Setting up your Audio device is the best way to minimize possible issues you may encounter during your Skype call.
Steps needed to execute / to Perform
Step 1:
Open your Skype Application
Step 2:
Click the More Options Button
Step 3:
Select "Audio & Video" Menu.
Step 4:
Under Audio Section Scroll down to Microphone then select your Headset / Microphone Device.
Step 5:
Under Audio Section Scroll down to Speakers then select your Headset / Microphone Device.