Lately, bacterial pathogens exhibiting multidrug resistance (MDR) have become very common in clinical settings, underscoring the importance of understanding underlying mechanisms of resistance. Quite often, the MDR phenotype is associated with the expression of multidrug efflux pumps - proteins that can pump drug molecules out of a bacterial cell against the concentration gradient, thus reducing the intracellular concentration of the drug. We are interested in one such protein family known as the Resistance-Nodulation-cell Division (RND) family. Efforts in my laboratory are focused towards understanding the mechanisms of function and regulatory pathways of these proteins in pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa in order to aid in designing effective drug therapy.
Watch us on YouTube