A research trial investigating whether Transcutaneous Vagus Nerve Stimulation (TVNS) paired with rehabilitation therapy can improve arm function in patients with arm weakness after a stroke.

The study is being led and sponsored by the Sheffield Teaching Hospitals NHS Foundation Trust.

The study is being managed by the Clinical Trials Research Unit at the University of Sheffield. 

The study is funded by the National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme.

Components of the mechanistic sub-study including the PET-MRI scans are funded by the NIHR Sheffield Biomedical Research Centre. 

All research in the NHS is looked at by an independent group of people, called a Research Ethics Committee to protect your safety, rights, wellbeing and dignity. This trial has been reviewed and given favourable opinion by East of England – Cambridge Central Research Ethics Committee (Ref: 22/EE/0209).