reis, P.J. Costa
Challenges in the local delivery of peptides and proteins for oral mucositis management.
European Journal of Pharmaceutics and Biopharmaceutics. 128(2018) 131-146.
- Vieira A.C.C., J. Magalhaes, S. Rocha, M.S. Cardoso, S.G. Santos, M. Borges, M. Pinheiro, S. Reis
Targeted macrophages delivery of rifampicin-loaded lipid nanoparticles to improve tuberculosis treatment.
Nanomedicine. 12(24) (2017) 2721-2736.
[DOI:10.2217/nnm-2017-0248]
- Granja A., A.C. Vieira, L.L. Chaves, C. Nunes, A.R. Neves, M. Pinheiro, S. Reis
Folate-targeted nanostructured lipid carriers for enhanced oral delivery of epigallocatechin-3-gallate.
Food Chemistry. 237(2017) 803-810.
[DOI:10.1016/j.foodchem.2017.06.019]
- Granja A., I. Frias, A.R. Neves, M. Pinheiro, S. Reis
Therapeutic potential of Epigallocatechin Gallate nanodelivery systems.
Biomed Research International, (2017).
[DOI:10.1155/2017/5813793]
- Ferreira M., L. Barreiros, M.A. Segundo, T. Torres, M. Selores, S.A.C. Lima, S. Reis
Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: A targeted approach for psoriasis management.
Colloids and Surfaces B-Biointerfaces. 159(2017) 23-29.
[DOI:10.1016/j.colsurfb.2017.07.080]
- Ferraz R., M. Pinheiro, A. Gomes, C. Teixeira, C. Prudencio, S. Reis, P. Gomes
Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models.
Bioorganic & Medicinal Chemistry Letters. 27(17) (2017) 4190-4193.
[DOI:10.1016/j.bmcl.2017.07.006]
- Chaves L.L., S.A.C. Lima, A.C.C. Vieira, L. Barreiros, M.A. Segundo, D. Ferreira, B. Sarmento, S. Reis
pH-sensitive nanoparticles for improved oral delivery of dapsone: risk assessment, design, optimization and characterization.
Nanomedicine. 12(16) (2017) 1975-1990.
[DOI:10.2217/nnm-2017-0105]
- Azevedo A.M.O., S.P.F. Costa, A.F. Dias, A.H.O. Marques, P.C.G. Pinto, K. Bica, A.K. Ressmann, M.L.C. Passos, A.R.T.S. Araujo, S. Reis, M.L.M.F.S. Saraiva
Anti-inflammatory choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parameters.
Journal of Molecular Liquids. 232(2017) 20-26.
[DOI:10.1016/j.molliq.2017.02.027]
- Alves A.C., D. Ribeiro, M. Horta, J.L.F.C. Lima, C. Nunes, S. Reis
A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity.
Journal of the Royal Society Interface. 14(133) (2017).
[DOI:10.1098/rsif.2017.0408]
- Alves A.C., A. Magarkar, M. Horta, J.L.F.C. Lima, A. Bunker, C. Nunes, S. Reis
Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies.
Scientific Reports. 7(2017).
[DOI:10.1038/s41598-017-06445-z]
- Alves A.C., Nunes C., Lima J.L.F.C., Reis S.
Daunorubicin and doxorubicin molecular interplay with 2D membrane models.
Colloids Surf B - Biointerfaces, 160 (2017) 610-618.
[DOI: 10.1016/j.colsurfb.2017.09.058]
- Pereira-Leite C. , Nunes C. , Jamal S. K., Cuccovia I. M., S. Reis
Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety.
Medicinal Research Reviews, 37(4) (2017) 802-859.
- Neves A. R., Queiroz J. F., Lima S. A. C., Reis S.
ApoE functionalization of solid lipid nanoparticles enhances brain drug delivery: uptake mechanism and transport pathways.
Bioconjugate Chem. 28 (2017) 995-1004.
[DOI: 10.1021/acs.bioconjchem.6b00705]
- Cavalcanti S.M.T., Nunes C., Costa Lima S.A., Soares-Sobrinho J.L., Reis S.
Multiple Lipid Nanoparticles, a New Generation of Lipid Nanoparticles for Drug Delivery Systems: Lamivudine-MLN Experimental Design.
Pharmaceutical Research, 34 (6) (2017) 1204-1216.
[DOI: 10.1007/s11095-017-2136-0]
- Silva, E., L. Barreiros, M.A. Segundo, S.A. Costa Lima, S. Reis,
Cellular interactions of a lipid-based nanocarrier model with human keratinocytes: Unravelling transport mechanisms.
Acta Biomater, 53 (2017) 439-444.
[DOI: 10.1016/j.actbio.2017.01.057]
- Costa Lima S.A., Gaspar A., Reis S., Durães L.
Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells.
Materials Science and Engineering: C 75 (2017) 1420–1426.
[DOI 10.1016/j.msec.2017.03.049]
- Loureiro J. A., Andrade S., Duarte A., Neves A. R., Queiroz J. F., Nunes C., Sevin E., Fenart L., Gosselet F., Coelho M. A. N., Pereira M. C.,
Resveratrol and Grape Extract-Loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s disease.
Molecules, 22 (2017 )277-285.
[DOI: 10.3390/molecules22020277]
- Seabra, C.L., C. Nunes, M. Gomez-Lazaro, M. Correia, J.C. Machado, I.C. Goncalves, C.A. Reis, S. Reis, M.C. Martins,
Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori.
Int J Pharm, 519(1-2) (2017) 128-137.
[DOI: 10.1016/j.ijpharm.2017.01.014]
- Lopes, D., C. Nunes, P. Fontaine, B. Sarmento, S. Reis,
Proof of pore formation and biophysical perturbations through a 2D amoxicillin-lipid membrane interaction approach.
Biochim Biophys Acta, 1859(5) (2017) 803-812.
[DOI: 10.1016/j.bbamem.2017.01.031]
- Alves, A.C., D. Ribeiro, M. Horta, J.L. Lima, C. Nunes, S. Reis,
The daunorubicin interplay with mimetic model membranes of cancer cells: A biophysical interpretation.
Biochim Biophys Acta, 1859(5) (2017) 941-948.
[DOI: 10.1016/j.bbamem.2017.01.034]
- Lopes, D., S. Jakobtorweihen, C. Nunes, B. Sarmento, S. Reis,
Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations.
Progress in Lipid Research, 65 (2017) 24-44.
[DOI: 10.1016/j.plipres.2016.12.001]
- Frias I., Neves A. R., Pinheiro M., Reis S.,
Design, development and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation.
Drug Des Devel Ther. 10 (2016) 3519-3528.
-Andrade F., Fonte P., Costa A., Reis C.C., Nunes R., Almeida A., Ferreira D., Oliva M., Sarmento B.
Pharmacological and toxicological assessment of innovative self-assembled polymeric micelles as powders for insulin pulmonary delivery.
Nanomedicine, 11 (17) (2016) 2305-2317.
- Barbosa J. P., Neves A. R., Silva A. M., Barbosa M. A., Reis S., Santos S. G.,
Nanostructured Lipid Carriers Loaded with Resveratrol Modulate Human Primary Dendritic Cells.
Int. J. Nanomedicine 11 (2016) 3501–3516.
- Neves A. R., Nunes C., Amenitsch H., Reis S.,
Resveratrol interaction with lipid bilayers: a synchrotron X-ray scattering study.
Langmuir 32 (2016) 12914-12922.
[DOI: 10.1021/acs.langmuir.6b03591]
- A.C. Alves, I.I. Ramos, C. Nunes, L.M. Magalhaes, H. Sklenarova, M.A. Segundo, J.L.F.C. Lima, S. Reis,
On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography,
Talanta, 146 (2016) 369-374.
[DOI: 10.1016/j.talanta.2015.08.070]
- A.C. Alves, D. Ribeiro, C. Nunes, S. Reis,
Biophysics in cancer: The relevance of drug-membrane interaction studies,
Biochimica Et Biophysica Acta-Biomembranes, 1858 (2016) 2231-2244.
[DOI: 10.1016/j.bbamem.2016.06.025]
- A. Costa, M. Pinheiro, J. Magalhaes, R. Ribeiro, V. Seabra, S. Reis, B. Sarmento,
The formulation of nanomedicines for treating tuberculosis,
Advanced Drug Delivery Reviews, 102 (2016) 102-115.
[DOI: 10.1016/j.addr.2016.04.012]
- M. Ferreira, E. Silva, L. Barreiros, M.A. Segundo, S.A. Costa Lima, S. Reis,
Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential,
International journal of pharmaceutics, 512 (2016) 14-21.
[DOI: 10.1016/j.ijpharm.2016.08.008]
- P. Fonte, F. Andrade, C. Azevedo, J. Pinto, V. Seabra, M. van de Weert, S. Reis, B. Sarmento,
Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization,
Pharm Res, 33 (2016) 2777-2793.
[DOI:10.1007/s11095-016-2004-3]
- P. Fonte, P.R. Lino, V. Seabra, A.J. Almeida, S. Reis, B. Sarmento,
Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles,
International Journal of Pharmaceutics, 503 (2016) 163-173.
[DOI:10.1016/j.ijpharm.2016.03.011]
- M.A. Segundo, V.L. Abreu, M.V. Osório, S. Nogueira, P.K. Lin, A. Cordeiro-da-Silva, S.A. Lima SA.
Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles.
Journal Pharmaceutis Biomedical Analysis 120 (2016) 290-296.
[DOI:10.1016/j.jpba.2015.12.033]
- P. Fonte, S. Reis, B. Sarmento,
Facts and evidences on the lyophilization of polymeric nanoparticles for drug delivery,
Journal of Controlled Release, 225 (2016) 75-86.
[DOI:10.1016/j.jconrel.2016.01.034]
- A. Granja, M. Pinheiro, S. Reis,
Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy,
Nutrients, 8 (2016).
- J. Lopes-De-Araujo, A.R. Neves, V.M. Gouveia, C.C. Moura, C. Nunes, S. Reis,
Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects,
Pharmaceutical Research, 33 (2016) 301-314.
[DOI: 10.1007/s11095-015-1788-x]
- A.R. Neves, S. Martins, M.A. Segundo, S. Reis,
Nanoscale Delivery of Resveratrol towards Enhancement of Supplements and Nutraceuticals,
Nutrients, 8 (2016).
- A.R. Neves, C. Nunes, H. Amenitsch, S. Reis,
Effects of resveratrol on the structure and fluidity of lipid bilayers: a membrane biophysical study,
Soft Matter, 12 (2016) 2118-2126.
- A.R. Neves, C. Nunes, S. Reis,
Resveratrol induces ordered domains formation in biomembranes: Implication for its pleiotropic action,
Biochimica Et Biophysica Acta-Biomembranes, 1858 (2016) 12-18.
[DOI: 10.1016/j.bbamem.2015.10.005]
- A.R. Neves, J.F. Queiroz, S.A.C. Lima, F. Figueiredo, R. Fernandes, S. Reis,
Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery,
Journal of Colloid and Interface Science, 463 (2016) 258-265.
[DOI: 10.1016/j.jcis.2015.10.057]
- A.R. Neves, J.F. Queiroz, S. Reis,
Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E,
Journal of Nanobiotechnology, 14 (2016).
[DOI: 10.1186/s12951-016-0177-x]
- M. Pinheiro, R. Ribeiro, A. Vieira, F. Andrade, S. Reis,
Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis,
Drug Design Development and Therapy, 10 (2016) 2467-2475.
- F. Rodrigues, A.C. Alves, C. Nunes, B. Sarmento, M.H. Amaral, S. Reis, M.B. Oliveira,
Permeation of topically applied caffeine from a food by-product in cosmetic formulations: Is nanoscale in vitro approach an option?,
Int J Pharm, 513 (2016) 496-503.
[DOI: 10.1016/j.ijpharm.2016.09.059]
- A.C. Vieira, L.L. Chaves, M. Pinheiro, D. Ferreira, B. Sarmento, S. Reis,
Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cells,
International journal of nanomedicine, 11 (2016) 2601-2617.
- Neves AR, Nunes C, and S Reis.,
New Insights on the Biophysical Interaction of Resveratrol with Biomembrane Models: Relevance for Its Biological Effects.
J. Phys. Chem. B., 2015. 119(35), 11664-72.
[DOI: 10.1021/acs.jpcb.5b05419]
- Ferreira M, Chaves LL, Lima SA and S Reis S.,
Optimization of nanostructured lipid carriers loaded with methotrexate: A tool for inflammatory and cancer therapy.
Int J Pharm. 2015. 492(1-2):65-72.
[DOI:10.1016/j.ijpharm.2015.07.013]
- Monteiro C, Pinheiro M, Fernandes M, Maia S, Seabra CL, Ferreira-da-Silva F, Reis S, Gomes P and MC Martins.,
A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells,
Mol Pharm. 2015. 12 (8), 2904–2911.
[DOI: 10.1021/acs.molpharmaceut.5b00113]
- Gouveia VM, Costa Lima SA, Nunes C, and S Reis.
Non-Biologic Nanodelivery Therapies for Rheumatoid Arthritis.
J. Biomed. Nanotechnol. 2015. 11, 1701-1721.
- Albuquerque J, Moura CC, Sarmento B and S Reis,
Solid Lipid Nanoparticles: A Potential Multifunctional Approach towards Rheumatoid Arthritis Theranostics.
Molecules 2015, 20(6), 11103-11118.
[DOI: 10.3390/molecules200611103]
- Costa Lima SA and S Reis,
Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis.
Colloids Surf B Biointerfaces. 2015 Apr 30.
[DOI: 10.1016/j.colsurfb.2015.04.048]
- Fonte P, Araújo F, Silva C, Pereira C, Reis S, Santos HA and B Sarmento,
Polymer-based nanoparticles for oral insulin delivery: Revisited approaches.
Biotechnol Adv. 2015 Feb 26.
[DOI: 10.1016/j.biotechadv.2015.02]
- Neves AR, Reis S, Segundo MA.
Development and validation of a HPLC method using a monolithic column for quantification of trans-resveratrol in lipid nanoparticles for intestinal permeability studies.
J. Agric. Food Chem. 2015, 63: p. 3114−3120.
[DOI: 10.1021/acs.jafc.5b00390]
- Monteiro C, Fernandes M, Pinheiro M, Maia S, Seabra CL, Ferreira-da-Silva F, Costa F, Reis S, Gomes P, Martins MC.
Antimicrobial properties of membrane-active dodecapeptides derived from MSI-78.
Biochim Biophys Acta, 2015. 1848: p. 1139-46.
[DOI:10.1016/j.bbamem.2015.02.001]
-Ferraro V., Madureira A. R., Fonte P., Sarmento B., Gomes A. M., Pintado M.
Evaluation of the interactions between rosmarinic acid and bovine milk casein.
RSC Advances, 5 (2015) 88529-88538.
-Madureira A. R., Campos D. A., Fonte P., Nunes S., Reis F., Gomes A. M., Sarmento B., Pintado M. M.
Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery.
RSC Advances, 5 (2015) 22665-22673.
-Lopes M., Abrahim-Vieira B., Oliveira C., Fonte P., Souza A., Lira T., Sequeira J., Rodrigues C., Cabral L., Sarmento B., Seiça R., Veiga F., Ribeiro A.
Probing insulin bioactivity in oral nanoparticles produced by ultrasonication-assisted emulsification/internal gelation.
International Journal of Nanomedicine, 10 (2015) 5865-5880.
-Castro P., Fonte P., Sousa F., Madureira R., Sarmento B., Pintado M.
Oral films as breakthrough tools for oral delivery of proteins/peptides.
Journal of Controlled Release, 211 (2015) 63-73.
[DOI: 10.1016/j.jconrel.2015.05.258]
-Andrade F., Fonte P., Oliva M., Videira M., Ferreira D., Sarmento B.
Solid state formulations composed by amphiphilic polymers for delivery of proteins: characterization and stability.
International Journal of Pharmaceutics, 486 (2015) 195-206.
[DOI: 10.1016/j.ijpharm.2015.03.050]
-Silva S., Amorim M., Fonte P., Madureira R., Ferreira D., Pintado M., Sarmento B.
Natural extracts into chitosan nanocarriers for rosmarinic acid drug delivery.
Pharmaceutical Biology, 53 (5) (2015) 642-652.
[DOI: 10.3109/13880209.2014.935949]
- Pinto M F, Moura CC; Nunes C, Segundo MA, Lima SAC and S. Reis.
A new topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers.
International Journal of Pharmaceutics. 2014. 477 (1-2): p. 519-526.
[DOI:10.1016/j.ijpharm.2014.10.067]
- Pinheiro M, Pisco S, Silva AS, Nunes C, and S Reis.
Evaluation of the effect of rifampicin on the biophysical properties of membranes: Significance for therapeutic and side effects.
International Journal of Pharmaceutics, 2014. 466(1-2): p. 190-197.
[DOI: 10.1016/j.ijpharm.2014.03.005]
- Lopes D, Nunes C, Martins MCL, Sarmento B, and S. Reis.
Eradication of Helicobacter pylori: Past, present and future.
Journal of Controlled Release, 2014. 189: p. 169-186.
[DOI: 10.1016/j.jconrel.2014.06.020]
- Chaves LL, Vieira ACC, Reis S, Sarmento B, and D.C. Ferreira.
Quality by Design: Discussing and Assessing the Solid Dispersions Risk.
Current Drug Delivery, 2014. 11(2): p. 253-269.
[DOI:10.2174/1567201811666140211110943]
- Pereira-Leite C, Nunes C, and S. Reis.
Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions.
Progress in Lipid Research, 2013. 52(4): p. 571-584.
[DOI: 10.1016/j.plipres.2013.08.003]
- Pinheiro M, Pereira-Leite C, Arede M, Nunes C, Caio JM, Moiteiro C, Giner-Casares JJ, Lucio M, Brezesinski G, Camacho L, and S. Reis.
Evaluation of the Structure-Activity Relationship of Rifabutin and Analogs: A Drug-Membrane Study.
Chemphyschem, 2013. 14(12): p. 2808-2816.
- Pinheiro M, Nunes C, Caio JM, Moiteiro C, Brezesinski G, and S. Reis.
Interactions of N '-acetyl-rifabutin and N '-butanoyl-rifabutin with lipid bilayers: A synchrotron X-ray study.
International Journal of Pharmaceutics. 2013. 453(2): p. 560-568.
[DOI: 10.1016/j.ijpharm.2013.06.018]
- Pinheiro M, Arede M, Giner-Casares JJ, Nunes C, Caio JM, Moiteiro C, Lucio M, Camacho L and S. Reis.
Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane.
Int J Pharm, 2013. 450(1-2): p. 268-77.
[DOI:10.1016/j.ijpharm.2013.03.062S0378-5173(13)00297-4 [pii]]
- Pinheiro M, Nunes C, Caio JM, Moiteiro C, Lucio M, Brezesinski G and S. Reis.
The influence of rifabutin on human and bacterial membrane models: implications for its mechanism of action.
J Phys Chem B, 2013. 117(20): p. 6187-93.
- Nunes C, Sousa CT, Proenca MP, Apolinario A, Lima JLFC, Reis S, Araujo JP, and M. Lucio.
Synchrotron small angle X-ray scattering for the evaluation of the interaction of silica nanotubes with lipid membranes.
Rsc Advances, 2013. 3(26): p. 10323-10328.
- Nunes C, Lopes D, Pinheiro M, Pereira-Leite C, and S. Reis.
In Vitro Assessment of NSAIDs-Membrane Interactions: Significance for Pharmacological Actions.
Pharmaceutical Research, 2013. 30(8): p. 2097-2107.
[DOI:10.1007/s11095-013-1066-8]
- Pinheiro M, Arede M, Caio JM, Moiteiro C, Lucio M, and S. Reis.
Drug-membrane interaction studies applied to N '-acetyl-rifabutin.
European Journal of Pharmaceutics and Biopharmaceutics, 2013. 85(3): p. 597-603.
[DOI: 10.1016/j.ejpb.2013.02.015]
- Pinheiro M, Arede M, Nunes C, Caio JM, Moiteiro C, Lucio M, and S. Reis.
Differential interactions of rifabutin with human and bacterial membranes: implication for its therapeutic and toxic effects.
J Med Chem, 2013. 56(2): p. 417-26.
- Pinheiro M, Giner-Casares JJ, Lucio M, Caio JM, Moiteiro C, Lima JLFC, Reis S and L. Camacho.
Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: A biophysical approach to disease.
Biochimica Et Biophysica Acta-Biomembranes, 2013. 1828(2): p. 896-905.
[DOI: 10.1016/j.bbamem.2012.09.015]
- Pereira-Leite C, Carneiro C, Soares JX, Afonso C, Nunes C, Lucio M, and S. Reis.
Biophysical characterization of the drug-membrane interactions: The case of propranolol and acebutolol.
Eur J Pharm Biopharm, 2013.
[DOI:pii: S0939-6411(12)00421-3. 10.1016/j.ejpb.2012.12.005]
- Neves AR, Lucio M, Martins S, Lima JLFC, and S. Reis.
Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability.
Int J Nanomedicine, 2013. 8: p. 177-87.
- Vilas-Boas V, Silva R, Nunes C, Reis S, Ferreira L, Vieira C, Carvalho F, Bastos MD and F. Remiao.
Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin.
Toxicology Letters, 2013. 220(3): p. 259-266.
[DOI: 10.1016/j.toxlet.2013.05.005]
- Soares S, Fonte P, Costa A, Andrade J, Seabra V, Ferreira D, Reis S and B. Sarmento.
Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles.
International Journal of Pharmaceutics, 2013. 456(2): p. 370-381.
[DOI: 10.1016/j.ijpharm.2013.08.076]
- Monteiro JP, Martins AF, Nunes C, Morais CM, Lucio M, Reis S, Pinheiro TJT, Geraldes CFGC, Oliveira PJ and A.S. Jurado.
A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects.
Biochimica Et Biophysica Acta-Biomembranes, 2013. 1828(8): p. 1899-1908.
[DOI: 10.1016/j.bbamem.2013.04.006]
- Martins SM, Sarmento B, Nunes C, Lucio M, Reis S, and D.C. Ferreira.
Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration.
European Journal of Pharmaceutics and Biopharmaceutics, 2013. 85(3): p. 488-502.
[DOI: 10.1016/j.ejpb.2013.08.011]
- Castro CM, Pinheiro M, Lucio M, Giner-Casares JJ, Camacho L, Lima JLFC, Reis S and M.A. Segundo.
Insights about alpha-tocopherol and Trolox interaction with phosphatidylcholine monolayers under peroxidation conditions through Brewster angle microscopy.
Colloids and Surfaces B-Biointerfaces, 2013. 111: p. 626-635.
[DOI: 10.1016/j.colsurfb.2013.06.043]
- Azevedo CMG, Afonso CMM, Sousa D, Lima RT, Vasconcelos MH, Pedro M, Barbosa J, Correa AG, Reis S and M.M.M. Pinto.
Multidimensional optimization of promising antitumor xanthone derivatives.
Bioorganic & Medicinal Chemistry, 2013. 21(11): p. 2941-2959.
[DOI: 10.1016/j.bmc.2013.03.079]
- Azevedo CMG, Afonso CMM, Soares JX, Reis S, Sousa D, Lima RT, Vasconcelos MH, Pedro M, Barbosa J, Gales L and M.M.M. Pinto.
Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models.
European Journal of Medicinal Chemistry, 2013. 69: p. 798-816.
[DOI: 10.1016/j.ejmech.2013.09.012]
- Azevedo AMO, Ribeiro DMG, Pinto PCAG, Lucio M, Reis S and M.L.M.F.S. Saraiva.
Imidazolium ionic liquids as solvents of pharmaceuticals: Influence on HSA binding and partition coefficient of nimesulide.
International Journal of Pharmaceutics, 2013. 443(1-2): p. 273-278.
[DOI: 10.1016/j.ijpharm.2012.12.030]
- Pereira-Leite C, Nunes C, Lima JLFC, Reis S and M. Lucio.
Interaction of Celecoxib with Membranes: The Role of Membrane Biophysics on its Therapeutic and Toxic Effects.
J Phys Chem B, 2012. 116(46): p.13608-13617.
- Pinheiro M, Lucio M, Reis S, Lima JLFC, Caio JM, Moiteiro C, Martin-Romero MT, Camacho L and J.J. Giner-Casares.
Molecular interaction of rifabutin on model lung surfactant monolayers.
J Phys Chem B, 2012. 116(38): p. 11635-45.
- Neves AR, Lucio M, Lima JLFC and S. Reis.
Resveratrol in medicinal chemistry: a critical review of its pharmacokinetics, drug-delivery, and membrane interactions.
Curr Med Chem, 2012. 19(11): p. 1663-81.
[DOI: CMC-EPUB-20120117-009[pii]]
- Nunes C, Sousa CT, Proenca MP, Leitao DC, Lima JLFC, Reis S, Araujo JP, and M. Lucio.
pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery.
Colloids and Surfaces B-Biointerfaces, 2012. 94: p. 288-295.
[DOI: 10.1016/j.colsurfb.2012.02.003]
- Cardoso AM, Trabulo S, Cardoso AL, Lorents A, Morais CM, Gomes P, Nunes C, Lucio M, Reis S, Padari K, Pooga M, Pedroso de Lima MC and A.S. Jurado.
S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization.
Biochim Biophys Acta, 2012. 1818(3): p. 877-88.
[DOI: 10.1016/j.bbamem.2011.12.022]
-Araújo F., Fonte P., Santos H., Sarmento B.
Oral delivery of glucagon-like peptide-1 and analogs: alternatives for diabetes control?
Journal of Diabetes Science and Technology, 2012. 6 (6), 1486-1497.
[DOI: 10.1177/193229681200600630]
- Pinheiro M, Lúcio M, Lima JLFC and S. Reis.
Liposomes as drug delivery systems for the treatment of TB.
Nanomedicine (Lond), 2011. 6(8): p. 1413-1428.
- Nunes C, Brezesinski G, Pereira-Leite C, Lima JLFC, Reis S, and M. Lucio.
NSAIDs interactions with membranes: a biophysical approach.
Langmuir, 2011. 27(17): p. 10847-10858.
- Nunes C, Brezesinski G, Lopes D, Lima JLFC, Reis S and M. Lucio.
Lipid-drug interaction: biophysical effects of tolmetin on membrane mimetic systems of different dimensionality.
J Phys Chem B, 2011. 115(43): p. 12615-12623.
- Nunes C, Brezesinski G, Lima JLFC, Reis S, and M. Lucio.
Effects of non-steroidal anti-inflammatory drugs on the structure of lipid bilayers: Therapeutical aspects.
Soft matter, 2011. 7(6): p. 3002-3010.
- Nunes C, Brezesinski G, Lima JLFC, Reis S, and M. Lucio.
Synchrotron SAXS and WAXS study of the interactions of NSAIDs with lipid membranes.
J Phys Chem B, 2011. 115(24): p. 8024-8032.
- Monteiro JP, Martins AF, Lucio M, Reis S, Pinheiro TJ, Geraldes CF, Oliveira PJ and A.S. Jurado.
Nimesulide interaction with membrane model systems: are membrane physical effects involved in nimesulide mitochondrial toxicity?
Toxicol In Vitro, 2011. 25(6): p. 1215-1223.
[DOI: 10.1016/j.tiv.2011.05.014]
- Monteiro JP, Martins AF, Lucio M, Reis S, Geraldes CF, Oliveira PJ and A.S. Jurado.
Interaction of carbonylcyanide p-trifluorometoxyphenylydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling.
J Bioenerg Biomembr, 2011. 43(3): p. 287-298.
[DOI: 10.1007/s10863-011-9359-2]
- Gaspar D, Lucio M, Rocha S, Lima JLFC and S. Reis.
Changes in PLA(2) activity after interacting with anti-inflammatory drugs and model membranes: evidence for the involvement of tryptophan residues.
Chem Phys Lipids, 2011. 164(4): p. 292-299.
[DOI: 10.1016/j.chemphyslip.2011.03.003]
-Fonte P., Nogueira T., Gehm C., Ferreira D., Sarmento B.
Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin.
Drug Delivery and Translational Research, 2011. 1(4): p. 299-308.
[DOI: 10.1007/s13346-011-0023-5]
- Segundo MA, Magalhaes LM, Ribeiro JP, Lucio M and S. Reis.
Determination of the scavenging capacity against reactive nitrogen species by automatic flow injection-based methodologies.
Methods Mol Biol, 2010. 704: p. 91-104.
[DOI:10.1007/978-1-61737-964-2_8]
- Magalhães LM, Nunes C, Lucio M, Segundo MA, Reis S, and J.L.F.C. Lima.
High-throughput microplate assay for the determination of drug partition coefficients.
Nat Protoc, 2010. 5(11): p. 1823-1830.
- Lucio M., Lima JLFC and S. Reis.
Drug-membrane interactions: significance for medicinal chemistry.
Curr Med Chem, 2010. 17(17): p. 1795-809.
[DOI: BSP/CMC/E-Pub/ 107 [pii]]
- Gaspar D, Lucio M, Wagner K, Brezesinski G, Rocha S, Lima JLFC and S. Reis.
A biophysical approach to phospholipase A2 activity and inhibition by anti-inflammatory drugs.
Biophys Chem, 2010. 152(1-3): p.109-17.
[DOI:10.1016/j.bpc.2010.08.006]
- Brittes J, Lucio M, Nunes C, Lima JLFC and S. Reis.
Effects of resveratrol on membrane biophysical properties: relevance for its pharmacological effects.
Chem Phys Lipids, 2010. 163(8): p. 747-54.
[DOI: 10.1016/j.chemphyslip.2010.07.004]
- Magalhães LM, Lucio M, Segundo MA, Reis S, and J.L.F.C. Lima.
Automatic flow injection based methodologies for determination of scavenging capacity against biologically relevant reactive species of oxygen and nitrogen.
Talanta, 2009. 78(4-5): p. 1219-26.
[DOI: 10.1016/j.talanta.2009.02.006]
- Lucio M, Nunes C, Gaspar D, Golebska K, Wisniewski M, Lima JLFC, Brezesinski G and S. Reis.
Effect of anti-inflammatory drugs in phosphatidylcholine membranes: A fluorescence and calorimetric study.
Chemical Physics Letters, 2009. 471(4-6): p. 300-309.
[DOI:10.1016/j.cplett.2009.02.047]
- Lucio M, Nunes C, Gaspar D, Ferreira H, Lima JLFC and S. Reis.
Antioxidant activity of vitamin E and Trolox: Understanding of the factors that govern lipid peroxidation studies in vitro.
Food Biophysics 2009. 4 (4): p. 312-320.
[DOI: 10.1007/s11483-009-9129-4]
- Araujo AR, Gaspar D, Lúcio M, Reis S, Saraiva ML and J.L.F.C. Lima.
Sequential injection system for phospholipase A2 activity evaluation: studies on liposomes using an environment-sensitive fluorescent probe.
Talanta, 2009. 79(4): p. 1125-9.