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TBA) Ring-size selective synthesis of β,γ-bicyclic butenolides via butenolide functionalization approach.
Manuscript in preparation
41) Total synthesis and determination of the absolute configuration of shodoamide C: An amphotericin B potentiator against Candida albicans.
Ueki, S.+; Hirata, A.+; Yagi, A.; Iwahori, M.; Tomoda, H.; Uchida, R.; Nagamitsu, T.;* Ohtawa, M.*
Org. Lett. 2025, 27, 3777-3781.
+U.S. and H.A. contributed equally.
40) Concise syntheses of habiterpenol and 2’,3’-epi-habiterpenol via redox radical cyclization.
Taguchi, H.; Kawaguchi, M.; Nagamitsu, T.*; Ohtawa, M.*
39) One-pot γ-lactonization of homopropargyl alcohol via intramolecular ketene trapping. 〜Its discovery, optimization, and application〜
Ohtawa, M.*
37) (–)-11-O-Debenzoyltashironin および (–)-bilobalide の全合成
大多和 正樹*, Ryan A. Shenvi*
36) Synthesis and evaluation of habiterpenol analogs.
Konya, M.; Arima, S.; Lee, D.; Ohtawa, M.; Shimoyama, K.; Fukuda, T.; Uchida, R.; Tomoda, H.; Yamaotsu, N.; Tanaka, N.; Nagamitsu, T.*
35) 特徴的な生物活性を有する天然有機化合物を基盤とした創薬研究，
全合成，及び反応開発研究 <日本薬学会関東支部奨励賞受賞記念総説>
大多和 正樹*
34) One-pot γ-lactonization of homopropargyl alcohols via intramolecular ketene trapping.
Yamane, D.+; Tanaka, H.+; Hirata, A.+; Tamura, Y.; Takahashi, D.; Takahashi, Y.; Nagamitsu, T.*; Ohtawa, M.*
Org. Lett. 2021, 23, 2831-2835.
+Y.D., T.H. and H.A. contributed equally.
33) Mixture of clopidogrel bisulfate and magnesium oxide tablets reduces clopidogrel dose administered through a feeding tube.
Aoki, M.*; Naya, M.; Arima, S.; Shinohara, K.; Shibuya, K.; Ohtawa, M.; Nagamitsu, T.; Otori, K.
32) Synthesis and mechanistic interrogation of Ginkgo Biloba chemical space en route to (–)-bilobalide.
Demoret, R. M.; Baker, M. A.; Ohtawa, M.; Chen, S.; Lam, C-C.; Foril, S.; Houk, K. N.; Shenvi, R. A.*
31) Repair of DNA damage induced by the novel nucleoside analogue CNDAG through homologous recombination.
Liu, X.; Jiang, Y.; Nowak, B.; Ichikawa, S.; Ohtawa, M.; Matsuda, A.; Plunkett, W.*
30) Concise asymmetric synthesis of (–)-bilobalide.
Baker, M. A.; Demoret, R. M.; Ohtawa, M.*; Shenvi, R. A.*
Highlighted in Synfacts. / Highlighted in Org. Chem. Highlights.
29) Total synthesis and absolute configuration of simpotentin, a potentiator of amphotericin B activity.
Ohtawa, M.; Shimizu, E.; Saito, A.; Sakamoto, S.; Waki, A.; Kondo, A.; Yagi, A.; Uchida, R.; Tomoda, H.; Nagamitsu, T.*
28) Structure-activity relationship studies of atpenin A5 analogs with chemical modification of the side chain moiety.
Ohtawa, M.; Yano, K.; Miyao, A.; Hiura, T.; Sugiyama, K.; Arima, S.; Kita, K.; Omura, S.; Nagamitsu, T.*
27) Total synthesis of 4’-epi-atpenin A5 as a potent nematode complex II inhibitor.
Lee, D.; Kondo, H.; Kuwayama, Y.; Takahashi, K.; Arima, S.; Ohtawa, M.*; Nagamitsu, T.*
Tetrahedron (invited), 2019, 75, 3178-3185.
Special issue in honor of Ryan Shenvi's receipt of the 2019 Tetrahedron Young Investigator Award
26) Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide receals a non-convulsant signature and potential for progression in neurodegenerative disease studies.
Witkin, J. M.*; Shenvi, R. A.; Li, X.; Gleason, S. D.; Weiss, J.; Morrow, D.; Catow, J. T.; Wakulchik, M.; Ohtawa, M.; Lu, H-H.; Martinez, M. D.; Schkeryantzs, J. M.; Carpenter, T. S.; Lightstone, F. C.; Cerne, R.
25) Design and synthesis of A-ring simplified pyripyropene A analogs as potent and selective synthetic SOAT2 inhibitors.
Ohtawa, M.; Arima, S.; Ichida, N.; Terayama, T.; Ohno, H.; Yamazaki, H.; Kobayashi, K.; Ohshiro, T.; Matsuda, D.; Sato, N.; Omura, H.; Tomoda, H.; Nagamitsu, T.*
ChemMedChem 2018, 13, 411-421.
–Selected as a Front Cover on ChemMedChem for Issue 5, 2018–
24) Novel polyketides with two linked scoop-like moieties produced by Streptomyces sp. BYK11038.
Uchida, R.; Lee, D.; Suwa, I.; Ohtawa, M.; Watanabe, N.; Demachi, A.; Ohte, S.; Katagiri, T.; Nagamitsu, T.*; Tomoda, H.*
23) Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside and alkaloid derivatives.
Fujii, H.*; Shimada, N.; Ohtawa, M.; Karaki, F.; Koshizuka, M.; Hayashida, K.; Kamimura, M.; Makino, K.; Nagamitsu, T.; Nagase, H.
22) Synthesis of (–)-11-O-debenzoyltashironin: Neurotrophic sesquiterpenes cause hyperexcitation.
Ohtawa, M.; Krambis, M. J.; Cerne, R.; Schkeryantz, J. M.; Witkin, J. M.; Shenvi, R. A.*
J. Am. Chem. Soc. 2017, 139, 9637-9644.
–Among the top 20 most read article on J. Am. Chem. Soc. for July 2017–
21) Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor.
Ohtawa, M.; Arima, S.; Shimizu, R.; Hanatani, N.; Shimizu, E.; Shiomi, K.; Kita, K.; Omura, S.; Nagamitsu. T.*
20) Simpifungin and valsafungins, antifungal antibiotics of fungal origin.
Ishijima, H.; Uchida, R.; Ohtawa, M.; Kondo, A.; Nagai, K.; Shima, K.; Nonaka, K.; Masuma, R.; Iwamoto, S.; Onodera, H.; Nagamitsu, T.; Tomoda, H.*
19) Total synthesis and structure revision of cyslabdan.
Ohtawa, M.; Hishinuma, Y.; Takagi, E.; Yamada, T.; Ito, F.; Uchida, R.; Kim, Y. P.; Omura, S.; Tomoda, H.; Nagamitsu. T.*
18) New pyripyropene derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse model.
Ohshiro, T.; Ohtawa, M.; Nagamitsu, T.; Matsuda, D.; Yagyu, H.; Davis, M. A.; Rudel, L. L.; Ishibashi, S.; Tomoda, H.*
17) Design, synthesis and biological evaluation of air-stable nafuredin-γ analogs as complex II inhibitors.
Ohtawa, M.; Matsunaga, M.; Fukunaga, K.; Shimizu, R.; Shimizu, E.; Arima, S.; Ohmori, J.; Kita, K.; Shiomi, K.; Omura, S.; Nagamitsu. T.*
16) Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.
Yamamuro, D.; Uchida, R.; Ohtawa, M.; Arima, S.; Futamura, Y.; Katane, M.; Homma, H.; Nagamitsu. T.; Osada, H.; Tomoda, H.*
15) In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.
Ohshiro, T.; Matsuda, D.; Ohtawa, M.; Yamazaki, H.; Nagamitsu. T.; Tomoda, H.*
13) Regioselective mono-deprotection of di-tert-butylsilylene acetal derived from 1,3-diol with ammonium fluoride.
Ohtawa, M.; Tomoda, H.; Nagamitsu. T.*
12) 新規脂質異常症予防治療薬を指向したACAT2選択的阻害剤pyripyropene Aの構造活性相関研究
大多和 正樹, 大村 智, 供田 洋, 長光 亨*
11) Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 3
Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L. L.; Omura, S.; Tomoda, H.; Nagamitsu. T.*
10) Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2
Ohtawa, M.; Yamazaki, H.; Matsuda, D.; Ohshiro, T.; Rudel, L. L.; Omura, S.; Tomoda, H.; Nagamitsu. T.*
9) Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1
Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L. L.; Omura, S.; Tomoda, H.; Nagamitsu. T.*
8) Stereoselective total synthesis of atpenins A4 and B, harzianopyridone, and NBRI23477B.
Ohtawa, M.; Sugiyama, K.; Hiura, T.; Izawa, S.; Shiomi, K.; Omura, S.; Nagamitsu, T.*
7) Potentiation of bleomycin in Jurket cells by fungal pycnidion.
Kaneko, M.; Matsuda, D.; Ohtawa, M.; Fukuda, T.; Nagamitsu, T.; Yamori, T.; Tomoda, H.*
6) Total synthesis of pyripyropene A.
Odani, A.; Ishihara, K.; Ohtawa, M.; Tomoda, H.; Omura, S.; Nagamitsu, T.*
5) Enantioselective total synthesis of atpenin A5.
Ohtawa, M.; Ogihara, S.; Sugiyama, K.; Shiomi, K.; Harigaya, Y.; Nagamitsu, T.; Omura, S.*
4) 9-(2-C-Cyano-2-deoxy-β-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with kaposi's sarcoma-associated herpesvirus.
Ichikawa, S.; Ohtawa, M.; Teishikata, Y.; Yamada, K.; Fujimuro, M.; Yokosawa, H.; Matsuda, A.*
Nucleic Acids Symposium Series 2009, 53, 95-96.
3) Selectivity of pyripyropene derivatives in inhibition toward Acyl-CoA:cholesterol acyl transferase 2 isozyme.
Ohshiro, T.; Ohte, S.; Matsuda, D.; Ohtawa, M.; Nagamitsu, T.; Sunazuka, T.; Harigaya, Y.; Rudel, L. L.; Omura, S.; Tomoda, H.*
2) The total synthesis and biological evaluation of nafuredin-γ and its analogues.
Nagamitsu, T.; Takano, D.; Seki, M.; Arima, S.; Ohtawa, M.; Shiomi, K.; Harigaya, Y.; Omura, S.*
1) 9-(2-C-Cyano-2-deoxy-β-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with kaposi's sarcoma-associated herpesvirus.
Ohtawa, M.; Ichikawa, S.; Teishikata, Y.; Fujimuro, M.; Yokosawa, H.; Matsuda, A.*
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