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RESEARCH EXPERIENCE
Research Associate/Lab manager (March 2014-Present)
Stanford University/VA Palo Alto Health Care System, Palo Alto, CA
Discover ACSL1 is a novel molecular target of the bile acid-activated farnesoid X receptor (FXR) and SREBP2, and a key role in liver cholesterol homeostasis.
Identified liver ACSL4 and LPCAT3 is a direct target gene of PPARδ transcription factor. Furthermore, dissected a key role in FA synthesis and glucose metabolism.
Cloned and characterized ACSL1, LPCAT3 gene promoter by using mutagenesis, EMSA and ChIP assay.
Cloned and constructed PPAR delta adenovirus vector for overexpression and gene knockdown.
Post-Doctoral Fellow (Jan 2012-Feb 2014)
Stanford University School of Medicine, Stanford, CA
Designed and executed cell-based assays to identify role of Raf/MEK/ERK signaling pathway in TRIB1 transcription regulation.
Collaborated with Intercept Pharmaceuticals Inc. to investigate lipid regulatory effects of Obeticholic acid (OCA), an FXR agonist in pre-clinical setting by using golden hamster and mouse models.
Developed and validated a novel Alb-Luc LDLR 3’UTR transgenic mouse model to study the regulation of LDL receptor mRNA stability noninvasively in living mice.
Identified mRNA decay-promoting factor HNRNPD, is a novel therapeutic target for LDL-cholesterol lowering and to prevent coronary heart disease.
Post-Doctoral Fellow (Jul 2009-Dec 2011)
Texas A&M Health Science Center, Temple, TX
Constructed reporter gene assay for retinoic acid receptor α (RARα) and retinoid X receptor α (RXRα) and optimized in neonatal rat cardiomyocytes and fibroblasts.
Designed and accomplished cell-based assays to discover role of MAP kinase in regulation of retinoid receptors (RAR/RXR) during hyperglycemia induced cardiomyocyte apoptosis.
Discovered a new mechanistic pathway for the development of hyperglycemia-induced cardiac remodeling in neonatal cardiomyocytes and in the heart of ZDF rats.
Ph.D. Student ( Aug 2004-Jun 2009)
Jawaharlal Nehru University, New Delhi/CDRI, Lucknow, India
Established and optimized gene promoter reporter assay for screening of novel nuclear receptor agonists from natural products and synthetic organic compounds.
Developed and validate an integrated efficient antidiabetic and lipid lowering drug screening platform consisting of highly translatable in vitro and in vivo models.
Published 10 research articles including a US Patent (PCT/IN2007/000326).
Supervised five master’s student and two research assistants.
EDUCATION
Ph.D. Biochemistry, Jawaharlal Nehru University, New Delhi/CDRI, Lucknow, India (2004-2010)
M.Sc. Biochemistry, Microbiology, and Molecular biology, BHU, Varanasi, India (2001-2003)
B.Sc. Biology and Chemistry, University of Allahabad, Allahabad, India (1998-2001)
FELLOWSHIP AND HONORS
Research Fellowship CSIR, Government of India, New Delhi Aug 2004-Jun 2009
Qualified National Eligibility Test CSIR, Government of India, New Delhi Dec 2003
EDITORIAL BOARD MEMBER
Clinical & Experimental Pharmacology
PEER-REVIWER
PLOS ONE
Journal of Diabetes
Natural Product Research
Phytomedicine
Human & Experimental Toxicology
Cardiovascular Pharmacology
Neoplasma
Cell & Developmental Biology
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