Home
"A true creative researcher has to have confidence in nonsense. It is not research unless half of the people involved think what you're trying to do is impossible" - Burt Rutan
Our lab researches synapse biology and neuron function and how synapse contributes to behavior in brain disorders. We study the changes in synapse structure and function in neurons. We focus on the signaling pathways and receptor trafficking mechanisms that control synaptic transmission and synapse strength. Many of our studies are conducted in cultured neurons, a highly versatile system for analyzing synapse function. We also employ genetically modified mice to study brain function and diseases. We extensively use techniques of cell biology, calcium imaging, biochemistry, and behavioral analysis, as well as electrophysiology to deduce molecular mechanisms that control synapses and behavior.