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The De lab was established in 2020 at the Sheffield Institute for Translational Neuroscience (SITraN) at the University of Sheffield. We aim to untangle the underlying mechanisms of protein aggregation and spread in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease etc) using molecular techniques.
Areas of work
Areas of work
Alzheimer's disease
Alzheimer's disease
Alzheimer's disease is the most common form of dementia. We use iPSC-based neuronal models and other molecular techniques to study protein pathogenesis in Alzheimer's disease.
Parkinson's disease
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disease. We examine the causative protein (Alpha synuclein) in human brain tissue and in cellular models.
Super-resolution microscopy
Super-resolution microscopy
We use super-resolution microscopy techniques to study the size, shape, post-translational modifications and mutations at the single-molecule level.
More detail on our work... We aim to discover the mechanistic pathways of protein misfolding, aggregation and deposition that are closely associated with the initiation and progression of various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. We aim to understand why disease causing protein species initially form, how they spread during disease progression and how their molecular features determine disease related dysfunctions. We use model systems, such as patient-derived cell models, to recapitulate the protein dysfunctions as it occurs in the human central nervous system and probe that process quantitatively using single-molecule/super-resolution imaging.
Key areas
Key areas
Protein pathology - Neurodegeneration - Cell culture - Molecular techniques - Super-res microscopy
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