Publications

Singh AB, Dong B, Kraemer FB, Liu J. FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR-B1-deficient mice fed ahigh-fat and high-cholesterol diet. Physiol Rep. 2020 Mar;8(5):e14387. doi: 10.14814/phy2.14387. PMID: 32170842

Singh AB, Liu J. Berberine decreases plasma triglyceride levels and upregulates hepatic TRIB1 in LDLR wild type mice and in LDLR deficient mice. Sci Rep. 2019 Oct 30;9(1):15641. doi: 10.1038/s41598-019-52253-y. PMID: 31666640

Dong B, Singh AB, Guo GL, Young M, Liu J. Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. Int J Mol Med. 2019 Mar 18. doi: 10.3892/ijmm.2019.4136.

Singh AB, Kan CFK, Kraemer FB, Sobel RA, Liu J. Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 2019 Feb 5. doi: 10.1152/ajpendo.00503.2018.

Singh AB, Dong B, Xu Y, Zhang Y, Liu J. Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):358-371.

Singh AB, Dong B, Kraemer FB, Xu Y, Zhang Y, Liu J. Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2448-2459. doi: 10.1161/ATVBAHA.118.311122. PubMed PMID: 30354208.

Dong B, Singh AB, Shende VR, Liu J. Hepatic HNF1 transcription factors control the induction of PCSK9 mediated by rosuvastatin in normolipidemic hamsters, Int J Mol Med. 2017, 39(3):749-756.

Dong B, Young M, Liu X, Singh AB, Liu J. Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters, J Lipid Res. 2016 Dec 9. pii: jlr.M070888. PubMed PMID: 27940481.

Singh AB, Liu J. Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated By Peroxisome Proliferator-activated Receptor δ . J Biol Chem. 2016 Dec 2. pii: jbc.M116.743575. PubMed PMID: 27913621.

Singh AB, Kan CF, Dong B, Liu J. SREBP2 activation induces hepatic long-chain acyl-CoA synthetase 1 expression in vivo and in vitro through a SRE motif of ACSL1 C-promoter. J Biol Chem. 2016 Mar 4;291(10):5373-84. PubMed PMID: 26728456.

Singh AB, Shende VR, Liu J. A novel peroxisome proliferator response element modulates hepatic low-density lipoprotein receptor gene transcription in response to PPARδ activation . Biochem J. 2015 Dec 15;472(3):275-86. PubMed PMID: 26443862.

Singh AB, Kan CF, Dong B, Liu J. A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression. J Lipid Res. 2014 May 2; 55(7):1397-1407.

Singh AB, Kan CF, Dong B, Shende VR, Liu J. PPARδ activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro. Biochim Biophys Acta. 2015 May; 1851(5):577-87.

Singh AB, Li H, Kan CF, Dong B, Nicolls MR, Liu J. The critical role of mRNA destabilizing protein heterogeneous nuclear ribonucleoprotein d in 3' untranslated region-mediated decay of low-density lipoprotein receptor mRNA in liver tissue. Arterioscler Thromb Vasc Biol. 2014, 34(1):8-16.

Singh AB, Guleria RS, Nizamutdinova IT, Baker KM, Pan J. High glucose induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling. J Cell Physiol. 2012 Jun; 227(6):2632-44. PubMed PMID: 21882190.

Dong B, Singh AB, Azhar S, Seidah NG, Liu J.High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels. Atherosclerosis. 2015 Apr; 239(2):364-74. PubMed PMID: 25682035.

Shende VR, Wu M, Singh AB, Dong B, Kan CF, Liu J. Reduction of circulating PCSK9 and LDL-C levels by liver-specific knockdown of HNF1α in normolipidemic mice. J Lipid Res. 2015 Apr; 56(4):801-9. PubMed PMID: 25652089.

Dong B, Li H, Singh AB, Cao A, Liu J. Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1α protein expression through the ubiquitin-proteasome degradation pathway. J Biol Chem. 2015 Feb 13; 290(7):4047-58.

Dong B, Singh AB, Fung C, Kan K, Liu J. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis. 2014 Aug; 235(2):449-62.PubMed PMID: 24950000.

Kan CF, Singh AB, Liu J. Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation. J Lipid Res. 2014 May 30; 55(8):1657-1667. PubMed PMID: 24879802.

Dong B, Kan CF, Singh AB, Liu J. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. J Lipid Res. 2013 May; 54(5):1241-54. PubMed PMID: 23427282.

Guleria RS, Singh AB, Nizamutdinova IT, Souslova T, Mohammad AA, Kendall JA Jr, Baker KM, Pan J. Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats, J Mol Cell Cardiol. 2013 Apr; 57:106-18.

Nizamutdinova IT, Guleria RS, Singh AB, Kendall JA Jr, Baker KM, Pan J. Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling pathway, J Cell Physiol. 2013 Feb; 228(2):380-92. PubMed PMID: 22718360.

Singh AB, Singh N, Akanksha, Maurya R, Srivastava A. Coagulanolide modulates hepatic glucose metabolism in C57BL/KsJ-db/db mice, Hum Exp Toxicol. 2012 Oct; 31(10):1056-65.

Verma AK, Singh H, Satyanarayana M, Srivastava SP, Tiwari P, Singh AB, Dwivedi AK, Singh SK, Srivastava M, Nath C, Raghubir R, Srivastava AK, Pratap R. Flavone-based novel antidiabetic and antidyslipidemic agents. J Med Chem. 2012 May 24; 55(10):4551-67.

Singh AB, Khaliq T, Chaturvedi JP, Narender T, Srivastava AK. Anti-diabetic and anti-oxidative effects of 4-hydroxypipecolic acid in C57BL/KsJ-db/db mice. Hum Exp Toxicol. 2012 Jan; 31(1):57-65.

Singh AB, Tamarkar AK, Narender T, Srivastava AK. Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice. Nat Prod Res. 2010; 24(3):258-65.

Singh AB, Yadav K, Maurya R, Srivastava AK. Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice, Nat Prod Res. 2009; 23(9):876-82.

Singh AB, Akanksha, Singh N, Maurya R and Srivastava AK. Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice, International Journal of Medicine and Medical Sciences. Vol. 1(12), pp. 536-544, Dec, 2009.

Singh AB, Chaturvedi JP, Narender T, Srivastava AK. Preliminary studies on the hypoglycemic effect of Peganum harmala L. Seeds ethanol extract on normal and streptozotocin-induced diabetic rats. Indian J Clin Biochem. 2008 Oct; 23(4):391-3.

Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Singh A, Mishra JS, Singh AB, Sanyal S, Maurya R, Manickavasagam L, Singh SP, Wahajuddin W, Jain GK, Chattopadhyay N, Singh D. Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. J Nutr Biochem. 2011 Apr; 22(4):318-27. PubMed PMID: 20579866.

Shukla N, Kumar M, Akanksha, Ahmad G, Rahuja N, Singh AB, Srivastava AK, Rajendran SM, Maurya R. Tectone, a new antihyperglycemic anthraquinone from Tectona grandis leaves. Nat Prod Commun. 2010 Mar; 5(3):427-30.

Kumar A, Maurya RA, Sharma S, Ahmad P, Singh AB, Bhatia G, Srivastava AK. Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents. Bioorg Med Chem Lett. 2009 Nov 15; 19(22):6447-51.

Bhargavan B, Gautam AK, Singh D, Kumar A, Yadav DK, Mishra JS, Singh AB, Sanyal S, Goel A, Maurya R, Chattopadhyay N. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem. 2009 Oct 1; 108(2):388-99.

Papi Reddy K, Singh AB, Puri A, Srivastava AK, Narender T. Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity. Bioorg Med Chem Lett. 2009 Aug 1; 19(15):4463-6.

Kumar A, Maurya RA, Sharma S, Ahmad P, Singh AB, Tamrakar AK, Srivastava AK. Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents. Bioorg Med Chem. 2009, 15; 17(14):5285-92.

Singh FV, Parihar A, Chaurasia S, Singh AB, Singh SP, Tamrakar AK, Srivastava AK, Goel A. 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2158-61.

Saxena AK, Pandey G, Gupta S, Singh AB, Srivastava AK. Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2320-3.

Tamrakar AK, Singh AB, Srivastava AK. db/+ Mice as an alternate model in antidiabetic drug discovery research. Arch Med Res. 2009 Feb; 40(2):73-8.

Raj K, Misra N, Pachauri G, Sharma M, Tamrakar AK, Singh AB, Srivastava AK, Phani Kiran K, Narasimha Rao CV, Prubhu SR. Novel class of hybrid natural products as antidiabetic agents. Nat Prod Res. 2009; 23(1):60-9.

Maurya R, Akanksha, Jayendra, Singh AB, Srivastava AK. Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity. Bioorg Med Chem Lett. 2008 Dec 15; 18 (24):6534-7.

Narender T, Khaliq T, Singh AB, Joshi MD, Mishra P, Chaturvedi JP, Srivastava AK, Maurya R, Agarwal SC. Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity. Eur J Med Chem. 2009 Mar; 44(3):1215-22.

Kumar A, Ahmad P, Maurya RA, Singh AB, Srivastava AK. Novel 2-aryl-naphtho [1,2-d] oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities. Eur J Med Chem. 2009 Jan; 44(1):109-16.

Dwivedi AP, Kumar S, Varshney V, Singh AB, Srivastava AK, Sahu DP. Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines. Bioorg Med Chem Lett. 2008 Apr 1; 18(7):2301-5.

Maurya R, Gupta P, Ahmad G, Yadav DK, Singh AB, Tamrakar AK, Srivastava AK. Synthesis of 3, 5-disubstituted isoxazolines as protein tyrosine phosphatase 1B inhibitors, Medicinal Chemistry Research, Volume 17, Numbers 2-7, 123-136.

Shukla P, Singh AB, Srivastava AK, Pratap R. Chalcone based aryloxypropanolamines as potential antihyperglycemic agents, Bioorg Med Chem Lett. 2007 Feb 1; 17(3):799-802.

PUBLISHED ABSTRACTS

Singh AB, Liu J. Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor Delta in Hepatic Cells and in Liver Tissue, Circulation. 2016;134:A11869.

Dong B, Singh AB, Shende VR, Liu J. Antagonism of Rosuvastatin-induced Elevation of Circulating PCSK9 in Hamsters by Liver-specific Knockdown of HNF1α or HNF1β , Circulation. 2015; 132: A9772

Singh AB, Liu J. Berberine Attenuates Hyperlipidemia in Mice by a Novel Underlying Mechanism Involving Trib1, Arteriosclerosis, Thrombosis, and Vascular Biology. 2015; 35: A337.

Shende V, Singh AB, Dong B and Liu J. Hepatic HNF1α Knockdown Reduces Circulating PCSK9 Levels and Increases Liver LDL Receptor Abundance in Mice, Circulation, 2014; 130: A16805.

Dong B, Singh AB, Kan CFK, and Liu J. CETP Inhibitor Anacetrapib Downregulates Both LDL Receptor and PCSK9 Expression in Cultured Liver Cells through a SREBP-Dependent Mechanism, Circulation. 2013; 128:A16185.

Dong B, Singh AB, Seidah NG, and Liu J. Fructose Diet Elevates Circulating PCSK9 and LDL-cholesterol Levels and Reduces Liver LDL Receptor Protein Abundance in Hamsters through a Novel Mechanism, Circulation. 2013; 128:A13997.

Singh AB, Kan CFK, Dong B, and Liu J. Identification of a Novel Regulatory Pathway for Acyl-CoA Synthetase 1 Expression by Cholesterol through Tissue Profiling in Cholesterol-Fed Hamsters,Circulation. 2013; 128:A15228.

Dong B, Kan CFK, Singh AB, and Liu J. High Fructose Diet Downregulates Acyl-coA Synthetase 3 Expression and Activity in Liver of Hamsters via Impairing LXR/RXR Signaling Pathway , Circulation. 2012;126:A11421.

Guleria RS, Singh AB, Nizamutdinova IT, Souslova T, Mohammad AA, Baker KM, and Pan J. Activation of Retinoid Receptor-Mediated Signaling Ameliorates Diabetes-Induced Cardiac Dysfunction in Zucker Diabetic Fatty Rats ,Circulation. 2012; 126:A10669.