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Studying the Role of Bone Morphogenetic Proteins in the Pathogenesis of Retinal Microvascular Dysfunction in Diabetic Retinopathy and Age-related Macular Degeneration.
Dr. Al-shabrawey’s findings suggested a role for BMP2 in retinal endothelial cell barrier dysfunction and hyperpermeability in diabetic retinopathy.
Bone Morphogenetic Proteins and Diabetic Retinopathy. Biomolecules. 2021 Apr 18;11(4):593.
Role of Bioactive Lipids in Neurovascular Dysfunction in Diabetic Retinopathy
Dr. Al-shabrawey’s lab has established the role of 12/15-lipoxygenase and the interaction between cytochrome-p450 and renin-angiotensin system in the development of endothelial cell dysfunction in diabetic retinopathy.
Bioactive lipids and pathological retinal angiogenesis. Br J Pharmacol. 2019 Jan;176(1):93-109.
New Model of Traumatic Optic Neuropathy (TON) and New Therapeutic Target to Mitigate Neurovascular Damage in TON
In further characterization of this model on the cellular level, we examined the response of neurons, glia, and microglia to the impact.
A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5548-5557.
Platelet/Endothelial Cell Interaction in Diabetic Retinopathy
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