S.M. Waldherr, M. Han, A. Saxton, T.A. Vadset, P. McMillan, J. Wheeler, N.F. Liachko, B.C. Kraemer. 2024. Endoplasmic reticulum unfolded protein response XBP-1s transcriptional targets mediate rescue from tauopathy. Communications Biology. 

M. Han, A. Saxton, H. Currey, S. Waldherr, N.F. Liachko, B.C. Kraemer. 2024. Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in C. elegans. Disease Models and Mechanisms. Mar 12:dmm05473. PMID: 38469687. 

V.S. Jadhav, J.G. Stair, R.J. Eck, S.N. Smukowski, H. Currey, L.G. Toscano, J.C. Hincks, C.S. Latimer, P.N. Valdmanis, B.C. Kraemer, N.F. Liachko. 2024. Transcriptomic evaluation of tau and TDP-43 synergy shows tauopathy predominance and reveals potential modulating targets. Neurobiology of Disease. Feb 18:106441. 

R.J. Eck, J.G. Stair, B.C. Kraemer, N.F. Liachko. 2024. Simple models to understand complex disease: 10 years of progress from C. elegans models of amyotrophic lateral sclerosis. Frontiers in Neuroscience. Jan 4;17:1300705. 

Currey, H. N., Kraemer, B. C., & Liachko, N. F. (2023). sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity. microPublication biology, 2023, 10.17912/micropub.biology.000844. 

McMillan, P. J., Benbow, S. J., Uhrich, R., Saxton, A., Baum, M., Strovas, T., Wheeler, J. M., Baker, J., Liachko, N. F., Keene, C. D., Latimer, C. S., & Kraemer, B. C. (2023). Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change. Brain : a journal of neurology, 146(8), 3206–3220.

Eck, R. J., Kow, R. L., Black, A. H., Liachko, N. F., & Kraemer, B. C. (2023). SPOP loss of function protects against tauopathy. Proceedings of the National Academy of Sciences of the United States of America, 120(1), e2207250120.

C.S. Latimer, J. Stair, J.C. Hincks, H.N. Currey, T.D. Bird, C.D. Keene, B.C. Kraemer, N.F. Liachko. 2022. TDP-43 promotes pathological tau phosphorylation and selective neurotoxicity. Disease Models and Mechanisms. Apr 1; 15(4). 

R.L. Kow, A.H. Black, A.D. Saxton, N.F. Liachko, B.C. Kraemer. 2022. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. GeroScience. Apr;44(2):747-761. 

H.N. Currey, N.F. Liachko. 2021. Evaluation of motor impairment in C. elegans models of amyotrophic lateral sclerosis (ALS). Journal of Visualized Experiments. September 2; (175). 

C.S. Latimer, N.F. Liachko. 2021. tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease (LOAD). GeroScience, Aug;43(4):1605-1614. 

R.J. Eck, B.C. Kraemer, N.F. Liachko. 2021. Regulation of TDP-43 Phosphorylation in Aging and Disease. GeroScience. Aug;43(4):1627-1634. 

P. McMillan†, J. Wheeler†, R.E. Gatlin, L. Taylor, T. Strovas, M. Baum, T.D. Bird, C. Latimer, C.D. Keene, B.C. Kraemer, N.F. Liachko. †Authors contributed equally. 2020. Adult onset pan-neuronal human Tau Tubulin Kinase 1 expression causes severe cerebellar neurodegeneration in mice reminiscent of human spinal cerebellar ataxia disorders. Acta Neuropathologica Communications. Nov 23;8(1):200. 

E. Rojas, L. Martinez-Gonzalez, N.F. Liachko, C. Perez, B. Monti, B.C. Kraemer, D. I. Perez, A. Martin-Requero, C. Gil, A. Martinez. 2020. Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: a new therapeutic approach for amyotrophic lateral sclerosis. European Journal of Medicinal Chemistry. Oct 28:112968. 

H.N. Currey, A. Melinkevich, P. Melquist, N.F. Liachko. 2020. ARENA-based activity profiling of tau and TDP-43 transgenic C. elegans. microPublication Biology. July 16;2020:10.17912. 

J.M. Wheeler, P.J. McMillan, T.J. Strovas, N.F. Liachko, A. Amelie-Wolf, R.L. Klein, P. Szot, L. Robinson, H. Currey, C. Guthrie, M.A. Behlke, N.M. Kanaan, M. Raskind, E. Peskind, J.Q. Trojanowski, V.M.Y. Lee, L.-S. Wang, C.D. Keene, T.D. Bird, G.D. Schellenberg, B.C. Kraemer. 2019. The poly(A) binding protein MSUT2 controls resilience to both pathological tau and gliosis. Science Translational Medicine. Dec 18; 11(523). 

N. F. Liachko†, A. D. Saxton†, P. J. McMillan, T. Strovas, C. D. Keene, T. D. Bird, B. C. Kraemer. †Authors contributed equally. 2019.  Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.  PLoS Genetics. Dec 13;15(12). 

M. Bartoletti†, D. Bosco†, S. Da Cruz†, C. Lagier-Tourenne†, N. Liachko†, S. Markmiller†, K. Webster, K. Wharton. †Authors contributed equally. 2019. Phenotypic suppression of ALS/FTD-associated neurodegeneration highlights mechanisms of dysfunction. J Neuroscience. 16 October; 39(42) 8217-8224. 

S.M. Waldherr, T.A. Vadset, T.J. Strovas, N.F. Liachko, B.C. Kraemer. 2019. Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau. Nature Communications. Sept 30;10(1):4443. 

L.M. Taylor, P.J. McMillan, B.C. Kraemer, N.F. Liachko. 2019. Tau tubulin kinases in proteinopathy. FEBS Journal. Jul;286(13):2434-2446. 

Latimer, C. S., Burke, B. T., Liachko, N. F., Currey, H. N., Kilgore, M. D., Gibbons, L. E., . . . Keene, C. D. (2019). Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathologica Communications, 7(1). doi:10.1186/s40478-019-0743-1  [original work]

Taylor, L. M., Mcmillan, P. J., Kraemer, B. C., & Liachko, N. F. (2019). Tau tubulin kinases in proteinopathy. The FEBS Journal. doi:10.1111/febs.14866 

Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., . . . Hegde, M. L. (2019). Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects. Proceedings of the National Academy of Sciences, 116(10), 4696-4705. doi:10.1073/pnas.1818415116 

Currey, H. N., & Liachko, N. F. A CRISPR/Cas9-generated cdc-7 loss of function mutation does not cause temperature-dependent fertility defects. MicroPublication Biology. https://doi.org/10.17912/MICROPUB.BIOLOGY.000085  [original work]

L .M. Taylor, P.J. McMillan, N.F. Liachko, T. Strovas, B. Ghetti, T.D. Bird, C.D. Keene, B.C. Kraemer. 2018. Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. Molecular Neurodegeneration.  Feb 6;13(1):7. [original work]

 J.C. Weeks, C. Leasure, B.M. Suzuki, K.J. Robinson, W.M. Roberts, H. Currey, A.D. Saxton, T.D. Bird, B.C. Kraemer, J.M. Hawdon, C.R. Caffrey, N.F. Liachko.  2018. Sertraline, paroxetine, and chlorpromazine are rapidly acting anthelmintic drugs capable of clinical repurposing.  Scientific Reports.  Jan 17;8(1)975. [original work]

E.N. Guerrero, H. Wang, J. Mitra, P.M. Hegde, S.E. Stowell, N.F. Liachko, B.C. Kraemer, R.M. Garruto, K.S. Rao, M.L. Hegde. 2016. TDP-43/ FUS in motor neuron disease: Complexity and challenges.  Progress in Neurobiology. Oct-Nov; 145-146:78-97. [review]

N. F. Liachko, A. Saxton, P.J. McMillan, T.J. Strovas, H.N. Currey, L.M. Taylor, J. M. Wheeler, A.L. Oblak, B. Ghetti, T.J. Montine, C.D. Keene, M. Raskind, T.D. Bird, B.C. Kraemer.  2016.  The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.  Acta Neuropathologica. Oct; 132(4):545-61. [original work] 

A. Jablonski, T. Lamitina, N. F. Liachko, M. Sabatella, J. Liu, L. Zhang, L. Ostrow, P. Gupta, C.-Y. Wu, S. Doshi, J. Mojsilovic-Petrovic, H. Lans, J. Wang, B. Kraemer, R. Kalb.  2015.  Loss of RAD-23 protects against models of motor neuron disease by enhancing mutant protein clearance.  J Neuroscience. Oct 21:35(42):14286-306. [original work]

N. F. Liachko, P.J. McMillan, T.J. Strovas, L. Greenup, B. Ghetti, M.A. Raskind, T.J. Montine, T.D. Bird, J.B. Leverenz, B.C. Kraemer.  2014.  The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.  PLoS Genetics. Dec 4;10(12).  [original work]

I.G. Salado, M. Redondo, M.L. Bello, C. Perez, N.F. Liachko, B.C. Kraemer, L. Miguel, M. Lecourtois, C. Gil, A. Martinez, D.I. Perez. 2014. Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem. 57(6):2755-72. [original work]

N.F. Liachko, P.J. McMillan, C.R. Guthrie, T.D. Bird, J.B. Leverenz, B.C. Kraemer. 2013. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration. Annals of Neurology.  74(1):39-52. [original work]

A.V. McCormick, J.M. Wheeler, C.R. Guthrie, N.F. Liachko, B.C. Kraemer. 2013. Dopamine D2 Receptor antagonism suppresses tau aggregation and neurotoxicity. Biological Psychiatry.  73(5):464-71. [original work]

N.F. Liachko, C.R. Guthrie, B.C. Kraemer.  2010. Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.  J Neuroscience. 30(48):16208-19. [original work]

N. Liachko, R. Davidowitz, S.S. Lee. 2008. Combined informatic and expression screen identifies the novel DAF-16 target HLH-13. Developmental Biology. 327(1):97-105. [original work] 

X. Zhao, H. Shi, A. Sevilimedu, N. Liachko, HC Nelson, JT Lis.  2006.  An RNA aptamer that interferes with the DNA binding of the HSF transcription activator. Nucleic Acids Research. 34(13):3763-3769. [original work]

C.D. Link, C.P. Tomberlin, N.F. Liachko.  2016.  Cold-tolerance is a fast and easy method to identify neuronal dysfunction in C. elegans. The Worm Breeders Gazette. July 1. [original work]