Publications
2024
2024
130. A. Choi, A. Das, A. J. H. M. Meijer, I. Proietti Silvestri, I. Coldham, Org. Biomol. Chem. 2024, 22, 1602–1607.
'Synthesis of Enantioenriched Spirocyclic 2-Arylpiperidines via Kinetic Resolution'
DOI: 10.1039/D4OB00011KD
'Synthesis of Enantioenriched Spirocyclic 2-Arylpiperidines via Kinetic Resolution'
DOI: 10.1039/D4OB00011KD
2023
2023
129. Z. M. Cheema, M. Nisar, H. Y. Gondal, S. A. Al-Hussain, M. E. A. Zaki, I. Coldham, J. Saudi Chem. Soc. 2023, 27, 101746.
'New benzotriazole-derived alpha-substituted hemiaminal ethers with enhanced cholinesterase inhibition activity: Synthesis, structural, and biological evaluations'
DOI: 10.1016/j.jscs.2023.101746128. S.-H. Yeo, A. Choi, S. Greaves, A. J. H. M. Meijer, I. Proietti Silvestri, I. Coldham, Chem. Eur. J. 2023, 29, e202300815.
'Kinetic Resolution of 2-Aryldihydroquinolines using Lithiation – Synthesis of Chiral 1,2- and 1,4-Dihydroquinolines'
DOI: 10.1002/chem.202300815127. A. Das, A. Choi, I. Coldham, Org. Lett. 2023, 25, 987–991.
'Photocatalysis and Kinetic Resolution by Lithiation to give Enantioenriched 2-Arylpiperazines'
DOI: 10.1021/acs.orglett.3c00074
'New benzotriazole-derived alpha-substituted hemiaminal ethers with enhanced cholinesterase inhibition activity: Synthesis, structural, and biological evaluations'
DOI: 10.1016/j.jscs.2023.101746128. S.-H. Yeo, A. Choi, S. Greaves, A. J. H. M. Meijer, I. Proietti Silvestri, I. Coldham, Chem. Eur. J. 2023, 29, e202300815.
'Kinetic Resolution of 2-Aryldihydroquinolines using Lithiation – Synthesis of Chiral 1,2- and 1,4-Dihydroquinolines'
DOI: 10.1002/chem.202300815127. A. Das, A. Choi, I. Coldham, Org. Lett. 2023, 25, 987–991.
'Photocatalysis and Kinetic Resolution by Lithiation to give Enantioenriched 2-Arylpiperazines'
DOI: 10.1021/acs.orglett.3c00074
2022
2022
126. A. Choi, A. J. H. M. Meijer, I. Proietti Silvestri, I. Coldham, J. Org. Chem. 2022, 87, 8819–8823.
'Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments'
DOI: 10.1021/acs.joc.2c00862125. A. El-Tunsi, N. Carter, S.-H. Yeo, J. D. Priest, A. Choi, C. M. Kobras, S. Ndlovu, I. Proietti Silvestri, A. K. Fenton, I. Coldham, Synthesis 2022, 54, 355–368.
'Kinetic Resolution by Lithiation: Highly Enantioselective Synthesis of Substituted Dihydrobenzoxazines and Tetrahydroquinoxalines'
DOI: 10.1055/a-1638-2478
'Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments'
DOI: 10.1021/acs.joc.2c00862125. A. El-Tunsi, N. Carter, S.-H. Yeo, J. D. Priest, A. Choi, C. M. Kobras, S. Ndlovu, I. Proietti Silvestri, A. K. Fenton, I. Coldham, Synthesis 2022, 54, 355–368.
'Kinetic Resolution by Lithiation: Highly Enantioselective Synthesis of Substituted Dihydrobenzoxazines and Tetrahydroquinoxalines'
DOI: 10.1055/a-1638-2478
2021
2021
124. A. Choi, A. El-Tunsi, Y. Wang, A. J. H. M. Meijer, J. Li, X. Li, I. Proietti Silvestri, I. Coldham,
Chem. Eur. J. 2021, 27, 11670–11675.
'Asymmetric Synthesis of 2-Arylindolines and 2,2-Disubstituted Indolines by Kinetic Resolution'
DOI: 10.1002/chem.202101248
Chem. Eur. J. 2021, 27, 11670–11675.
'Asymmetric Synthesis of 2-Arylindolines and 2,2-Disubstituted Indolines by Kinetic Resolution'
DOI: 10.1002/chem.202101248
2020
2020
123. A. K. Jayavelu, T. M. Schnöder, F. Perner, C. Herzog, A. Meiler, G. Krishnamoorthy, N. Huber, J. Mohr, B. Edelmann-Stephan, R. Austin, S. Brandt, F. Palandri, N. Schröder, B. Isermann, F. Edlich, A. U. Sinha, M. Ungelenk, C. A. Hübner, R. Zeiser, S. Rahmig, C. Waskow, I. Coldham, T. Ernst, A. Hochhaus, S. Jilg, P. J. Jost, A. Mullally, L. Bullinger, P. R. Mertens, S. W. Lane, M. Mann, F. H. Heidel, Nature 2020, 588, 157–163.
'Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms'
DOI: 10.1038/s41586-020-2968-3122. V. K. Aggarwal, S. K. Armstrong, L. Caggiano, K. Chibale, J. Clayden, I. Coldham, N. Greeves, R. C. Hartley, J. G. Knight, N. Kuhnert, H. J. Mitchell, A. Nelson, P. O'Brien, S. P. Thomas, P. Wyatt, Org. Biomol. Chem. 2020, 18, 7236–7237.
'Stuart Warren (24 Dec 1938 - 22 Mar 2020)'
DOI: 10.1039/D0OB90121K121. A. Choi, J. Castle, R. Saruengkhanphasit, I. Coldham, Synthesis 2020, 52, 1273–1278.
'Synthesis of Spirocyclic Amines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Azomethine Imines'
DOI: 10.1055/s-0039-1691588
'Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms'
DOI: 10.1038/s41586-020-2968-3122. V. K. Aggarwal, S. K. Armstrong, L. Caggiano, K. Chibale, J. Clayden, I. Coldham, N. Greeves, R. C. Hartley, J. G. Knight, N. Kuhnert, H. J. Mitchell, A. Nelson, P. O'Brien, S. P. Thomas, P. Wyatt, Org. Biomol. Chem. 2020, 18, 7236–7237.
'Stuart Warren (24 Dec 1938 - 22 Mar 2020)'
DOI: 10.1039/D0OB90121K121. A. Choi, J. Castle, R. Saruengkhanphasit, I. Coldham, Synthesis 2020, 52, 1273–1278.
'Synthesis of Spirocyclic Amines by 1,3-Dipolar Cycloaddition of Azomethine Ylides and Azomethine Imines'
DOI: 10.1055/s-0039-1691588
2019
2019
120. A. Choi, I. Coldham, Tetrahedron Lett. 2019, 60, 151023.
'Three-component couplings for the synthesis of pyrroloquinoxalinones by azomethine ylide 1,3-dipolar cycloaddition chemistry'
DOI: 10.1016/j.tetlet.2019.151023119. R. A. Talk, A. El-Tunsi, C. C. Robertson, I. Coldham, Eur. J. Org. Chem. 2019, 5294–5301.
'Regioselective lithiation and electrophilic quench of N-Boc-3-phenyltetrahydroisoquinoline'
DOI: 10.1002/ejoc.201900238118. A. Choi, R. M. Morley, I. Coldham, Beilstein J. Org. Chem. 2019, 15, 1480–1484.
'Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts'
DOI: 10.3762/bjoc.15.149117. I. Mannaerts, L. F. R. Thoen, N. Eysackers, F. J. Cubero, S. B. Leite, I. Coldham, I. Colle, C. Trautwein, L. A. van Grunsven, Cell Death Dis. 2019, 10, e98 (1–12).
'Unfolded protein response is an early, non-critical event during hepatic stellate cell activation'
DOI: 10.1038/s41419-019-1327-5116. Z. T. I. Alkayar, I. Coldham, Org. Biomol. Chem. 2019, 17, 66–73.
'Cascade cyclization and intramolecular nitrone dipolar cycloaddition and formal synthesis of 19-hydroxyibogamine'
DOI: 10.1039/C8OB02839G
'Three-component couplings for the synthesis of pyrroloquinoxalinones by azomethine ylide 1,3-dipolar cycloaddition chemistry'
DOI: 10.1016/j.tetlet.2019.151023119. R. A. Talk, A. El-Tunsi, C. C. Robertson, I. Coldham, Eur. J. Org. Chem. 2019, 5294–5301.
'Regioselective lithiation and electrophilic quench of N-Boc-3-phenyltetrahydroisoquinoline'
DOI: 10.1002/ejoc.201900238118. A. Choi, R. M. Morley, I. Coldham, Beilstein J. Org. Chem. 2019, 15, 1480–1484.
'Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts'
DOI: 10.3762/bjoc.15.149117. I. Mannaerts, L. F. R. Thoen, N. Eysackers, F. J. Cubero, S. B. Leite, I. Coldham, I. Colle, C. Trautwein, L. A. van Grunsven, Cell Death Dis. 2019, 10, e98 (1–12).
'Unfolded protein response is an early, non-critical event during hepatic stellate cell activation'
DOI: 10.1038/s41419-019-1327-5116. Z. T. I. Alkayar, I. Coldham, Org. Biomol. Chem. 2019, 17, 66–73.
'Cascade cyclization and intramolecular nitrone dipolar cycloaddition and formal synthesis of 19-hydroxyibogamine'
DOI: 10.1039/C8OB02839G
2018
2018
115. T. Aeyad, C. G. Jones, I. Coldham, Eur. J. Org. Chem. 2018, 5289–5296.
'Preparation of Substituted Tetrahydro-1-benzazepines by Lithiation-Trapping'
DOI: 10.1002/ejoc.201800868114. N. Carter, X. Li, L. Reavey, A. J. H. M. Meijer, I. Coldham, Chem. Sci. 2018, 9, 1352–1357.
'Synthesis and Kinetic Resolution of Substituted Tetrahydroquinolines by Lithiation then Electrophilic Quench'
DOI: 10.1039/C7SC04435F
'Preparation of Substituted Tetrahydro-1-benzazepines by Lithiation-Trapping'
DOI: 10.1002/ejoc.201800868114. N. Carter, X. Li, L. Reavey, A. J. H. M. Meijer, I. Coldham, Chem. Sci. 2018, 9, 1352–1357.
'Synthesis and Kinetic Resolution of Substituted Tetrahydroquinolines by Lithiation then Electrophilic Quench'
DOI: 10.1039/C7SC04435F
2017
2017
113. T. Aeyad, J. D. Williams, A. J. H. M. Meijer, I. Coldham, Synlett 2017, 28, 2765–2768.
'Lithiation–substitution of N-Boc-2-phenylazepane'
DOI: 10.1055/s-0036-1590857112. R. Saruengkhanphasit, D. Collier, I. Coldham, J. Org. Chem. 2017, 82, 6489–6496.
'Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones'
DOI: 10.1021/acs.joc.7b00959111. M. R. Alshawish, G. Barker, N. D. Measom , I. Coldham, Comptes Rendus Chimie 2017, 20, 601–608.
'Metallation–substitution of an alpha-oxygenated chiral nitrile'
DOI: 10.1016/j.crci.2016.11.006110. A. Sadhukhan, M. C. Hobbs, A. J. H. M. Meijer, I. Coldham, Chem. Sci. 2017, 8, 1436–1441.
'Highly enantioselective metallation–substitution alpha to a chiral nitrile'
DOI: 10.1039/C6SC03712GSee highlight in Synform 2017, A80–A82.
'Lithiation–substitution of N-Boc-2-phenylazepane'
DOI: 10.1055/s-0036-1590857112. R. Saruengkhanphasit, D. Collier, I. Coldham, J. Org. Chem. 2017, 82, 6489–6496.
'Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones'
DOI: 10.1021/acs.joc.7b00959111. M. R. Alshawish, G. Barker, N. D. Measom , I. Coldham, Comptes Rendus Chimie 2017, 20, 601–608.
'Metallation–substitution of an alpha-oxygenated chiral nitrile'
DOI: 10.1016/j.crci.2016.11.006110. A. Sadhukhan, M. C. Hobbs, A. J. H. M. Meijer, I. Coldham, Chem. Sci. 2017, 8, 1436–1441.
'Highly enantioselective metallation–substitution alpha to a chiral nitrile'
DOI: 10.1039/C6SC03712GSee highlight in Synform 2017, A80–A82.
2016
2016
109. R. C. Furnival, R. Saruengkhanphasit, H. E. Holberry, J. R. Shewring, H. D. S. Guerrand, H. Adams, I. Coldham, Org. Biomol. Chem. 2016, 14, 10953–10962.
'Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition'
DOI: 10.1039/C6OB01871H108. R. A. Talk, A. Duperray, X. Li, I. Coldham, Org. Biomol. Chem. 2016, 14, 4908–4917.
'Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench'
DOI: 10.1039/C6OB00577B107. V. J. B. Gotham, M. C. Hobbs, R. Burgin, D. Turton, C. Smythe, I. Coldham, Org. Biomol. Chem. 2016, 14, 1559–1563.
'Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay'
DOI: 10.1039/C5OB02482J106. Z. T. I. Alkayar, H. Adams, I. Coldham, Synlett 2016, 27, 447–449.
'Regiochemical and stereochemical studies of the intramolecular dipolar cycloaddition of nitrones derived from quaternary aldehydes'
DOI: 10.1055/s-0035-1560906
'Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition'
DOI: 10.1039/C6OB01871H108. R. A. Talk, A. Duperray, X. Li, I. Coldham, Org. Biomol. Chem. 2016, 14, 4908–4917.
'Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench'
DOI: 10.1039/C6OB00577B107. V. J. B. Gotham, M. C. Hobbs, R. Burgin, D. Turton, C. Smythe, I. Coldham, Org. Biomol. Chem. 2016, 14, 1559–1563.
'Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay'
DOI: 10.1039/C5OB02482J106. Z. T. I. Alkayar, H. Adams, I. Coldham, Synlett 2016, 27, 447–449.
'Regiochemical and stereochemical studies of the intramolecular dipolar cycloaddition of nitrones derived from quaternary aldehydes'
DOI: 10.1055/s-0035-1560906
2015
2015
105. I. Coldham and N. S. Sheikh, Applications of Domino Transformations in Organic Synthesis 2 (Science of Synthesis Reference Library 2015/4b), ed. S. A. Snyder, Georg Thieme Verlag KG, Stuttgart, 2015, ch. 2.1.2, pp 47–91.
'Domino reactions including [2+2], [3+2], or [5+2] cycloadditions'
ISBN: 978-3-13-221141-4104. E. J. Cochrane, L. A. Hassall, I. Coldham, J. Org. Chem. 2015, 80, 5964–5969.
'Preparation of 1-substituted tetrahydro-beta-carbolines by lithiation–substitution'
DOI: 10.1021/acs.joc.5b00725103. R. Pathak, B. C. Dobson, N. Ghosh, K. A. Ageel, M. R. Alshawish, R. Saruengkhanphasit, I. Coldham, Org. Biomol. Chem. 2015, 13, 3331–3340.
'Synthesis of the tricyclic core of manzamine A'
DOI: 10.1039/C4OB02582B
'Domino reactions including [2+2], [3+2], or [5+2] cycloadditions'
ISBN: 978-3-13-221141-4104. E. J. Cochrane, L. A. Hassall, I. Coldham, J. Org. Chem. 2015, 80, 5964–5969.
'Preparation of 1-substituted tetrahydro-beta-carbolines by lithiation–substitution'
DOI: 10.1021/acs.joc.5b00725103. R. Pathak, B. C. Dobson, N. Ghosh, K. A. Ageel, M. R. Alshawish, R. Saruengkhanphasit, I. Coldham, Org. Biomol. Chem. 2015, 13, 3331–3340.
'Synthesis of the tricyclic core of manzamine A'
DOI: 10.1039/C4OB02582B
2014
2014
102. E. J. Cochrane, D. Leonori, L. A. Hassall, I. Coldham, Chem. Commun. 2014, 50, 9910–9913.
'Synthesis and kinetic resolution of N-Boc-2-arylpiperidines'
DOI: 10.1039/c4cc04576a101. X. Li, I. Coldham, J. Am. Chem. Soc. 2014, 136, 5551–5554.
'Synthesis of 1,1-Disubstituted Tetrahydroisoquinolines by Lithiation and Substitution, with in Situ IR Spectroscopy and Configurational Stability Studies'
DOI: 10.1021/ja500485f100. D. Mortimer, M. Whiting, J. P. A. Harrity, S. Jones, I. Coldham, Tetrahedron Lett. 2014, 55, 1255–1257.
'Synthesis of an azabicyclic framework towards actinophyllic acid'
DOI: 10.1016/j.tetlet.2014.01.01999. D. Nath, M. C. Skilbeck, I. Coldham, F. F. Fleming, Org. Lett. 2014, 16, 62–65.
'Arylthio-Metal Exchange of alpha-Arylthioalkanenitriles'
DOI: 10.1021/ol403020s
'Synthesis and kinetic resolution of N-Boc-2-arylpiperidines'
DOI: 10.1039/c4cc04576a101. X. Li, I. Coldham, J. Am. Chem. Soc. 2014, 136, 5551–5554.
'Synthesis of 1,1-Disubstituted Tetrahydroisoquinolines by Lithiation and Substitution, with in Situ IR Spectroscopy and Configurational Stability Studies'
DOI: 10.1021/ja500485f100. D. Mortimer, M. Whiting, J. P. A. Harrity, S. Jones, I. Coldham, Tetrahedron Lett. 2014, 55, 1255–1257.
'Synthesis of an azabicyclic framework towards actinophyllic acid'
DOI: 10.1016/j.tetlet.2014.01.01999. D. Nath, M. C. Skilbeck, I. Coldham, F. F. Fleming, Org. Lett. 2014, 16, 62–65.
'Arylthio-Metal Exchange of alpha-Arylthioalkanenitriles'
DOI: 10.1021/ol403020s
2013
2013
98. G. Barker, M. R. Alshawish, M. C. Skilbeck, I. Coldham, Angew. Chem. Int. Ed. 2013, 52, 7700–7703.
'Remarkable Configurational Stability of Magnesiated Nitriles'
DOI: 10.1002/anie.20130344297. X. Li, D. Leonori, N. S. Sheikh, I. Coldham, Chem. Eur. J. 2013, 19, 7724–7730.
'Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quench guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine'
DOI: 10.1002/chem.20130109696. O. Garcia-Calvo, E. Coya, S. Lage, I. Coldham, N. Sotomayor, E. Lete, Eur. J. Org. Chem. 2013, 1460–1470.
'Intramolecular carbolithiation reactions in the construction of medium size rings. Synthesis of pyrroloisoquinolines, benzazepines and benzazocines'
DOI: 10.1002/ejoc.201200994
'Remarkable Configurational Stability of Magnesiated Nitriles'
DOI: 10.1002/anie.20130344297. X. Li, D. Leonori, N. S. Sheikh, I. Coldham, Chem. Eur. J. 2013, 19, 7724–7730.
'Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quench guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine'
DOI: 10.1002/chem.20130109696. O. Garcia-Calvo, E. Coya, S. Lage, I. Coldham, N. Sotomayor, E. Lete, Eur. J. Org. Chem. 2013, 1460–1470.
'Intramolecular carbolithiation reactions in the construction of medium size rings. Synthesis of pyrroloisoquinolines, benzazepines and benzazocines'
DOI: 10.1002/ejoc.201200994
2012
2012
95. I. Coldham, S. P. Robinson, C. A. Baxter, Synlett 2012, 23, 2405–2407.
'Asymmetric Synthesis of 2-Arylpyrrolidines by Cationic Cyclization'
DOI: 10.1055/s-0032-131711494. N. S. Sheikh, D. Leonori, G. Barker, J. D. Firth, K. R. Campos, A. J. H. M. Meijer, P. O'Brien, I. Coldham, J. Am. Chem. Soc. 2012, 134, 5300–5308.
'An Experimental and In Situ IR Spectroscopic Study of the Lithiation-Substitution of N-Boc 2-phenylpyrrolidine and piperidine: Controlling the Formation of Quaternary Stereocenters'
DOI: 10.1021/ja211398b93. M. J. Thompson, J. C. Louth, S. M. Little, M. P. Jackson, Y. Boursereau, B. Chen, I. Coldham, Chem. Med. Chem. 2012, 7, 578–586.
'Synthesis and Evaluation of 1-Amino-6-halo-beta-carbolines as Antimalarial and Antiprion Agents'
DOI: 10.1002/cmdc.20120000292. H. H. Ince, B. Dedeoglu, S. Gul, V. Aviyente, I. Coldham, Molecular Physics 2012, 110, 353–359.
'Selectivity in the aggregates of the chiral organolithium N-Boc-2-lithiopiperidine with a chiral ligand: A DFT study'
DOI: 10.1080/00268976.2011.64710391. I. Coldham, A. J. M. Burrell, H. D. S. Guerrand, L. Watson, N. G. Martin, N. Oram, Beilstein J. Org. Chem. 2012, 8, 107–111.
'Synthesis of fused tricyclic amines unsubstituted at the ring-junction positions by a cascade condensation, cyclization, cycloaddition then decarbonylation strategy'
DOI: 10.3762/bjoc.8.1190. I. Coldham, A. J. M. Burrell, L. Watson, N. Oram, N. G. Martin, Heterocycles 2012, 84, 597–613.
'Synthesis of fused tricyclic heterocycles by condensation, cyclization, dipolar cycloaddition cascade of alpha-benzenesulfonyl and alpha-phenylthio substituted aldehydes'
DOI: 10.3987/COM-11-S(P)29
'Asymmetric Synthesis of 2-Arylpyrrolidines by Cationic Cyclization'
DOI: 10.1055/s-0032-131711494. N. S. Sheikh, D. Leonori, G. Barker, J. D. Firth, K. R. Campos, A. J. H. M. Meijer, P. O'Brien, I. Coldham, J. Am. Chem. Soc. 2012, 134, 5300–5308.
'An Experimental and In Situ IR Spectroscopic Study of the Lithiation-Substitution of N-Boc 2-phenylpyrrolidine and piperidine: Controlling the Formation of Quaternary Stereocenters'
DOI: 10.1021/ja211398b93. M. J. Thompson, J. C. Louth, S. M. Little, M. P. Jackson, Y. Boursereau, B. Chen, I. Coldham, Chem. Med. Chem. 2012, 7, 578–586.
'Synthesis and Evaluation of 1-Amino-6-halo-beta-carbolines as Antimalarial and Antiprion Agents'
DOI: 10.1002/cmdc.20120000292. H. H. Ince, B. Dedeoglu, S. Gul, V. Aviyente, I. Coldham, Molecular Physics 2012, 110, 353–359.
'Selectivity in the aggregates of the chiral organolithium N-Boc-2-lithiopiperidine with a chiral ligand: A DFT study'
DOI: 10.1080/00268976.2011.64710391. I. Coldham, A. J. M. Burrell, H. D. S. Guerrand, L. Watson, N. G. Martin, N. Oram, Beilstein J. Org. Chem. 2012, 8, 107–111.
'Synthesis of fused tricyclic amines unsubstituted at the ring-junction positions by a cascade condensation, cyclization, cycloaddition then decarbonylation strategy'
DOI: 10.3762/bjoc.8.1190. I. Coldham, A. J. M. Burrell, L. Watson, N. Oram, N. G. Martin, Heterocycles 2012, 84, 597–613.
'Synthesis of fused tricyclic heterocycles by condensation, cyclization, dipolar cycloaddition cascade of alpha-benzenesulfonyl and alpha-phenylthio substituted aldehydes'
DOI: 10.3987/COM-11-S(P)29
2011
2011
89. H. D. S. Guerrand, H. Adams, I. Coldham, Org. Biomol. Chem. 2011, 9, 7921–7928.
'Cascade Cyclization, Dipolar Cycloaddition of Azomethine Imines for the Synthesis of Pyrazolidines'
DOI: 10.1039/C1OB06122D88. M. J. Thompson, J. C. Louth, S. M. Little, B. Chen, I. Coldham, Bioorg. Med. Chem. Lett. 2011, 21, 3644–3647.
'2,4-Diarylthiazole antiprion compounds as a novel structural class of antimalarial leads'
DOI: 10.1016/j.bmcl.2011.04.09087. I. Coldham, L. Watson, H. Adams, N. G. Martin, J. Org. Chem. 2011, 76, 2360–2366.
'Synthesis of the Core Ring System of the Yuzurimine Type Daphniphyllum Alkaloids by Cascade Condensation, Cyclization, Cycloaddition Chemistry'
DOI: 10.1021/jo200086886. I. Coldham, A. J. M. Burrell, H. D. S. Guerrand, N. Oram, Org. Lett. 2011, 13, 1267–1269.
'Cascade Cyclization, Dipolar Cycloaddition to Bridged Tricyclic Amines Related to the Daphniphyllum Alkaloids'
DOI: 10.1021/ol102961x85. A. I. Franklin, D. Bensa, H. Adams, I. Coldham, Org. Biomol. Chem. 2011, 9, 1901–1907.
'Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids'
DOI: 10.1039/C0OB01019G84. Kh. M. Shakhidoyatov, I. Coldham, T. F. Ibragimov, Chem. Nat. Compds. 2011, 46, 929–931.
'Lithiation of deoxypeganinine and chiral synthesis of deoxypeganine derivatives'
DOI: 10.1007/s10600-011-9785-883. O. Garcia-Calvo, N. Sotomayor, E. Lete, I. Coldham, Arkivoc 2011, v, 957–66.
'Organolithium or Heck-type cyclization of N-ortho-iodobenzyl-2-alkenylpyrrolidines to give indolizidines'
ISSN: 1551-7012, WB-5621EP
'Cascade Cyclization, Dipolar Cycloaddition of Azomethine Imines for the Synthesis of Pyrazolidines'
DOI: 10.1039/C1OB06122D88. M. J. Thompson, J. C. Louth, S. M. Little, B. Chen, I. Coldham, Bioorg. Med. Chem. Lett. 2011, 21, 3644–3647.
'2,4-Diarylthiazole antiprion compounds as a novel structural class of antimalarial leads'
DOI: 10.1016/j.bmcl.2011.04.09087. I. Coldham, L. Watson, H. Adams, N. G. Martin, J. Org. Chem. 2011, 76, 2360–2366.
'Synthesis of the Core Ring System of the Yuzurimine Type Daphniphyllum Alkaloids by Cascade Condensation, Cyclization, Cycloaddition Chemistry'
DOI: 10.1021/jo200086886. I. Coldham, A. J. M. Burrell, H. D. S. Guerrand, N. Oram, Org. Lett. 2011, 13, 1267–1269.
'Cascade Cyclization, Dipolar Cycloaddition to Bridged Tricyclic Amines Related to the Daphniphyllum Alkaloids'
DOI: 10.1021/ol102961x85. A. I. Franklin, D. Bensa, H. Adams, I. Coldham, Org. Biomol. Chem. 2011, 9, 1901–1907.
'Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids'
DOI: 10.1039/C0OB01019G84. Kh. M. Shakhidoyatov, I. Coldham, T. F. Ibragimov, Chem. Nat. Compds. 2011, 46, 929–931.
'Lithiation of deoxypeganinine and chiral synthesis of deoxypeganine derivatives'
DOI: 10.1007/s10600-011-9785-883. O. Garcia-Calvo, N. Sotomayor, E. Lete, I. Coldham, Arkivoc 2011, v, 957–66.
'Organolithium or Heck-type cyclization of N-ortho-iodobenzyl-2-alkenylpyrrolidines to give indolizidines'
ISSN: 1551-7012, WB-5621EP
2010
2010
82. A. J. M. Burrell, L. Watson, N. G. Martin, N. Oram, I. Coldham, Org. Biomol. Chem. 2010, 8, 4530–4532.
'Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular cycloaddition'
DOI: 10.1039/C0OB00408A81. A. J. M. Burrell, I. Coldham, Curr. Org. Synth. 2010, 7, 312–331.
'Synthesis of Natural Products using Intramolecular Dipolar Cycloaddition Reactions'
ISSN: 1570-1794/1080. I. Coldham, D. Leonori, J. Org. Chem. 2010, 75, 4069–4077.
'Regioselective and Stereoselective Copper(I)-Promoted Allylation and Conjugate Addition of N-Boc-2-lithiopyrrolidine and N-Boc-2-lithiopiperidine'
DOI: 10.1021/jo100415x79. S. P. Robinson, N. S. Sheikh, C. A. Baxter, I. Coldham, Tetrahedron Lett. 2010, 51, 3642–3644.
'Dynamic thermodynamic resolution of lithiated N-Boc-N'-alkylpiperazines'
DOI: 10.1016/j.tetlet.2010.05.01978. D. Stead, G. Carbone, P. O'Brien, K. R. Campos, I. Coldham, A. Sanderson, J. Am. Chem. Soc. 2010, 132, 7260–7261.
'Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects'
DOI: 10.1021/ja102043e77. I. Coldham, H. Adams, N. J. Ashweek, T. A. Barker, A. T. Reeder, M. C. Skilbeck, Tetrahedron Lett. 2010, 51, 2457–2460.
'Synthesis of 2-hydroxy-3-indolinones and 3-hydroxy-2-indolinones by anionic cyclization, in situ oxidation and rearrangement'
DOI: 10.1016/j.tetlet.2010.02.15976. I. Coldham, S. Raimbault, D. T. E. Whittaker, P. T. Chovatia, D. Leonori, J. J. Patel, N. S. Sheikh, Chem. Eur. J. 2010, 16, 4082–4090.
'Asymmetric Substitutions of 2-Lithiated N-Boc-piperidine and N-Boc-azepine by Dynamic Resolution'
DOI: 10.1002/chem.20090305975. I. Coldham, N. S. Sheikh, Top. Stereochem. 2010, 26, 253–293.
'Dynamic Resolutions of Chiral Organolithiums'
ISBN 978-3-906390-61-1
'Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular cycloaddition'
DOI: 10.1039/C0OB00408A81. A. J. M. Burrell, I. Coldham, Curr. Org. Synth. 2010, 7, 312–331.
'Synthesis of Natural Products using Intramolecular Dipolar Cycloaddition Reactions'
ISSN: 1570-1794/1080. I. Coldham, D. Leonori, J. Org. Chem. 2010, 75, 4069–4077.
'Regioselective and Stereoselective Copper(I)-Promoted Allylation and Conjugate Addition of N-Boc-2-lithiopyrrolidine and N-Boc-2-lithiopiperidine'
DOI: 10.1021/jo100415x79. S. P. Robinson, N. S. Sheikh, C. A. Baxter, I. Coldham, Tetrahedron Lett. 2010, 51, 3642–3644.
'Dynamic thermodynamic resolution of lithiated N-Boc-N'-alkylpiperazines'
DOI: 10.1016/j.tetlet.2010.05.01978. D. Stead, G. Carbone, P. O'Brien, K. R. Campos, I. Coldham, A. Sanderson, J. Am. Chem. Soc. 2010, 132, 7260–7261.
'Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects'
DOI: 10.1021/ja102043e77. I. Coldham, H. Adams, N. J. Ashweek, T. A. Barker, A. T. Reeder, M. C. Skilbeck, Tetrahedron Lett. 2010, 51, 2457–2460.
'Synthesis of 2-hydroxy-3-indolinones and 3-hydroxy-2-indolinones by anionic cyclization, in situ oxidation and rearrangement'
DOI: 10.1016/j.tetlet.2010.02.15976. I. Coldham, S. Raimbault, D. T. E. Whittaker, P. T. Chovatia, D. Leonori, J. J. Patel, N. S. Sheikh, Chem. Eur. J. 2010, 16, 4082–4090.
'Asymmetric Substitutions of 2-Lithiated N-Boc-piperidine and N-Boc-azepine by Dynamic Resolution'
DOI: 10.1002/chem.20090305975. I. Coldham, N. S. Sheikh, Top. Stereochem. 2010, 26, 253–293.
'Dynamic Resolutions of Chiral Organolithiums'
ISBN 978-3-906390-61-1
2009
2009
74. D. Leonori, I. Coldham, Adv. Synth. Cat. 2009, 351, 2619-2623.
'Direct Preparation of 7-Allyl- and 7-Arylindolines'
DOI: 10.1002/adsc.20090049973. I. Coldham, D. Leonori, T. K. Beng, R. E. Gawley, Chem. Commun. 2009, 45, 5239–5241.
'The Barrier to Enantiomerization and Dynamic Resolution of N-Boc-2-lithiopiperidine and the Effect of TMEDA'
DOI: 10.1039/B911024K72. T. K. Beng, T. I. Yousaf, I. Coldham, R. E. Gawley, J. Am. Chem. Soc. 2009, 131, 6908-6909.
'Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine'
DOI: 10.1021/ja900755a71. A. J. M. Burrell, I. Coldham, N. Oram, Org. Lett. 2009, 11, 1515–1518.
'Synthesis of Fused Tricyclic Amines from Enolisable Acyclic Aldehydes by Cyclization then Dipolar Cycloaddition Cascade: Synthesis of Myrioxazine A'
DOI: 10.1021/ol900165370. I. Coldham, S. Jana, L. Watson, N. G. Martin, Org. Biomol. Chem. 2009, 7, 1674–1679.
'Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (±)-crispine A'
DOI: 10.1039/B822743H69. A. J. M. Burrell, I. Coldham, L. Watson, N. Oram, C. D. Pilgram, N. G. Martin, J. Org. Chem. 2009, 74, 2290–2300.
'Stereoselective Formation of Fused Tricyclic Amines from Acyclic Aldehydes by a Cascade Process Involving Condensation, Cyclization and Dipolar Cycloaddition'
DOI: 10.1021/jo-2008-019913.R1
'Direct Preparation of 7-Allyl- and 7-Arylindolines'
DOI: 10.1002/adsc.20090049973. I. Coldham, D. Leonori, T. K. Beng, R. E. Gawley, Chem. Commun. 2009, 45, 5239–5241.
'The Barrier to Enantiomerization and Dynamic Resolution of N-Boc-2-lithiopiperidine and the Effect of TMEDA'
DOI: 10.1039/B911024K72. T. K. Beng, T. I. Yousaf, I. Coldham, R. E. Gawley, J. Am. Chem. Soc. 2009, 131, 6908-6909.
'Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine'
DOI: 10.1021/ja900755a71. A. J. M. Burrell, I. Coldham, N. Oram, Org. Lett. 2009, 11, 1515–1518.
'Synthesis of Fused Tricyclic Amines from Enolisable Acyclic Aldehydes by Cyclization then Dipolar Cycloaddition Cascade: Synthesis of Myrioxazine A'
DOI: 10.1021/ol900165370. I. Coldham, S. Jana, L. Watson, N. G. Martin, Org. Biomol. Chem. 2009, 7, 1674–1679.
'Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (±)-crispine A'
DOI: 10.1039/B822743H69. A. J. M. Burrell, I. Coldham, L. Watson, N. Oram, C. D. Pilgram, N. G. Martin, J. Org. Chem. 2009, 74, 2290–2300.
'Stereoselective Formation of Fused Tricyclic Amines from Acyclic Aldehydes by a Cascade Process Involving Condensation, Cyclization and Dipolar Cycloaddition'
DOI: 10.1021/jo-2008-019913.R1
2008
2008
68. I. Coldham, D. Leonori, Org. Lett. 2008, 10, 3923–3925.
'Synthesis of 2-Arylpiperidines by Palladium Couplings of Aryl Bromides with Organozinc Species Derived from Deprotonation of N-Boc-piperidine'
DOI: 10.1021/ol801579r67. I. Coldham, S. Raimbault, P. T. Chovatia, J. J. Patel, D. Leonori, N. S. Sheikh, D. T. E. Whittaker, Chem. Commun. 2008, 44, 4174–4176.
'Dynamic Resolution of N-Boc-2-lithiopiperidine'
DOI: 10.1039/b810988e66. I. Coldham, S. Jana, L. Watson, C. D. Pilgram, Tetrahedron Lett. 2008, 49, 5408–5410.
'Cascade Cyclization Intermolecular Dipolar Cycloaddition by Multi-component Couplings - Synthesis of Indolizidines and Pyrrolizidines'
DOI: 10.1016/j.tetlet.2008.07.01065. D. Bensa, I. Coldham, P. Feinäugle, R. B. Pathak, R. J. Butlin, Org. Biomol. Chem. 2008, 6, 1410–1415.
'Synthesis of carboxylic amides by ring-opening of oxazolidinones with Grignard reagents'
DOI: 10.1039/b800849c64. I. Coldham, J. J. Patel, S. Raimbault, D. T. E. Whittaker, H. Adams, G. Y. Fang, V. K. Aggarwal, Org. Lett. 2008, 10, 141–143.
'Asymmetric Lithiation–Substitution of Amines Involving Rearrangement of Borates'
DOI: 10.1021/ol702734u63. T. I. Yousaf, R. L. Williams, I. Coldham, R. E. Gawley, Chem. Commun. 2008, 44, 97–98.
'The Barrier to Enantiomerization of N-Boc-2-lithiopyrrolidine: The Effect of Chiral and Achiral Diamines'
DOI: 10.1039/b714302h
'Synthesis of 2-Arylpiperidines by Palladium Couplings of Aryl Bromides with Organozinc Species Derived from Deprotonation of N-Boc-piperidine'
DOI: 10.1021/ol801579r67. I. Coldham, S. Raimbault, P. T. Chovatia, J. J. Patel, D. Leonori, N. S. Sheikh, D. T. E. Whittaker, Chem. Commun. 2008, 44, 4174–4176.
'Dynamic Resolution of N-Boc-2-lithiopiperidine'
DOI: 10.1039/b810988e66. I. Coldham, S. Jana, L. Watson, C. D. Pilgram, Tetrahedron Lett. 2008, 49, 5408–5410.
'Cascade Cyclization Intermolecular Dipolar Cycloaddition by Multi-component Couplings - Synthesis of Indolizidines and Pyrrolizidines'
DOI: 10.1016/j.tetlet.2008.07.01065. D. Bensa, I. Coldham, P. Feinäugle, R. B. Pathak, R. J. Butlin, Org. Biomol. Chem. 2008, 6, 1410–1415.
'Synthesis of carboxylic amides by ring-opening of oxazolidinones with Grignard reagents'
DOI: 10.1039/b800849c64. I. Coldham, J. J. Patel, S. Raimbault, D. T. E. Whittaker, H. Adams, G. Y. Fang, V. K. Aggarwal, Org. Lett. 2008, 10, 141–143.
'Asymmetric Lithiation–Substitution of Amines Involving Rearrangement of Borates'
DOI: 10.1021/ol702734u63. T. I. Yousaf, R. L. Williams, I. Coldham, R. E. Gawley, Chem. Commun. 2008, 44, 97–98.
'The Barrier to Enantiomerization of N-Boc-2-lithiopyrrolidine: The Effect of Chiral and Achiral Diamines'
DOI: 10.1039/b714302h
2007
2007
62. I. Coldham, J. J. Patel, S. Raimbault, D. T. E. Whittaker, Chem. Commun. 2007, 43, 4534–4536.
'Dynamic Kinetic and Kinetic Resolution of N-Boc-2-lithiopiperidine'
DOI: 10.1039/b710066c61. I. Coldham, P. O'Brien, J. J. Patel, S. Raimbault, A. J. Sanderson, D. Stead, D. T. E. Whittaker, Tetrahedron: Asymmetry 2007, 18, 2113–2119.
'Asymmetric deprotonation of N-Boc-piperidines'
DOI: 10.1016/j.tetasy.2007.09.00160. I. Coldham, A. J. M. Burrell, L. E. White, H. Adams, N. Oram, Angew. Chem. Int. Ed. 2007, 46, 6159–6162.
'Highly Efficient Synthesis of Tricyclic Amines by Cyclization/Cycloaddition Cascade: Total Syntheses of Aspidospermine, Aspidospermidine and Quebrachamine'
DOI: 10.1002/anie.20070194359. I. Coldham, B. C. Dobson, S. R. Fletcher, A. I. Franklin, Eur. J. Org. Chem. 2007, 2676–2686.
'Intramolecular Dipolar Cycloaddition Reactions to give Substituted Indoles - a Formal Synthesis of Deethylibophyllidine'
DOI: 10.1002/ejoc.20070004558. I. Coldham, B. C. Dobson, A. I. Franklin, S. R. Fletcher, Tetrahedron Lett. 2007, 48, 873–875.
'Synthesis of Tetracyclic Indole-containing Ring Systems by Intramolecular Cycloadditions of Azomethine Ylides'
DOI: 10.1016/j.tetlet.2006.11.130
'Dynamic Kinetic and Kinetic Resolution of N-Boc-2-lithiopiperidine'
DOI: 10.1039/b710066c61. I. Coldham, P. O'Brien, J. J. Patel, S. Raimbault, A. J. Sanderson, D. Stead, D. T. E. Whittaker, Tetrahedron: Asymmetry 2007, 18, 2113–2119.
'Asymmetric deprotonation of N-Boc-piperidines'
DOI: 10.1016/j.tetasy.2007.09.00160. I. Coldham, A. J. M. Burrell, L. E. White, H. Adams, N. Oram, Angew. Chem. Int. Ed. 2007, 46, 6159–6162.
'Highly Efficient Synthesis of Tricyclic Amines by Cyclization/Cycloaddition Cascade: Total Syntheses of Aspidospermine, Aspidospermidine and Quebrachamine'
DOI: 10.1002/anie.20070194359. I. Coldham, B. C. Dobson, S. R. Fletcher, A. I. Franklin, Eur. J. Org. Chem. 2007, 2676–2686.
'Intramolecular Dipolar Cycloaddition Reactions to give Substituted Indoles - a Formal Synthesis of Deethylibophyllidine'
DOI: 10.1002/ejoc.20070004558. I. Coldham, B. C. Dobson, A. I. Franklin, S. R. Fletcher, Tetrahedron Lett. 2007, 48, 873–875.
'Synthesis of Tetracyclic Indole-containing Ring Systems by Intramolecular Cycloadditions of Azomethine Ylides'
DOI: 10.1016/j.tetlet.2006.11.130
2006
2006
57. C. Stratmann, G. Christoph, I. Coldham, D. Hoppe, Org. Lett. 2006, 8, 4469–4471.
'Asymmetric Synthesis of 3-Hydroxy-pyrrolidines via Tin–Lithium Exchange and Cyclization'
DOI: 10.1021/ol061615p56. I. Coldham, S. Dufour, T. F. N. Haxell, J. J. Patel, G. Sanchez-Jimenez, J. Am. Chem. Soc. 2006, 128, 10943–10951.
'Dynamic Thermodynamic and Dynamic Kinetic Resolution of 2-Lithiopyrrolidines'
DOI: 10.1021/ja061963m
'Asymmetric Synthesis of 3-Hydroxy-pyrrolidines via Tin–Lithium Exchange and Cyclization'
DOI: 10.1021/ol061615p56. I. Coldham, S. Dufour, T. F. N. Haxell, J. J. Patel, G. Sanchez-Jimenez, J. Am. Chem. Soc. 2006, 128, 10943–10951.
'Dynamic Thermodynamic and Dynamic Kinetic Resolution of 2-Lithiopyrrolidines'
DOI: 10.1021/ja061963m
2005
2005
55. I. Coldham, R. Hufton, Chem. Rev. 2005, 105, 2765–2810.
'Intramolecular Dipolar Cycloaddition Reactions of Azomethine Ylides'
DOI: 10.1021/cr040004c54. I. Coldham, S. M. Pih, R. Rabot, Synlett 2005, 1743–1745.
'Dipolar Cycloaddition and Ring-Closing Metathesis in the Synthesis of the Tetracyclic ABCE Ring System of Manzamine A'
DOI: 10.1055/s-2005-87153853. I. Coldham, J. J. Patel, G. Sanchez-Jimenez, Chem. Commun. 2005, 41, 3083–3085.
'Dynamic Kinetic Resolution of N-Boc-2-lithiopyrrolidine'
DOI: 10.1039/B504015A52. R. E. Gawley, R. Klein, N. J. Ashweek, I. Coldham, Tetrahedron 2005, 61, 3271–3280.
'NMR Structural Studies of {6Li} 2-Lithiopyrrolidines'
DOI: 10.1016/j.tet.2005.01.09851. I. Coldham, S. Dufour, T. F. N. Haxell, G. P. Vennall, Tetrahedron 2005, 61, 3205–3220.
'Dynamic Resolution of N-Alkyl-2-lithiopyrrolidines with the Chiral Ligand (–)-Sparteine'
DOI: 10.1016/j.tet.2005.01.09650. N. J. Ashweek, P. Brandt, I. Coldham, S. Dufour, R. E. Gawley, F. Haeffner, R. Klein, G. Sanchez-Jimenez, J. Am. Chem. Soc. 2005, 127, 449–457.
'The Barrier to Enantiomerization of Unstabilized, Chelated, and Dipole-Stabilized 2-Lithiopyrrolidines'
DOI: 10.1021/ja048090l
'Intramolecular Dipolar Cycloaddition Reactions of Azomethine Ylides'
DOI: 10.1021/cr040004c54. I. Coldham, S. M. Pih, R. Rabot, Synlett 2005, 1743–1745.
'Dipolar Cycloaddition and Ring-Closing Metathesis in the Synthesis of the Tetracyclic ABCE Ring System of Manzamine A'
DOI: 10.1055/s-2005-87153853. I. Coldham, J. J. Patel, G. Sanchez-Jimenez, Chem. Commun. 2005, 41, 3083–3085.
'Dynamic Kinetic Resolution of N-Boc-2-lithiopyrrolidine'
DOI: 10.1039/B504015A52. R. E. Gawley, R. Klein, N. J. Ashweek, I. Coldham, Tetrahedron 2005, 61, 3271–3280.
'NMR Structural Studies of {6Li} 2-Lithiopyrrolidines'
DOI: 10.1016/j.tet.2005.01.09851. I. Coldham, S. Dufour, T. F. N. Haxell, G. P. Vennall, Tetrahedron 2005, 61, 3205–3220.
'Dynamic Resolution of N-Alkyl-2-lithiopyrrolidines with the Chiral Ligand (–)-Sparteine'
DOI: 10.1016/j.tet.2005.01.09650. N. J. Ashweek, P. Brandt, I. Coldham, S. Dufour, R. E. Gawley, F. Haeffner, R. Klein, G. Sanchez-Jimenez, J. Am. Chem. Soc. 2005, 127, 449–457.
'The Barrier to Enantiomerization of Unstabilized, Chelated, and Dipole-Stabilized 2-Lithiopyrrolidines'
DOI: 10.1021/ja048090l
2004
2004
49. W. Carruthers, I. Coldham, 'Modern Methods of Organic Synthesis'
4th edition, CUP, Cambridge, 2004 (493 printed pages)
ISBN 9780521778305
4th edition, CUP, Cambridge, 2004 (493 printed pages)
ISBN 9780521778305
48. Y. Boursereau, I. Coldham, Bioorg. Med. Chem. Lett. 2004, 14, 5841–5844.
'Synthesis and Biological Studies of 1-Amino beta-Carbolines'
DOI: 10.1016/j.bmcl.2004.09.03647. R. E. Gawley, I. Coldham, 'The Chemistry of Organolithium Compounds'
eds. Z. Rappoport, I. Marek, Wiley, 2004, Ch. 16, p. 997–1053.
'α-Amino-organolithium Compounds'
ISBN 978-0-470-84339-0
'Synthesis and Biological Studies of 1-Amino beta-Carbolines'
DOI: 10.1016/j.bmcl.2004.09.03647. R. E. Gawley, I. Coldham, 'The Chemistry of Organolithium Compounds'
eds. Z. Rappoport, I. Marek, Wiley, 2004, Ch. 16, p. 997–1053.
'α-Amino-organolithium Compounds'
ISBN 978-0-470-84339-0
2003
2003
46. I. Coldham, K. N. Price, R. E. Rathmell, Org. Biomol. Chem. 2003, 1, 2111–2119.
'Intramolecular Carbolithiation Reactions for the Preparation of 3-Alkenylpyrrolidines'
DOI: 10.1039/B303670G45. N. J. Ashweek, I. Coldham, T. F. N. Haxell, S. Howard, Org. Biomol. Chem. 2003, 1, 1532–1544.
'Preparation of Diamines by Lithiation–Substitution of Imidazolidines and Pyrimidines'
DOI: 10.1039/B301502E
'Intramolecular Carbolithiation Reactions for the Preparation of 3-Alkenylpyrrolidines'
DOI: 10.1039/B303670G45. N. J. Ashweek, I. Coldham, T. F. N. Haxell, S. Howard, Org. Biomol. Chem. 2003, 1, 1532–1544.
'Preparation of Diamines by Lithiation–Substitution of Imidazolidines and Pyrimidines'
DOI: 10.1039/B301502E
2002
2002
44. I. Coldham, S. Dufour, T. F. N. Haxell, S. Howard, G. P. Vennall, Angew. Chem. Int. Ed. 2002, 41, 3887–3889.
'Enantioselective Synthesis of Substituted Pyrrolidines by Dynamic Resolution'
DOI: 10.1002/1521-3773(20021018)41:20<3887::AID-ANIE3887>3.0.CO;2-J43. I. Coldham, K. M. Crapnell, J.-C. Fernandez, J. D. Moseley, R. Rabot, J. Org. Chem. 2002, 67, 6181–6187.
'Synthesis of the ABC Ring System of Manzamine A'
DOI: 10.1021/jo016376s42. I. Coldham, G.P. Vennall, 'Science of Synthesis'
eds. E. J. Thomas and M. Moloney, Georg Thieme Verlag, 2002, Vol. 5, p. 451–461.
'1-Halo-, 1-Hydroxy-, 1-Alkoxy-, and 1-Aminoalkylstannanes'
ISBN 978-0-865-77944-041. I. Coldham, G.P. Vennall, 'Science of Synthesis'
eds. E. J. Thomas and M. Moloney, Georg Thieme Verlag, 2002, Vol. 5, p. 441–450.
'1-Halo-, 1-Alkoxy-, and 1-Aminovinylstannanes'
ISBN 978-0-865-77944-040. N. J. Ashweek, I. Coldham, D. J. Snowden, G. P. Vennall, Chem. Eur. J. 2002, 8, 195–207.
'Intramolecular Carbolithiation Reactions of Chiral α-Amino-organolithium Species'
DOI: 10.1002/1521-3765(20020104)8:1<195::AID-CHEM195>3.0.CO;2-H
'Enantioselective Synthesis of Substituted Pyrrolidines by Dynamic Resolution'
DOI: 10.1002/1521-3773(20021018)41:20<3887::AID-ANIE3887>3.0.CO;2-J43. I. Coldham, K. M. Crapnell, J.-C. Fernandez, J. D. Moseley, R. Rabot, J. Org. Chem. 2002, 67, 6181–6187.
'Synthesis of the ABC Ring System of Manzamine A'
DOI: 10.1021/jo016376s42. I. Coldham, G.P. Vennall, 'Science of Synthesis'
eds. E. J. Thomas and M. Moloney, Georg Thieme Verlag, 2002, Vol. 5, p. 451–461.
'1-Halo-, 1-Hydroxy-, 1-Alkoxy-, and 1-Aminoalkylstannanes'
ISBN 978-0-865-77944-041. I. Coldham, G.P. Vennall, 'Science of Synthesis'
eds. E. J. Thomas and M. Moloney, Georg Thieme Verlag, 2002, Vol. 5, p. 441–450.
'1-Halo-, 1-Alkoxy-, and 1-Aminovinylstannanes'
ISBN 978-0-865-77944-040. N. J. Ashweek, I. Coldham, D. J. Snowden, G. P. Vennall, Chem. Eur. J. 2002, 8, 195–207.
'Intramolecular Carbolithiation Reactions of Chiral α-Amino-organolithium Species'
DOI: 10.1002/1521-3765(20020104)8:1<195::AID-CHEM195>3.0.CO;2-H
2001
2001
39. I. Coldham, R. C. B. Copley, T. F. N. Haxell, S. Howard, Org. Lett. 2001, 3, 3799–3801.
'Synthesis of Chiral 1,2-Diamines by Asymmetric Lithiation–Substitution'
DOI: 10.1021/ol016818m38. I. Coldham, K. M. Crapnell, J. D. Moseley, R. Rabot, J. Chem. Soc., Perkin Trans. 1 2001, 1758–1763.
'Intramolecular Azomethine Ylide Cycloaddition Reactions to give Octahydroindoles'
DOI: 10.1039/B104390K37. I. Coldham, R. Hufton, K. N. Price, R. E. Rathmell, D. J. Snowden and G. P. Vennall, Synthesis 2001, 1523–1531.
'Stereoselective Synthesis of Pyrrolidines and Pyrrolizidines by Intramolecular Carbolithiation'
DOI: 10.1055/s-2001-16074
'Synthesis of Chiral 1,2-Diamines by Asymmetric Lithiation–Substitution'
DOI: 10.1021/ol016818m38. I. Coldham, K. M. Crapnell, J. D. Moseley, R. Rabot, J. Chem. Soc., Perkin Trans. 1 2001, 1758–1763.
'Intramolecular Azomethine Ylide Cycloaddition Reactions to give Octahydroindoles'
DOI: 10.1039/B104390K37. I. Coldham, R. Hufton, K. N. Price, R. E. Rathmell, D. J. Snowden and G. P. Vennall, Synthesis 2001, 1523–1531.
'Stereoselective Synthesis of Pyrrolidines and Pyrrolizidines by Intramolecular Carbolithiation'
DOI: 10.1055/s-2001-16074
2000
2000
36. I. Coldham, G.P. Vennall, Chem. Commun. 2000, 1569–1570.
'Chiral Organolithium Species: Determination of the Rate of Cyclization and Extent of Racemization'
DOI: 10.1039/B004519P35. I. Coldham, J.-C. Fernandez, K. N. Price, D. J. Snowden, J. Org. Chem. 2000, 65, 3788–3795.
'Intramolecular Carbolithiation Reactions for the Preparation of Azabicyclo[2.2.1]heptanes'
DOI: 10.1021/jo000088z34. N. J. Ashweek, I. Coldham, G. P. Vennall, Tetrahedron Lett. 2000, 41, 2235–2237.
'A Convenient Route to N-Alkyl-2-tributylstannyl-pyrrolidines Involving Reductive Amination'
DOI: 10.1016/S0040-4039(00)00137-433. A. P. A. Arboré, D. J. Cane-Honeysett, I. Coldham, M. L. Middleton, Synlett 2000, 236–238.
'A Rapid Approach to Amino-Acid Derivatives by [2,3]-Stevens Rearrangement'
DOI: 10.1055/s-2000-6494
'Chiral Organolithium Species: Determination of the Rate of Cyclization and Extent of Racemization'
DOI: 10.1039/B004519P35. I. Coldham, J.-C. Fernandez, K. N. Price, D. J. Snowden, J. Org. Chem. 2000, 65, 3788–3795.
'Intramolecular Carbolithiation Reactions for the Preparation of Azabicyclo[2.2.1]heptanes'
DOI: 10.1021/jo000088z34. N. J. Ashweek, I. Coldham, G. P. Vennall, Tetrahedron Lett. 2000, 41, 2235–2237.
'A Convenient Route to N-Alkyl-2-tributylstannyl-pyrrolidines Involving Reductive Amination'
DOI: 10.1016/S0040-4039(00)00137-433. A. P. A. Arboré, D. J. Cane-Honeysett, I. Coldham, M. L. Middleton, Synlett 2000, 236–238.
'A Rapid Approach to Amino-Acid Derivatives by [2,3]-Stevens Rearrangement'
DOI: 10.1055/s-2000-6494
Pre-2000
Pre-2000
32. I. Coldham, S. J. Coles, K. M. Crapnell, J.-C. Fernandez, T. F. N. Haxell, M. B. Hursthouse, J. D. Moseley, A. B. Treacy, Chem. Commun. 1999, 1757–1758.
'A New, Stereoselective Approach to the Manzamine Alkaloids'31. J. E. H. Buston, I. Coldham, K. R. Mulholland, J. Chem. Soc., Perkin Trans. 1 1999, 2327–2334.
'Meisenheimer Rearrangements of N-Allyl 2-Azabornane Derivatives'30. I. Coldham, J.-C. Fernandez, D. J. Snowden, Tetrahedron Lett. 1999, 40, 1819–1822.
'Synthesis of 7-Azabicyclo[2.2.1]heptanes by Anionic Cyclization'29. I. Coldham, R. A. Judkins, D. R. Witty, Tetrahedron 1998, 54, 14255–14264.
'Proton Abstraction and Electrophilic Quench at C-2 of Imidazolidines'28. I. Coldham, M. L. Middleton, P. L. Taylor, J. Chem. Soc., Perkin Trans. 1 1998, 2817–2821.
'Investigations into the [2,3]-Aza-Wittig Rearrangement of N-Alkyl N-Allyl α-Amino Esters'27. J. E. H. Buston, I. Coldham, K. R. Mulholland, Tetrahedron: Asymmetry 1998, 9, 1995–2009.
'Studies into the Asymmetric Meisenheimer Rearrangement'26. I. Coldham, P. M. A. Houdayer, R. A. Judkins, D. R. Witty, Synthesis 1998, 1463–1466.
'N,N'-Bisacylimidazolidines from 1,2-Diamines'25. I. Coldham, J. Chem. Soc., Perkin Trans. 1 1998, 1343–1364.
'Main Group Organometallics in Synthesis'24. I. Coldham, M. M. S. Lang-Anderson, R. E. Rathmell, D. J. Snowden, Tetrahedron Lett. 1997, 38, 7621–7624.
'Synthesis of Pyrrolidines by Anionic Cyclization onto Allylic Ethers, Alkynes and Carboxylic Groups'23. I. Coldham, R. Hufton, R. E. Rathmell, Tetrahedron Lett. 1997, 38, 7617–7620.
'Stereoselective Anionic Cyclizations to Pyrrolidines'22. I. Coldham, M. L. Middleton, P. L. Taylor, J. Chem. Soc., Perkin Trans. 1 1997, 2951–2952.
'N-Alkylation and [2,3]-Sigmatropic Rearrangement of N-Allyl α-Amino Esters'21. I. Coldham, S. Holman, M. M. S. Lang-Anderson, J. Chem. Soc., Perkin Trans. 1 1997, 1481–1485.
'Preparation of β-Amino-alcohols by Carbon-Carbon Bond Formation using Substituted Lithiomethylpyrrolidines'20. I. Coldham, Contemporary Organic Synthesis 1997, 136–163.
'Main Group Organometallics in Synthesis'19. J. E. H. Buston, I. Coldham, K. R. Mulholland, Synlett 1997, 322–324.
'Chirality Transfer from Nitrogen to Carbon in the [2,3]-Meisenheimer Rearrangement'18. I. Coldham, P. M. A. Houdayer, R. A. Judkins, D. R. Witty, Synlett 1996, 1109–1111.
'One-Pot Synthesis of N,N'-Bisacylimidazolidines; Potential New Acyl Anion Equivalents'17. I. Coldham, R. Hufton, Tetrahedron 1996, 52, 12541–12552.
'Synthesis of 3-Alkylpyrrolidines by Anionic Cyclization'16. I. Coldham, A. J. Collis, R. J. Mould, Electronic Conference on Heterocyclic Chemistry eds. H. Rzepa and J. Snyder, 1996, page:
http://www.ch.ic.ac.uk/ectoc/echet96/papers/012
'Vinylaziridines from vinylepoxides'15. I. Coldham, R. Hufton, D. J. Snowden, J. Am. Chem. Soc. 1996, 118, 5322–5323.
'Anionic Cyclizations of α-Aminoorganolithiums. Determination of the Stereoselectivity at the Carbanion Center and the Synthesis of (+)-Pseudoheliotridane'14. I. Coldham, A. J. Collis, R. J. Mould, R. E. Rathmell, J. Chem. Soc., Perkin Trans. 1 1995, 2739–2745.
'Synthesis of 4-Phenylpiperidines by tandem Wittig Olefination-Aza-Wittig Rearrangement of 2-Benzoylaziridines'13. I. Coldham, A. J. Collis, R. J. Mould, D. E. Robinson, Synthesis 1995, 1147–1150.
'Pyrrolidines by 1,3-Dipolar Cycloaddition of Conjugated Azomethine Ylides'12. I. Coldham, A. J. Collis, R. J. Mould, R. E. Rathmell, Tetrahedron Lett. 1995, 36, 3557–3560.
'Ring Expansion of Aziridines to Piperidines using the Aza-Wittig Rearrangement'11. I. Coldham, R. Hufton, Tetrahedron Lett. 1995, 36, 2157–2160.
'A New Route to Cyclic Amines by Anionic Cyclization'10. I. Coldham, 'Comprehensive Organic Functional Group Transformations'
eds. A. R. Katritzky, O. Meth-Cohn and C. W. Rees, Pergamon, Oxford, 1995, Vol. 1, p. 377–423.
'One or More CH and/or CC Bond(s) by Rearrangement'9. P. Magnus, J. Lacour, I. Coldham, B. Mugrage, W. B. Bauta, Tetrahedron 1995, 51, 11087–11100.
'New Trialkylsilyl Enol Ether Chemistry: α-N-Tosylamination of Triisopropylsilyl Enol Ethers'8. I. Coldham, J. Chem. Soc., Perkin Trans. 1 1993, 1275–1276.
'Aza-Wittig Rearrangements and Cyclizations by Transmetallation of N-Benzylaminomethylstannanes'7. I. Coldham, S. Warren, J. Chem. Soc., Perkin Trans. 1 1993, 1637–1656.
'Synthesis of Cyclic Amines and Allylic Sulfides by Phenylthio Migration of β-Hydroxy Sulfides'6. I. Coldham, S. Warren, J. Chem. Soc., Perkin Trans. 1 1993, 2303–2307.
'Stereospecific Phenylthio Migrations in the Synthesis of Spirocyclic Lactones and Ethers from N-Methyl-4-Piperidone and Quinuclidin-3-one'5. P. Magnus, I. Coldham, J. Am. Chem. Soc. 1991, 113, 672–673.
'New Trialkylsilyl Enol Ether Chemistry. Synthesis of the Benzomorphanone Core Structure Using a Stereoelectronic Conformational Lock'4. V. K. Aggarwal, I. Coldham, S. McIntyre, S. Warren, J. Chem. Soc., Perkin Trans. 1 1991, 451–460.
'Transformation of Cyclic α-Phenylthio Aldehydes by Stereoselective Aldol Reactions and Phenylthio Migration into Spirocyclic Lactones and Ethers, and E-Allylic Alcohols with 1,4-Related Chiral Centres'3. I. Coldham, S. Warren, Tetrahedron Lett. 1989, 30, 5937–5940.
'Stereocontrolled Amidocyclizations with Phenylthio Migration'2. I. Coldham, E. W. Collington, P. Hallett, S. Warren, Tetrahedron Lett. 1988, 29, 5321–5324.
'Stereochemically Controlled Synthesis of Spirocyclic Lactones and Ethers from N-Methyl-4-Piperidone and 3-Quinuclidinone by Phenylthio Migration'1. V. K. Aggarwal, I. Coldham, S. McIntyre, F. H. Sansbury, M.-J. Villa, S. Warren, Tetrahedron Lett. 1988, 29, 4885–4888.
'Stereochemical Control in the Synthesis of Tetrahydrofurans by Cyclization of Diols with Phenylthio Migration'
'A New, Stereoselective Approach to the Manzamine Alkaloids'31. J. E. H. Buston, I. Coldham, K. R. Mulholland, J. Chem. Soc., Perkin Trans. 1 1999, 2327–2334.
'Meisenheimer Rearrangements of N-Allyl 2-Azabornane Derivatives'30. I. Coldham, J.-C. Fernandez, D. J. Snowden, Tetrahedron Lett. 1999, 40, 1819–1822.
'Synthesis of 7-Azabicyclo[2.2.1]heptanes by Anionic Cyclization'29. I. Coldham, R. A. Judkins, D. R. Witty, Tetrahedron 1998, 54, 14255–14264.
'Proton Abstraction and Electrophilic Quench at C-2 of Imidazolidines'28. I. Coldham, M. L. Middleton, P. L. Taylor, J. Chem. Soc., Perkin Trans. 1 1998, 2817–2821.
'Investigations into the [2,3]-Aza-Wittig Rearrangement of N-Alkyl N-Allyl α-Amino Esters'27. J. E. H. Buston, I. Coldham, K. R. Mulholland, Tetrahedron: Asymmetry 1998, 9, 1995–2009.
'Studies into the Asymmetric Meisenheimer Rearrangement'26. I. Coldham, P. M. A. Houdayer, R. A. Judkins, D. R. Witty, Synthesis 1998, 1463–1466.
'N,N'-Bisacylimidazolidines from 1,2-Diamines'25. I. Coldham, J. Chem. Soc., Perkin Trans. 1 1998, 1343–1364.
'Main Group Organometallics in Synthesis'24. I. Coldham, M. M. S. Lang-Anderson, R. E. Rathmell, D. J. Snowden, Tetrahedron Lett. 1997, 38, 7621–7624.
'Synthesis of Pyrrolidines by Anionic Cyclization onto Allylic Ethers, Alkynes and Carboxylic Groups'23. I. Coldham, R. Hufton, R. E. Rathmell, Tetrahedron Lett. 1997, 38, 7617–7620.
'Stereoselective Anionic Cyclizations to Pyrrolidines'22. I. Coldham, M. L. Middleton, P. L. Taylor, J. Chem. Soc., Perkin Trans. 1 1997, 2951–2952.
'N-Alkylation and [2,3]-Sigmatropic Rearrangement of N-Allyl α-Amino Esters'21. I. Coldham, S. Holman, M. M. S. Lang-Anderson, J. Chem. Soc., Perkin Trans. 1 1997, 1481–1485.
'Preparation of β-Amino-alcohols by Carbon-Carbon Bond Formation using Substituted Lithiomethylpyrrolidines'20. I. Coldham, Contemporary Organic Synthesis 1997, 136–163.
'Main Group Organometallics in Synthesis'19. J. E. H. Buston, I. Coldham, K. R. Mulholland, Synlett 1997, 322–324.
'Chirality Transfer from Nitrogen to Carbon in the [2,3]-Meisenheimer Rearrangement'18. I. Coldham, P. M. A. Houdayer, R. A. Judkins, D. R. Witty, Synlett 1996, 1109–1111.
'One-Pot Synthesis of N,N'-Bisacylimidazolidines; Potential New Acyl Anion Equivalents'17. I. Coldham, R. Hufton, Tetrahedron 1996, 52, 12541–12552.
'Synthesis of 3-Alkylpyrrolidines by Anionic Cyclization'16. I. Coldham, A. J. Collis, R. J. Mould, Electronic Conference on Heterocyclic Chemistry eds. H. Rzepa and J. Snyder, 1996, page:
http://www.ch.ic.ac.uk/ectoc/echet96/papers/012
'Vinylaziridines from vinylepoxides'15. I. Coldham, R. Hufton, D. J. Snowden, J. Am. Chem. Soc. 1996, 118, 5322–5323.
'Anionic Cyclizations of α-Aminoorganolithiums. Determination of the Stereoselectivity at the Carbanion Center and the Synthesis of (+)-Pseudoheliotridane'14. I. Coldham, A. J. Collis, R. J. Mould, R. E. Rathmell, J. Chem. Soc., Perkin Trans. 1 1995, 2739–2745.
'Synthesis of 4-Phenylpiperidines by tandem Wittig Olefination-Aza-Wittig Rearrangement of 2-Benzoylaziridines'13. I. Coldham, A. J. Collis, R. J. Mould, D. E. Robinson, Synthesis 1995, 1147–1150.
'Pyrrolidines by 1,3-Dipolar Cycloaddition of Conjugated Azomethine Ylides'12. I. Coldham, A. J. Collis, R. J. Mould, R. E. Rathmell, Tetrahedron Lett. 1995, 36, 3557–3560.
'Ring Expansion of Aziridines to Piperidines using the Aza-Wittig Rearrangement'11. I. Coldham, R. Hufton, Tetrahedron Lett. 1995, 36, 2157–2160.
'A New Route to Cyclic Amines by Anionic Cyclization'10. I. Coldham, 'Comprehensive Organic Functional Group Transformations'
eds. A. R. Katritzky, O. Meth-Cohn and C. W. Rees, Pergamon, Oxford, 1995, Vol. 1, p. 377–423.
'One or More CH and/or CC Bond(s) by Rearrangement'9. P. Magnus, J. Lacour, I. Coldham, B. Mugrage, W. B. Bauta, Tetrahedron 1995, 51, 11087–11100.
'New Trialkylsilyl Enol Ether Chemistry: α-N-Tosylamination of Triisopropylsilyl Enol Ethers'8. I. Coldham, J. Chem. Soc., Perkin Trans. 1 1993, 1275–1276.
'Aza-Wittig Rearrangements and Cyclizations by Transmetallation of N-Benzylaminomethylstannanes'7. I. Coldham, S. Warren, J. Chem. Soc., Perkin Trans. 1 1993, 1637–1656.
'Synthesis of Cyclic Amines and Allylic Sulfides by Phenylthio Migration of β-Hydroxy Sulfides'6. I. Coldham, S. Warren, J. Chem. Soc., Perkin Trans. 1 1993, 2303–2307.
'Stereospecific Phenylthio Migrations in the Synthesis of Spirocyclic Lactones and Ethers from N-Methyl-4-Piperidone and Quinuclidin-3-one'5. P. Magnus, I. Coldham, J. Am. Chem. Soc. 1991, 113, 672–673.
'New Trialkylsilyl Enol Ether Chemistry. Synthesis of the Benzomorphanone Core Structure Using a Stereoelectronic Conformational Lock'4. V. K. Aggarwal, I. Coldham, S. McIntyre, S. Warren, J. Chem. Soc., Perkin Trans. 1 1991, 451–460.
'Transformation of Cyclic α-Phenylthio Aldehydes by Stereoselective Aldol Reactions and Phenylthio Migration into Spirocyclic Lactones and Ethers, and E-Allylic Alcohols with 1,4-Related Chiral Centres'3. I. Coldham, S. Warren, Tetrahedron Lett. 1989, 30, 5937–5940.
'Stereocontrolled Amidocyclizations with Phenylthio Migration'2. I. Coldham, E. W. Collington, P. Hallett, S. Warren, Tetrahedron Lett. 1988, 29, 5321–5324.
'Stereochemically Controlled Synthesis of Spirocyclic Lactones and Ethers from N-Methyl-4-Piperidone and 3-Quinuclidinone by Phenylthio Migration'1. V. K. Aggarwal, I. Coldham, S. McIntyre, F. H. Sansbury, M.-J. Villa, S. Warren, Tetrahedron Lett. 1988, 29, 4885–4888.
'Stereochemical Control in the Synthesis of Tetrahydrofurans by Cyclization of Diols with Phenylthio Migration'