CV and publications

 

Career History

Honours and Distinctions

 Publications

I have an h-index of 64 (ISI WoS) and 17000 citations, or find me on google scholar, where I have an h-index of 72 and 25000 citations. Currently 239 publications.

I have written two books. 

The NOE in structural and conformational analysis, D Neuhaus and M P Williamson. Published by Wiley in 1989, and brought out in a completely revised and reprinted second edition in 2000.

And the more recent book:

How Proteins Work, M P Williamson

Published by Garland Press in July 2011. This is a major new undergraduate text and available from all good bookstores (and online). It has been adopted as a course text by Universities including ANU and Sydney (Australia), Northwestern (USA), McMaster (Canada), Technical University of Denmark, and University of Tokyo. Reviews include 'a really nice book' (Chemistry World), 'really good', 'a great text', 'a great overview' (Amazon). Also published by Zanichelli in Italian, and Nankodo in Japanese. Cheap at half the price.

 Publications

2024

Williamson MP. An autocatalytic origin of life. Life 2024 14, 590.

Trevitt CR, Kumar YDR, Fowler NJ, Williamson MP. Interactions between the protein barnase and co-solutes studied by NMR. Communications Chem. 2024 7, 44.

Galley NF, Greetham D, Alaman-Zarate MG, Williamson MP, Evans CA, Spittal WD, Buddle JE, Freeman J, Davis GL, Dickman MJ, Wilcox MH, Fagan RP, Lovering AL and Mesnage S. Clostridioides difficile canonical L,D-transpeptidases catalyse a novel type of peptidoglycan crosslinks and are not required for beta-lactam resistance. J. Biol. Chem. 2024 300, 105529.

2023

Hassan MU, Choudhuri R and Williamson MP. The role of DUF916 and DUF3324 in the WxL protein cluster. Protein Science 32, e4806.

Asakura T and Williamson MP. A review on the structure of Bombyx mori silk fibroin fiber studied using solid-state NMR: an antipolar lamella with an 8-repeat structure. Int J Biol Macromol 2023 245, 125537.

Fowler NJ, Albalwi MF, Lee S, Hounslow AM and Williamson MP. Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: the SH2 domain of SH2B1. Structure 2023, 31

Williamson MP. Protein binding: a fuzzy concept. Life 2023, 13, 855.

Hasssan MU and Williamson MP. Bioinformatic analysis of WxL domain proteins. Saudi J Biol Sci 2023, 30, 103526 

2022

Makwana MV, Williamson MP, Jackson RFW, Muimo R. Quantitation of phosphohistidine in proteins in a mammalian cell line by 31P  NMR . PLoS One 2022 17, e0273797.

Hobbs B, Drant J, Williamson MP. The measurement of binding affinities by NMR chemical shift perturbation. J Biomol NMR 2022 doi: 10.1007/s10858-022-00402-3. 

Lyon RF, Southam HM, Trevitt CR, Liao C, El-Khamisy SF, Poole RK, Williamson MP. CORM-3 induces DNA damage through Ru(II) binding to DNA. Biochemical Journal 2022 479, 1429-1439.

Davis JL, Hounslow AM, Baxter NJ, Mesnage S, Williamson MP. 1H, 13C and 15N resonance assignments of a conserved putative cell wall binding domain from Enterococcus faecalis. Biomolecular NMR Assignments 2022 doi: 10.1007/s12104-022-10087-2. 

Fowler NJ, Williamson MP. The accuracy of protein structures in solution determined by AlphaFold and NMR. Structure 2022 30, 1-9.

Abosamaha A, Williamson MP and Gilmour DJ. Utilization and accumulation of compatible solutes in Halomonas pacifica: a novel species of moderately halophilic bacteria isolated from a saline lake in south Libya. Access Microbiology 2022 4 000359. 

2021

Fowler NJ, Sljoka A, Williamson MP. The accuracy of NMR protein structures in the Protein Data Bank. Structure. 2021 Jul 28:S0969-2126(21)00251-3. doi: 10.1016/j.str.2021.07.001.

Southam HM, Williamson MP, Chapman JA, Lyon RL, Trevitt CR, Henderson PJF, Poole RK. 'Carbon-monoxide-releasing-molecule-2' (CORM-2) is a misnomer: Ruthenium toxicity, not CO release, accounts for its antimicrobial effects. Antioxidants (Basel). 2021 Jun 5;10(6):915. doi: 10.3390/antiox10060915. 

2020

Hassan MU, Nayab H, Shafique F, Williamson MP, Almansouri T, Asim N, Shafi N, Attacha S, Khalid M, Ali N and Akbar N. Probiotic properties of Lactobacillus helveticus and Lactobacillus plantaurum spp. isolated from traditional Pakistani yoghurt.  Biomedical Research International, 2020, 8889198 

Fowler NJ, Sljoka A, Williamson MP. A method for validating the accuracy of NMR protein structures. Nat Commun. 2020 11(1):6321.

Hassan MU, Nayab H, Rehman TU, Williamson MP, Haq KU, Shafi N, Shafique F. Characterisation of bacteriocins produced by Lactobacillus spp. isolated from the traditional Pakistani yoghurt and their antimicrobial activity against common foodborne pathogens. Biomed Res Int . 2020:8281623 

Asakura T, Ogawa T, Naito A, Williamson MP. Chain-folded lamellar structure and dynamics of the crystalline fraction of Bombyx mori silk fibroin and of (Ala-Gly-Ser-Gly-Ala-Gly)n model peptides. Int J Biol Macromol. 2020 164:3974-3983.

Gonzalez-Delgado LS, Walters-Morgan H, Salamaga B, Robertson AJ, Hounslow AM, Jagielska E, Sabała I, Williamson MP, Lovering AL, Mesnage S. Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b. Nat Chem Biol. 2020 16(1):24-30.

2019

Iwakawa N, Baxter NJ, Wai DCC, Fowler NJ, Morales RAV, Sugase K, Norton RS, Williamson MP. Conformational exchange in the potassium channel blocker ShK. Sci Rep. 2019 9:19307. doi: 10.1038/s41598-019-55806-3 

Wakamoto T, Ikeya T, Kitazawa S, Baxter NJ, Williamson MP, Kitahara R. Paramagnetic relaxation enhancement-assisted structural characterization of a partially disordered conformation of ubiquitin. Protein Sci. 2019 28(11):1993-2003. doi: 10.1002/pro.3734 

Williamson MP. Drawing single NMR spins and understanding relaxation. Natural Products Communications, 2019; 14; 1-9. 

Smith RE, Salamaga B, Szkuta P, Hajdamowicz N, Prajsnar TK, Bulmer GS, Fontaine T, Kołodziejczyk J, Herry JM, Hounslow AM, Williamson MP, Serror P, Mesnage S. Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system. PLoS Pathog. 2019;15(5):e1007730 

Fairbanks SD, Robertson CC, Keene FR, Thomas JA, Williamson MP. Structural investigation into the threading intercalation of a chiral dinuclear ruthenium (II) polypyridyl complex through a B-DNA oligonucleotide. J Amer Chem Soc 2019 141:4644-4652 

Williamson MP. The Nuclear Overhauser Effect. NMR Spectroscopy Techniques, Encyclopedia of Analytical Science, 3rd Ed (Worsfold P, Townshend A, Poole C, Eds), Elsevier, pp 264-271 DOI 10.1016/B978-0-12-409547-2.14490-7 

Williamson MP, Kitahara R. Characterisation of low-lying excited states of proteins by high-pressure NMR. Biochim Biophys Acta Proteins Proteomics 2019 1867:350-358 

2018

Pandya MJ, Schiffers S, Hounslow AM, Baxter NJ, Williamson MP. Why the energy landscape of barnase is hierarchical. Frontiers in Molecular Biosciences 2018 5:115 

Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M, Williamson MP, Henderson PJF, Poole RK. A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. Redox Biology 2018 18:114-123 

2017

B. K. Kudhair, A. M. Hounslow, M. D. Rolfe, J. C. Crack, D. M. Hunt, R. S. Buxton, L. J. Smith, N. E. LeBrun, M. P. Williamson and J. Green. Structure of a Wbl protein and implications for NO sensing by M. tuberculosis. Nature Communications 2017 8:2280 

N. J. Baxter, T. Zacharchenko, I. L. Barsukov and M. P. Williamson. Pressure-dependent chemical shifts in the R3 domain of talin show that it is thermodynamically poised for binding to either vinculin or RIAM. Structure 2017 25:1856-1866 

Heyam A, Coupland CE, Dégut C, Haley RA, Baxter NJ, Jakob L, Aguiar PM, Meister G, Williamson MP, Lagos D, Plevin MJ. Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins. Nucleic Acids Res. 2017 Oct 17. doi: 10.1093/nar/gkx928 

Williamson MP. Chemical Shift Perturbation. Modern Magnetic Resonance, 2nd Ed (Eds G. A. Webb and H. Saito), Springer Verlag, 2017, doi:10.1007/978-3-319-28275-6_76-1 

Williamson MP. The Transferred NOE. Modern Magnetic Resonance, 2nd Ed (Eds G. A. Webb and D. Craik), Springer Verlag, 2017, doi:10.1007/978-3-319-28275-6_123-1 

Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A. MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet. 201713(8):e1006957 

J.D. Eaton and M.P.Williamson. Multisite binding of epigallocatechin gallate to human serum albumin measured by NMR and isothermal calorimetry. Bioscience Reports 2017, 37, BSR20170209 

2016

J. W. Bye, N. J. Baxter, A. M. Hounslow, R. J. Falconer and M. P. Williamson. A molecular mechanism for the Hofmeister effect derived from NMR and DSC measurements on barnase. ACS Omega 2016, 1, 669-679 

Yasid NA, Rolfe MD, Green J, Williamson MP. Homeostasis of metabolites in Escherichia coli on transition from anaerobic to aerobic conditions and the transient secretion of pyruvate. R Soc Open Sci. 2016 Aug 24;3(8):160187 

A.E. Rawlings, J. P. Bramble, A. M. Hounslow, M. P. Williamson, A. E. Monnington, D. J. Cooke and S. S. Staniland. Ferrous iron key to Mms6 magnetite biomineralisation: A mechanistic study to understand magnetite formation using pH titration and NMR spectroscopy. Chem. Eur. J. 2016, 22, 7885-7894 

S. Hollingshead, J. Kopečná, D. R. Armstrong, L. Bučinská, P. J. Jackson, G. E. Chen, M. J. Dickman, M. P. Williamson, R. Sobotka and C. N. Hunter. Synthesis of chlorophyll-binding proteins in a fully-segregated Delycf54 strain of the cyanobacterium Synechocystis PCC 6803. Frontiers in Plant Science 2016, 7, 292 

Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga JP, Wessely O, Williamson MP and Ong ACM. The Polycystin-1, Lipoxygenase and alpha-Toxin domain regulates polycystin-1 trafficking. J Am Soc Nephrol 2016 27:1159-1173 

2015

Williamson MP. Pressure-dependent conformation and fluctuation in folded protein molecules. High Pressure Bioscience – Basic Concepts, Applications and Frontiers (Ed. K. Akasaka and H. Matsuki), 2015, Springer, Ch. 6, pp 109-127 

Xu Y, Ong ACM, Williamson MP and Hounslow AM. Backbone assignment and secondary structure of the PLAT domain of human polycystin-1. Biomolecular NMR Assignments 2015  9:369-373 

Asakura T, Okushita K and Williamson MP. Analysis of the structure of Bombyx mori silk fibroin by NMR. Macromolecules 2015 48:2345-2357 

Asakura T, Ohata T, Kametani S, Okushita K, Yazawa K, Nishiyama Y, Nishimura K, Aoki A, Suzuki F, Kaji H,  Ulrich AS and Williamson MP. Inter-molecular packing in B. mori silk fibroin: multinuclear NMR study of the model peptide (Ala-Gly)15 defines a heterogeneous antiparallel antipolar mode of assembly in the Silk II form. Macromolecules 2015 48:28-36 

2014

Okushita K, Asano A, Williamson MP, Asakura T. Local structure and dynamics of serine in the heterogeneous structure of the crystalline domain of Bombyx mori silk fibroin in Silk II form studied by 2D 13C-13C homonuclear correlation NMR and relaxation time observation. Macromolecules 2014 47:4308-16 

Mesnage S, Dellarole M, Baxter NJ, Rouget JB, Dimitrov JD, Wang N, Fujimoto Y, Hounslow AM, Lacroix-Desmazes S, Fukase K, Foster SJ, Williamson MP. Molecular basis for bacterial peptidoglycan recognition by LysM domains. Nat Commun. 2014 5:4269 

Kitazawa S, Kameda T, Kumo A, Yagi-Utsumi M, Baxter NJ, Kato K, Williamson MP, Kitahara R. Close identity between alternatively folded state N2 of ubiquitin and the conformation of the protein bound to the ubiquitin-activating enzyme. Biochemistry 2014 53 447-449 

2013

Wilson T, Costa PJ, Félix V, Williamson MP, Thomas JA. Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an atiparallel folded human telomere sequence. J Med Chem 2013 56 8674-8683 

Williamson MP. Using chemical shift perturbation to characterise ligand binding. Progr Nucl Magn Reson Spectrosc 2013 73 1-16 

Williamson MP, Hounslow AM, Ford J, Fowler K, Hebditch M, Hansen PE. Detection of salt bridges to lysines in solution in barnase. Chem Commun 2013 49 9824-9826 

Kitahara R, Hata K, Li H, Williamson MP, Akasaka K. Pressure-induced chemical shifts as probes for conformational fluctuations in proteins. Prog Nucl Magn Reson Spectrosc 2013 71 35-58 

Kitazawa S, Kameda T, Yagi-Utsumi M, Sugase K, Baxter NJ, Kato K, Williamson MP, Kitahara R. Solution structure of the Q41N variant of ubiquitin as a model for the alternatively folded N2 state of ubiquitin. Biochemistry 2013 52(11) 1874-1885 

Moody RG, Williamson MP. Structure and function of a bacterial Fasciclin Domain Protein elucidates function of related cell adhesion proteins such as TGFBIp and periostin. FEBS Open Bio 2013 3 71-77 

2012

Williamson MP, Potts JR. Intrinsically disordered proteins: administration not executive. Biochem Soc Trans 2012 40(5) 945-949 

Asakura T, Okonogi M, Horiguchi K, Aoki A, Saitô H, Knight DP, Williamson MP. Two different packing arrangements of antiparallel polyalanine. Angewandte Chemie Int Ed 2012 51(5) 1212-1215 

Tomlinson JH, Williamson MP. Amide temperature coefficients in the protein G B1 domain. J Biomol NMR 2012 52(1) 57-64 

2011

Trotter EW, Rolfe MD, Hounslow AM, Craven CJ, Williamson MP, Sanguinetti G, Poole RK, Green J. Reprogramming of Escherichia coli K-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment. PLoS One 2011 6(9):e25501 

Ullah S, Ishimoto T, Williamson MP, Hansen PE. Ab initio calculations of deuterium isotope effects on chemical shifts of salt-bridged lysines. J Phys Chem B 2011 115(12):3208-3215 

Ratcliffe EC, Tunnicliffe RB, Ng IW, Adams PG, Qian P, Holden-Dye K, Jones MR, Williamson MP, Hunter CN. Experimental evidence that the membrane-spanning helix of PufX adopts a bent conformation that facilitates dimerisation of the Rhodobacter sphaeroides RC-LH1 complex through N-terminal interactions. Biochim Biophys Acta. 2011 1807(1):95-107 

2010

Tomlinson JH, Green VL, Baker PJ, Williamson MP. Structural origins of pH-dependent chemical shifts in the B1 domain of protein G. Proteins 2010 78(14):3000-16 

Williamson MP, Sutcliffe MJ. Protein-protein interactions. Biochem Soc Trans 2010 38(4):875-8 

Correia MA, Abbott DW, Gloster TM, Fernandes VO, Prates JA, Montanier C, Dumon C, Williamson MP, Tunnicliffe RB, Liu Z, Flint JE, Davies GJ, Henrissat B, Coutinho PM, Fontes CM, Gilbert HJ. Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module. Biochemistry 2010 49(29):6193-205 

Wilson T, Williamson MP, Thomas JA. Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(II) complex with four-stranded DNA structures. Org Biomol Chem 2010 8(11):2617-21 

Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré, Williamson MP, Obara T, Ong AC, Delmas P. A polycystin-2 dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 29(7):1176-1191 

Waywell P, Gonzalez V, Gill MR, Adams H, Meijer AJHM, Williamson MP, Thomas JA. Structure of the complex of [Ru(tpm)(dppz)py]2+ with a B-DNA oligonucleotide - a single-residue binding switch for a metallo-intercalator. Chem Eur J 2010 16(8):2407-2417 

Tomlinson JH, Craven CJ, Williamson MP, Pandya MJ. Dimerization of protein G B1 domain at low pH: a conformational switch caused by loss of a single hydrogen bond. Proteins: Struct Funct Bioinf 2010 78:1652-1661 

Long J, Garner TP, Pandya MJ, Craven CJ, Chen P, Shaw B, Williamson MP, Layfield R, Searle MS. Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling. J Mol Biol 2010 396(1):178-194 

Waywell P, Thomas JA, Williamson MP. Structural analysis of the binding of the diquaternary pyridophenazine derivative dqdppn to B-DNA oligonucleotides. Org Biomol Chem 2010 8(3):648-654 

2009

Wilton DJ, Kitahara R, Akasaka K, Pandya MJ, Williamson MP. Pressure-dependent structure changes in barnase on ligand binding reveal intermediate rate fluctuations. Biophys J 2009 97(5):1482-90 

Suzuki Y, Takahashi R, Shimizu T, Tansho M, Yamauchi K, Williamson MP, Asakura T. Intra- and intermolecular effects on 1H chemical shifts in a silk model peptide determined by high-field solid state 1H NMR and empirical calculations. J Phys Chem B 2009 113(29):9756-61 

Wilton DJ, Kitahara R, Akasaka K, Williamson MP. Pressure-dependent 13C chemical shifts in proteins: origins and applications. J Biomol NMR 2009 44(1):25-33 

Tomlinson JH, Ullah S, Hansen PE, Williamson MP. Characterisation of salt bridges to lysines in the Protein G B1 domain. J Am Chem Soc 2009 131(13):4674-84 

Nakazawa Y, Suzuki Y, Williamson MP, Saito H, Asakura T. The interaction of amyloid Abeta(1-40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR. Chem Phys Lipids 2009 158(1):54-60 

Williamson MP. Applications of NOEs in molecular biology. Annual Reports on NMR 2009 65 Ch 3, pp 77-109 

Williamson MP. NOESY. in Encyclopedia of Magnetic Resonance (Ed Harris RK, Wasylishen R) John Wiley, Chichester 2009 

Williamson MP, Craven CJ. Automated protein structure calculation from NMR data. J Biomol NMR. 2009 43(3):131-143 

Cioffi M, Hunter CA, Packer MJ, Pandya MJ, Williamson MP. Use of quantitative 1H NMR chemical shift changes for ligand docking into barnase. J Biomol NMR. 2009 43(1):11-9 

2008

Wilton DJ, Ghosh M, Chary KV, Akasaka K, Williamson MP. Structural change in a B-DNA helix with hydrostatic pressure. Nucleic Acids Res. 2008 36(12):4032-7 

Bocian W, Kawecki R, Bednarek E, Sitkowski J, Williamson MP, Hansen PE, Kozerski L. Binding of topotecan to a nicked DNA oligomer in solution. Chemistry a European Journal 2008;14(9):2788-94 

Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP. Pressure-induced changes in the solution structure of the GB1 domain of protein G. Proteins 2008 71(3):1432-40 

2007

Nagy T, Tunnicliffe RB, Higgins LD, Walters C, Gilbert HJ, Williamson MP. Characterization of a double dockerin from the cellulosome of the anaerobic fungus Piromyces equi. J Mol Biol. 2007 373(3):612-22 

Cicortas Gunnarsson L, Montanier C, Tunnicliffe RB, Williamson MP, Gilbert HJ, Nordberg Karlsson E, Ohlin M. Novel xylan-binding properties of an engineered family 4 carbohydrate-binding module. Biochem J. 2007 406(2):209-14 

Moody RG, Phillips-Jones MK, Williamson MP. 1H, 13C and 15N assignments for the Rhodobacter sphaeroides fasciclin 1 domain protein (Fdp). Biomol NMR Assignments 2007 1(1):11-12 

2006

Williamson MP. The transferred NOE. in Modern Magnetic Resonance (Ed Craik D) Vol 2 Medical Uses Kluwer Academic Press 2006 1339-1344 

Williamson MP. The Nuclear Overhauser Effect. in Modern Magnetic Resonance (Ed Asakura T, Saito H, Ando I) Vol 1 Chemistry Kluwer Academic Press 2006 405-408 

Tunnicliffe RB, Ratcliffe EC, Hunter CN, Williamson MP. The solution structure of the PufX polypeptide from Rhodobacter sphaeroides. FEBS Letts 2006 580(30):6967-71 

Williamson MP, McCormick TG, Nance CL, Shearer WT. Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy. J Allergy Clin Immunol. 2006 118(6):1369-74 

Williamson MP, Suzuki Y, Bourne NT, Asakura T. Binding of amyloid beta to ganglioside micelles is dependent on histidine 13. Biochem J. 2006 397(3):483-90 

Laguri C, Stenzel RA, Donohue TJ, Phillips-Jones MK, Williamson MP. Activation of the global gene regulator PrrA (RegA) from Rhodobacter sphaeroides. Biochemistry. 2006 45(25):7872-81 

Joebstl E, Howse JR, Fairclough JP, Williamson MP. Noncovalent Cross-Linking of Casein by Epigallocatechin Gallate Characterized by Single Molecule Force Microscopy. J Agric Food Chem. 2006 54(12):4077-4081 

Potter CA, Jeong EL, Williamson MP, Henderson PJ, Phillips-Jones MK. Redox-responsive in vitro modulation of the signalling state of the isolated PrrB sensor kinase of Rhodobacter sphaeroides NCIB 8253. FEBS Lett. 2006 580(13):3206-10 

Leon-Kempis Mdel R, Guccione E, Mulholland F, Williamson MP, Kelly DJ. The Campylobacter jejuni PEB1a adhesin is an aspartate/glutamate-binding protein of an ABC transporter essential for microaerobic growth on dicarboxylic amino acids. Mol Microbiol. 2006 60(5):1262-75 

2005

Tunnicliffe RB, Waby JL, Williams RJ, Williamson MP. An experimental investigation of conformational fluctuations in proteins G and L. Structure. 2005 13(11):1677-84 

Joebstl E, Fairclough JP, Davies AP, Williamson MP. Creaming in black tea. J Agric Food Chem. 2005 53(20):7997-8002 

Williamson MP. Systems biology: will it work? Biochem Soc Trans. 2005 33(3):503-6 

Flint J, Bolam DN, Nurizzo D, Taylor EJ, Williamson MP, Walters C, Davies GJ, Gilbert HJ. Probing the mechanism of ligand recognition in family 29 carbohydrate binding. J Biol Chem. 2005 280:23718-23726 

Exley RM, Shaw J, Mowe E, Sun Y-H, West NP, Williamson MP, Botto, M, Smith H, Tang CM. Available carbon source influences the resistance of Neisseria meningitidis against complement. J Exp Med. 2005;201:1637-1645 

Tunnicliffe RB, Bolam DN, Pell G, Gilbert HJ, Williamson MP. Structure of a mannan-specific family 35 carbohydrate-binding module: evidence for significant conformational changes upon ligand binding. J Mol Biol. 2005 347(2):287-96 

2004

Bocian W, Kawecki R, Bednarek E, Sitkowski J, Pietrzyk A, Williamson MP, Hansen PE, Kozerski L. Multiple binding modes of the camptothecin family to DNA oligomers. Chemistry, a European Journal. 2004 10(22):5776-87. 

Joebstl E, O'Connell J, Fairclough JP, Williamson MP. Molecular model for astringency produced by polyphenol/protein interactions. Biomacromolecules. 2004 5(3):942-9 

Nakano E, Williamson MP, Williams NH, Powers HJ. Copper-mediated LDL oxidation by homocysteine and related compounds depends largely on copper ligation. Biochim Biophys Acta. 2004 1688(1):33-42 

2003

Laguri C, Phillips-Jones MK, Williamson MP. Solution structure and DNA binding of the effector domain from the global regulator PrrA (RegA) from Rhodobacter sphaeroides: insights into DNA binding specificity. Nucleic Acids Res. 2003 31(23):6778-87 

Williamson MP. Many residues in cytochrome c populate alternative states under equilibrium conditions. Proteins. 2003 53(3):731-9 

Williamson MP, Akasaka K, Refaee M. The solution structure of bovine pancreatic trypsin inhibitor at high pressure. Protein Sci. 2003 12(9):1971-9 

Pell G, Williamson MP, Walters C, Du H, Gilbert HJ, Bolam DN. Importance of hydrophobic and polar residues in ligand binding in the family 15 carbohydrate-binding module from Cellvibrio japonicus Xyn10C. Biochemistry. 2003 42(31):9316-23 

Refaee M, Tezuka T, Akasaka K, Williamson MP. Pressure-dependent changes in the solution structure of hen egg-white lysozyme. J Mol Biol 2003 327(4):857-65 

Horsburgh GJ, Atrih A, Williamson MP, Foster SJ. LytG of Bacillus subtilis is a novel peptidoglycan hydrolase: the major active glucosaminidase. Biochemistry 2003 42(2):257-64 

Jakeman DL, Ivory AJ, Blackburn GM, Williamson MP.  Orientation of 1,3-bisphosphoglycerate analogs bound to phosphoglycerate kinase. J Biol Chem 2003 278(13):10957-62 

2002

Charlton AJ, Haslam E, Williamson MP. Multiple conformations of the proline-rich protein/epigallocatechin gallate complex determined by time-averaged nuclear Overhauser effects. J Am Chem Soc 2002 124(33):9899-905 

Potter CA, Ward A, Laguri C, Williamson MP, Henderson PJ, Phillips-Jones MK. Expression, Purification and Characterisation of Full-length Histidine Protein Kinase RegB from Rhodobacter sphaeroides. J Mol Biol 2002 320(2):201-13 

Abou-Hachem M, Karlsson EN, Simpson PJ, Linse S, Sellers P, Williamson MP, Jamieson SJ, Gilbert HJ, Bolam DN, Holst O. Calcium binding and thermostability of carbohydrate binding module CBM4-2 of Xyn10A from Rhodothermus marinus. Biochemistry. 2002 41(18):5720-9 

Simpson PJ, Jamieson SJ, Abou-Hachem M, Karlsson EN, Gilbert HJ, Holst O, Williamson MP. The solution structure of the CBM4-2 carbohydrate binding module from a thermostable Rhodothermus marinus xylanase. Biochemistry. 2002 41(18):5712-9 

Charlton AJ, Baxter NJ, Khan ML, Moir AJ, Haslam E, Davies AP, Williamson MP. Polyphenol/peptide binding and precipitation. J Agric Food Chem. 2002 50(6):1593-601 

Jamieson SJ, Williamson MP, Abou-Hachem M, Nordberg KE, Simpson PJ. Virtually complete 1H, 13C and 15N resonance assignments of the second family 4 xylan binding module of Rhodothermus marinus xylanase 10A. J Biomol NMR. 2002 22(2):187-8 

2001

Raghothama S, Eberhardt RY, Simpson P, Wigelsworth D, White P, Hazlewood GP, Nagy T, Gilbert HJ, Williamson MP. Characterization of a cellulosome dockerin domain from the anaerobic fungus Piromyces equi. Nat Struct Biol. 2001 8(9):775-8 

Xie H, Gilbert HJ, Charnock SJ, Davies GJ, Williamson MP, Simpson PJ, Raghothama S, Fontes CM, Dias FM, Ferreira LM, Bolam DN. Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding. Biochemistry. 2001 40(31):9167-76 

Leighton MP, Kelly DJ, Williamson MP, Shaw JG. An NMR and enzyme study of the carbon metabolism of Neisseria meningitidis. Microbiology. 2001 147(6):1473-82 

Bolam DN, Xie H, White P, Simpson PJ, Hancock SM, Williamson MP, Gilbert HJ. Evidence for synergy between family 2b carbohydrate binding modules in Cellulomonas fimi xylanase 11A. Biochemistry. 2001 40(8):2468-77 

Xie H, Bolam DN, Nagy T, Szabo L, Cooper A, Simpson PJ, Lakey JH, Williamson MP, Gilbert HJ. Role of hydrogen bonding in the interaction between a xylan binding module and xylan. Biochemistry. 2001 40(19):5700-7 

Iwadate M, Asakura T, Dubovskii PV, Yamada H, Akasaka K, Williamson MP. Pressure-dependent changes in the structure of the melittin alpha-helix determined by NMR. J Biomol NMR. 2001 19(2):115-24 

Kozerski L, Mazurek AP, Kawecki R, Bocian W, Krajewski P, Bednarek E, Sitkowski J, Williamson MP, Moir AJ, Hansen PE. A nicked duplex decamer DNA with a PEG(6) tether. Nucleic Acids Res. 2001 29(5):1132-43 

A selection of papers from 2000 backwards

'The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains', B. K. Kay, M. P. Williamson and M. Sudol, FASEB J., 2000, 14, 231-241 an important review, cited nearly 1000 times 

'The structural basis for the ligand specificity of family 2 carbohydrate binding modules', P. J. Simpson, H. Xie, D. N. Bolam, H. J. Gilbert and M. P. Williamson, J. Biol. Chem., 2000, 275, 41137-41142 classic structure-activity combined with site-directed mutagenesis 

'The solution structure of Rb. sphaeroides LH1ß reveals two helical domains separated by a flexible region: Structural consequences for the LH1 complex' M. J. Conroy, W. Westerhuis, P. S. Parkes-Loach, P. A. Loach, C. N. Hunter and M. P. Williamson, J. Mol. Biol., 2000, 298, 83-94 atomic level details of a large membrane-bound complex 

'Ca and Cß carbon-13 shifts in proteins from an empirical database', M. Iwadate, T. Asakura and M. P. Williamson, J. Biomol. NMR, 1999, 13, 199-211 

'The starch-binding domain from glucoamylase disrupts the structure of starch' S. M. Southall, P. J. Simpson, H. J. Gilbert, G. Williamson and M. P. Williamson, FEBS Letts, 1999, 447, 58-60 more or less my only enzymological paper, demonstrating the unusual role of the starch binding domain 

'Characterisation of low free-energy excited states of proteins', N. J. Baxter, L. L. P. Hosszu, J. P. Waltho and M. P. Williamson, J. Mol. Biol. 1998, 284, 1625-1639 the work which set us on the path to studying protein excited states 

'Temperature dependence of 1H chemical shifts in proteins', N. J. Baxter and M. P. Williamson, J. Biomol. NMR, 1997, 9, 359-369 still the best work out there (in my humble opinion) on temperature effects on HN protons 

'Solution structure of the granular starch binding domain of Aspergillus niger glucoamylase bound to ß-cyclodextrin', K. Sorimachi, M-F. Le Gal-Coeffet, G. Williamson, D. B. Archer and M. P. Williamson, Structure, 1997, 5, 647-661 an unusual structure because there are two functionally different binding sites 

'The relationship between amide proton chemical shifts and secondary structure in proteins', T. Asakura, K. Taoka, M. Demura and M. P. Williamson, J. Biomol. NMR, 1995, 6, 227-236 important because of the widespread use of HSQC spectra eg for chemical shift mapping 

'Application of 1H NMR chemical shifts to measure the quality of protein structures', M. P. Williamson, J. Kikuchi and T. Asakura, J. Mol. Biol., 1995, 247, 541-546 which demonstrates the importance of chemical shifts as a measure of structure quality 

'The structure and function of proline-rich regions in proteins', M. P. Williamson, Biochem. J., 1994, 297, 249-260 an important review, cited over 800 times

'Empirical comparisons of models for chemical shift calculation in proteins', M. P. Williamson and T. Asakura, J. Magn. Reson., Series B, 1993, 101, 63-71. one of several papers in which we developed methods for calculating chemical shifts in proteins 

'Rapid pulsing artifacts in double-quantum filtered COSY', A. E. Derome and M. P. Williamson, J. Magn. Reson. 1990, 88, 177-185 a surprise hit, widely adopted as a standard method for DQF-COSY 

'Secondary-structure dependent chemical shifts in proteins', M. P. Williamson, Biopolymers 1990, 29, 1423-31 in which I showed the structural significance of chemical shifts in proteins 

'Solution conformation of the proteinase inhibitor IIA from bull seminal plasma by 1H nuclear magnetic resonance and distance geometry', M. P. Williamson, T. F. Havel and K. Wüthrich, J. Mol. Biol. 1985, 182, 295-315 the first NMR structure of a globular protein, cited over 500 times  

'Interactions of vancomycin and ristocetin with peptides as a model for protein binding', M. P. Williamson, D. H. Williams and S. J. Hammond, Tetrahedron 1984, 40, 569-577 In which we developed several ideas later expanded and worked on extensively by the Williams group to understand intermolecular interactions 

'Structure revision of the antibiotic vancomycin. The use of nuclear Overhauser effect difference spectroscopy', M. P. Williamson and D. H. Williams, J. Amer. Chem. Soc. 1981, 103, 6580-5 for the first time, the correct structure of vancomycin

'Manipulation of the nuclear Overhauser effect by the use of a viscous solvent: the solution conformation of the antibiotic echinomycin', M. P. Williamson and D. H. Williams, J. C. S. Chem. Commun. 1981, 165-6 an influential paper, showing that the NOE can be made much larger by increasing the molecular correlation time (since rediscovered several times!)

'Structure of the antibiotic ristocetin A', D. H. Williams, V. Rajananda, G. F. Bojesen and M. P. Williamson, J. C. S. Chem. Commun. 1979, 906-8 my first paper!