Projects - Current

Please also see PhD projects under current team!

antifungal polymers

With long term collaborators Prof Stephen Rimmer and Dr Tom Swift at Bradford University, we have developed antifungal PNIPAM polymers functionalised with amphotericin B that are less toxic than AmpB itself. We have previously published the work here and are continuing to work with the polymer on a wider range of fungi.

LIPUS (ultrasound) to improve antibiofilm treatment

Using low intensity pulsed ultrasound (LIPUS) to improve antibiofilm treatments. Antimicrobial resistance (AMR) is a huge global challenge, and biofilm bacteria are far less sensitive to antibiotics. We are investigating the potential for LIPUS to be used as an adjunct to improve antimicrobial efficacy in treating biofilms, focussing on the common and important pathogen Staphylococcus aureus, and in doing so, improving antibiotic stewardship.

Anti Quorum sensing polymers

Working with long term collaborators Prof Stephen Rimmer, Dr Tom Swift and Dr William Martin of the School of Chemistry and Bioscience at Bradford University, we are investigating the ability of a PNIPAM polymer produced by the Bradford team functionalised with a signalling molecule, homoserine lactone (HSL) to disrupt bacterial conversations via quorum sensing (QS) in the pathogenic bacterium Pseudomonas aeruginosa. We are using the polymers to measure the effects of blocking QS signalling on P.aeruginosa viruence factors and biofilm formation. See the paper that this project leads on from here

cerium-containing electrospun scaffolds

Alongside School of Clinical dentistry colleague Dr Ilida Ortega Asencio, and PDRA Dr Emilia Barker, we are creating electrospun scaffolds containing cerium, with the objective of developing antimicrobial wound dressings that contour to deep wounds. This work was funded by the EPSRC and is in collaboration with Floreon.

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