Two-photon excited time-resolved photoluminescence imaging and spectroscopy studies on single polymer-stabilized gold nanoparticles towards their applicability as contrast agents

POSTDOCTORAL RESEARCH PROJECT

Project overview


  • Project code: PN-III-P1-1.1-PD-2016-0088
  • Funding: Romanian National Authority for Scientific Research, UEFISCDI
  • Program from PNIII: P1 - The development of national CD system
  • Subprogram: Human Resources, Postdoctoral research projects (PD)
  • Budget: 245.421 lei (~ 52 000 EUR)
  • Period: November 2019 - November 2021
  • Contract no.: 32/2018

Project summary

The project entitled “Two-photon excited time-resolved photoluminescence imaging and spectroscopy studies on single polymer-stabilized gold nanoparticles towards their applicability as optical contrast agents” addresses a challenging research subject related to the intrinsic photoluminescence in plasmonic nanostructures. The project aims to offer a deeper understanding on an interesting second-order non-linear effect, that is the two-photon excited photoluminescence (TPE PL) occurring in a particular type of gold nanoparticles (AuNPs) (i.e. gold nanorods (AuNRs)), by performing optical spectroscopy and microscopy studies on AuNRs deposited on solid substrate and inserted in tissue-imitating phantoms. The main objectives of the project are: (i) to investigate the origin of intrinsic PL in single and coupled as-prepared polymer-stabilized AuNRs by performing steady-state and time-resolved TPE PL and dark-field scattering combined microscopy and spectroscopy studies on P-AuNRs immobilized on substrate, and (ii) to demonstrate the ability of the prepared P-AuNRs to perform as optical contrast agents by monitoring their TPE PL in tissue-like phantoms under non-invasive NIR excitation.